# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/hh10053.fasta.nr -Q ../query/KIAA1169.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA1169, 857 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7825127 sequences Expectation_n fit: rho(ln(x))= 4.9785+/-0.000185; mu= 14.6476+/- 0.010 mean_var=77.6655+/-15.509, 0's: 31 Z-trim: 47 B-trim: 3124 in 2/65 Lambda= 0.145533 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|219689113|ref|NP_001137291.1| two pore segment ( 888) 5635 1193.3 0 gi|119618453|gb|EAW98047.1| two pore segment chann ( 902) 5635 1193.3 0 gi|109098844|ref|XP_001111625.1| PREDICTED: simila ( 888) 5569 1179.5 0 gi|125991219|sp|Q9ULQ1.3|TPC1_HUMAN RecName: Full= ( 816) 5349 1133.2 0 gi|193787523|dbj|BAG52729.1| unnamed protein produ ( 816) 5342 1131.8 0 gi|114647093|ref|XP_509396.2| PREDICTED: two pore ( 816) 5339 1131.1 0 gi|73994647|ref|XP_534690.2| PREDICTED: similar to ( 819) 5041 1068.6 0 gi|194214286|ref|XP_001492405.2| PREDICTED: simila ( 818) 5032 1066.7 0 gi|76639252|ref|XP_588037.2| PREDICTED: similar to ( 816) 4992 1058.3 0 gi|81881850|sp|Q9EQJ0.1|TPC1_MOUSE RecName: Full=T ( 817) 4903 1039.6 0 gi|221041242|dbj|BAH12298.1| unnamed protein produ ( 748) 4894 1037.7 0 gi|73994649|ref|XP_862357.1| PREDICTED: similar to ( 830) 4850 1028.5 0 gi|123797698|sp|Q9WTN5.2|TPC1_RAT RecName: Full=Tw ( 817) 4847 1027.8 0 gi|74229032|ref|NP_647548.2| two pore channel 1 [R ( 817) 4846 1027.6 0 gi|74215812|dbj|BAE23435.1| unnamed protein produc ( 797) 4709 998.9 0 gi|126324481|ref|XP_001378552.1| PREDICTED: simila ( 819) 4645 985.4 0 gi|149063454|gb|EDM13777.1| two pore channel 1, is ( 761) 4339 921.2 0 gi|119618452|gb|EAW98046.1| two pore segment chann ( 704) 4023 854.8 0 gi|122891062|emb|CAM14442.1| novel protein similar ( 805) 3819 812.0 0 gi|148744355|gb|AAI42665.1| TPCN1 protein [Homo sa ( 618) 3737 794.7 0 gi|221040548|dbj|BAH11951.1| unnamed protein produ ( 550) 3282 699.1 1.3e-198 gi|194043024|ref|XP_001924261.1| PREDICTED: simila ( 503) 3074 655.4 1.7e-185 gi|74213753|dbj|BAE43360.1| unnamed protein produc ( 488) 2707 578.3 2.7e-162 gi|148687817|gb|EDL19764.1| two pore channel 1, is ( 450) 2668 570.1 7.3e-160 gi|167410137|gb|ABZ79726.1| two-pore calcium chann ( 882) 2452 525.0 5.3e-146 gi|148687818|gb|EDL19765.1| two pore channel 1, is ( 801) 2438 522.0 3.8e-145 gi|210094140|gb|EEA42328.1| hypothetical protein B ( 639) 2364 506.4 1.5e-140 gi|149063455|gb|EDM13778.1| two pore channel 1, is ( 422) 2332 499.5 1.2e-138 gi|212509576|gb|EEB12945.1| conserved hypothetical ( 827) 2159 463.5 1.7e-127 gi|91085073|ref|XP_967004.1| PREDICTED: similar to ( 781) 2062 443.1 2.2e-121 gi|156537807|ref|XP_001608064.1| PREDICTED: simila ( 843) 1997 429.5 3e-117 gi|193697448|ref|XP_001943733.1| PREDICTED: simila ( 779) 1979 425.7 3.8e-116 gi|47226534|emb|CAG08550.1| unnamed protein produc ( 832) 1940 417.5 1.2e-113 gi|156226709|gb|EDO47517.1| predicted protein [Nem ( 722) 1679 362.6 3.3e-97 gi|149592243|ref|XP_001519904.1| PREDICTED: simila ( 509) 1361 295.7 3.2e-77 gi|22760924|dbj|BAC11385.1| unnamed protein produc ( 252) 1332 289.4 1.3e-75 gi|163779430|gb|EDQ93044.1| predicted protein [Mon ( 663) 1309 284.9 7.6e-74 gi|215490699|gb|EEC00342.1| conserved hypothetical ( 551) 1250 272.5 3.5e-70 gi|209155758|gb|ACI34111.1| Two pore calcium chann ( 783) 908 200.8 1.9e-48 gi|210108869|gb|EEA56755.1| hypothetical protein B ( 717) 866 191.9 8e-46 gi|164507450|gb|ABY59792.1| two pore channel 3 [Ga ( 752) 844 187.3 2e-44 gi|164507452|gb|ABY59793.1| two pore channel 3 [Or ( 766) 815 181.3 1.4e-42 gi|167410142|gb|ABZ79728.1| two-pore calcium chann ( 840) 699 156.9 3.2e-35 gi|75166464|sp|Q94KI8.1|TPC1_ARATH RecName: Full=T ( 733) 658 148.3 1.1e-32 gi|75324674|sp|Q6S5H8.1|TPC1_HORVU RecName: Full=T ( 742) 656 147.9 1.5e-32 gi|14041819|dbj|BAB55460.1| two-pore calcium chann ( 733) 651 146.8 3.2e-32 gi|195609574|gb|ACG26617.1| voltage-dependent calc ( 749) 637 143.9 2.5e-31 gi|4206210|gb|AAD11598.1| putative calcium channel ( 724) 635 143.4 3.2e-31 