# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/ha07036.fasta.nr -Q ../query/KIAA0253.ptfa /cdna2/lib/nr/nr 2 FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 KIAA0253, 708 aa vs /cdna2/lib/nr/nr library 2693465022 residues in 7827732 sequences statistics sampled from 60000 to 7827167 sequences Expectation_n fit: rho(ln(x))= 5.2143+/-0.000179; mu= 12.6101+/- 0.010 mean_var=69.0458+/-13.512, 0's: 29 Z-trim: 32 B-trim: 3 in 1/66 Lambda= 0.154350 FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2 join: 38, opt: 26, open/ext: -10/-2, width: 16 The best scores are: opt bits E(7827732) gi|12231037|sp|Q92542.2|NICA_HUMAN RecName: Full=N ( 709) 4693 1054.4 0 gi|114560635|ref|XP_001171763.1| PREDICTED: nicast ( 709) 4670 1049.3 0 gi|55729123|emb|CAH91298.1| hypothetical protein [ ( 709) 4658 1046.6 0 gi|67969014|dbj|BAE00862.1| unnamed protein produc ( 709) 4649 1044.6 0 gi|55728550|emb|CAH91017.1| hypothetical protein [ ( 709) 4647 1044.1 0 gi|109017653|ref|XP_001117544.1| PREDICTED: nicast ( 709) 4640 1042.6 0 gi|55959864|emb|CAI15010.1| nicastrin [Homo sapien ( 689) 4525 1017.0 0 gi|28839464|gb|AAH47621.1| NCSTN protein [Homo sap ( 689) 4518 1015.4 0 gi|114560649|ref|XP_001171706.1| PREDICTED: nicast ( 689) 4514 1014.5 0 gi|114560633|ref|XP_001171686.1| PREDICTED: nicast ( 742) 4506 1012.7 0 gi|109017663|ref|XP_001117531.1| PREDICTED: nicast ( 689) 4472 1005.2 0 gi|109017651|ref|XP_001117528.1| PREDICTED: nicast ( 742) 4464 1003.4 0 gi|194035833|ref|XP_001928821.1| PREDICTED: simila ( 709) 4373 983.1 0 gi|149755967|ref|XP_001504481.1| PREDICTED: simila ( 709) 4287 964.0 0 gi|29611958|sp|P57716.2|NICA_MOUSE RecName: Full=N ( 708) 4216 948.2 0 gi|9992880|gb|AAG11413.1|AF240469_1 nicastrin [Mus ( 708) 4211 947.0 0 gi|37081094|sp|Q8CGU6.1|NICA_RAT RecName: Full=Nic ( 708) 4206 945.9 0 gi|148707097|gb|EDL39044.1| nicastrin [Mus musculu ( 708) 4205 945.7 0 gi|74192605|dbj|BAE43077.1| unnamed protein produc ( 708) 4202 945.0 0 gi|74213239|dbj|BAE41750.1| unnamed protein produc ( 708) 4191 942.6 0 gi|74006303|ref|XP_545755.2| PREDICTED: similar to ( 687) 4188 941.9 0 gi|114560651|ref|XP_001171696.1| PREDICTED: nicast ( 615) 4047 910.5 0 gi|74267600|gb|AAI02756.1| Nicastrin [Bos taurus] ( 717) 4016 903.6 0 gi|109017665|ref|XP_001117524.1| PREDICTED: nicast ( 615) 4008 901.8 0 gi|114560645|ref|XP_001171745.1| PREDICTED: nicast ( 638) 3946 888.0 0 gi|114560647|ref|XP_001171664.1| PREDICTED: nicast ( 620) 3942 887.1 0 gi|109017661|ref|XP_001117513.1| PREDICTED: nicast ( 654) 3935 885.6 0 gi|109017659|ref|XP_001117535.1| PREDICTED: nicast ( 638) 3932 884.9 0 gi|126307279|ref|XP_001379384.1| PREDICTED: hypoth ( 707) 3678 828.4 0 gi|149040719|gb|EDL94676.1| nicastrin, isoform CRA ( 602) 3583 807.2 0 gi|38607472|gb|AAR25612.1| nicastrin [Gallus gallu ( 717) 3324 749.5 9.3e-214 gi|53133690|emb|CAG32174.1| hypothetical protein [ ( 717) 3310 746.4 8.1e-213 gi|74213022|dbj|BAE41658.1| unnamed protein produc ( 550) 3268 737.0 4.3e-210 gi|114560639|ref|XP_001171729.1| PREDICTED: nicast ( 687) 3215 725.2 1.8e-206 gi|109017657|ref|XP_001117538.1| PREDICTED: nicast ( 687) 3202 722.4 1.4e-205 gi|194382274|dbj|BAG58892.1| unnamed protein produ ( 451) 2928 661.2 2.2e-187 gi|189441985|gb|AAI67321.1| LOC100170459 protein [ ( 702) 2862 646.6 8.5e-183 gi|114560641|ref|XP_001171784.1| PREDICTED: nicast ( 685) 2629 594.8 3.5e-167 gi|47213076|emb|CAF92655.1| unnamed protein produc ( 679) 2589 585.8 1.7e-164 gi|194386768|dbj|BAG61194.1| unnamed protein produ ( 571) 2437 551.9 2.2e-154 gi|114560643|ref|XP_001171803.1| PREDICTED: nicast ( 674) 2225 504.8 4.1e-140 gi|190336694|gb|AAI62515.1| Nicastrin [Danio rerio ( 707) 2074 471.2 5.7e-130 gi|54042471|gb|AAV28475.1| nicastrin [Danio rerio] ( 707) 2061 468.3 4.2e-129 gi|55959865|emb|CAI15011.1| nicastrin [Homo sapien ( 319) 1763 401.7 2.1e-109 gi|55959867|emb|CAI15013.1| nicastrin [Homo sapien ( 274) 1507 344.7 2.7e-92 gi|74137394|dbj|BAE35745.1| unnamed protein produc ( 245) 1428 327.0 4.9e-87 gi|55959862|emb|CAI15008.1| nicastrin [Homo sapien ( 255) 1310 300.8 4.1e-79 gi|55959861|emb|CAI15007.1| nicastrin [Homo sapien ( 232) 1179 271.6 2.3e-70 gi|198428015|ref|XP_002119351.1| PREDICTED: simila ( 707) 1165 268.8 4.9e-69 gi|55959866|emb|CAI15012.1| nicastrin [Homo