hmmpfam - search one or more sequences against HMM database
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file:                 /db/iprscan/data/Pfam.bin
Sequence file:            /db/iprscan/tmp/20080502/iprscan-20080502-01560359/chunk_1/iprscan-20080502-01560359.nocrc
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Query sequence: KIAA1406
Accession:      [none]
Description:    [none]

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PF00888.12.ls Cullin family                                  328.4    1.1e-95   1
PF00888.12.fs Cullin family                                  326.8    3.4e-95   1
PF08672.1.ls Anaphase promoting complex (APC) subunit 2     114.2    3.6e-31   1
PF08672.1.fs Anaphase promoting complex (APC) subunit 2     112.2    4.1e-31   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PF00888.12.fs   1/1      70   484 ..     1   656 []   326.8  3.4e-95
PF00888.12.ls   1/1      70   484 ..     1   656 []   328.4  1.1e-95
PF08672.1.fs   1/1     506   566 ..     1    63 []   112.2  4.1e-31
PF08672.1.ls   1/1     506   566 ..     1    63 []   114.2  3.6e-31

Alignments of top-scoring domains:
PF00888.12.fs: domain 1 of 1, from 70 to 484: score 326.8, E = 3.4e-95
                   *->WekLrdaidkiltnlknfsslsymeLYtaVYnmCtstsavphklgek
                      ++++r+++++++  +++++sl+ +eL+++V+++              
    KIAA1406    70    LRRWRCHVQRFF--YRIYASLRIEELFSIVRDF-------------- 100  

                   LYnrLkeyleeyvkalrkslleisddenlLkeyikeWkdfttsmkmindi
                                                                     
    KIAA1406     - -------------------------------------------------- -    

                   fmYLdRyyvkrnidgkkevyeiyeLgLdiWrellfdnikdrlidalLelI
                                                                     
    KIAA1406     - -------------------------------------------------- -    

                   ekeRlGeaidrliknvidmlvsLgldekDmkkqklevYkedFEkpFLeaT
                                                                     
    KIAA1406     - -------------------------------------------------- -    

                   seFYkkesskfLqen.svseYmkkvEkrLeeEeeRvrlYLhsstekkLie
                               +++++++e +k++ +r +++++++              
    KIAA1406   101 ------------PDSrPAIEDLKYCLERTDQRQQLLV------------- 125  

                   vvekvLIekHletLlmehsefqLldnnkieDLrrMYrLlsRvpnGLeplr
                                                                  +l+
    KIAA1406   126 -----------------------------------------------SLK 128  

                   kilekhvkkeGlaavskla...............................
                   ++le+++ + G +++++++   +  +  +  +++    +   ++ ++  +
    KIAA1406   129 AALETRLLHPGVNTCDIITlyisaikalrvldpsmvilevacepirrylr 178  

                   ..................................................
                   +++++ ++   + +++++++++   + +++++ + +++++++++++++++
    KIAA1406   179 tredtvrqivagltgdsdgtgdlavelsktdpasletgqdseddsgeped 228  

                   .....aetdpkdyVeeLLelhdkydslvneaFnnDplFlnaLdkAfesfi
                     ++++++dp                                        
    KIAA1406   229 wvpdpVDADP---------------------------------------- 238  

                   NsnvvtkrskspELLAkYcDdlLKKgsKgleeeeleekldkiivlfkyie
                                          K++s       + ++ d+i++l+++++
    KIAA1406   239 ----------------------GKSSS-------KRRSSDIISLLVSIYG 259  

                   dKDvFekfYrkmLAkRLLngkSasLddaEkrmiskLKqvecGyefTsKLe
                   +KD+F+++Yr++LA+RLL++ S+s  + E+r++++LK  ++G++ ++ +e
    KIAA1406   260 SKDLFINEYRSLLADRLLHQFSFS-PEREIRNVELLKL-RFGEAPMHFCE 307  

                   gMfkDislSkelnnsFknhlennndnldlkledeeneEgidlsvlvLstg
                   +M+kD+ +S+++n++++++ e+++ +++          ++ +++ +Ls++
    KIAA1406   308 VMLKDMADSRRINANIREEDEKRPAEEQP---------PFGVYAVILSSE 348  

                   fWPtlp.epsinfnLPeelekalerFeefYlkkhsgpdRkLtWlhsLGkg
                   fWP++++e+   + +Pe++++ale +++ Y++ +    R L+W+h LG +
    KIAA1406   349 FWPPFKdEK---LEVPEDIRAALEAYCKKYEQLKAM--RTLSWKHTLGLV 393  

                   elkaefndgtkskyeltVstyQmavLLlFNdkeeltyeelqeatqipdde
                   ++++e+ d+t   +++ V+++Q+++LL+F+d+ ++t+eel++a ++p+++
    KIAA1406   394 TMDVELADRT---LSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVAL 440  

                   LrrtLqsLlkakvllllllryetigekspkdkeispntkfslNsdft<-*
                   Lrr+++ +l+++vl+++ +++++    +++++ ++ ++++ ++sd +   
    KIAA1406   441 LRRRMSVWLQQGVLREEPPGTFS---VIEEERPQDRDNMVLIDSDDE    484  

