hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-21450705/chunk_1/iprscan-20080501-21450705.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1256 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00018.18.ls SH3 domain 327.8 1.8e-95 5 PF00018.18.fs SH3 domain 318.4 1.2e-92 5 PF07653.7.ls Variant SH3 domain 217.3 3.2e-62 5 PF07653.7.fs Variant SH3 domain 208.4 1.5e-59 5 PF00621.11.fs RhoGEF domain 106.5 2.9e-31 1 PF00168.20.fs C2 domain 104.3 1.9e-30 1 PF00621.11.ls RhoGEF domain 108.3 2.1e-29 1 PF00168.20.ls C2 domain 106.2 8.9e-29 1 PF00036.22.ls EF hand 47.2 5.1e-11 2 PF00036.22.fs EF hand 43.2 9.8e-11 2 PF00169.19.fs PH domain 25.4 2.8e-07 1 PF00169.19.ls PH domain 27.4 4.7e-05 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00036.22.ls 1/2 64 92 .. 1 29 [] 23.6 0.00065 PF00036.22.fs 1/2 64 92 .. 1 29 [] 21.6 7.7e-05 PF00036.22.fs 2/2 287 315 .. 1 29 [] 21.6 7.7e-05 PF00036.22.ls 2/2 287 315 .. 1 29 [] 23.6 0.00065 PF00018.18.ls 1/5 739 795 .. 1 59 [] 64.8 2.5e-16 PF07653.7.ls 1/5 740 795 .. 1 69 [] 23.7 0.00063 PF00018.18.fs 1/5 741 795 .. 3 59 .] 63.1 1.7e-16 PF00018.18.fs 2/5 880 933 .. 1 59 [] 50.9 3.8e-13 PF00018.18.ls 2/5 880 933 .. 1 59 [] 52.8 1e-12 PF07653.7.ls 2/5 881 933 .. 1 69 [] 60.7 4.6e-15 PF07653.7.fs 2/5 881 933 .. 1 69 [] 58.9 2.5e-16 PF00018.18.fs 3/5 963 1016 .. 1 59 [] 73.8 2.1e-19 PF00018.18.ls 3/5 963 1016 .. 1 59 [] 75.7 1.4e-19 PF07653.7.ls 3/5 964 1016 .. 1 69 [] 37.1 5.7e-08 PF07653.7.fs 3/5 964 1016 .. 1 69 [] 35.3 1.6e-09 PF00018.18.ls 4/5 1035 1094 .. 1 59 [] 47.5 4.2e-11 PF00018.18.fs 4/5 1035 1094 .. 1 59 [] 45.5 1.1e-11 PF07653.7.ls 4/5 1036 1094 .. 1 69 [] 39.7 9e-09 PF07653.7.fs 4/5 1036 1094 .. 1 69 [] 37.9 2.8e-10 PF00018.18.ls 5/5 1109 1163 .. 1 59 [] 87.0 5.4e-23 PF00018.18.fs 5/5 1109 1163 .. 1 59 [] 85.1 1.7e-22 PF07653.7.fs 5/5 1110 1162 .. 1 69 [] 54.4 5e-15 PF07653.7.ls 5/5 1110 1162 .. 1 69 [] 56.1 1e-13 PF00621.11.fs 1/1 1192 1373 .. 1 207 [] 106.5 2.9e-31 PF00621.11.ls 1/1 1192 1373 .. 1 207 [] 108.3 2.1e-29 PF00169.19.ls 1/1 1414 1523 .. 1 92 [] 27.4 4.7e-05 PF00169.19.fs 1/1 1414 1523 .. 1 92 [] 25.4 2.8e-07 PF00168.20.fs 1/1 1550 1631 .. 1 88 [] 104.3 1.9e-30 PF00168.20.ls 1/1 1550 1631 .. 