sapien ( 219) 1121 258.6 1.7e-66 >>gi|12231037|sp|Q92542.2|NICA_HUMAN RecName: Full=Nicas (709 aa) initn: 4693 init1: 4693 opt: 4693 Z-score: 5641.5 bits: 1054.4 E(): 0 Smith-Waterman score: 4693; 100.000% identity (100.000% similar) in 708 aa overlap (1-708:2-709) 10 20 30 40 50 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 10 20 30 40 50 60 60 70 80 90 100 110 KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 130 140 150 160 170 180 180 190 200 210 220 230 KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 190 200 210 220 230 240 240 250 260 270 280 290 KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 310 320 330 340 350 360 360 370 380 390 400 410 KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 370 380 390 400 410 420 420 430 440 450 460 470 KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 550 560 570 580 590 600 600 610 620 630 640 650 KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 610 620 630 640 650 660 660 670 680 690 700 KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY ::::::::::::::::::::::::::::::::::::::::::::::::: gi|122 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 670 680 690 700 >>gi|114560635|ref|XP_001171763.1| PREDICTED: nicastrin (709 aa) initn: 4670 init1: 4670 opt: 4670 Z-score: 5613.8 bits: 1049.3 E(): 0 Smith-Waterman score: 4670; 99.718% identity (99.718% similar) in 708 aa overlap (1-708:2-709) 10 20 30 40 50 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI ::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 MATAGGGSVADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 10 20 30 40 50 60 60 70 80 90 100 110 KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 130 140 150 160 170 180 180 190 200 210 220 230 KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 190 200 210 220 230 240 240 250 260 270 280 290 KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 310 320 330 340 350 360 360 370 380 390 400 410 KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: gi|114 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRTNQSQ 370 380 390 400 410 420 420 430 440 450 460 470 KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 550 560 570 580 590 600 600 610 620 630 640 650 KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 610 620 630 640 650 660 660 670 680 690 700 KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY ::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 670 680 690 700 >>gi|55729123|emb|CAH91298.1| hypothetical protein [Pong (709 aa) initn: 4658 init1: 4658 opt: 4658 Z-score: 5599.3 bits: 1046.6 E(): 0 Smith-Waterman score: 4658; 99.153% identity (99.576% similar) in 708 aa overlap (1-708:2-709) 10 20 30 40 50 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: gi|557 MATAGGGSGADPGSRGLLRLLSFSVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 10 20 30 40 50 60 60 70 80 90 100 110 KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|557 GCQSSISGDTGVIHVLEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 130 140 150 160 170 180 180 190 200 210 220 230 KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 190 200 210 220 230 240 240 250 260 270 280 290 KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 310 320 330 340 350 360 360 370 380 390 400 410 KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 370 380 390 400 410 420 420 430 440 450 460 470 KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: gi|557 TDTAKALADVATVLGRALYELAGGTNFSDRVQADPQTVTRLLYGFLIKANNSWFQSILRQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 550 560 570 580 590 600 600 610 620 630 640 650 KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 610 620 630 640 650 660 660 670 680 690 700 KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::.::: ::::::::::.:::::::::::::::::::::::: gi|557 FLIASKELEFITLIVGFGILIFSLVVTYCINAKADVLFIAPREPGAVSY 670 680 690 700 >>gi|67969014|dbj|BAE00862.1| unnamed protein product [M (709 aa) initn: 4649 init1: 4649 opt: 4649 Z-score: 5588.5 bits: 1044.6 E(): 0 Smith-Waterman score: 4649; 98.870% identity (99.718% similar) in 708 aa overlap (1-708:2-709) 10 20 30 40 50 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 10 20 30 40 50 60 60 70 80 90 100 110 KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG :::::::::::::::::.::::::::::::::::::::::: :::::::::::::::::: gi|679 GCQSSISGDTGVIHVVEREEDLQWVLTDGPNPPYMVLLESKLFTRDLMEKLKGRTSRIAG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 LAVSLTKPNPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 130 140 150 160 170 180 180 190 200 210 220 230 KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 190 200 210 220 230 240 240 250 260 270 280 290 KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 310 320 330 340 350 360 360 370 380 390 400 410 KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: gi|679 SFVELGQVALRTSLELWMHTDPVSQKNDSVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 370 380 390 400 410 420 420 430 440 450 460 470 KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 550 560 570 580 590 600 600 610 620 630 640 650 KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: gi|679 EYSWVQGPLNSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 610 620 630 640 650 660 660 670 680 690 700 KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::.::: ::::::.:::::::::::::::::::::::::::: gi|679 FLIASKELEFITLIVGFGILVFSLIVTYCINAKADVLFIAPREPGAVSY 670 680 690 700 >>gi|55728550|emb|CAH91017.1| hypothetical protein [Pong (709 aa) initn: 4647 init1: 4647 opt: 4647 Z-score: 5586.1 bits: 1044.1 E(): 0 Smith-Waterman score: 4647; 98.729% identity (99.576% similar) in 708 aa overlap (1-708:2-709) 10 20 30 40 50 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: gi|557 MATAGGGSGADPGSRGLLRLLSFSVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 10 20 30 40 50 60 60 70 80 90 100 110 KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: gi|557 GCQSSISGDTGVIHVLEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 130 140 150 160 170 180 180 190 200 210 220 230 KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF :::::::::::::::::::.::::::.::::::::::::::::::::::::::::::::: gi|557 FLLEDENETKVIKQCYQDHDLSQNGSTPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 190 200 210 220 230 240 240 250 260 270 280 290 KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 310 320 330 340 350 360 360 370 380 390 400 410 KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 370 380 390 400 410 420 420 430 440 450 460 470 KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ ::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::: gi|557 TDTAKALADVATVLGRALYELAGGTNFSDRVQADPQTVTRLLYGFLIKANNSWFQSILRQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 550 560 570 580 590 600 600 610 620 630 640 650 KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|557 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 610 620 630 640 650 660 660 670 680 690 700 KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::.::: ::::::::::..::::::::::::::::::::::: gi|557 FLIASKELEFITLIVGFGILIFSLVITYCINAKADVLFIAPREPGAVSY 670 680 690 700 >>gi|109017653|ref|XP_001117544.1| PREDICTED: nicastrin (709 aa) initn: 4640 init1: 4640 opt: 4640 Z-score: 5577.7 bits: 1042.6 E(): 0 Smith-Waterman score: 4640; 98.729% identity (99.576% similar) in 708 aa overlap (1-708:2-709) 10 20 30 40 50 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 10 20 30 40 50 60 60 70 80 90 100 110 KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG :::::::::::::::::.::::::::::::::::::::::: ::: :::::::::::::: gi|109 GCQSSISGDTGVIHVVEREEDLQWVLTDGPNPPYMVLLESKLFTRHLMEKLKGRTSRIAG 70 80 90 100 110 120 120 130 140 150 160 170 KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 LAVSLTKPNPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 130 140 150 160 170 180 180 190 200 210 220 230 KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 190 200 210 220 230 240 240 250 260 270 280 290 KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 250 260 270 280 290 300 300 310 320 330 340 350 KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 310 320 330 340 350 360 360 370 380 390 400 410 KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: gi|109 SFVELGQVALRTSLELWMHTDPVSQKNDSVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 370 380 390 400 410 420 420 430 440 450 460 470 KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 430 440 450 460 470 480 480 490 500 510 520 530 KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ 490 500 510 520 530 540 540 550 560 570 580 590 KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 