hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-18332554/chunk_1/iprscan-20080501-18332554.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA1142 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00069.15.ls Protein kinase domain 298.1 1.5e-86 1 PF00069.15.fs Protein kinase domain 296.2 5.5e-86 1 PF07714.7.fs Protein tyrosine kinase 91.9 1.5e-26 1 PF07714.7.ls Protein tyrosine kinase 90.7 4.1e-24 1 PF00786.18.fs P21-Rho-binding domain 73.1 3.7e-20 1 PF00786.18.ls P21-Rho-binding domain 75.1 2e-19 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00786.18.fs 1/1 39 96 .. 1 60 [] 73.1 3.7e-20 PF00786.18.ls 1/1 39 96 .. 1 60 [] 75.1 2e-19 PF07714.7.fs 1/1 197 406 .. 1 234 [. 91.9 1.5e-26 PF00069.15.fs 1/1 197 448 .. 1 287 [] 296.2 5.5e-86 PF00069.15.ls 1/1 197 448 .. 1 287 [] 298.1 1.5e-86 PF07714.7.ls 1/1 197 448 .. 1 272 [] 90.7 4.1e-24 Alignments of top-scoring domains: PF00786.18.fs: domain 1 of 1, from 39 to 96: score 73.1, E = 3.7e-20 *->eIStPLtnFkHvvHVGfDgqtGfftGlPpeWekllkssgiskpeqkk eIS+P +nF+H+vH+GfD+ + +ftGlP +W++l s +p++ + KIAA1142 39 EISAP-SNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES-ARRPKPLV 83 npqavldvlkfys<-* +p++++++++ + KIAA1142 84 DPACITSIQPGAP 96 PF00786.18.ls: domain 1 of 1, from 39 to 96: score 75.1, E = 2e-19 *->eIStPLtnFkHvvHVGfDgqtGfftGlPpeWekllkssgiskpeqkk eIS+P +nF+H+vH+GfD+ + +ftGlP +W++l s +p++ + KIAA1142 39 EISAP-SNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES-ARRPKPLV 83 npqavldvlkfys<-* +p++++++++ + KIAA1142 84 DPACITSIQPGAP 96 PF07714.7.fs: domain 1 of 1, from 197 to 406: score 91.9, E = 1.5e-26 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l k+GeG+ G V+ +t + + + VAVK++ + ++ KIAA1142 197 LDNFIKIGEGSTGIVCIATVR----SSGKLVAVKKM---DLRKQQ-- 234 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+++l +E+ iM+ + +H+N+V ++ + g+ l++V+E+ egG KIAA1142 235 RRELLFnEVVIMRDY-QHENVVEMYNSYLV-GDE----LWVVMEFLEGGA 278 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + + + +++ +l + ++++ L++++ +HRD+ +L+ KIAA1142 279 LTDIVTHT----RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILL 324 senlvVKIsDFGLaRdiynddyYvrkkgggk.lPvkWmAPEslkygkFts ++++ VK sDFG + ++ +++ + + ++ WmAPE ++ + KIAA1142 325 THDGRVKLSDFGFCAQV-SKE---VPRRKSLvGTPYWMAPELISRLPYGP 370 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedG<-* + D+WS G++ E++ Ge+P Y + ++ ++++ +d+ KIAA1142 371 EVDIWSLGIMVIEMVD-GEPP-YFNEPPLKAMKMI-RDN 406 PF00069.15.fs: domain 1 of 1, from 197 to 448: score 296.2, E = 5.5e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + k+G+Gs G V++a+ +++gk+VAvK++++rk+ ++ +++ KIAA1142 197 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFN 241 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ i++ +H+N+v+++ ++ +d+l++V+E++egG L d+++ KIAA1142 242 --EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGG----ALTDIVT- 284 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++++ e+++ ++l +l++l LH++g+iHRD+K++ ILl ++g KIAA1142 285 ---HTRM--NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 329 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD v K++DFG+++++ + ++ +++vGTp++mAPE++ + +yg++vD KIAA1142 330 V----KLSDFGFCAQV-SkEVPrRKSLVGTPYWMAPELIS-RLPYGPEVD 373 vWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewds +WSlG++++e++ G+pP+ +e ++l +++ir +l+p+l+ + KIAA1142 374 IWSLGIMVIEMVDGEPPYFNE---PpLKAMKMIRDNLPPRLKNLHKVS-- 418 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +++k +++++L +DP++R ta+e+l+HP++ KIAA1142 419 -------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL 448 PF00069.15.ls: domain 1 of 1, from 197 to 448: score 298.1, E = 1.5e-86 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr + k+G+Gs G V++a+ +++gk+VAvK++++rk+ ++ +++ KIAA1142 197 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFN 241 lsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrvldLfdylse E+ i++ +H+N+v+++ ++ +d+l++V+E++egG L d+++ KIAA1142 242 --EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGG----ALTDIVT- 284 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldnngv ++++ e+++ ++l +l++l LH++g+iHRD+K++ ILl ++g KIAA1142 285 ---HTRM--NEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGR 329 vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD v K++DFG+++++ + ++ +++vGTp++mAPE++ + +yg++vD KIAA1142 330 V----KLSDFGFCAQV-SkEVPrRKSLVGTPYWMAPELIS-RLPYGPEVD 373 vWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewds +WSlG++++e++ G+pP+ +e ++l +++ir +l+p+l+ + KIAA1142 374 IWSLGIMVIEMVDGEPPYFNE---PpLKAMKMIRDNLPPRLKNLHKVS-- 418 isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +++k +++++L +DP++R ta+e+l+HP++ KIAA1142 419 -------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL 448 PF07714.7.ls: domain 1 of 1, from 197 to 448: score 90.7, E = 4.1e-24 *->lklgkkLGeGaFGeVykGtlkgsgdgteikVAVKtLkeigaseeeie l k+GeG+ G V+ +t + + + VAVK++ + ++ KIAA1142 197 LDNFIKIGEGSTGIVCIATVR----SSGKLVAVKKM---DLRKQQ-- 234 redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd r+++l +E+ iM+ + +H+N+V ++ + g+ l++V+E+ egG KIAA1142 235 RRELLFnEVVIMRDY-QHENVVEMYNSYLV-GDE----LWVVMEFLEGGA 278 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV L d + + + +++ +l + ++++ L++++ +HRD+ +L+ KIAA1142 279 LTDIVTHT----RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILL 324 senlvVKIsDFGLaRdiynddyYvrkkgggk.lPvkWmAPEslkygkFts ++++ VK sDFG + ++ +++ + + ++ WmAPE ++ + KIAA1142 325 THDGRVKLSDFGFCAQV-SKE---VPRRKSLvGTPYWMAPELISRLPYGP 370 kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyR..LprPenC + D+WS G++ E++ Ge+P Y + ++ ++++ +d+ ++L+ ++ KIAA1142 371 EVDIWSLGIMVIEMVD-GEPP-YFNEPPLKAMKMI-RDNLPprLKNLHKV 417 PdelYdlMlqCWaedPedRPtFsel..veeL<-* ++ l + + +dP++R t +el ++ +L KIAA1142 418 SPSLKGFLDRLLVRDPAQRATAAELlkHPFL 448 //