1 88 [] 106.2 8.9e-29 Alignments of top-scoring domains: PF00036.22.ls: domain 1 of 2, from 64 to 92: score 23.6, E = 0.00065 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* l e++++ D ++DGk + +Ef a+k + KIAA1256 64 VLAEIWALSDLNKDGKMDQQEFSIAMKLI 92 PF00036.22.fs: domain 1 of 2, from 64 to 92: score 21.6, E = 7.7e-05 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* l e++++ D ++DGk + +Ef a+k + KIAA1256 64 VLAEIWALSDLNKDGKMDQQEFSIAMKLI 92 PF00036.22.fs: domain 2 of 2, from 287 to 315: score 21.6, E = 7.7e-05 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* +l ++ ++D+DgDG++ eEf+ a++ + KIAA1256 287 QLATIWTLADVDGDGQLKAEEFILAMHLT 315 PF00036.22.ls: domain 2 of 2, from 287 to 315: score 23.6, E = 0.00065 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* +l ++ ++D+DgDG++ eEf+ a++ + KIAA1256 287 QLATIWTLADVDGDGQLKAEEFILAMHLT 315 PF00018.18.ls: domain 1 of 5, from 739 to 795: score 64.8, E = 2.5e-16 *->kkvvALYDYearesdELsFkkGDvitvleksdd.pgWWkgrlkgtgG ++ALY++ear+ dE+sF GD+i+v ek+ ++pgW++g + G KIAA1256 739 VNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGePGWLYGSFQ---G 782 keGliPsNYVepv<-* +G++P+NYVe++ KIAA1256 783 NFGWFPCNYVEKM 795 PF07653.7.ls: domain 1 of 5, from 740 to 795: score 23.7, E = 0.00063 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskddd..gw +ra+ ++a ++ +e +s+ Gd++ V +k +++gw KIAA1256 740 NYRALYPFEA-RNHDE------MSFNSGDIIQVD----EKTVGepGW 775 wegeslggGrrrRGlvPssaveel<-* +g+ G G++P ++ve++ KIAA1256 776 LYGSF--QGNF--GWFPCNYVEKM 795 PF00018.18.fs: domain 1 of 5, from 741 to 795: score 63.1, E = 1.7e-16 *->vvALYDYearesdELsFkkGDvitvleksdd.pgWWkgrlkgtgGke ++ALY++ear+ dE+sF GD+i+v ek+ ++pgW++g + G + KIAA1256 741 YRALYPFEARNHDEMSFNSGDIIQVDEKTVGePGWLYGSFQ---GNF 784 GliPsNYVepv<-* G++P+NYVe++ KIAA1256 785 GWFPCNYVEKM 795 PF00018.18.fs: domain 2 of 5, from 880 to 933: score 50.9, E = 3.8e-13 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgGk k++AL +a +++L F k D+itvle++++ WW+g+++ G KIAA1256 880 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN--WWFGEVH---GG 921 eGliPsNYVepv<-* +G++P +YV + KIAA1256 922 RGWFPKSYVKII 933 PF00018.18.ls: domain 2 of 5, from 880 to 933: score 52.8, E = 1e-12 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgGk k++AL +a +++L F k D+itvle++++ WW+g+++ G KIAA1256 880 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN--WWFGEVH---GG 921 eGliPsNYVepv<-* +G++P +YV + KIAA1256 922 RGWFPKSYVKII 933 PF07653.7.ls: domain 2 of 5, from 881 to 933: score 60.7, E = 4.6e-15 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe +++a+++++a + n+ L++ k+d++ V+ + +++ww+ KIAA1256 881 KAQALCSWTA-KKDNH------LNFSKHDIITVL-----EQQENWWF 915 geslggGrrrRGlvPssaveel<-* ge+ +G r G++P s+v+++ KIAA1256 916 GEV--HGGR--GWFPKSYVKII 933 PF07653.7.fs: domain 2 of 