gi|33235553|dbj|BAC80148.1| calcium channel [Oryza ( 757) 634 143.2 3.8e-31 gi|75325199|sp|Q6YLX9.1|TPC1_WHEAT RecName: Full=T ( 742) 632 142.8 5.1e-31 >>gi|219689113|ref|NP_001137291.1| two pore segment chan (888 aa) initn: 5635 init1: 5635 opt: 5635 Z-score: 6389.1 bits: 1193.3 E(): 0 Smith-Waterman score: 5635; 100.000% identity (100.000% similar) in 857 aa overlap (1-857:32-888) 10 20 30 KIAA11 DASNGGVSEQHPWPSGFERELKPETISSPG :::::::::::::::::::::::::::::: gi|219 ESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPG 10 20 30 40 50 60 40 50 60 70 80 90 KIAA11 YHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 YHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQA 70 80 90 100 110 120 100 110 120 130 140 150 KIAA11 PSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 PSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFY 130 140 150 160 170 180 160 170 180 190 200 210 KIAA11 LMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 LMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIR 190 200 210 220 230 240 220 230 240 250 260 270 KIAA11 HKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 HKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSL 250 260 270 280 290 300 280 290 300 310 320 330 KIAA11 PPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 PPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPS 310 320 330 340 350 360 340 350 360 370 380 390 KIAA11 YSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 YSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLL 370 380 390 400 410 420 400 410 420 430 440 450 KIAA11 ISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 ISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALK 430 440 450 460 470 480 460 470 480 490 500 510 KIAA11 WKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 WKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGN 490 500 510 520 530 540 520 530 540 550 560 570 KIAA11 FFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 FFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNM 550 560 570 580 590 600 580 590 600 610 620 630 KIAA11 EPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 EPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFF 610 620 630 640 650 660 640 650 660 670 680 690 KIAA11 CGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 CGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNW 670 680 690 700 710 720 700 710 720 730 740 750 KIAA11 YIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 YIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGI 730 740 750 760 770 780 760 770 780 790 800 810 KIAA11 TLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|219 TLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLS 790 800 810 820 830 840 820 830 840 850 KIAA11 LKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT ::::::::::::::::::::::::::::::::::::::::::::::: gi|219 LKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT 850 860 870 880 >>gi|119618453|gb|EAW98047.1| two pore segment channel 1 (902 aa) initn: 5635 init1: 5635 opt: 5635 Z-score: 6389.0 bits: 1193.3 E(): 0 Smith-Waterman score: 5635; 100.000% identity (100.000% similar) in 857 aa overlap (1-857:46-902) 10 20 30 KIAA11 DASNGGVSEQHPWPSGFERELKPETISSPG :::::::::::::::::::::::::::::: gi|119 ESCYIAQAGLELLGSSSSPTLTSQSAEITEDASNGGVSEQHPWPSGFERELKPETISSPG 20 30 40 50 60 70 40 50 60 70 80 90 KIAA11 YHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQA 80 90 100 110 120 130 100 110 120 130 140 150 KIAA11 PSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFY 140 150 160 170 180 190 160 170 180 190 200 210 KIAA11 LMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIR 200 210 220 230 240 250 220 230 240 250 260 270 KIAA11 HKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 HKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSL 260 270 280 290 300 310 280 290 300 310 320 330 KIAA11 PPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 PPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPS 320 330 340 350 360 370 