hmmpfam - search one or more sequences against HMM database
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file:                 /db/iprscan/data/Pfam.bin
Sequence file:            /db/iprscan/tmp/20080502/iprscan-20080502-00543670/chunk_1/iprscan-20080502-00543670.nocrc
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Query sequence: KIAA1369
Accession:      [none]
Description:    [none]

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
PF00069.15.fs Protein kinase domain                       185.4    1.3e-52   2
PF00069.15.ls Protein kinase domain                       160.6    3.8e-45   1
PF07714.7.fs Protein tyrosine kinase                      45.4    4.5e-13   3

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
PF00069.15.fs   1/2     190   262 ..     1    75 [.    69.6  1.2e-19
PF07714.7.fs   1/3     190   250 ..     1    68 [.    18.7  2.4e-05
PF00069.15.ls   1/1     190   606 ..     1   287 []   160.6  3.8e-45
PF00069.15.fs   2/2     403   606 ..    75   287 .]   115.9  8.4e-33
PF07714.7.fs   2/3     455   488 ..   128   160 ..    24.4  5.5e-07

Alignments of top-scoring domains:
PF00069.15.fs: domain 1 of 2, from 190 to 262: score 69.6, E = 1.2e-19
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      +e l +lG+G++G+Vyk ++k +g+ +A+K+i  +++ + +++  +r
    KIAA1369   190    FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR 236  

                   lsEiqilkrLsHpNIvrlidvfedkdhl<-*
                     E+++l+ L+HpNIv ++ ++ ++ h+   
    KIAA1369   237 --EVKVLAGLQHPNIVGYHTAWIEHVHV    262  

PF07714.7.fs: domain 1 of 3, from 190 to 250: score 18.7, E = 2.4e-05
                   *->lklgkkLGeGaFGeVyk......GtlkgsgdgteikVAVKtL.keig
                      ++ +  LG+G +G+Vyk +++ +G ++          A+K++  + g
    KIAA1369   190    FEELAILGKGGYGRVYKvrnkldGQYY----------AIKKIlIK-G 225  

                   aseeeieredFlrEAsiMkklGdHpNiV<-*
                   a+   +   + lrE++++  l +HpNiV   
    KIAA1369   226 ATKTVC--MKVLREVKVLAGL-QHPNIV    250  

PF00069.15.ls: domain 1 of 1, from 190 to 606: score 160.6, E = 3.8e-45
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      +e l +lG+G++G+Vyk ++k +g+ +A+K+i  +++ + +++  +r
    KIAA1369   190    FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLR 236  

                   lsEiqilkrLsHpNIvrlidvfed..........................
                     E+++l+ L+HpNIv ++ ++ ++ +  +++ ++   + ++ +  ++++
    KIAA1369   237 --EVKVLAGLQHPNIVGYHTAWIEhvhviqpradraaielpslevlsdqe 284  

                   ..................................................
                   +++++ + +++++++++    +++++++++ ++++++++++++ + +++ 
    KIAA1369   285 edreqcgvkndesssssiifaeptpekekrfgesdtenqnnksvkyttnl 334  

                   ..................................................
                     +++++ +++ + ++++  + + ++  +++ + +++++ +++ ++++++
    KIAA1369   335 viresgelestlelqenglaglsassiveqqlplrrnshleesftstees 384  

                   ...............kdhlylVlEycegGLrvldLfdyls......e...
                   ++++ +  ++++ + +  l++ + +ce      +L+d++ ++++++++  
    KIAA1369   385 seenvnflgqteaqyHLMLHIQMQLCEL-----SLWDWIVernkrgReyv 429  

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.nng
                   +++ +p+    ++a ki+ ++++g+ Y+H++gi+HRDLKP NI+l++ + 
    KIAA1369   430 DESACPY-VMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQ 478  

                   vvdaflKiaDFGlAkkls............t.sss.lttfvGTpwYmAPE
                   +v    Ki+DFGlA+  +  +++++ ++++ ++ ++ t++vGT  Y++PE
    KIAA1369   479 QV----KIGDFGLACT-DilqkntdwtnrnGkRTPtHTSRVGTCLYASPE 523  

                   vllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilg
                    l  g++y+ k+D++SlGv+l el+    PF  e        +++   + 
    KIAA1369   524 QLE-GSEYDAKSDMYSLGVVLLELFQ---PFGTE----MERAEVLTGLRT 565  

                   pplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeil
                   ++l+++  + ++++               + i  + +++ s+R++a ++l
    KIAA1369   566 GQLPESLRKRCPVQ--------------AKYIQHLTRRNSSQRPSAIQLL 601  

                   qHPwf<-*
                   q++ f   
    KIAA1369   602 QSELF    606  

PF00069.15.fs: domain 2 of 2, from 403 to 606: score 115.9, E = 8.4e-33
                   *->lylVlEycegGLrvldLfdyls......e...trrkgpllfsedeak
                      l++ + +ce      +L+d++ ++++++++  +++ +p+    ++a 
    KIAA1369   403    LHIQMQLCEL-----SLWDWIVernkrgReyvDESACPY-VMANVAT 443  

                   kialQilrgleYLHsngiiHRDLKPeNILld.nngvvdaflKiaDFGlAk
                   ki+ ++++g+ Y+H++gi+HRDLKP NI+l++ + +v    Ki+DFGlA+
    KIAA1369   444 KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQV----KIGDFGLAC 489  

                   kls............t.sss.lttfvGTpwYmAPEvllggngygtkvDvW
                     +  +++++ ++++ ++ ++ t++vGT  Y++PE l  g++y+ k+D++
    KIAA1369   490 T-DilqkntdwtnrnGkRTPtHTSRVGTCLYASPEQLE-GSEYDAKSDMY 537  

                   SlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsisr
                   SlGv+l el+    PF  e        +++   + ++l+++  + ++++ 
    KIAA1369   538 SLGVVLLELFQ---PFGTE----MERAEVLTGLRTGQLPESLRKRCPVQ- 579  

                   sefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-*
                                 + i  + +++ s+R++a ++lq++ f   
    KIAA1369   580 -------------AKYIQHLTRRNSSQRPSAIQLLQSELF    606  

PF07714.7.fs: domain 2 of 3, from 455 to 488: score 24.4, E = 5.5e-07
                   *->YLesknfvHRDLAARNcLVsenl.vVKIsDFGLa<-*
                      Y +++++vHRDL  RN+ ++ + ++VKI+DFGLa   
    KIAA1369   455    YIHNMGIVHRDLKPRNIFLHGPDqQVKIGDFGLA    488  

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