5, from 881 to 933: score 58.9, E = 2.5e-16 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe +++a+++++a + n+ L++ k+d++ V+ + +++ww+ KIAA1256 881 KAQALCSWTA-KKDNH------LNFSKHDIITVL-----EQQENWWF 915 geslggGrrrRGlvPssaveel<-* ge+ +G r G++P s+v+++ KIAA1256 916 GEV--HGGR--GWFPKSYVKII 933 PF00018.18.fs: domain 3 of 5, from 963 to 1016: score 73.8, E = 2.1e-19 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgGk + ++ALY+Y +e+++L+F++G++i v +k+ + +WW+g ++ KIAA1256 963 EEYIALYPYSSVEPGDLTFTEGEEILVTQKD-G-EWWTGSIG---DR 1004 eGliPsNYVepv<-* G++PsNYV p+ KIAA1256 1005 SGIFPSNYVKPK 1016 PF00018.18.ls: domain 3 of 5, from 963 to 1016: score 75.7, E = 1.4e-19 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgGk + ++ALY+Y +e+++L+F++G++i v +k+ + +WW+g ++ KIAA1256 963 EEYIALYPYSSVEPGDLTFTEGEEILVTQKD-G-EWWTGSIG---DR 1004 eGliPsNYVepv<-* G++PsNYV p+ KIAA1256 1005 SGIFPSNYVKPK 1016 PF07653.7.ls: domain 3 of 5, from 964 to 1016: score 37.1, E = 5.7e-08 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe ++a+ y + +++ L++++G+ + V+ ++d++ww KIAA1256 964 EYIALYPYSS-VEPGD------LTFTEGEEILVT-----QKDGEWWT 998 geslggGrrrRGlvPssaveel<-* g+ g r G +Ps++v++ KIAA1256 999 GSI--GDRS--GIFPSNYVKPK 1016 PF07653.7.fs: domain 3 of 5, from 964 to 1016: score 35.3, E = 1.6e-09 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe ++a+ y + +++ L++++G+ + V+ ++d++ww KIAA1256 964 EYIALYPYSS-VEPGD------LTFTEGEEILVT-----QKDGEWWT 998 geslggGrrrRGlvPssaveel<-* g+ g r G +Ps++v++ KIAA1256 999 GSI--GDRS--GIFPSNYVKPK 1016 PF00018.18.ls: domain 4 of 5, from 1035 to 1094: score 47.5, E = 4.2e-11 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgG. +++++ +Y+a++s+ Ls+ +G i +l+k+ + gWW g+l+ + G+ KIAA1256 1035 EIAQVTSAYVASGSEQLSLAPGQLILILKKNTS-GWWQGELQAR-Gk 1079 ..keGliPsNYVepv<-* ++++G++P++ V + KIAA1256 1080 krQKGWFPASHVKLL 1094 PF00018.18.fs: domain 4 of 5, from 1035 to 1094: score 45.5, E = 1.1e-11 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgG. +++++ +Y+a++s+ Ls+ +G i +l+k+ + gWW g+l+ + G+ KIAA1256 1035 EIAQVTSAYVASGSEQLSLAPGQLILILKKNTS-GWWQGELQAR-Gk 1079 ..keGliPsNYVepv<-* ++++G++P++ V + KIAA1256 1080 krQKGWFPASHVKLL 1094 PF07653.7.ls: domain 4 of 5, from 1036 to 1094: score 39.7, E = 9e-09 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe ++++ yva ++ + Lsl G+++ ++ +k+ gww+ KIAA1256 1036 IAQVTSAYVA-SGSEQ------LSLAPGQLILIL----KKNTSGWWQ 1071 geslggGrrr.RGlvPssaveel<-* ge+ ++G++r+ G++P+s+v+ l KIAA1256 1072 GELQARGKKRqKGWFPASHVKLL 1094 PF07653.7.fs: domain 