340 350 360 370 380 390 KIAA11 YSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLL 380 390 400 410 420 430 400 410 420 430 440 450 KIAA11 ISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 ISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALK 440 450 460 470 480 490 460 470 480 490 500 510 KIAA11 WKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 WKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGN 500 510 520 530 540 550 520 530 540 550 560 570 KIAA11 FFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 FFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNM 560 570 580 590 600 610 580 590 600 610 620 630 KIAA11 EPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 EPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFF 620 630 640 650 660 670 640 650 660 670 680 690 KIAA11 CGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 CGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNW 680 690 700 710 720 730 700 710 720 730 740 750 KIAA11 YIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 YIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGI 740 750 760 770 780 790 760 770 780 790 800 810 KIAA11 TLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|119 TLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLS 800 810 820 830 840 850 820 830 840 850 KIAA11 LKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT ::::::::::::::::::::::::::::::::::::::::::::::: gi|119 LKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT 860 870 880 890 900 >>gi|109098844|ref|XP_001111625.1| PREDICTED: similar to (888 aa) initn: 5569 init1: 5569 opt: 5569 Z-score: 6314.2 bits: 1179.5 E(): 0 Smith-Waterman score: 5569; 98.716% identity (99.650% similar) in 857 aa overlap (1-857:32-888) 10 20 30 KIAA11 DASNGGVSEQHPWPSGFERELKPETISSPG ::::::.::::::::::::::::::::::: gi|109 ESCYLAQAGLELLGSSSSPTLTSQSAGITKDASNGGISEQHPWPSGFERELKPETISSPG 10 20 30 40 50 60 40 50 60 70 80 90 KIAA11 YHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQA .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 HHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQA 70 80 90 100 110 120 100 110 120 130 140 150 KIAA11 PSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFY ::::: : :::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 PSLSSEGGSSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFY 130 140 150 160 170 180 160 170 180 190 200 210 KIAA11 LMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIR 190 200 210 220 230 240 220 230 240 250 260 270 KIAA11 HKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSL ::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::: gi|109 HKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGIRRNLRQIFQSL 250 260 270 280 290 300 280 290 300 310 320 330 KIAA11 PPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 PPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPS 310 320 330 340 350 360 340 350 360 370 380 390 KIAA11 YSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 YSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLL 370 380 390 400 410 420 400 410 420 430 440 450 KIAA11 ISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALK .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 VSQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALK 430 440 450 460 470 480 460 470 480 490 500 510 KIAA11 WKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 WKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGN 490 500 510 520 530 540 520 530 540 550 560 570 KIAA11 FFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 FFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNM 550 560 570 580 590 600 580 590 600 610 620 630 KIAA11 EPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 EPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFF 610 620 630 640 650 660 640 650 660 670 680 690 KIAA11 CGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 CGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNW 670 680 690 700 710 720 700 710 720 730 740 750 KIAA11 YIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 YIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGI 730 740 750 760 770 780 760 770 780 790 800 810 KIAA11 TLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLS :::::::::::::::::::::.::::::::::::::::::::: :::::::::::::::: gi|109 TLEKEISKEELVAVLELYREAQGASSDVTRLLETLSQMERYQQCSMVFLGRRSRTKSDLS 790 800 810 820 830 840 820 830 840 850 KIAA11 LKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT ::::::::::::::::::::::::::::::::..:::.::::::::: gi|109 LKMYQEEIQEWYEEHAREQEQQRQLSSSAAPATEQPPSSRQRSQTVT 850 860 870 880 >>gi|125991219|sp|Q9ULQ1.3|TPC1_HUMAN RecName: Full=Two (816 aa) initn: 5349 init1: 5349 opt: 5349 Z-score: 6065.1 bits: 1133.2 E(): 0 Smith-Waterman score: 5349; 100.000% identity (100.000% similar) in 816 aa overlap (42-857:1-816) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::::::::::::::: gi|125 MAVSLDDDVPLILTLDEGGSAPLAPSNGLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY 700 710 720 730 740 750 800 810 820 830 840 850 KIAA11 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|125 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ 760 770 780 790 800 810 KIAA11 RSQTVT :::::: gi|125 RSQTVT >>gi|193787523|dbj|BAG52729.1| unnamed protein product [ (816 aa) initn: 5342 init1: 5342 opt: 5342 Z-score: 6057.1 bits: 1131.8 E(): 0 Smith-Waterman score: 5342; 99.877% identity (100.000% similar) in 816 aa overlap (42-857:1-816) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::::::::::::::: gi|193 MAVSLDDDVPLILTLDEGGSAPLAPSNGLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: gi|193 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRLYKPRMSARERYLTFKALNQNN 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY 700 710 720 730 740 750 800 810 820 830 840 850 KIAA11 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|193 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ 760 770 780 790 800 810 KIAA11 RSQTVT :::::: gi|193 RSQTVT >>gi|114647093|ref|XP_509396.2| PREDICTED: two pore segm (816 aa) initn: 5339 init1: 5339 opt: 5339 Z-score: 6053.7 bits: 1131.1 E(): 0 Smith-Waterman score: 5339; 99.755% identity (100.000% similar) in 816 aa overlap (42-857:1-816) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::::::::::::::: gi|114 MAVSLDDDVPLILTLDEGGSAPLAPSNGLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: gi|114 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPVHNWEMNYQEAAIYLQEGENNDKFFTH 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMV 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLV 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSI 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNN 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLV 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLF 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASL 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNF 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAF 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERY 700 710 720 730 740 750 800 810 820 830 840 850 KIAA11 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: gi|114 QQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQKQQRQLSSSAAPAAQQPPGSRQ 760 770 780 790 800 810 KIAA11 RSQTVT :::::: gi|114 RSQTVT >>gi|73994647|ref|XP_534690.2| PREDICTED: similar to two (819 aa) initn: 5104 init1: 4604 opt: 5041 Z-score: 5715.6 bits: 1068.6 E(): 0 Smith-Waterman score: 5041; 93.284% identity (98.657% similar) in 819 aa overlap (42-857:1-819) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::::::::::::.:: gi|739 MAVSLDDDVPLILTLDEGGSAPLAPSNSLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPA-HNWEMNYQEAAIYLQEGENNDKFFT :::::..::::::..:::. ::. :::: ::::. ::::.:::::::::::::::::::: gi|739 QEELPNRNGGSYAVQDSQTSSLGLGGESPPSSPTGHNWEINYQEAAIYLQEGENNDKFFT 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 HPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALM :::.::::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|739 HPKNAKALAAYLFAHNHLFYLMELSTALLLLLLSLCEAPAVPALRLGIYVHATLELFALM 