hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080502/iprscan-20080502-03471188/chunk_1/iprscan-20080502-03471188.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA0465 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF00435.11.fs Spectrin repeat 749.4 2e-222 27 PF00435.11.ls Spectrin repeat 739.9 1.6e-219 25 PF02187.8.fs Growth-Arrest-Specific Protein 2 Domain 188.8 5.3e-57 1 PF02187.8.ls Growth-Arrest-Specific Protein 2 Domain 190.8 3.1e-54 1 PF00036.22.ls EF hand 56.9 6e-14 2 PF00036.22.fs EF hand 52.9 2.2e-13 2 PF02996.8.fs Prefoldin subunit 19.2 7.3e-05 7 PF02370.7.ls M protein repeat 24.0 0.0005 9 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF00435.11.ls 1/25 680 792 .. 1 111 [] 4.8 0.016 PF00435.11.fs 3/27 948 1024 .. 1 82 [. 23.7 1.6e-06 PF00435.11.ls 2/25 948 1051 .. 1 111 [] 22.4 0.0006 PF00435.11.fs 4/27 1065 1175 .. 1 111 [] 37.8 1e-10 PF00435.11.ls 3/25 1065 1175 .. 1 111 [] 39.7 9.2e-09 PF00435.11.ls 4/25 1178 1284 .. 1 111 [] 1.0 0.032 PF00435.11.ls 5/25 1393 1507 .. 1 111 [] 20.5 0.00086 PF00435.11.ls 6/25 1510 1619 .. 1 111 [] 43.7 5.7e-10 PF00435.11.fs 7/27 1510 1619 .. 1 111 [] 41.8 6.6e-12 PF00435.11.ls 7/25 1622 1730 .. 1 111 [] 13.4 0.0032 PF00435.11.ls 8/25 1843 1950 .. 1 111 [] 49.9 8.2e-12 PF00435.11.fs 9/27 1843 1950 .. 1 111 [] 47.9 9.7e-14 PF00435.11.ls 9/25 1953 2057 .. 1 111 [] 32.7 1.2e-06 PF00435.11.fs 10/27 1953 2057 .. 1 111 [] 30.8 1.2e-08 PF00435.11.ls 10/25 2278 2386 .. 1 111 [] 17.1 0.0016 PF00435.11.fs 11/27 2309 2386 .. 35 111 .] 25.1 6.1e-07 PF00435.11.ls 11/25 2389 2495 .. 1 111 [] 48.3 2.3e-11 PF00435.11.fs 12/27 2389 2495 .. 1 111 [] 46.4 2.8e-13 PF00435.11.fs 13/27 2498 2604 .. 1 111 [] 28.0 8.4e-08 PF00435.11.ls 12/25 2498 2604 .. 1 111 [] 29.9 8.3e-06 PF00435.11.ls 13/25 2607 2713 .. 1 111 [] 8.1 0.0085 PF00435.11.ls 14/25 2716 2822 .. 1 111 [] 22.6 0.00058 PF00435.11.ls 15/25 2825 2930 .. 1 111 [] 19.4 0.0011 PF00435.11.ls 16/25 2936 3046 .. 1 111 [] 3.0 0.022 PF00435.11.fs 18/27 3049 3155 .. 1 111 [] 35.7 4.3e-10 PF00435.11.ls 17/25 3049 3155 .. 1 111 [] 37.6 4e-08 PF00435.11.fs 19/27 3158 3265 .. 1 111 [] 36.0 3.5e-10 PF00435.11.ls 18/25 3158 3265 .. 1 111 [] 37.9 3.2e-08 PF00435.11.fs 20/27 3268 3374 .. 1 111 [] 68.6 7.1e-20 PF00435.11.ls 19/25 3268 3374 .. 1 111 [] 70.5 5e-18 PF00435.11.ls 20/25 3377 3484 .. 1 111 [] 24.1 0.00044 PF00435.11.fs 21/27 3377 3484 .. 1 111 [] 22.2 4.5e-06 PF00435.11.fs 22/27 3487 3593 .. 1 111 [] 52.5 4.4e-15 PF00435.11.ls 21/25 3487 3593 .. 1 111 [] 54.4 3.5e-13 PF00435.11.ls 22/25 3596 3703 .. 1 111 [] 45.1 2.3e-10 PF00435.11.fs 23/27 3596 3703 .. 1 111 [] 43.2 2.6e-12 PF00435.11.ls 23/25 3704 3811 .. 1 111 [] 43.3 7.8e-10 PF00435.11.fs 24/27 3710 3811 .. 5 111 .] 43.8 1.6e-12 PF00435.11.ls 24/25 3814 3920 .. 1 111 [] 44.9 2.6e-10 PF00435.11.fs 25/27 3814 3920 .. 1 111 [] 42.9 3e-12 PF00435.11.ls 25/25 3923 4057 .. 1 111 [] 5.7 0.014 PF00036.22.fs 1/2 4090 4118 .. 1 29 [] 27.1 2.4e-06 PF00036.22.ls 1/2 4090 4118 .. 1 29 [] 29.1 1.4e-05 PF00036.22.ls 2/2 4126 4154 .. 