# /hgtech/tools/fasta-34.26.5_v890/fasta34_t -T 8 -b50 -d10 -E0.01 -H -O./tmp/ha07036.fasta.nr -Q ../query/KIAA0253.ptfa /cdna2/lib/nr/nr 2
FASTA searches a protein or DNA sequence data bank version 34.26.5 April 26, 2007
Please cite:
 W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

 KIAA0253, 708 aa
 vs /cdna2/lib/nr/nr library

2693465022 residues in 7827732 sequences
 statistics sampled from 60000 to 7827167 sequences
  Expectation_n fit: rho(ln(x))= 5.2143+/-0.000179; mu= 12.6101+/- 0.010
 mean_var=69.0458+/-13.512, 0's: 29 Z-trim: 32  B-trim: 3 in 1/66
 Lambda= 0.154350

FASTA (3.5 Sept 2006) function [optimized, BL50 matrix (15:-5)] ktup: 2
 join: 38, opt: 26, open/ext: -10/-2, width:  16
The best scores are:                                      opt bits E(7827732)
gi|12231037|sp|Q92542.2|NICA_HUMAN RecName: Full=N ( 709) 4693 1054.4       0
gi|114560635|ref|XP_001171763.1| PREDICTED: nicast ( 709) 4670 1049.3       0
gi|55729123|emb|CAH91298.1| hypothetical protein [ ( 709) 4658 1046.6       0
gi|67969014|dbj|BAE00862.1| unnamed protein produc ( 709) 4649 1044.6       0
gi|55728550|emb|CAH91017.1| hypothetical protein [ ( 709) 4647 1044.1       0
gi|109017653|ref|XP_001117544.1| PREDICTED: nicast ( 709) 4640 1042.6       0
gi|55959864|emb|CAI15010.1| nicastrin [Homo sapien ( 689) 4525 1017.0       0
gi|28839464|gb|AAH47621.1| NCSTN protein [Homo sap ( 689) 4518 1015.4       0
gi|114560649|ref|XP_001171706.1| PREDICTED: nicast ( 689) 4514 1014.5       0
gi|114560633|ref|XP_001171686.1| PREDICTED: nicast ( 742) 4506 1012.7       0
gi|109017663|ref|XP_001117531.1| PREDICTED: nicast ( 689) 4472 1005.2       0
gi|109017651|ref|XP_001117528.1| PREDICTED: nicast ( 742) 4464 1003.4       0
gi|194035833|ref|XP_001928821.1| PREDICTED: simila ( 709) 4373 983.1       0
gi|149755967|ref|XP_001504481.1| PREDICTED: simila ( 709) 4287 964.0       0
gi|29611958|sp|P57716.2|NICA_MOUSE RecName: Full=N ( 708) 4216 948.2       0
gi|9992880|gb|AAG11413.1|AF240469_1 nicastrin [Mus ( 708) 4211 947.0       0
gi|37081094|sp|Q8CGU6.1|NICA_RAT RecName: Full=Nic ( 708) 4206 945.9       0
gi|148707097|gb|EDL39044.1| nicastrin [Mus musculu ( 708) 4205 945.7       0
gi|74192605|dbj|BAE43077.1| unnamed protein produc ( 708) 4202 945.0       0
gi|74213239|dbj|BAE41750.1| unnamed protein produc ( 708) 4191 942.6       0
gi|74006303|ref|XP_545755.2| PREDICTED: similar to ( 687) 4188 941.9       0
gi|114560651|ref|XP_001171696.1| PREDICTED: nicast ( 615) 4047 910.5       0
gi|74267600|gb|AAI02756.1| Nicastrin [Bos taurus]  ( 717) 4016 903.6       0
gi|109017665|ref|XP_001117524.1| PREDICTED: nicast ( 615) 4008 901.8       0
gi|114560645|ref|XP_001171745.1| PREDICTED: nicast ( 638) 3946 888.0       0
gi|114560647|ref|XP_001171664.1| PREDICTED: nicast ( 620) 3942 887.1       0
gi|109017661|ref|XP_001117513.1| PREDICTED: nicast ( 654) 3935 885.6       0
gi|109017659|ref|XP_001117535.1| PREDICTED: nicast ( 638) 3932 884.9       0
gi|126307279|ref|XP_001379384.1| PREDICTED: hypoth ( 707) 3678 828.4       0
gi|149040719|gb|EDL94676.1| nicastrin, isoform CRA ( 602) 3583 807.2       0
gi|38607472|gb|AAR25612.1| nicastrin [Gallus gallu ( 717) 3324 749.5 9.3e-214
gi|53133690|emb|CAG32174.1| hypothetical protein [ ( 717) 3310 746.4 8.1e-213
gi|74213022|dbj|BAE41658.1| unnamed protein produc ( 550) 3268 737.0 4.3e-210
gi|114560639|ref|XP_001171729.1| PREDICTED: nicast ( 687) 3215 725.2 1.8e-206
gi|109017657|ref|XP_001117538.1| PREDICTED: nicast ( 687) 3202 722.4 1.4e-205
gi|194382274|dbj|BAG58892.1| unnamed protein produ ( 451) 2928 661.2 2.2e-187
gi|189441985|gb|AAI67321.1| LOC100170459 protein [ ( 702) 2862 646.6 8.5e-183
gi|114560641|ref|XP_001171784.1| PREDICTED: nicast ( 685) 2629 594.8 3.5e-167
gi|47213076|emb|CAF92655.1| unnamed protein produc ( 679) 2589 585.8 1.7e-164
gi|194386768|dbj|BAG61194.1| unnamed protein produ ( 571) 2437 551.9 2.2e-154
gi|114560643|ref|XP_001171803.1| PREDICTED: nicast ( 674) 2225 504.8 4.1e-140
gi|190336694|gb|AAI62515.1| Nicastrin [Danio rerio ( 707) 2074 471.2 5.7e-130
gi|54042471|gb|AAV28475.1| nicastrin [Danio rerio] ( 707) 2061 468.3 4.2e-129
gi|55959865|emb|CAI15011.1| nicastrin [Homo sapien ( 319) 1763 401.7 2.1e-109
gi|55959867|emb|CAI15013.1| nicastrin [Homo sapien ( 274) 1507 344.7 2.7e-92
gi|74137394|dbj|BAE35745.1| unnamed protein produc ( 245) 1428 327.0 4.9e-87
gi|55959862|emb|CAI15008.1| nicastrin [Homo sapien ( 255) 1310 300.8 4.1e-79
gi|55959861|emb|CAI15007.1| nicastrin [Homo sapien ( 232) 1179 271.6 2.3e-70
gi|198428015|ref|XP_002119351.1| PREDICTED: simila ( 707) 1165 268.8 4.9e-69
gi|55959866|emb|CAI15012.1| nicastrin [Homo sapien ( 219) 1121 258.6 1.7e-66


