hmmpfam - search one or more sequences against HMM database
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file:                 /db/iprscan/data/Pfam.bin
Sequence file:            /db/iprscan/tmp/20080501/iprscan-20080501-21515809/chunk_1/iprscan-20080501-21515809.nocrc
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Query sequence: KIAA1260
Accession:      [none]
Description:    [none]

Scores for sequence family classification (score includes all domains):
Model      Description                                  Score    E-value  N 
--------   -----------                                  -----    ------- ---
PF00135.18.ls Carboxylesterase                             740.7     9e-220   1
PF00135.18.fs Carboxylesterase                             738.6   3.7e-219   1

Parsed for domains:
Model      Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------   ------- ----- -----    ----- -----      -----  -------
PF00135.18.fs   1/1      26   591 ..     1   592 []   738.6 3.7e-219
PF00135.18.ls   1/1      26   591 ..     1   592 []   740.7   9e-220

Alignments of top-scoring domains:
PF00135.18.fs: domain 1 of 1, from 26 to 591: score 738.6, E = 3.7e-219
                   *->mllllllllllllflavvataptspedpvVeTsyvgGkvrGlrvkvd
                       ll+l+ l++ ++++ ++a+   +    vV+T+y  Gk+rGlr +  
    KIAA1260    26    VLLWLTALAIKFTLIDSQAQY--P----VVNTNY--GKIRGLRTPLP 64   

                   g.gnkpvyaFlGIPYAkPPvGeLRFkkPqPpepWtgvldATkygpaCpQ.
                   +++ +pv+++lG+PYA PP+Ge+RF++P+Pp++Wtg++++T+++++CpQ+
    KIAA1260    65 NeILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQh 114  

                   ndlgfpgfslal.h.vgsemwnkntg......ksmSEDCLYLNVytPkla
                    d+       +l h++++ ++++n+ +  +  +++ EDCLYLN+y+P+ +
    KIAA1260   115 LDER------SLlHdMLPIWFTANLDtlmtyvQDQNEDCLYLNIYVPTED 158  

                   senk...klPVmVwIHGGGFqsGsassvslddydgpdlaasedVVVVtiN
                   +  ++++k PVmV+IHGG +++G++     ++ dg++la++++V+V+tiN
    KIAA1260   159 DIHDqnsKKPVMVYIHGGSYMEGTG-----NMIDGSILASYGNVIVITIN 203  

                   YRLGalGFLstgdselppppGNaGLlDQvlALrWVqeNIaaFGGDPdnVT
                   YRLG+lGFLstgd+ ++   GN+GLlDQ++ALrW+ eN+ aFGGDP++VT
    KIAA1260   204 YRLGILGFLSTGDQAAK---GNYGLLDQIQALRWIEENVGAFGGDPKRVT 250  

                   lFGeSAGAaSVsllllSppqsrGLFhrAIlqSGsalspwaitsppearnr
                   +FG +AGA++Vsll+lS  +s+GLF++AI+qSG+als+wa++++p   ++
    KIAA1260   251 IFGSGAGASCVSLLTLS-HYSEGLFQKAIIQSGTALSSWAVNYQP--AKY 297  

                   akrlAkllGCpgedseelveCLRkksaeelldaqwklllleefgffplfp
                   ++ lA ++GC++ d +++veCLR+k+ +el+ ++    ++++   f    
    KIAA1260   298 TRILADKVGCNMLDTTDMVECLRNKNYKELIQQTI--TPATYHIAFG--- 342  

                   FgPVvdGdtpdaflpkdPeellkegnfnkvPlliGvtsdEGllflayvl.
                     PV+dGd    ++p+dP++l+++g+f ++++++Gv++ EGl f+  + +
    KIAA1260   343 --PVIDGD----VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVd 386  

                   dp.lsadllseidnedlflellpellpgase.steklreeiadaikeeYt
                   +++ +       d+++   +++ ++l+g++e++     + ++++ik++Yt
    KIAA1260   387 NEdGV----TPNDFDF-SVSNFVDNLYGYPEgK-----DTLRETIKFMYT 426  

                   dddd.nseesrrdalldllsDylFvcPilrlalaraakagspvYlYrFdy
                   d++d+ ++e+rr+ l+ l++D+++v+P +++ ++ +a++gsp+Y+Y F +
    KIAA1260   427 DWADkENPETRRKTLVALFTDHQWVAP-AVATADLHAQYGSPTYFYAFYH 475  

                   rssdsfnqyrinllwppwrgvsHgdelsYvFGnpls.k.ly....sseee
                   ++          +++p w    Hgde++YvFG p++++++  + ++s+ +
    KIAA1260   476 HCQ--------SEMKPSWADSAHGDEVPYVFGIPMIgPtELfscnFSKND 517  

                   emlssrrmmrywtnFAktGnPN.............ngessglvkWppytk
                   +mls +++m+ywtnFAktG+PN++ +++++  +++++  +++v W +y++
    KIAA1260   518 VMLS-AVVMTYWTNFAKTGDPNqpvpqdtkfihtkPNR-FEEVAWSKYNP 565  

                   eeqkyylpitllnitqk.lreedPrkvkcafw<-*
                   ++q  yl+i+l++++++++r+++     +afw   
    KIAA1260   566 KDQ-LYLHIGLKPRVRDhYRATK-----VAFW    591  