1 29 [] 27.8 3.4e-05 PF00036.22.fs 2/2 4126 4154 .. 1 29 [] 25.9 5.4e-06 PF02187.8.fs 1/1 4165 4237 .. 1 75 [] 188.8 5.3e-57 PF02187.8.ls 1/1 4165 4237 .. 1 75 [] 190.8 3.1e-54 Alignments of top-scoring domains: PF00435.11.ls: domain 1 of 25, from 680 to 792: score 4.8, E = 0.016 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH +++ +++++dl sW ++e+ L+ + +++ aL+k + + KIAA0465 680 KQQNTCHQQLEDLCSWVGQAERALAGHQG-RTTQQDLSALQKNQsDL 725 kaleaelaahqdrvealninelaekLiideg.....hyaseeiqerleeL k+l+++++++ + + ++ + e + ++e++++ ++ + +++e+l + KIAA0465 726 KDLQDDIQNRATSFATVV--KDIEGF-MEENqtklsPRELTALREKLHQA 772 nerWeqLlelaaeRkqkLee<-* e++e+L+e + +++Lee KIAA0465 773 KEQYEALQEETRVAQKELEE 792 PF00435.11.fs: domain 3 of 27, from 948 to 1024: score 23.7, E = 1.6e-06 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +lq+F++d +++esW+e e+ L ++ ++g ++e++ +Llk ++ KIAA0465 948 DELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLK--RQG 992 aleaelaahqdrvealninelaekLiideghyase<-* + +++ h++ ++ ++ ++k+ +d + + e KIAA0465 993 SFSEDVISHKGDLRFVT--ISGQKV-LDMENSFKE 1024 PF00435.11.ls: domain 2 of 25, from 948 to 1051: score 22.4, E = 0.0006 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +lq+F++d +++esW+e e+ L ++ ++g ++e++ +Llk ++ KIAA0465 948 DELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLK--RQG 992 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq + +++ h++ ++ ++ ++k+ +d + + + +e+ + ++ KIAA0465 993 SFSEDVISHKGDLRFVT--ISGQKV-LDMENSFK--EGKEPSEIGNLVKD 1037 LlelaaeRkqkLee<-* l+ a eR +L+ KIAA0465 1038 KLKDATERYTALHS 1051 PF00435.11.fs: domain 4 of 27, from 1065 to 1175: score 37.8, E = 1e-10 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH +++qFq+ ad l++W++ ea + + + +++ +L++ql KIAA0465 1065 GQYHQFQNSADSLQAWMQACEANV-EKLLSDTVASDPGVLQEQLaTT 1110 kaleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLne k+l++ela hq ve+l+ ++a+++ ++ ++++ +++ ++qe+ + + + KIAA0465 1111 KQLQEELAEHQVPVEKLQ--KVARDI-MEIEgepAPDHRHVQETTDSILS 1157 rWeqLlelaaeRkqkLee<-* ++++L +aeR L+ KIAA0465 1158 HFQSLSYSLAERSSLLQK 1175 PF00435.11.ls: domain 3 of 25, from 1065 to 1175: score 39.7, E = 9.2e-09 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH +++qFq+ ad l++W++ ea + + + +++ +L++ql KIAA0465 1065 GQYHQFQNSADSLQAWMQACEANV-EKLLSDTVASDPGVLQEQLaTT 1110 kaleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLne k+l++ela hq ve+l+ ++a+++ ++ ++++ +++ ++qe+ + + + KIAA0465 1111 KQLQEELAEHQVPVEKLQ--KVARDI-MEIEgepAPDHRHVQETTDSILS 1157 rWeqLlelaaeRkqkLee<-* ++++L +aeR L+ KIAA0465 1158 HFQSLSYSLAERSSLLQK 1175 PF00435.11.ls: domain 4 of 25, from 1178 to 1284: score 1.0, E = 0.032 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH + q q ++ l++ i e e+ L + + + +++++l KIAA0465 1178 AQSQSVQESLESLLQSIGEVEQNLEGKQV---SSLSSGVIQEALaTN 1221 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe l+ ++a ++ +ea e+ ++++++ ++ +q +l+e+ +r+e KIAA0465 1222 MKLKQDIARQKSSLEATR--EMVTRFMETADSTTAAVLQGKLAEVSQRFE 1269 qLlelaaeRkqkLee<-* qL+ + +e++ L KIAA0465 1270 QLCLQQQEKESSLKK 1284 PF00435.11.ls: domain 5 of 25, from 1393 