>>gi|12231037|sp|Q92542.2|NICA_HUMAN RecName: Full=Nicas  (709 aa)
 initn: 4693 init1: 4693 opt: 4693  Z-score: 5641.5  bits: 1054.4 E():    0
Smith-Waterman score: 4693;  100.000% identity (100.000% similar) in 708 aa overlap (1-708:2-709)

                10        20        30        40        50         
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
               10        20        30        40        50        60

      60        70        80        90       100       110         
KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
               70        80        90       100       110       120

     120       130       140       150       160       170         
KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
              130       140       150       160       170       180

     180       190       200       210       220       230         
KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
              190       200       210       220       230       240

     240       250       260       270       280       290         
KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
              250       260       270       280       290       300

     300       310       320       330       340       350         
KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
              310       320       330       340       350       360

     360       370       380       390       400       410         
KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
              430       440       450       460       470       480

     480       490       500       510       520       530         
KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
              550       560       570       580       590       600

     600       610       620       630       640       650         
KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
              610       620       630       640       650       660

     660       670       680       690       700        
KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       :::::::::::::::::::::::::::::::::::::::::::::::::
gi|122 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
              670       680       690       700         

>>gi|114560635|ref|XP_001171763.1| PREDICTED: nicastrin   (709 aa)
 initn: 4670 init1: 4670 opt: 4670  Z-score: 5613.8  bits: 1049.3 E():    0
Smith-Waterman score: 4670;  99.718% identity (99.718% similar) in 708 aa overlap (1-708:2-709)

                10        20        30        40        50         
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
        ::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 MATAGGGSVADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
               10        20        30        40        50        60

      60        70        80        90       100       110         
KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
               70        80        90       100       110       120

     120       130       140       150       160       170         
KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
              130       140       150       160       170       180

     180       190       200       210       220       230         
KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
              190       200       210       220       230       240

     240       250       260       270       280       290         
KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
              250       260       270       280       290       300

     300       310       320       330       340       350         
KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
              310       320       330       340       350       360

     360       370       380       390       400       410         
KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
gi|114 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRTNQSQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
              430       440       450       460       470       480

     480       490       500       510       520       530         
KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
              550       560       570       580       590       600

     600       610       620       630       640       650         
KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
              610       620       630       640       650       660

     660       670       680       690       700        
KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       :::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
              670       680       690       700         

>>gi|55729123|emb|CAH91298.1| hypothetical protein [Pong  (709 aa)
 initn: 4658 init1: 4658 opt: 4658  Z-score: 5599.3  bits: 1046.6 E():    0
Smith-Waterman score: 4658;  99.153% identity (99.576% similar) in 708 aa overlap (1-708:2-709)

