hmmpfam - search one or more sequences against HMM database
HMMER 2.3.2 (Oct 2003)
Copyright (C) 1992-2003 HHMI/Washington University School of Medicine
Freely distributed under the GNU General Public License (GPL)
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HMM file:                 /db/iprscan/data/Pfam.bin
Sequence file:            /db/iprscan/tmp/20080501/iprscan-20080501-22174466/chunk_1/iprscan-20080501-22174466.nocrc
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Query sequence: KIAA0277
Accession:      [none]
Description:    [none]

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PF00617.10.ls RasGEF domain                                  178.5    1.5e-50   1
PF00617.10.fs RasGEF domain                                  176.7    5.3e-50   1
PF00618.10.fs Guanine nucleotide exchange factor for Ras-l    76.5      1e-21   1
PF00618.10.ls Guanine nucleotide exchange factor for Ras-l    78.3    2.2e-20   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PF00618.10.fs   1/1      74   178 ..     1   109 []    76.5    1e-21
PF00618.10.ls   1/1      74   178 ..     1   109 []    78.3  2.2e-20
PF00617.10.fs   1/1     345   529 ..     1   227 []   176.7  5.3e-50
PF00617.10.ls   1/1     345   529 ..     1   227 []   178.5  1.5e-50

Alignments of top-scoring domains:
PF00618.10.fs: domain 1 of 1, from 74 to 178: score 76.5, E = 1e-21
                   *->qvkagtlekLvehLt........shsklDssFvstFLlTYRsFttpa
                       v +gt+ek++ehL+++ + ++ +++ +++ ++ +FLlTY +F+t+ 
    KIAA0277    74    VVVSGTPEKILEHLLndlhleevQDKETET-LLDDFLLTYTVFMTTD 119  

                   eLlekLieRywseippp.nl.qssknsweekkkllkpiqlrvlnvlrhWv
                   +L+++L+++y     + ++ + +s++          + +++vl+++++W+
    KIAA0277   120 DLCQALLRHY--SAKKYqGKeENSDV---------PRRKRKVLHLVSQWI 158  

                   enyfeDFadeddpellsrLleF<-*
                     y + +  ++d++ +++L+++   
    KIAA0277   159 ALYKDWL--PEDEHSKMFLKTI    178  

PF00618.10.ls: domain 1 of 1, from 74 to 178: score 78.3, E = 2.2e-20
                   *->qvkagtlekLvehLt........shsklDssFvstFLlTYRsFttpa
                       v +gt+ek++ehL+++ + ++ +++ +++ ++ +FLlTY +F+t+ 
    KIAA0277    74    VVVSGTPEKILEHLLndlhleevQDKETET-LLDDFLLTYTVFMTTD 119  

                   eLlekLieRywseippp.nl.qssknsweekkkllkpiqlrvlnvlrhWv
                   +L+++L+++y     + ++ + +s++          + +++vl+++++W+
    KIAA0277   120 DLCQALLRHY--SAKKYqGKeENSDV---------PRRKRKVLHLVSQWI 158  

                   enyfeDFadeddpellsrLleF<-*
                     y + +  ++d++ +++L+++   
    KIAA0277   159 ALYKDWL--PEDEHSKMFLKTI    178  

PF00617.10.fs: domain 1 of 1, from 345 to 529: score 176.7, E = 5.3e-50
                   *->LlldplelAkQLTLlEhelfkkItpfefLgsKmKHEGPqvWgkksfk
                      L    ++lA +L  ++ +lf +I   e+ +         + ++    
    KIAA0277   345    LGMNTWDLALELMNFDWSLFNSIHEQELIY--------FTFSRQ--- 380  

                   vkneripnidktiknfNqltnfvsetIlkqeFPTNPEFSKkvdpkkRaev
                   ++ e + n+ ++  + N+++ +v+++Il+                kR+++
    KIAA0277   381 GSGEHTANLSLLLQRCNEVQLWVATEILLCS-----------QLGKRVQL 419  

                   iqkfIqVAdhcReLnNFnSllaIisALysspIyRLkkTWekvppqslklI
                   ++kfI +A hc++ +N+nS +aI+ +L++++++RL+ TWek+p + +kl 
    KIAA0277   420 VKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKL- 468  

                   feeLnkLmdsdrNfsnyRelLksigplappnLdddfvraPCVPFfGvYLs
                   f+eL+ L+d++ N++ yR+  k++ p             P +PF +++L+
    KIAA0277   469 FSELESLTDPSLNHKAYRDAFKKMKP-------------PKIPFMPLLLK 505  

                   DLtfleeGnpdyleekKINtnlvNFsKrrk<-*
                   D tf++eGn+++l       nlvNF+K ++   
    KIAA0277   506 DVTFIHEGNKTFLD------NLVNFEKLHM    529  

PF00617.10.ls: domain 1 of 1, from 345 to 529: score 178.5, E = 1.5e-50
                   *->LlldplelAkQLTLlEhelfkkItpfefLgsKmKHEGPqvWgkksfk
                      L    ++lA +L  ++ +lf +I   e+ +         + ++    
    KIAA0277   345    LGMNTWDLALELMNFDWSLFNSIHEQELIY--------FTFSRQ--- 380  

                   vkneripnidktiknfNqltnfvsetIlkqeFPTNPEFSKkvdpkkRaev
                   ++ e + n+ ++  + N+++ +v+++Il+                kR+++
    KIAA0277   381 GSGEHTANLSLLLQRCNEVQLWVATEILLCS-----------QLGKRVQL 419  

                   iqkfIqVAdhcReLnNFnSllaIisALysspIyRLkkTWekvppqslklI
                   ++kfI +A hc++ +N+nS +aI+ +L++++++RL+ TWek+p + +kl 
    KIAA0277   420 VKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKL- 468  

                   feeLnkLmdsdrNfsnyRelLksigplappnLdddfvraPCVPFfGvYLs
                   f+eL+ L+d++ N++ yR+  k++ p             P +PF +++L+
    KIAA0277   469 FSELESLTDPSLNHKAYRDAFKKMKP-------------PKIPFMPLLLK 505  

                   DLtfleeGnpdyleekKINtnlvNFsKrrk<-*
                   D tf++eGn+++l       nlvNF+K ++   
    KIAA0277   506 DVTFIHEGNKTFLD------NLVNFEKLHM    529  

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