to 1507: score 20.5, E = 0.00086 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH ++l +F + ++ +++W+ e+e + ++ ++++L kq++ + KIAA0465 1393 EQLDEFRKLVRTFQKWLKETEGSI---PP-TETSMSAKELEKQIeHL 1435 kaleaelaahqdrvealni.nelaekLiideghyas......eeiqerle k l ++ a + ve++n + + e Li++ ++s+++++ eiq ++ KIAA0465 1436 KSLLDDWASKGTLVEEINCkGTSLENLIMEITAPDSqgktdlTEIQCDMS 1485 eLnerWeqLlelaaeRkqkLee<-* ++n ++e+L + eR++ L++ KIAA0465 1486 DVNLKYEKLGGVLHERQESLQA 1507 PF00435.11.ls: domain 6 of 25, from 1510 to 1619: score 43.7, E = 5.7e-10 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH +++++ +++a+ +++W+e ke++L s+d +++ +++ + q + KIAA0465 1510 NRMEEVHKEANSVLQWLESKEEVLKSMDA-MSSPTKTETVKAQAeSN 1555 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe ka+ ael+++ ++++++ +la L++ + +++e+ ++ +eeLn+rWe KIAA0465 1556 KAFLAELEQNSPKIQKVK-EALAGLLVTYPNSQEAENWKKIQEELNSRWE 1604 qLlelaaeRkqkLee<-* + e + +R+++Lee KIAA0465 1605 RATEVTVARQRQLEE 1619 PF00435.11.fs: domain 7 of 27, from 1510 to 1619: score 41.8, E = 6.6e-12 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH +++++ +++a+ +++W+e ke++L s+d +++ +++ + q + KIAA0465 1510 NRMEEVHKEANSVLQWLESKEEVLKSMDA-MSSPTKTETVKAQAeSN 1555 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe ka+ ael+++ ++++++ +la L++ + +++e+ ++ +eeLn+rWe KIAA0465 1556 KAFLAELEQNSPKIQKVK-EALAGLLVTYPNSQEAENWKKIQEELNSRWE 1604 qLlelaaeRkqkLee<-* + e + +R+++Lee KIAA0465 1605 RATEVTVARQRQLEE 1619 PF00435.11.ls: domain 7 of 25, from 1622 to 1730: score 13.4, E = 0.0032 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +l Fq ++l W+ eke +++ + d+ ++ a ++ + KIAA0465 1622 SHLACFQAAESQLRPWLMEKELMMgVLGPL-SIDPNMLNAQKQ--QV 1665 kaleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLne + + +e +a++ + e+ln e a+ + +++ ++ ++ ++q+ l+ +n+ KIAA0465 1666 QFMLKEFEARRQQHEQLN--EAAQGI-LTGPgdvSLSTSQVQKELQSINQ 1712 rWeqLlelaaeRkqkLee<-* +W +L + + +R + + KIAA0465 1713 KWVELTDKLNSRSSQIDQ 1730 PF00435.11.ls: domain 8 of 25, from 1843 to 1950: score 49.9, E = 8.2e-12 *->lllqqFqrdaddlesWieek.ealLssedyegkdleevqaLlkql.k qqFq+ d+l W+++k+ +++ + + ++ L++ql+ KIAA0465 1843 ASTQQFQQMFDELRTWLDDKqSQQA---KN-CPISAKLERLQSQLqE 1885 HkaleaelaahqdrvealninelaekLiideg..hyaseeiqerleeLne +++++ l++h + e + +++e L + + +++++ +q +l eL KIAA0465 1886 NEEFQKSLNQHSGSYEVIV--AEGESL-LLSVppGEEKRTLQNQLVELKN 1932 rWeqLlelaaeRkqkLee<-* +We+L + +a+R+ +L + KIAA0465 1933 HWEELSKKTADRQSRLKD 1950 PF00435.11.fs: domain 9 of 27, from 1843 to 1950: score 47.9, E = 9.7e-14 *->lllqqFqrdaddlesWieek.ealLssedyegkdleevqaLlkql.k qqFq+ d+l W+++k+ +++ + + ++ L++ql+ KIAA0465 1843 ASTQQFQQMFDELRTWLDDKqSQQA---KN-CPISAKLERLQSQLqE 1885 HkaleaelaahqdrvealninelaekLiideg..hyaseeiqerleeLne +++++ l++h + e + +++e L + + +++++ +q +l eL KIAA0465 1886 NEEFQKSLNQHSGSYEVIV--AEGESL-LLSVppGEEKRTLQNQLVELKN 1932 rWeqLlelaaeRkqkLee<-* +We+L + +a+R+ +L + KIAA0465 1933 HWEELSKKTADRQSRLKD 1950 PF00435.11.ls: domain 9 of 25, from 1953 to 2057: score 32.7, E = 1.2e-06 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +++q++q++++dl Wie+ +a +s+ + d+ +++ l + k KIAA0465 1953 QKAQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLL--RSK 1996 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+ +e++ ++ +e ln a+ L i+++ +++ i++ ++++n++ ++ KIAA0465 1997 AMLNEVEKRRSLLEILN--SAADIL-INSSEADEDGIRDEKAGINQNMDA 2043 LlelaaeRkqkLee<-* + e ++++ Lee KIAA0465 2044 VTEELQAKTGSLEE 2057 PF00435.11.fs: domain 10 of 27, from 1953 to 2057: score 30.8, E = 1.2e-08 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +++q++q++++dl Wie+ +a +s+ + d+ +++ l + k KIAA0465 1953 QKAQKYQWHVEDLVPWIEDCKAKMSELRV-TLDPVQLESSLL--RSK 1996 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq a+ +e++ ++ +e ln a+ L i+++ +++ i++ ++++n++ ++ KIAA0465 1997 AMLNEVEKRRSLLEILN--SAADIL-INSSEADEDGIRDEKAGINQNMDA 2043 LlelaaeRkqkLee<-* + e ++++ Lee KIAA0465 2044 VTEELQAKTGSLEE 2057 PF00435.11.ls: domain 10 of 25, from 2278 to 2386: score 17.1, E = 0.0016 *->lllqqFqrdaddlesWieek.ealLssedyegkdleevqaLlkql.k + + F+r+++ l+ + ++ea + +++ +ev+ + +ql KIAA0465 2278 GRVEDFYRKLKGLNDATTAAeEAEA----LQWVVGTEVEIINQQLaD 2320 Hkaleaelaa.hqdrvealninelaekLiideghyas.eeiqerleeLne +k +++e +++q +++++n l++ Li+++g+++ + +++ +ee+n+ KIAA0465 2321 FKMFQKEQVDpLQMKLQQVN--GLGQGLIQSAGKDCDvQGLEHDMEEINA 2368 rWeqLlelaaeRkqkLee<-* rW L + +a+R ++L+e KIAA0465 2369 RWNTLNKKVAQRIAQLQE 2386 PF00435.11.fs: domain 11 of 27, from 2309 to 2386: score 25.1, E = 6.1e-07 *->eevqaLlkql.kHkaleaelaa.hqdrvealninelaekLiideghy +ev+ + +ql +k +++e +++q +++++n l++ Li+++g++ KIAA0465 2309 TEVEIINQQLaDFKMFQKEQVDpLQMKLQQVN--GLGQGLIQSAGKD 2353 as.eeiqerleeLnerWeqLlelaaeRkqkLee<-* + + +++ +ee+n+rW L + +a+R ++L+e KIAA0465 2354 CDvQGLEHDMEEINARWNTLNKKVAQRIAQLQE 2386 PF00435.11.ls: domain 11 of 25, from 2389 to 2495: score 48.3, E = 2.3e-11 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+ +Fq ++ l+sW+ ++e+l++++ + + v+a + +k KIAA0465 2389 LHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ--EQK 2433 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +l++ l++++ v+ l+ +++ +++++++ + e i+ +le L++rW + KIAA0465 2434 LLQRLLDDRKATVDMLQ--AEGGRIAQSAELADREKITGQLESLESRWTE 2481 LlelaaeRkqkLee<-* Ll aa+R+++Le+ KIAA0465 2482 LLSKAAARQKQLED 2495 PF00435.11.fs: domain 12 of 27, from 2389 to 2495: score 46.4, E = 2.8e-13 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l+ +Fq ++ l+sW+ ++e+l++++ + + v+a + +k KIAA0465 2389 LHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQ--EQK 2433 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +l++ l++++ v+ l+ +++ +++++++ + e i+ +le L++rW + KIAA0465 2434 LLQRLLDDRKATVDMLQ--AEGGRIAQSAELADREKITGQLESLESRWTE 2481 LlelaaeRkqkLee<-* Ll aa+R+++Le+ KIAA0465 2482 LLSKAAARQKQLED 2495 PF00435.11.fs: domain 13 of 27, from 2498 to 2604: score 28.0, E = 8.4e-08 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH l+ qF+ a+ + ++ +e+ L +se + g + +q+ +H KIAA0465 2498 VLAKQFHETAEPISDFLSVTEKKLaNSEPV-GTQTAKIQQQII--RH 2541 kaleaelaahqdrvealninelaekLiideg.hyaseeiqerleeLnerW kal +e+ +++ +v++ + +++L + + ++++ iqe+l+++ +r+ KIAA0465 2542 KALNEEIVNRKKNVDQAI--KNGQAL-LKQTtGEEVLLIQEKLDGIKTRY 2588 eqLlelaaeRkqkLee<-* +++ ++Le+ KIAA0465 