PF00888.12.ls: domain 1 of 1, from 70 to 484: score 328.4, E = 1.1e-95
                   *->WekLrdaidkiltnlknfsslsymeLYtaVYnmCtstsavphklgek
                      ++++r+++++++  +++++sl+ +eL+++V+++              
    KIAA1406    70    LRRWRCHVQRFF--YRIYASLRIEELFSIVRDF-------------- 100  

                   LYnrLkeyleeyvkalrkslleisddenlLkeyikeWkdfttsmkmindi
                                                                     
    KIAA1406     - -------------------------------------------------- -    

                   fmYLdRyyvkrnidgkkevyeiyeLgLdiWrellfdnikdrlidalLelI
                                                                     
    KIAA1406     - -------------------------------------------------- -    

                   ekeRlGeaidrliknvidmlvsLgldekDmkkqklevYkedFEkpFLeaT
                                                                     
    KIAA1406     - -------------------------------------------------- -    

                   seFYkkesskfLqen.svseYmkkvEkrLeeEeeRvrlYLhsstekkLie
                               +++++++e +k++ +r +++++++              
    KIAA1406   101 ------------PDSrPAIEDLKYCLERTDQRQQLLV------------- 125  

                   vvekvLIekHletLlmehsefqLldnnkieDLrrMYrLlsRvpnGLeplr
                                                                  +l+
    KIAA1406   126 -----------------------------------------------SLK 128  

                   kilekhvkkeGlaavskla...............................
                   ++le+++ + G +++++++   +  +  +  +++    +   ++ ++  +
    KIAA1406   129 AALETRLLHPGVNTCDIITlyisaikalrvldpsmvilevacepirrylr 178  

                   ..................................................
                   +++++ ++   + +++++++++   + +++++ + +++++++++++++++
    KIAA1406   179 tredtvrqivagltgdsdgtgdlavelsktdpasletgqdseddsgeped 228  

                   .....aetdpkdyVeeLLelhdkydslvneaFnnDplFlnaLdkAfesfi
                     ++++++dp                                        
    KIAA1406   229 wvpdpVDADP---------------------------------------- 238  

                   NsnvvtkrskspELLAkYcDdlLKKgsKgleeeeleekldkiivlfkyie
                                          K++s       + ++ d+i++l+++++
    KIAA1406   239 ----------------------GKSSS-------KRRSSDIISLLVSIYG 259  

                   dKDvFekfYrkmLAkRLLngkSasLddaEkrmiskLKqvecGyefTsKLe
                   +KD+F+++Yr++LA+RLL++ S+s  + E+r++++LK  ++G++ ++ +e
    KIAA1406   260 SKDLFINEYRSLLADRLLHQFSFS-PEREIRNVELLKL-RFGEAPMHFCE 307  

                   gMfkDislSkelnnsFknhlennndnldlkledeeneEgidlsvlvLstg
                   +M+kD+ +S+++n++++++ e+++ +++          ++ +++ +Ls++
    KIAA1406   308 VMLKDMADSRRINANIREEDEKRPAEEQP---------PFGVYAVILSSE 348  

                   fWPtlp.epsinfnLPeelekalerFeefYlkkhsgpdRkLtWlhsLGkg
                   fWP++++e+   + +Pe++++ale +++ Y++ +    R L+W+h LG +
    KIAA1406   349 FWPPFKdEK---LEVPEDIRAALEAYCKKYEQLKAM--RTLSWKHTLGLV 393  

                   elkaefndgtkskyeltVstyQmavLLlFNdkeeltyeelqeatqipdde
                   ++++e+ d+t   +++ V+++Q+++LL+F+d+ ++t+eel++a ++p+++
    KIAA1406   394 TMDVELADRT---LSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVAL 440  

                   LrrtLqsLlkakvllllllryetigekspkdkeispntkfslNsdft<-*
                   Lrr+++ +l+++vl+++ +++++    +++++ ++ ++++ ++sd +   
    KIAA1406   441 LRRRMSVWLQQGVLREEPPGTFS---VIEEERPQDRDNMVLIDSDDE    484  

PF08672.1.fs: domain 1 of 1, from 506 to 566: score 112.2, E = 4.1e-31
                   *->YIvGMLTNlgSLpLdRIHsMLkMfvlpkdsgytfVtqdELkeFLdgl
                      YI++MLTNl+SL+LdRI++ML+Mfv +++ + ++ +++EL+++L+++
    KIAA1406   506    YIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEI-DLQELQGYLQKK 551  

                   VaEgKLefvsGGsYkL<-*
                   V++++L + s G+Y+L   
    KIAA1406   552 VRDQQLVY-SAGVYRL    566  

PF08672.1.ls: domain 1 of 1, from 506 to 566: score 114.2, E = 3.6e-31
                   *->YIvGMLTNlgSLpLdRIHsMLkMfvlpkdsgytfVtqdELkeFLdgl
                      YI++MLTNl+SL+LdRI++ML+Mfv +++ + ++ +++EL+++L+++
    KIAA1406   506    YIQAMLTNLESLSLDRIYNMLRMFVVTGPALAEI-DLQELQGYLQKK 551  

                   VaEgKLefvsGGsYkL<-*
                   V++++L + s G+Y+L   
    KIAA1406   552 VRDQQLVY-SAGVYRL    566  

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