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFL :::::::::::::::::::::::::::::::::::.::::::::: :::::::::::::: gi|739 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFIEAIVVLVRQTSHVRVTRALRCIFL 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 VDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 VDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 IVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 IVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 KFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQN ::::::::::::::::: :::::::::::::::::::::::.:::::::::::::::::. gi|739 KFKSLLLHKRTAIQHAYCLLISQRRPAGISYRQFEGLMRFYRPRMSARERYLTFKALNQS 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 NTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYL ::::::::::::::::::::::::.:::::::::::::.::::::::::::::::::::: gi|739 NTPLLSLKDFYDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYL 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNL ::::::::::::::::::::::::::::::.:::::::::::::::::::.::::::::: gi|739 VVAVNGVWILVETFMLKGGNFFSKHVPWSYVVFLTIYGVELFLKVAGLGPLEYLSSGWNL 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 FDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMAS ::::::.::::::::::.:::::::::::::::::::::::.:::::::::::::::::: gi|739 FDFSVTLFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMAS 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 LGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN :::::::::::.:::::::::::..:::::::::.::::: ::::::::::.:::::::: gi|739 LGLTLLIFYYSLAIVGMEFFCGILYPNCCNTSTVSDAYRWLNHTVGNRTVVDEGYYYLNN 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|739 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 FVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMER ::::::::::::::::::::::::::::.::.::::::::.:::.::.:::: .:::::. gi|739 FVFRMNYSRKNQDSEVDGGITLEKEISKDELLAVLELYREVRGATSDITRLLTVLSQMEK 700 710 720 730 740 750 800 810 820 830 840 KIAA11 YQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQE-QQRQLSSSA-APAAQQPPG ..:...:::::::::::::::::::::::::::::::.:: ::::::::. .:..:: :: gi|739 HEQNTVVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEEQQRQLSSSGQVPTTQQLPG 760 770 780 790 800 810 850 KIAA11 SRQRSQTVT :::::::.: gi|739 SRQRSQTIT >>gi|194214286|ref|XP_001492405.2| PREDICTED: similar to (818 aa) initn: 5131 init1: 4552 opt: 5032 Z-score: 5705.4 bits: 1066.7 E(): 0 Smith-Waterman score: 5032; 93.276% identity (98.533% similar) in 818 aa overlap (42-857:1-818) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::::::::::::.:: gi|194 MAVSLDDDVPLILTLDEGGSAPLAPSNSLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPA-HNWEMNYQEAAIYLQEGENNDKFFT ::::::.:::::::.:::::::::: :::::::. ::::::::::::::::::::::::: gi|194 QEELPSRNGGSYAIRDSQAPSLSSGTESSPSSPTRHNWEMNYQEAAIYLQEGENNDKFFT 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 HPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALM :::::.::::::::::::::::::.::::::::::::::::::::::::::::::::::: gi|194 HPKDARALAAYLFAHNHLFYLMELSTALLLLLLSLCEAPAVPALRLGIYVHATLELFALM 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFL :::::::::::::::::::::::::::::::::::.::::::::: ::.::::::::::: gi|194 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFIEAIVVLVRQTSHMRVTRALRCIFL 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 VDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: gi|194 VDCRYCGGVRRNLRQIFQSLPPFVDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 IVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 IVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 KFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQN ::::::::::::::::::::.:::.:::::::::::::::::::::: :::::::::::. gi|194 KFKSLLLHKRTAIQHAYRLLVSQRKPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQS 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 NTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYL ::::::::::::::::::::::::.::::::: :::::.::::::::::::::::::::: gi|194 NTPLLSLKDFYDIYEVAALKWKAKSNREHWFDALPRTAFLIFKGINILVKSKAFQYFMYL 