# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/fg04370.fasta.nr -Q ../query/KIAA1299.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1299, 730 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7820235 sequences Expectation_n fit: rho(ln(x))= 6.3217+/-0.000202; mu= 8.6325+/- 0.011 mean_var=124.9622+/-23.741, 0's: 29 Z-trim: 36 B-trim: 5 in 1/66 Lambda= 0.114732 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|119572385|gb|EAW52000.1| SH2-B homolog, isoform ( 671) 4610 774.6 0 gi|8163911|gb|AAF73913.1|AF227968_1 SH2-B beta sig ( 671) 4605 773.7 0 gi|158261687|dbj|BAF83021.1| unnamed protein produ ( 671) 4596 772.2 0 gi|73958600|ref|XP_849871.1| PREDICTED: similar to ( 671) 4458 749.4 9.8e-214 gi|149725790|ref|XP_001502284.1| PREDICTED: SH2B a ( 671) 4383 737.0 5.4e-210 gi|194678406|ref|XP_872072.3| PREDICTED: similar t ( 670) 4363 733.7 5.3e-209 gi|119572384|gb|EAW51999.1| SH2-B homolog, isoform ( 683) 4327 727.7 3.4e-207 gi|8163913|gb|AAF73914.1|AF227969_1 SH2-B gamma si ( 683) 4322 726.9 5.9e-207 gi|119572386|gb|EAW52001.1| SH2-B homolog, isoform ( 756) 4316 725.9 1.3e-206 gi|172046610|sp|Q9NRF2.2|SH2B1_HUMAN RecName: Full ( 756) 4311 725.1 2.3e-206 gi|193786184|dbj|BAG51467.1| unnamed protein produ ( 756) 4311 725.1 2.3e-206 gi|148685415|gb|EDL17362.1| SH2B adaptor protein 1 ( 670) 4277 719.4 1e-204 gi|2772908|gb|AAC33414.1| Pro-rich, PH and SH2 dom ( 670) 4273 718.8 1.6e-204 gi|149067906|gb|EDM17458.1| SH2-B PH domain contai ( 670) 4256 716.0 1.1e-203 gi|2920648|gb|AAC04575.1| SH2 domain-containing ad ( 670) 4244 714.0 4.5e-203 gi|148685424|gb|EDL17371.1| SH2B adaptor protein 1 ( 770) 4181 703.6 6.9e-200 gi|149725792|ref|XP_001502291.1| PREDICTED: SH2B a ( 757) 4127 694.7 3.3e-197 gi|109128054|ref|XP_001096611.1| PREDICTED: simila ( 747) 4079 686.7 8.1e-195 gi|148685421|gb|EDL17368.1| SH2B adaptor protein 1 ( 682) 4040 680.2 6.7e-193 gi|148685419|gb|EDL17366.1| SH2B adaptor protein 1 ( 724) 4037 679.7 9.9e-193 gi|16226081|gb|AAL16070.1|AF421139_1 Pro-rich, PH ( 682) 4036 679.6 1.1e-192 gi|15787983|gb|AAL07566.1| PSM/SH2-B delta [Mus mu ( 724) 4033 679.1 1.6e-192 gi|148685417|gb|EDL17364.1| SH2B adaptor protein 1 ( 756) 4031 678.8 2e-192 gi|172045833|sp|Q91ZM2.2|SH2B1_MOUSE RecName: Full ( 756) 4027 678.1 3.2e-192 gi|149067907|gb|EDM17459.1| SH2-B PH domain contai ( 682) 4014 675.9 1.3e-191 gi|149067915|gb|EDM17467.1| SH2-B PH domain contai ( 724) 4013 675.8 1.5e-191 gi|81863196|sp|Q62985.1|SH2B1_RAT RecName: Full=SH ( 756) 4005 674.5 4e-191 gi|4884171|emb|CAB43208.1| hypothetical protein [H ( 540) 3349 565.7 1.5e-158 gi|148685423|gb|EDL17370.1| SH2B adaptor protein 1 ( 498) 3067 519.0 1.6e-144 gi|149067911|gb|EDM17463.1| SH2-B PH domain contai ( 517) 3040 514.6 3.7e-143 gi|14042200|dbj|BAB55148.1| unnamed protein produc ( 426) 2942 498.3 2.4e-138 gi|14715079|gb|AAH10704.1| SH2B1 protein [Homo sap ( 426) 2937 497.5 4.3e-138 gi|148685420|gb|EDL17367.1| SH2B adaptor protein 1 ( 659) 2748 466.3 1.6e-128 gi|5305448|gb|AAD41655.1|AF074329_1 SH2-B PH domai ( 662) 2738 464.7 4.9e-128 gi|116283254|gb|AAH11422.1| Sh2b1 protein [Mus mus ( 443) 2733 463.7 6.5e-128 gi|149067909|gb|EDM17461.1| SH2-B PH domain contai ( 437) 2720 461.5 2.9e-127 gi|149067910|gb|EDM17462.1| SH2-B PH domain contai ( 443) 2720 461.6 2.9e-127 gi|119572387|gb|EAW52002.1| SH2-B homolog, isoform ( 405) 2395 407.7 4.2e-111 gi|194386066|dbj|BAG59597.1| unnamed protein produ ( 335) 2320 395.2 2e-107 gi|194391288|dbj|BAG60762.1| unnamed protein produ ( 373) 2171 370.6 5.8e-100 gi|114661868|ref|XP_001138906.1| PREDICTED: hypoth ( 438) 2106 359.9 1.1e-96 gi|148685422|gb|EDL17369.1| SH2B adaptor protein 1 ( 206) 1371 238.0 2.7e-60 gi|149067916|gb|EDM17468.1| SH2-B PH domain contai ( 206) 1363 236.6 6.9e-60 gi|149067918|gb|EDM17470.1| SH2-B PH domain contai ( 260) 1120 196.5 1e-47 gi|149067917|gb|EDM17469.1| SH2-B PH domain contai ( 292) 1112 195.2 2.8e-47 gi|194170043|gb|EDW84944.1| GK12864 [Drosophila wi ( 769) 827 