4 of 5, from 1036 to 1094: score 37.9, E = 2.8e-10 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe ++++ yva ++ + Lsl G+++ ++ +k+ gww+ KIAA1256 1036 IAQVTSAYVA-SGSEQ------LSLAPGQLILIL----KKNTSGWWQ 1071 geslggGrrr.RGlvPssaveel<-* ge+ ++G++r+ G++P+s+v+ l KIAA1256 1072 GELQARGKKRqKGWFPASHVKLL 1094 PF00018.18.ls: domain 5 of 5, from 1109 to 1163: score 87.0, E = 5.4e-23 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgGk +v+A YDY+a+++dELsF kG i v +k+d +WW g+ + G KIAA1256 1109 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDP-DWWQGEIN---GV 1151 eGliPsNYVepv<-* +Gl+PsNYV + KIAA1256 1152 TGLFPSNYVKMT 1163 PF00018.18.fs: domain 5 of 5, from 1109 to 1163: score 85.1, E = 1.7e-22 *->kkvvALYDYearesdELsFkkGDvitvleksddpgWWkgrlkgtgGk +v+A YDY+a+++dELsF kG i v +k+d +WW g+ + G KIAA1256 1109 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDP-DWWQGEIN---GV 1151 eGliPsNYVepv<-* +Gl+PsNYV + KIAA1256 1152 TGLFPSNYVKMT 1163 PF07653.7.fs: domain 5 of 5, from 1110 to 1162: score 54.4, E = 5e-15 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe ++a+ dy a ++++e Ls+ kG+++ V +kdd++ww+ KIAA1256 1110 QVIAMYDYAA-NNEDE------LSFSKGQLINVM----NKDDPDWWQ 1145 geslggGrrrRGlvPssaveel<-* ge +G++ Gl+Ps++v ++ KIAA1256 1146 GEI--NGVT--GLFPSNYV-KM 1162 PF07653.7.ls: domain 5 of 5, from 1110 to 1162: score 56.1, E = 1e-13 *->ygraiedyvaAtdknenleeeeLslkkGdvvkVidvggskdddgwwe ++a+ dy a ++++e Ls+ kG+++ V +kdd++ww+ KIAA1256 1110 QVIAMYDYAA-NNEDE------LSFSKGQLINVM----NKDDPDWWQ 1145 geslggGrrrRGlvPssaveel<-* ge +G++ Gl+Ps++v ++ KIAA1256 1146 GEI--NGVT--GLFPSNYV-KM 1162 PF00621.11.fs: domain 1 of 1, from 1192 to 1373: score 106.5, E = 2.9e-31 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskplLtpddietiF + El++TE+ Y dL +++ v+ k++ e+ +Lt ++ iF KIAA1256 1192 YIHELIQTEERYMADLQLVVEVFQKRMAESG-----FLTEGEMALIF 1233 sNiediyefhreFLkssLear....isssnfedlDekkiepsaqrlGdlF N +++ ++ +Lk +L r++++ + + q +Gd++ KIAA1256 1234 VNWKELIMSNTKLLK-ALRVRkktgGEKM------------PVQMIGDIL 1270 lelkaeflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassnt + ++++ q Y ++cs + + ll + + ++F+efl+++ + + KIAA1256 1271 AAELSHM-QAYIRFCSCQLNGAALLQQ--KTDEDTDFKEFLKKLASDPRC 1317 gAkddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedssesedLkk L+s+LlkP+qRi+rYpLL + +L tpe ++ ++ +Lk+ KIAA1256 1318 K------GMPLSSFLLKPMQRITRYPLLIRSILENTPE--SHADHSSLKL 1359 aldalqdlaksiNe<-* al+ ++l +++Ne KIAA1256 1360 ALERAEELCSQVNE 1373 PF00621.11.ls: domain 1 of 1, from 1192 to 1373: score 108.3, E = 2.1e-29 