2589 ADITVTSSKALRTLEQ 2604 PF00435.11.ls: domain 12 of 25, from 2498 to 2604: score 29.9, E = 8.3e-06 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH l+ qF+ a+ + ++ +e+ L +se + g + +q+ +H KIAA0465 2498 VLAKQFHETAEPISDFLSVTEKKLaNSEPV-GTQTAKIQQQII--RH 2541 kaleaelaahqdrvealninelaekLiideg.hyaseeiqerleeLnerW kal +e+ +++ +v++ + +++L + + ++++ iqe+l+++ +r+ KIAA0465 2542 KALNEEIVNRKKNVDQAI--KNGQAL-LKQTtGEEVLLIQEKLDGIKTRY 2588 eqLlelaaeRkqkLee<-* +++ ++Le+ KIAA0465 2589 ADITVTSSKALRTLEQ 2604 PF00435.11.ls: domain 13 of 25, from 2607 to 2713: score 8.1, E = 0.0085 *->lllqqFqrdaddlesWieekealLssedyegkdleevq..aLlkqlk +l+ +Fq+ ++l+ W++e e+ L++ g+++++ q ++ ++ + KIAA0465 2607 QLATKFQSTYEELTGWLREVEEELATSG--GQSPTGEQipQFQQ--R 2649 HkaleaelaahqdrvealninelaekLiideg.hyaseeiqerleeLner +k+l++e+ h+ ++++n e+ ++L ++ + a e + + +++ ne+ KIAA0465 2650 QKELKKEVMEHRLVLDTVN--EVSRAL-LELVpWRAREGLDKLVSDANEQ 2696 WeqLlelaaeRkqkLee<-* ++ + + + +R + + KIAA0465 2697 YKLVSDTIGQRVDEIDA 2713 PF00435.11.ls: domain 14 of 25, from 2716 to 2822: score 22.6, E = 0.00058 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH ++ qq+ + ad +++W e+++ L + + + + a l+ + KIAA0465 2716 QRSQQYEQAADAELAWVAETKRKLmALGPI-RLEQDQTTAQLQ--VQ 2759 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe ka+ ++ h+d +++l+ + e + + g ++ +qe+ e L +++e KIAA0465 2760 KAFSIDIIRHKDSMDELF-SHRSEIF-GTCGEEQKTVLQEKTESLIQQYE 2807 qLlelaaeRkqkLee<-* ++ l eR ++Le+ KIAA0465 2808 AISLLNSERYARLER 2822 PF00435.11.ls: domain 15 of 25, from 2825 to 2930: score 19.4, E = 0.0011 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk l qF ++l Wiee++al+ ++ +++ q ++q + KIAA0465 2825 VLVNQFWETYEELSPWIEETRALI-AQLP-SPAIDHEQLRQQQEEMR 2869 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq +l++ +a h++++++l +++ +L + ++++ e ++e+ + + ++q KIAA0465 2870 QLRESIAEHKPHIDKLL--KIGPQL-KELNPEEGEMVEEKYQKAENMYAQ 2916 LlelaaeRkqkLee<-* ++e + +R +L e KIAA0465 2917 IKEEVRQRALALDE 2930 PF00435.11.ls: domain 16 of 25, from 2936 to 3046: score 3.0, E = 0.022 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH ++ +F+ +++ +++ +e L +++ ++ev + + ++ KIAA0465 2936 TQITEFHDKIEPMLETLENLSSRL---RMPPLIPAEVDKIRECIsDN 2979 kaleaelaahqdrvealninelaekLiideg.....hyaseeiqerleeL k el+ +q+ +eal +e+L i ++++ +++ a++eiq++l++ KIAA0465 2980 KSATVELEKLQPSFEALK--RRGEEL-IGRSqgadkDLAAKEIQDKLDQM 3026 nerWeqLlelaaeRkqkLee<-* We+++++a+eR+ k ++ KIAA0465 3027 VFFWEDIKARAEEREIKFLD 3046 PF00435.11.fs: domain 18 of 27, from 3049 to 3155: score 35.7, E = 4.3e-10 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +l+++F +d++ l+ i ++ ++ + + +g d++ +++ + + KIAA0465 3049 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVE--AAE 3093 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq ++++e +++ + +e + l+++Li++ g + +e+++ ++e n +We+ KIAA0465 3094 TIKEETDGLHEELEFIR--ILGADLIFACGETEKPEVRKSIDEMNNAWEN 3141 LlelaaeRkqkLee<-* L + ++eR +kLe+ KIAA0465 3142 LNKTWKERLEKLED 3155 PF00435.11.ls: domain 17 of 25, from 3049 to 3155: score 37.6, E = 4e-08 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkqlkHk +l+++F +d++ l+ i ++ ++ + + +g d++ +++ + + KIAA0465 3049 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVE--AAE 3093 aleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeq ++++e +++ + +e + l+++Li++ g + +e+++ ++e n +We+ KIAA0465 3094 TIKEETDGLHEELEFIR--ILGADLIFACGETEKPEVRKSIDEMNNAWEN 3141 LlelaaeRkqkLee<-* L + ++eR +kLe+ KIAA0465 3142 LNKTWKERLEKLED 3155 PF00435.11.fs: domain 19 of 27, from 3158 to 3265: score 36.0, E = 3.5e-10 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH + + q+q ++ + W++ + L + + + g dl +v+ l KIAA0465 3158 QAAVQYQDTLQAMFDWLDNTVIKLcTMPPV-GTDLNTVKDQLN--EM 3201 kaleaelaahqdrvealninelaekLiideghyas..eeiqerleeLner k+++ e+ ++q +e+ln +++e + + ++++++ i+e l eL ++ KIAA0465 3202 KEFKVEVYQQQIEMEKLN--HQGELM-LKKATDETdrDIIREPLTELKHL 3248 WeqLlelaaeRkqkLee<-* We+L e +a R++kLe KIAA0465 3249 WENLGEKIAHRQHKLEG 3265 PF00435.11.ls: domain 18 of 25, from 3158 to 3265: score 37.9, E = 3.2e-08 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH + + q+q ++ + W++ + L + + + g dl +v+ l KIAA0465 3158 QAAVQYQDTLQAMFDWLDNTVIKLcTMPPV-GTDLNTVKDQLN--EM 3201 kaleaelaahqdrvealninelaekLiideghyas..eeiqerleeLner k+++ e+ ++q +e+ln +++e + + ++++++ i+e l eL ++ KIAA0465 3202 KEFKVEVYQQQIEMEKLN--HQGELM-LKKATDETdrDIIREPLTELKHL 3248 WeqLlelaaeRkqkLee<-* We+L e +a R++kLe KIAA0465 3249 WENLGEKIAHRQHKLEG 3265 PF00435.11.fs: domain 20 of 27, from 3268 to 3374: score 68.6, E = 7.1e-20 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH l l qFq+ +++l+sW++ +e+lL d + ++++++ +l kH KIAA0465 3268 LALGQFQHALEELMSWLTHTEELL---DAQRPISGDPKVIEVELaKH 3311 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe l++++ ahq ve++n + +++L +++ ++++ +++rle+ n++We KIAA0465 3312 HVLKNDVLAHQATVETVN--KAGNELLESSAGDDASSLRSRLEAMNQCWE 3359 qLlelaaeRkqkLee<-* ++l+ ++eR+q+L+ KIAA0465 3360 SVLQKTEEREQQLQS 3374 PF00435.11.ls: domain 19 of 25, from 3268 to 3374: score 70.5, E = 5e-18 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH l l qFq+ +++l+sW++ +e+lL d + ++++++ +l kH KIAA0465 3268 LALGQFQHALEELMSWLTHTEELL---DAQRPISGDPKVIEVELaKH 3311 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe l++++ ahq ve++n + +++L +++ ++++ +++rle+ n++We KIAA0465 3312 HVLKNDVLAHQATVETVN--KAGNELLESSAGDDASSLRSRLEAMNQCWE 3359 qLlelaaeRkqkLee<-* ++l+ ++eR+q+L+ KIAA0465 3360 SVLQKTEEREQQLQS 3374 PF00435.11.ls: domain 20 of 25, from 3377 to 3484: score 24.1, E = 0.00044 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +++q F+++++d+++ ++ +e +L++s g +e++++ l+ H KIAA0465 3377 QQAQGFHSEIEDFLLELTRMESQLsASKPT-GGLPETAREQLD--TH 3420 kaleaelaahqdrvealninelaekLiideghyas.eeiqerleeLnerW +l l a ++ ++l + ++ + +++ + s+ +++ ++ L+++W KIAA0465 3421 MELYSQLKAKEETYNQLL--DKGRLMLLSRDDSGSgSKTEQSVALLEQKW 3468 eqLlelaaeRkqkLee<-* + ++eRk kLee KIAA0465 3469 HVVSSKMEERKSKLEE 3484 PF00435.11.fs: domain 21 of 27, from 3377 to 3484: score 22.2, E = 4.5e-06 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +++q F+++++d+++ ++ +e +L++s g +e++++ l+ H KIAA0465 3377 QQAQGFHSEIEDFLLELTRMESQLsASKPT-GGLPETAREQLD--TH 3420 kaleaelaahqdrvealninelaekLiideghyas.eeiqerleeLnerW +l l a ++ ++l + ++ + +++ + s+ +++ ++ L+++W KIAA0465 3421 MELYSQLKAKEETYNQLL--DKGRLMLLSRDDSGSgSKTEQSVALLEQKW 3468 eqLlelaaeRkqkLee<-* + ++eRk kLee KIAA0465 3469 HVVSSKMEERKSKLEE 3484 PF00435.11.fs: domain 22 of 27, from 3487 to 3593: score 52.5, E = 4.4e-15 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +l+ +Fq+ ++++ +W++ +e+ L+ + l +v + + H KIAA0465 3487 NLATEFQNSLQEFINWLTLAEQSLnIASPP-SLILNTVLSQIE--EH 3530 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe k + +e++ah+d++ +l+ +++++L++ +++++ i+ l + +rWe KIAA0465 3531 KVFANEVNAHRDQIIELD--QTGNQLKFLSQKQDVVLIKNLLVSVQSRWE 3578 qLlelaaeRkqkLee<-* ++ ++ eR + L + KIAA0465 3579 KVVQRSIERGRSLDD 3593 PF00435.11.ls: domain 21 of 25, from 3487 to 3593: score 54.4, E = 3.5e-13 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +l+ +Fq+ ++++ +W++ +e+ L+ + l +v + + H KIAA0465 3487 NLATEFQNSLQEFINWLTLAEQSLnIASPP-SLILNTVLSQIE--EH 3530 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe k + +e++ah+d++ +l+ +++++L++ +++++ i+ l + +rWe KIAA0465 3531 KVFANEVNAHRDQIIELD--QTGNQLKFLSQKQDVVLIKNLLVSVQSRWE 3578 qLlelaaeRkqkLee<-* ++ ++ eR + L + KIAA0465 3579 KVVQRSIERGRSLDD 3593 PF00435.11.ls: domain 22 of 25, from 3596 to 3703: score 45.1, E = 2.3e-10 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +++ qF+ + l W+e++e +L+s+ ++ +d++ ++ l+ kH KIAA0465 3596 KRAKQFHEAWKKLIDWLEDAESHLdSELEI-SNDPDKIKLQLS--KH 3639 kaleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLne k++++ l + q+ ++ ++++L e++ +++s+ + l e+++ KIAA0465 3640 KEFQKTLGGKQPVYDTTI--RTGRAL--KEKtllPEDSQKLDNFLGEVRD 3685 rWeqLlelaaeRkqkLee<-* +W+ ++ eR++kLee KIAA0465 3686 KWDTVCGKSVERQHKLEE 3703 PF00435.11.fs: domain 23 of 27, from 3596 to 3703: score 43.2, E = 2.6e-12 *->lllqqFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkH +++ qF+ + l W+e++e +L+s+ ++ +d++ ++ l+ kH KIAA0465 3596 KRAKQFHEAWKKLIDWLEDAESHLdSELEI-SNDPDKIKLQLS--KH 3639 kaleaelaahqdrvealninelaekLiideg...hyaseeiqerleeLne k++++ l + q+ ++ ++++L e++ +++s+ + l e+++ KIAA0465 3640 KEFQKTLGGKQPVYDTTI--RTGRAL--KEKtllPEDSQKLDNFLGEVRD 3685 rWeqLlelaaeRkqkLee<-* +W+ ++ eR++kLee KIAA0465 3686 KWDTVCGKSVERQHKLEE 3703 PF00435.11.ls: domain 23 of 25, from 3704 to 3811: score 43.3, E = 7.8e-10 *->lllq..qFqrdaddlesWieekealL.ssedyegkdleevqaLlkql ll+++qF ++ l W+ + e++L ++ + dl+ v++L++ KIAA0465 3704 ALLFsgQFMDALQALVDWLYKVEPQLaEDQPV-HGDLDLVMNLMD-- 3747 kHkaleaelaahqdrvealninelaekLiideghyaseeiqerleeLner Hk +++el + + v+ l +++L i+++ +++ ++ +l+eL +r KIAA0465 3748 AHKVFQKELGKRTGTVQVLK--RSGREL-IENSRDDTTWVKGQLQELSTR 3794 WeqLlelaaeRkqkLee<-* W+ +++l +++ +Le+ KIAA0465 3795 WDTVCKLSVSKQSRLEQ 3811 PF00435.11.fs: domain 24 of 27, from 3710 to 3811: score 43.8, E = 1.6e-12 *->qFqrdaddlesWieekealL.ssedyegkdleevqaLlkqlkHkale qF ++ l W+ + e++L ++ + dl+ v++L++ Hk ++ KIAA0465 3710 QFMDALQALVDWLYKVEPQLaEDQPV-HGDLDLVMNLMD--AHKVFQ 3753 aelaahqdrvealninelaekLiideghyaseeiqerleeLnerWeqLle +el + + v+ l +++L i+++ +++ ++ +l+eL +rW+ +++ KIAA0465 3754 KELGKRTGTVQVLK--RSGREL-IENSRDDTTWVKGQLQELSTRWDTVCK 3800 laaeRkqkLee<-* l +++ +Le+ KIAA0465 