148.4 9.1e-33 gi|194152657|gb|EDW68091.1| GJ22738 [Drosophila vi ( 765) 812 146.0 5.1e-32 gi|54638936|gb|EAL28338.1| GA14482 [Drosophila pse ( 718) 811 145.8 5.4e-32 gi|194111986|gb|EDW34029.1| GL21796 [Drosophila pe ( 722) 811 145.8 5.4e-32 gi|193899731|gb|EDV98597.1| GH22307 [Drosophila gr ( 744) 802 144.3 1.6e-31 >>gi|119572385|gb|EAW52000.1| SH2-B homolog, isoform CRA (671 aa) initn: 4610 init1: 4610 opt: 4610 Z-score: 4129.4 bits: 774.6 E(): 0 Smith-Waterman score: 4610; 100.000% identity (100.000% similar) in 671 aa overlap (60-730:1-671) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|119 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::::::::::::::::::::::::::::::::::::::::: gi|119 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP 640 650 660 670 >>gi|8163911|gb|AAF73913.1|AF227968_1 SH2-B beta signali (671 aa) initn: 4605 init1: 4605 opt: 4605 Z-score: 4124.9 bits: 773.7 E(): 0 Smith-Waterman score: 4605; 99.851% identity (100.000% similar) in 671 aa overlap (60-730:1-671) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|816 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: gi|816 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::::::::::::::::::::::::::::::::::::::::: gi|816 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP 640 650 660 670 >>gi|158261687|dbj|BAF83021.1| unnamed protein product [ (671 aa) initn: 4596 init1: 4596 opt: 4596 Z-score: 4116.9 bits: 772.2 E(): 0 Smith-Waterman score: 4596; 99.702% identity (99.851% similar) in 671 aa overlap (60-730:1-671) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|158 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: gi|158 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGDSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 GEPEGGEGGQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|158 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::::::::::::::::::::::::::::::::::::::::: gi|158 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP 640 650 660 670 >>gi|73958600|ref|XP_849871.1| PREDICTED: similar to SH2 (671 aa) initn: 4458 init1: 4458 opt: 4458 Z-score: 3993.4 bits: 749.4 E(): 9.8e-214 Smith-Waterman score: 4458; 96.572% identity (98.510% similar) in 671 aa overlap (60-730:1-671) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::: ::::::::::::::: gi|739 MNGAPSPEDGASPSPPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK ::::::::.:: :::::::::::::::::::::::::::::::::::::::::::::::: gi|739 ILAPLSPGVEIPPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::.: gi|739 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSPAGPLETSSGPPVLGGNSNSNSSGGAGTIG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::.:: gi|739 RGLVSDGTSPGDRWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGMGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::.::: ::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|739 GGGAAGPTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::.::.:: :::::::::::::::::::.:::::::: gi|739 TTTALEMPDRENTFVVKVEGPSEYILETTDALHVKAWVSDIQECLSPGPCPSTSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: gi|739 PLAPGTSFLTRENTDSLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: gi|739 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :: :::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|739 GESEGGEGDQPLSGYPWFHGMLSRLKAAQLVLAGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: gi|739 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVVSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::::::::::::::::: :.:::: ::::::::::::.::: gi|739 QQGREQAGSHAGVCEGDRCYPDASSTLMPFGASDCVTEHLP 640 650 660 670 >>gi|149725790|ref|XP_001502284.1| PREDICTED: SH2B adapt (671 aa) initn: 4383 init1: 4383 opt: 4383 Z-score: 3926.3 bits: 737.0 E(): 5.4e-210 Smith-Waterman score: 4383; 94.933% identity (97.466% similar) in 671 aa overlap (60-730:1-671) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC ::::: :::::::: ::::::::::::::: gi|149 MNGAPPPEDGASPSPPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|149 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK .::::::..:: :::::::::::::::.:::: ::::::::::::::::::::::::::: gi|149 VLAPLSPSVEIPPHDLSLESCRVGGPLSVLGPFRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::: :::::::::::::::::::::::::::.: gi|149 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSPAGPLETSSGPPVLGGNSNSNSSGGAGTIG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR ::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::: gi|149 RGLVSDATSPGDRWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::.::: ::::::::::::::::::::::::::::::::::::::::::::::.::::: gi|149 GGGAAGPTSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSTITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::.::.:: :::::::::::::::::::::::.:::: gi|149 TTTALEMPDRENTFVVKVEGPSEYILETADALHVKAWVSDIQECLSPGPCPATSPHPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI ::::::::::::: ::::: :::::::::::::::::::::::::::::::::::::::: gi|149 PLAPGTSFLTRENIDSLELPCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ ::::::: :::::::::::::::::::::::::.:::::: ::::::::::::::::::: gi|149 SPSSASINASHFDSMELLPPELPPRIPIEEGPPAGTVHPLPAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :: :: ::::::::::::::::::::::::::.:: :::::::::::::::::::::::: gi|149 GESEGREGDQPLSGYPWFHGMLSRLKAAQLVLAGGPGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::. gi|149 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVVSSQQ 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::::::::::::::::: :.:::: ::::::::::::.::: gi|149 QQGREQAGSHAGVCEGDRCYPDASSTLMPFGASDCVTEHLP 640 650 660 670 >>gi|194678406|ref|XP_872072.3| PREDICTED: similar to SH (670 aa) initn: 2438 init1: 2438 opt: 4363 Z-score: 3908.5 bits: 733.7 E(): 5.3e-209 Smith-Waterman score: 4363; 94.784% identity (97.914% similar) in 671 aa overlap (60-730:1-670) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::: ::::::::::::::: gi|194 MNGAPSPEDGASPSPPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK .:::::::.:. ::::::::::.::::::::::::::::::::::::::::::::::::: gi|194 LLAPLSPGVEVPPHDLSLESCRAGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::: ::::::.::::.::::::::::::::::. gi|194 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSPAGPLETASGPPALGGNSNSNSSGGAGTVS 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::.:::::::::::::::::::::::.:::::::::::::::::::::::: gi|194 RGLVSDGTSPGDRWTHRFERLRLSRGGGALKDGAGVVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::.::: :::::::::::::::::::::::: :::::::::::::::::::::.::::: gi|194 GGGAAGPTSGGGGQPQWQKCRLLLRSEGEGGG-SRLEFFVPPKASRPRLSIPCSTITDVR 280 290 300 310 320 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::.::.:: ::::::::::::::::: :::::::::: gi|194 TTTALEMPDRENTFVVKVEGPSEYILETADALHVKAWVSDIQECLSPGPYPATSPRPMTL 330 340 350 360 370 380 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::: :::: :::::: ::::::::.::::::::::::::::::: gi|194 PLAPGTSFLTRENTDSLEPPCLNHLESLPSQGLLLGPSESSDRLSQGAYGGLSDRPSASI 390 400 410 420 430 440 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::.::::::.:::::::::::::::.::: gi|194 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLAAPYPPLDTPETATGSLLFQ 450 460 470 480 490 500 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: gi|194 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLAGGTGSHGVFLVRQSETRRGEYVLTFNF 510 520 530 540 550 560 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::.::::::::::::::::::: :::: gi|194 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRMHPIPLESGGSSDVVLVSYVVSSQR 570 580 590 600 610 620 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::::::::::::::::: :.:::: ::::::::::::.::: gi|194 QQGREQAGSHAGVCEGDRCYPDASSTLMPFGASDCVTEHLP 630 640 650 660 670 >>gi|119572384|gb|EAW51999.1| SH2-B homolog, isoform CRA (683 aa) initn: 4451 init1: 4322 opt: 4327 Z-score: 3876.1 bits: 727.7 E(): 3.4e-207 Smith-Waterman score: 4337; 94.298% identity (95.906% similar) in 684 aa overlap (60-729:1-681) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|119 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQG--------------REQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::: : .:::. :. .: : . . : :: : .: .... gi|119 QQGEQSRSAGEEVPVHPRSEAGSRLGAMRG--CAREMDATPMP-PAPSCPSERVTV 640 650 660 670 680 >>gi|8163913|gb|AAF73914.1|AF227969_1 SH2-B gamma signal (683 aa) initn: 4446 init1: 4317 opt: 4322 Z-score: 3871.7 bits: 726.9 E(): 5.9e-207 Smith-Waterman score: 4332; 94.152% identity (95.906% similar) in 684 aa overlap (60-729:1-681) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|816 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: gi|816 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|816 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQG--------------REQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP ::: : .:::. :. .: : . . : :: : .: .... gi|816 QQGEQSRSAGEEVPVHPRSEAGSRLGAMRG--CAREMDATPMP-PAPSCPSERVTV 640 650 660 670 680 >>gi|119572386|gb|EAW52001.1| SH2-B homolog, isoform CRA (756 aa) initn: 4312 init1: 4312 opt: 4316 Z-score: 3865.7 bits: 725.9 E(): 1.3e-206 Smith-Waterman score: 4316; 99.219% identity (99.375% similar) in 640 aa overlap (60-699:1-638) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|119 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP :: : . :: gi|119 QQ--EPTTSHDPPQPPEPPSWTDPPQPGAEEASRAPEVAAAAAAAAKERQEKEKAGGGGV 640 650 660 670 680 >>gi|172046610|sp|Q9NRF2.2|SH2B1_HUMAN RecName: Full=SH2 (756 aa) initn: 4307 init1: 4307 opt: 4311 Z-score: 3861.3 bits: 725.1 E(): 2.3e-206 Smith-Waterman score: 4311; 99.062% identity (99.375% similar) in 640 aa overlap (60-699:1-638) 30 40 50 60 70 80 KIAA12 FAAAAAHPSSSGCLPLCAPQAPPLHLLGPIMNGAPSPEDGASPSSPPLPPPPPPSWREFC :::::::::::::::::::::::::::::: gi|172 MNGAPSPEDGASPSSPPLPPPPPPSWREFC 10 20 30 90 100 110 120 130 140 KIAA12 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 ESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELFLQHFEAEVARASGSLSPP 40 50 60 70 80 90 150 160 170 180 190 200 KIAA12 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 ILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLK 100 110 120 130 140 150 210 220 230 240 250 260 KIAA12 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 KRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSSGPPVLGGNSNSNSSGGAGTVG 160 170 180 190 200 210 270 280 290 300 310 320 KIAA12 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 RGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGAEEAAPDPAGVGR 220 230 240 250 260 270 330 340 350 360 370 380 KIAA12 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 GGGVAGPPSGGGGQPQWQKCRLLLRSEGEGGGGSRLEFFVPPKASRPRLSIPCSSITDVR 280 290 300 310 320 330 390 400 410 420 430 440 KIAA12 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWVSDIQECLSPGPCPATSPRPMTL 340 350 360 370 380 390 450 460 470 480 490 500 KIAA12 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 PLAPGTSFLTRENTDSLELSCLNHSESLPSQDLLLGPSESNDRLSQGAYGGLSDRPSASI 400 410 420 430 440 450 510 520 530 540 550 560 KIAA12 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPLDTPETATGSFLFQ :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: gi|172 SPSSASIAASHFDSMELLPPELPPRIPIEEGPPAGTVHPLSAPYPPLDTPETATGSFLFQ 460 470 480 490 500 510 570 580 590 600 610 620 KIAA12 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 GEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNF 520 530 540 550 560 570 630 640 650 660 670 680 KIAA12 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|172 QGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLVSYVPSSQR 580 590 600 610 620 630 690 700 710 720 730 KIAA12 QQGREQAGSHAGVCEGDGCHPDASCTLMPFGASDCVTDHLP :: : . :: gi|172 QQ--EPTTSHDPPQPPEPPSWTDPPQPGAEEASRAPEVAAAAAAAAKERQEKEKAGGGGV 640 650 660 670 680 730 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Wed Mar 4 09:01:32 2009 done: Wed Mar 4 09:05:24 2009 Total Scan time: 1669.720 Total Display time: 0.380 Function used was FASTA [version 34.26.5 April 26, 2007]