550 560 570 580 590 600 600 610 620 630 640 650 KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI :::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::: gi|109 EYSWVQGPLNSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 610 620 630 640 650 660 660 670 680 690 700 KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::.::: ::::::.:::::::::::::::::::::::::::: gi|109 FLIASKELEFITLIVGFGILVFSLIVTYCINAKADVLFIAPREPGAVSY 670 680 690 700 >>gi|55959864|emb|CAI15010.1| nicastrin [Homo sapiens] (689 aa) initn: 4525 init1: 4525 opt: 4525 Z-score: 5439.5 bits: 1017.0 E(): 0 Smith-Waterman score: 4525; 98.984% identity (99.710% similar) in 689 aa overlap (20-708:1-689) 10 20 30 40 50 60 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG ..: ..: .:::::::::::::::::::::::::::::::: gi|559 MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG 10 20 30 40 70 80 90 100 110 120 KIAA02 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL 50 60 70 80 90 100 130 140 150 160 170 180 KIAA02 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF 110 120 130 140 150 160 190 200 210 220 230 240 KIAA02 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS 170 180 190 200 210 220 250 260 270 280 290 300 KIAA02 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS 230 240 250 260 270 280 310 320 330 340 350 360 KIAA02 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS 290 300 310 320 330 340 370 380 390 400 410 420 KIAA02 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP 350 360 370 380 390 400 430 440 450 460 470 480 KIAA02 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT 410 420 430 440 450 460 490 500 510 520 530 540 KIAA02 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD 470 480 490 500 510 520 550 560 570 580 590 600 KIAA02 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE 530 540 550 560 570 580 610 620 630 640 650 660 KIAA02 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|559 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF 590 600 610 620 630 640 670 680 690 700 KIAA02 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::::::::::::::::::::::::::::::::::::::::: gi|559 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 650 660 670 680 >>gi|28839464|gb|AAH47621.1| NCSTN protein [Homo sapiens (689 aa) initn: 4518 init1: 4518 opt: 4518 Z-score: 5431.0 bits: 1015.4 E(): 0 Smith-Waterman score: 4518; 98.839% identity (99.710% similar) in 689 aa overlap (20-708:1-689) 10 20 30 40 50 60 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG ..: ..: .:::::::::::::::::::::::::::::::: gi|288 MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG 10 20 30 40 70 80 90 100 110 120 KIAA02 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL 50 60 70 80 90 100 130 140 150 160 170 180 KIAA02 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF 110 120 130 140 150 160 190 200 210 220 230 240 KIAA02 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS 170 180 190 200 210 220 250 260 270 280 290 300 KIAA02 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS 230 240 250 260 270 280 310 320 330 340 350 360 KIAA02 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS 290 300 310 320 330 340 370 380 390 400 410 420 KIAA02 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP 350 360 370 380 390 400 430 440 450 460 470 480 KIAA02 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT 410 420 430 440 450 460 490 500 510 520 530 540 KIAA02 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD 470 480 490 500 510 520 550 560 570 580 590 600 KIAA02 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|288 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE 530 540 550 560 570 580 610 620 630 640 650 660 KIAA02 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: gi|288 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIHARIF 590 600 610 620 630 640 670 680 690 700 KIAA02 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::::::::::::::::::::::::::::::::::::::::: gi|288 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 650 660 670 680 >>gi|114560649|ref|XP_001171706.1| PREDICTED: nicastrin (689 aa) initn: 4514 init1: 4514 opt: 4514 Z-score: 5426.2 bits: 1014.5 E(): 0 Smith-Waterman score: 4514; 98.839% identity (99.565% similar) in 689 aa