PF00135.18.ls: domain 1 of 1, from 26 to 591: score 740.7, E = 9e-220
                   *->mllllllllllllflavvataptspedpvVeTsyvgGkvrGlrvkvd
                       ll+l+ l++ ++++ ++a+   +    vV+T+y  Gk+rGlr +  
    KIAA1260    26    VLLWLTALAIKFTLIDSQAQY--P----VVNTNY--GKIRGLRTPLP 64   

                   g.gnkpvyaFlGIPYAkPPvGeLRFkkPqPpepWtgvldATkygpaCpQ.
                   +++ +pv+++lG+PYA PP+Ge+RF++P+Pp++Wtg++++T+++++CpQ+
    KIAA1260    65 NeILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQh 114  

                   ndlgfpgfslal.h.vgsemwnkntg......ksmSEDCLYLNVytPkla
                    d+       +l h++++ ++++n+ +  +  +++ EDCLYLN+y+P+ +
    KIAA1260   115 LDER------SLlHdMLPIWFTANLDtlmtyvQDQNEDCLYLNIYVPTED 158  

                   senk...klPVmVwIHGGGFqsGsassvslddydgpdlaasedVVVVtiN
                   +  ++++k PVmV+IHGG +++G++     ++ dg++la++++V+V+tiN
    KIAA1260   159 DIHDqnsKKPVMVYIHGGSYMEGTG-----NMIDGSILASYGNVIVITIN 203  

                   YRLGalGFLstgdselppppGNaGLlDQvlALrWVqeNIaaFGGDPdnVT
                   YRLG+lGFLstgd+ ++   GN+GLlDQ++ALrW+ eN+ aFGGDP++VT
    KIAA1260   204 YRLGILGFLSTGDQAAK---GNYGLLDQIQALRWIEENVGAFGGDPKRVT 250  

                   lFGeSAGAaSVsllllSppqsrGLFhrAIlqSGsalspwaitsppearnr
                   +FG +AGA++Vsll+lS  +s+GLF++AI+qSG+als+wa++++p   ++
    KIAA1260   251 IFGSGAGASCVSLLTLS-HYSEGLFQKAIIQSGTALSSWAVNYQP--AKY 297  

                   akrlAkllGCpgedseelveCLRkksaeelldaqwklllleefgffplfp
                   ++ lA ++GC++ d +++veCLR+k+ +el+ ++    ++++   f    
    KIAA1260   298 TRILADKVGCNMLDTTDMVECLRNKNYKELIQQTI--TPATYHIAFG--- 342  

                   FgPVvdGdtpdaflpkdPeellkegnfnkvPlliGvtsdEGllflayvl.
                     PV+dGd    ++p+dP++l+++g+f ++++++Gv++ EGl f+  + +
    KIAA1260   343 --PVIDGD----VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVd 386  

                   dp.lsadllseidnedlflellpellpgase.steklreeiadaikeeYt
                   +++ +       d+++   +++ ++l+g++e++     + ++++ik++Yt
    KIAA1260   387 NEdGV----TPNDFDF-SVSNFVDNLYGYPEgK-----DTLRETIKFMYT 426  

                   dddd.nseesrrdalldllsDylFvcPilrlalaraakagspvYlYrFdy
                   d++d+ ++e+rr+ l+ l++D+++v+P +++ ++ +a++gsp+Y+Y F +
    KIAA1260   427 DWADkENPETRRKTLVALFTDHQWVAP-AVATADLHAQYGSPTYFYAFYH 475  

                   rssdsfnqyrinllwppwrgvsHgdelsYvFGnpls.k.ly....sseee
                   ++          +++p w    Hgde++YvFG p++++++  + ++s+ +
    KIAA1260   476 HCQ--------SEMKPSWADSAHGDEVPYVFGIPMIgPtELfscnFSKND 517  

                   emlssrrmmrywtnFAktGnPN.............ngessglvkWppytk
                   +mls +++m+ywtnFAktG+PN++ +++++  +++++  +++v W +y++
    KIAA1260   518 VMLS-AVVMTYWTNFAKTGDPNqpvpqdtkfihtkPNR-FEEVAWSKYNP 565  

                   eeqkyylpitllnitqk.lreedPrkvkcafw<-*
                   ++q  yl+i+l++++++++r+++     +afw   
    KIAA1260   566 KDQ-LYLHIGLKPRVRDhYRATK-----VAFW    591  

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