3801 LSVSKQSRLEQ 3811 PF00435.11.ls: domain 24 of 25, from 3814 to 3920: score 44.9, E = 2.6e-10 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH ++++ F + l++W++e+e+ L ++g +++++aL++ ++ H KIAA0465 3814 KQAEVFRDTVHMLLEWLSEAEQTL---RFRGALPDDTEALQSLIdTH 3857 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe k++++ ++ + v++ +++e + + ++++ i++++ +++r+e KIAA0465 3858 KEFMKKVEEKRVDVNSAV--AMGEVILAVCHPDCITTIKHWITIIRARFE 3905 qLlelaaeRkqkLee<-* ++l++a++++q+Le KIAA0465 3906 EVLTWAKQHQQRLET 3920 PF00435.11.fs: domain 25 of 27, from 3814 to 3920: score 42.9, E = 3e-12 *->lllqqFqrdaddlesWieekealLssedyegkdleevqaLlkql.kH ++++ F + l++W++e+e+ L ++g +++++aL++ ++ H KIAA0465 3814 KQAEVFRDTVHMLLEWLSEAEQTL---RFRGALPDDTEALQSLIdTH 3857 kaleaelaahqdrvealninelaekLiideghyaseeiqerleeLnerWe k++++ ++ + v++ +++e + + ++++ i++++ +++r+e KIAA0465 3858 KEFMKKVEEKRVDVNSAV--AMGEVILAVCHPDCITTIKHWITIIRARFE 3905 qLlelaaeRkqkLee<-* ++l++a++++q+Le KIAA0465 3906 EVLTWAKQHQQRLET 3920 PF00435.11.ls: domain 25 of 25, from 3923 to 4057: score 5.7, E = 0.014 *->lllqqFqrdaddlesWieekealL..ssedyegkdleevqaLlkqlk +l + +++l++Wi+ +e+ L + +++ ++ ++ v+aL KIAA0465 3923 SELVANAELLEELLAWIQWAETTLiqRDQEPIPQNIDRVKALIA--E 3967 HkaleaelaahqdrvealninelaekLiideghyas.............. H+++++e+ q+ v+ ++ ++ ++ e +a+ ++++++++++ + KIAA0465 3968 HQTFMEEMTRKQPDVDRVT--KTYKRK-NIEPTHAPfieksrsggrksls 4014 .............eeiqerleeLnerWeqLlelaaeRkqkLee<-* ++++++ + +++e+ r+++L +rW+q+ la eR++kL + KIAA0465 4015 qptpppmpilsqsEAKNPRINQLSARWQQVWLLALERQRKLND 4057 PF00036.22.fs: domain 1 of 2, from 4090 to 4118: score 27.1, E = 2.4e-06 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* ++ ++F+ +DkD+DGkI+++Ef++++ + KIAA0465 4090 RVMDFFRRIDKDQDGKITRQEFIDGILAS 4118 PF00036.22.ls: domain 1 of 2, from 4090 to 4118: score 29.1, E = 1.4e-05 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* ++ ++F+ +DkD+DGkI+++Ef++++ + KIAA0465 4090 RVMDFFRRIDKDQDGKITRQEFIDGILAS 4118 PF00036.22.ls: domain 2 of 2, from 4126 to 4154: score 27.8, E = 3.4e-05 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* e+ ++ ++fD+DgDG+I++ Ef+aal+ KIAA0465 4126 EMTAVADIFDRDGDGYIDYYEFVAALHPN 4154 PF00036.22.fs: domain 2 of 2, from 4126 to 4154: score 25.9, E = 5.4e-06 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* e+ ++ ++fD+DgDG+I++ Ef+aal+ KIAA0465 4126 EMTAVADIFDRDGDGYIDYYEFVAALHPN 4154 PF02187.8.fs: domain 1 of 1, from 4165 to 4237: score 188.8, E = 5.3e-57 *->dkldDeVkrivedPPCkCpdkFrveqvseGKYRfGDsqlLrlvrilr dk++DeV+r+v++ CkC+++F+veq++e+KYRfGDsq+Lrlvrilr KIAA0465 4165 DKIEDEVTRQVAQ--CKCAKRFQVEQIGENKYRFGDSQQLRLVRILR 4209 shVMVRVGGGWetLdeyLlKhDPCRasq<-* s+VMVRVGGGW++Lde+L+K+DPCRa++ KIAA0465 4210 STVMVRVGGGWMALDEFLVKNDPCRARG 4237 PF02187.8.ls: domain 1 of 1, from 4165 to 4237: score 190.8, E = 3.1e-54 *->dkldDeVkrivedPPCkCpdkFrveqvseGKYRfGDsqlLrlvrilr dk++DeV+r+v++ CkC+++F+veq++e+KYRfGDsq+Lrlvrilr KIAA0465 4165 DKIEDEVTRQVAQ--CKCAKRFQVEQIGENKYRFGDSQQLRLVRILR 4209 shVMVRVGGGWetLdeyLlKhDPCRasq<-* s+VMVRVGGGW++Lde+L+K+DPCRa++ KIAA0465 4210 STVMVRVGGGWMALDEFLVKNDPCRARG 4237 //