overlap (20-708:1-689) 10 20 30 40 50 60 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG ..: ..: .:::::::::::::::::::::::::::::::: gi|114 MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG 10 20 30 40 70 80 90 100 110 120 KIAA02 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL 50 60 70 80 90 100 130 140 150 160 170 180 KIAA02 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF 110 120 130 140 150 160 190 200 210 220 230 240 KIAA02 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS 170 180 190 200 210 220 250 260 270 280 290 300 KIAA02 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS 230 240 250 260 270 280 310 320 330 340 350 360 KIAA02 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS 290 300 310 320 330 340 370 380 390 400 410 420 KIAA02 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: gi|114 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRTNQSQP 350 360 370 380 390 400 430 440 450 460 470 480 KIAA02 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT 410 420 430 440 450 460 490 500 510 520 530 540 KIAA02 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD 470 480 490 500 510 520 550 560 570 580 590 600 KIAA02 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE 530 540 550 560 570 580 610 620 630 640 650 660 KIAA02 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF 590 600 610 620 630 640 670 680 690 700 KIAA02 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY :::::::::::::::::::::::::::::::::::::::::::::::: gi|114 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 650 660 670 680 >>gi|114560633|ref|XP_001171686.1| PREDICTED: nicastrin (742 aa) initn: 4506 init1: 4506 opt: 4506 Z-score: 5416.1 bits: 1012.7 E(): 0 Smith-Waterman score: 4594; 95.277% identity (95.277% similar) in 741 aa overlap (1-708:2-742) 10 20 KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGL------------------------------ ::::::: ::::::::::::::::::::: gi|114 MATAGGGSVADPGSRGLLRLLSFCVLLAGLFLDFEPDPLPLCPDVSFFPQPQPPTPQSKG 10 20 30 40 50 60 30 40 50 60 70 80 KIAA02 ---CRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLT 70 80 90 100 110 120 90 100 110 120 130 140 KIAA02 DGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 DGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGV 130 140 150 160 170 180 150 160 170 180 190 200 KIAA02 YSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 YSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSA 190 200 210 220 230 240 210 220 230 240 250 260 KIAA02 PTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 PTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTG 250 260 270 280 290 300 270 280 290 300 310 320 KIAA02 TLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 TLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMF 310 320 330 340 350 360 330 340 350 360 370 380 KIAA02 VFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 VFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKN 370 380 390 400 410 420 390 400 410 420 430 440 KIAA02 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGA :::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::: gi|114 ESVRNQVEDLLATLEKSGAGVPAVILRRTNQSQPLPPSSLQRFLRARNISGVVLADHSGA 430 440 450 460 470 480 450 460 470 480 490 500 KIAA02 FHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 FHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNF 490 500 510 520 530 540 510 520 530 540 550 560 KIAA02 SDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 SDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVV 550 560 570 580 590 600 570 580 590 600 610 620 KIAA02 QYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 QYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARL 610 620 630 640 650 660 630 640 650 660 670 680 KIAA02 ARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: gi|114 ARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVT 670 680 690 700 710 720 690 700 KIAA02 YCINAKADVLFIAPREPGAVSY :::::::::::::::::::::: gi|114 YCINAKADVLFIAPREPGAVSY 730 740 708 residues in 1 query sequences 2693465022 residues in 7827732 library sequences Tcomplib [34.26] (8 proc) start: Wed Mar 4 07:50:02 2009 done: Wed Mar 4 07:53:39 2009 Total Scan time: 1538.420 Total Display time: 0.410 Function used was FASTA [version 34.26.5 April 26, 2007]