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskplLtpddietiF + El++TE+ Y dL +++ v+ k++ e+ +Lt ++ iF KIAA1256 1192 YIHELIQTEERYMADLQLVVEVFQKRMAESG-----FLTEGEMALIF 1233 sNiediyefhreFLkssLear....isssnfedlDekkiepsaqrlGdlF N +++ ++ +Lk +L r++++ + + q +Gd++ KIAA1256 1234 VNWKELIMSNTKLLK-ALRVRkktgGEKM------------PVQMIGDIL 1270 lelkaeflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassnt + ++++ q Y ++cs + + ll + + ++F+efl+++ + + KIAA1256 1271 AAELSHM-QAYIRFCSCQLNGAALLQQ--KTDEDTDFKEFLKKLASDPRC 1317 gAkddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedssesedLkk L+s+LlkP+qRi+rYpLL + +L tpe ++ ++ +Lk+ KIAA1256 1318 K------GMPLSSFLLKPMQRITRYPLLIRSILENTPE--SHADHSSLKL 1359 aldalqdlaksiNe<-* al+ ++l +++Ne KIAA1256 1360 ALERAEELCSQVNE 1373 PF00169.19.ls: domain 1 of 1, from 1414 to 1523: score 27.4, E = 4.7e-05 *->vikeGwLlkkggkkswkkRyfvLfddvLlyykdkk............ + ++G L+k + s k+ + +Lf+d Ll+ k+ ++++++ KIAA1256 1414 LLHSGKLYKTK---SNKELHGFLFNDFLLLTYMVKqfavssgseklf 1457 ........kkpkgsipLsgiqvtkvpdn.krkncFeirt.dretlllqae +++++ + k +k i L+++ v+ ++d++ ++ +F i++ dr +++l+++ KIAA1256 1458 ssksnaqfKMYKTPIFLNEVLVKLPTDPsSDEPVFHISHiDR-VYTLRTD 1506 seeerkeWvkaiqsair<-* + er+ Wv+ i+ a+ KIAA1256 1507 NINERTAWVQKIKAASE 1523 PF00169.19.fs: domain 1 of 1, from 1414 to 1523: score 25.4, E = 2.8e-07 *->vikeGwLlkkggkkswkkRyfvLfddvLlyykdkk............ + ++G L+k + s k+ + +Lf+d Ll+ k+ ++++++ KIAA1256 1414 LLHSGKLYKTK---SNKELHGFLFNDFLLLTYMVKqfavssgseklf 1457 ........kkpkgsipLsgiqvtkvpdn.krkncFeirt.dretlllqae +++++ + k +k i L+++ v+ ++d++ ++ +F i++ dr +++l+++ KIAA1256 1458 ssksnaqfKMYKTPIFLNEVLVKLPTDPsSDEPVFHISHiDR-VYTLRTD 1506 seeerkeWvkaiqsair<-* + er+ Wv+ i+ a+ KIAA1256 1507 NINERTAWVQKIKAASE 1523 PF00168.20.fs: domain 1 of 1, from 1550 to 1631: score 104.3, E = 1.9e-30 *->LrVtvieAknLppkDkkngksDPYVkvylggdkkdqkkkTkvikktl L V+vieA L+++ +ngks+PY+++++g q + T++i++tl KIAA1256 1550 LMVHVIEATELKACK-PNGKSNPYCEISMGS----QSYTTRTIQDTL 1591 NPvWNEtFtFevpppdlqe.tLeieVyDydrfgrddflGevs<-* NP+WN ++F dl +++L ++++D+d f+ ddflG+++ KIAA1256 1592 NPKWNFNCQFF--IKDLYQdVLCLTLFDRDQFSPDDFLGRTE 1631 PF00168.20.ls: domain 1 of 1, from 1550 to 1631: score 106.2, E = 8.9e-29 *->LrVtvieAknLppkDkkngksDPYVkvylggdkkdqkkkTkvikktl L V+vieA L+++ +ngks+PY+++++g q + T++i++tl KIAA1256 1550 LMVHVIEATELKACK-PNGKSNPYCEISMGS----QSYTTRTIQDTL 1591 NPvWNEtFtFevpppdlqe.tLeieVyDydrfgrddflGevs<-* NP+WN ++F dl +++L ++++D+d f+ ddflG+++ KIAA1256 1592 NPKWNFNCQFF--IKDLYQdVLCLTLFDRDQFSPDDFLGRTE 1631 //