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNL ::::::::::::::::::::::::::::::.::::::.:::::::::::::::::::::: gi|194 VVAVNGVWILVETFMLKGGNFFSKHVPWSYVVFLTIYAVELFLKVAGLGPVEYLSSGWNL 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 FDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMAS ::::::..:::::::::.:::::::::::::::::::::::.:::::::::::::::::: gi|194 FDFSVTALAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMAS 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 LGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN :::::::::::::::::::::::..::::::::::::::: .:: :: :.:::::::::: gi|194 LGLTLLIFYYSFAIVGMEFFCGILYPNCCNTSTVADAYRWLSHTEGNSTAVEEGYYYLNN 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|194 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 FVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMER :::::::::::::::::::::::::::..:::::::::::::.:.::.::::. :::.:: gi|194 FVFRMNYSRKNQDSEVDGGITLEKEISRDELVAVLELYREARAATSDITRLLKILSQIER 700 710 720 730 740 750 800 810 820 830 840 KIAA11 YQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQE-QQRQLSSSAAPAAQQPPGS ..:...::::::::::::::::::::::.::::::::.:: :: :::.:..::.:::::: gi|194 HEQNAVVFLGRRSRTKSDLSLKMYQEEIKEWYEEHARKQEEQQPQLSGSGGPATQQPPGS 760 770 780 790 800 810 850 KIAA11 RQRSQTVT : ::::.: gi|194 RLRSQTIT >>gi|76639252|ref|XP_588037.2| PREDICTED: similar to Two (816 aa) initn: 4939 init1: 4510 opt: 4992 Z-score: 5660.0 bits: 1058.3 E(): 0 Smith-Waterman score: 4992; 92.044% identity (98.286% similar) in 817 aa overlap (42-857:1-816) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::::::::::::::: gi|766 MAVSLDDDVPLILTLDEGGSAPLAPSNGLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPA-HNWEMNYQEAAIYLQEGENNDKFFT ..:::.:::.:..::::::::: ::.:::::. :.::::::::::::::::::::::: gi|766 PDDLPSRNGGKYTVHDSQAPSLSLEGENSPSSPTEHDWEMNYQEAAIYLQEGENNDKFFT 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 HPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALM :::.::::::::::::::::::::..:::::::::::::::::::::::::::::::::. gi|766 HPKNAKALAAYLFAHNHLFYLMELSAALLLLLLSLCEAPAVPALRLGIYVHATLELFALV 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFL :::::::::::::::::::::.::::::::::::::::::::::: ::.::::::::::: gi|766 VVVFELCMKLRWLGLHTFIRHRRTMVKTSVLVVQFVEAIVVLVRQTSHMRVTRALRCIFL 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 VDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|766 VDCRYCGGVRRNLRQMFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 IVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|766 IISLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 KFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQN ::::::::::::::::::::.:::::::::::::::::::::::::: :::::::::::. gi|766 KFKSLLLHKRTAIQHAYRLLVSQRRPAGISYRQFEGLMRFYKPRMSAGERYLTFKALNQS 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 NTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYL ::::::::::.:::::::::::::.:::::::::::::.::::::::::::::::::::: gi|766 NTPLLSLKDFHDIYEVAALKWKAKRNREHWFDELPRTAFLIFKGINILVKSKAFQYFMYL 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNL ::::::::::::::::::::: :.:::::.:::::::.::::::::::::.::::::::: gi|766 VVAVNGVWILVETFMLKGGNFVSRHVPWSHLVFLTIYAVELFLKVAGLGPIEYLSSGWNL 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 FDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMAS ::::::.::::::::::.:::::::::::::::::::::::.:::::::::::::::::: gi|766 FDFSVTAFAFLGLLALAFNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMAS 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 LGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN :::::::::::::::::::: ::..::::::::::::::: ::.:::::::::::::::: gi|766 LGLTLLIFYYSFAIVGMEFFYGILYPNCCNTSTVADAYRWLNHSVGNRTVVEEGYYYLNN 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|766 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 FVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMER ::::::::::::::::: :::::::.::.::::::.::::: ::.::...::. :::.:: gi|766 FVFRMNYSRKNQDSEVDDGITLEKELSKDELVAVLKLYREAGGANSDIAQLLKILSQLER 700 710 720 730 740 750 800 810 820 830 840 850 KIAA11 YQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSR :.:...:::::::::::::::::::::::::::::::.::. ::::: ..::.::::::: gi|766 YEQNTLVFLGRRSRTKSDLSLKMYQEEIQEWYEEHARKQEE-RQLSSCVVPATQQPPGSR 760 770 780 790 800 KIAA11 QRSQTVT :::::.: gi|766 QRSQTIT 810 >>gi|81881850|sp|Q9EQJ0.1|TPC1_MOUSE RecName: Full=Two p (817 aa) initn: 4589 init1: 4589 opt: 4903 Z-score: 5559.0 bits: 1039.6 E(): 0 Smith-Waterman score: 4903; 90.942% identity (97.062% similar) in 817 aa overlap (42-857:1-817) 20 30 40 50 60 70 KIAA11 PWPSGFERELKPETISSPGYHILRATGEENMAVSLDDDVPLILTLDEGGSAPLAPSNGLG :::::::::::::::::. :::: :::.:: gi|818 MAVSLDDDVPLILTLDEAESAPLPPSNSLG 10 20 30 80 90 100 110 120 130 KIAA11 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPA-HNWEMNYQEAAIYLQEGENNDKFFT ::.::::::::..::.::.::: ::..: ::::. :::::::::::::::::.::::::: gi|818 QEQLPSKNGGSHSIHNSQVPSLVSGADSPPSSPTGHNWEMNYQEAAIYLQEGQNNDKFFT 40 50 60 70 80 90 140 150 160 170 180 190 KIAA11 HPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALM :::::.:::::::.:::.::.::: ::::::::::::.::::.:.: :::::::::::: gi|818 HPKDARALAAYLFVHNHFFYMMELLTALLLLLLSLCESPAVPVLKLHTYVHATLELFALM 100 110 120 130 140 150 200 210 220 230 240 250 KIAA11 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFL ::::::::::::::.:::.::::::::::::::::.::::::::: :::::::::::::: gi|818 VVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSHVRVTRALRCIFL 160 170 180 190 200 210 260 270 280 290 300 310 KIAA11 VDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENS :::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::: gi|818 VDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSDPYFSTLENS 220 230 240 250 260 270 320 330 340 350 360 370 KIAA11 IVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKR ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::. gi|818 IVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKH 280 290 300 310 320 330 380 390 400 410 420 430 KIAA11 KFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQN ::::::::::::::::: :: :::::::::::::::::::::::::::::.::::::::. gi|818 KFKSLLLHKRTAIQHAYGLLASQRRPAGISYRQFEGLMRFYKPRMSARERFLTFKALNQS 340 350 360 370 380 390 440 450 460 470 480 490 KIAA11 NTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYL :::::::::::::::::::.::::.::.::::::::::.::::::::::.:::::::::: gi|818 NTPLLSLKDFYDIYEVAALQWKAKRNRQHWFDELPRTAFLIFKGINILVNSKAFQYFMYL 400 410 420 430 440 450 500 510 520 530 540 550 KIAA11 VVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNL ::::::::::::::::::::: ::::::::::::::::::::.::::::::::::::::: gi|818 VVAVNGVWILVETFMLKGGNFTSKHVPWSYLVFLTIYGVELFMKVAGLGPVEYLSSGWNL 460 470 480 490 500 510 560 570 580 590 600 610 KIAA11 FDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMAS ::::::.:::::::::.::::::::::::::::::::::::.:::::::::::::::::: gi|818 FDFSVTAFAFLGLLALTLNMEPFYFIVVLRPLQLLRLFKLKKRYRNVLDTMFELLPRMAS 520 530 540 550 560 570 620 630 640 650 660 670 KIAA11 LGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN :::::: ::::::::::::: : . ::::::::::::::. ::::::.: :::::::::: gi|818 LGLTLLTFYYSFAIVGMEFFNGRLTPNCCNTSTVADAYRFINHTVGNKTKVEEGYYYLNN 580 590 600 610 620 630 680 690 700 710 720 730 KIAA11 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|818 FDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEA 640 650 660 670 680 690 740 750 760 770 780 790 KIAA11 FVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMER ::::::::::.::::::.::..:::.:::::.:::::::: ::.::::::::.::::::. gi|818 FVFRMNYSRKSQDSEVDSGIVIEKEMSKEELMAVLELYREERGTSSDVTRLLDTLSQMEK 700 710 720 730 740 750 800 810 820 830 840 850 KIAA11 YQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSR :::.::::::::::::::::::::::::::::::::::::::. .: .:::::::::: gi|818 YQQNSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQKLRGSVPGPAAQQPPGSR 760 770 780 790 800 810 KIAA11 QRSQTVT ::::::: gi|818 QRSQTVT 857 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Wed Mar 4 00:07:10 2009 done: Wed Mar 4 00:10:42 2009 Total Scan time: 1613.030 Total Display time: 0.570 Function used was FASTA [version 34.26.5 April 26, 2007]