                10        20        30        40        50         
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
        :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
gi|557 MATAGGGSGADPGSRGLLRLLSFSVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
               10        20        30        40        50        60

      60        70        80        90       100       110         
KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
       :::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
gi|557 GCQSSISGDTGVIHVLEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
               70        80        90       100       110       120

     120       130       140       150       160       170         
KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
              130       140       150       160       170       180

     180       190       200       210       220       230         
KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
              190       200       210       220       230       240

     240       250       260       270       280       290         
KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
              250       260       270       280       290       300

     300       310       320       330       340       350         
KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
              310       320       330       340       350       360

     360       370       380       390       400       410         
KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
              430       440       450       460       470       480

     480       490       500       510       520       530         
KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
gi|557 TDTAKALADVATVLGRALYELAGGTNFSDRVQADPQTVTRLLYGFLIKANNSWFQSILRQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
              550       560       570       580       590       600

     600       610       620       630       640       650         
KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
              610       620       630       640       650       660

     660       670       680       690       700        
KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       :::::::::.::: ::::::::::.::::::::::::::::::::::::
gi|557 FLIASKELEFITLIVGFGILIFSLVVTYCINAKADVLFIAPREPGAVSY
              670       680       690       700         

>>gi|67969014|dbj|BAE00862.1| unnamed protein product [M  (709 aa)
 initn: 4649 init1: 4649 opt: 4649  Z-score: 5588.5  bits: 1044.6 E():    0
Smith-Waterman score: 4649;  98.870% identity (99.718% similar) in 708 aa overlap (1-708:2-709)

                10        20        30        40        50         
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
               10        20        30        40        50        60

      60        70        80        90       100       110         
KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
       :::::::::::::::::.::::::::::::::::::::::: ::::::::::::::::::
gi|679 GCQSSISGDTGVIHVVEREEDLQWVLTDGPNPPYMVLLESKLFTRDLMEKLKGRTSRIAG
               70        80        90       100       110       120

     120       130       140       150       160       170         
KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
       ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 LAVSLTKPNPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
              130       140       150       160       170       180

     180       190       200       210       220       230         
KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
              190       200       210       220       230       240

     240       250       260       270       280       290         
KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
              250       260       270       280       290       300

     300       310       320       330       340       350         
KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
              310       320       330       340       350       360

     360       370       380       390       400       410         
KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
       :::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
gi|679 SFVELGQVALRTSLELWMHTDPVSQKNDSVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
              430       440       450       460       470       480

     480       490       500       510       520       530         
KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
              550       560       570       580       590       600

     600       610       620       630       640       650         
KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
       :::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
gi|679 EYSWVQGPLNSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
              610       620       630       640       650       660

     660       670       680       690       700        
KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       :::::::::.::: ::::::.::::::::::::::::::::::::::::
gi|679 FLIASKELEFITLIVGFGILVFSLIVTYCINAKADVLFIAPREPGAVSY
              670       680       690       700         

>>gi|55728550|emb|CAH91017.1| hypothetical protein [Pong  (709 aa)
 initn: 4647 init1: 4647 opt: 4647  Z-score: 5586.1  bits: 1044.1 E():    0
Smith-Waterman score: 4647;  98.729% identity (99.576% similar) in 708 aa overlap (1-708:2-709)

                10        20        30        40        50         
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
        :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::
gi|557 MATAGGGSGADPGSRGLLRLLSFSVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
               10        20        30        40        50        60

      60        70        80        90       100       110         
KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
       :::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
gi|557 GCQSSISGDTGVIHVLEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
               70        80        90       100       110       120

     120       130       140       150       160       170         
KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
              130       140       150       160       170       180

     180       190       200       210       220       230         
KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
       :::::::::::::::::::.::::::.:::::::::::::::::::::::::::::::::
gi|557 FLLEDENETKVIKQCYQDHDLSQNGSTPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
              190       200       210       220       230       240

     240       250       260       270       280       290         
KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
              250       260       270       280       290       300

     300       310       320       330       340       350         
KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
              310       320       330       340       350       360

     360       370       380       390       400       410         
KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
              430       440       450       460       470       480

     480       490       500       510       520       530         
KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
       ::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
gi|557 TDTAKALADVATVLGRALYELAGGTNFSDRVQADPQTVTRLLYGFLIKANNSWFQSILRQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
              550       560       570       580       590       600

     600       610       620       630       640       650         
KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|557 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
              610       620       630       640       650       660

     660       670       680       690       700        
KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       :::::::::.::: ::::::::::..:::::::::::::::::::::::
gi|557 FLIASKELEFITLIVGFGILIFSLVITYCINAKADVLFIAPREPGAVSY
              670       680       690       700         

>>gi|109017653|ref|XP_001117544.1| PREDICTED: nicastrin   (709 aa)
 initn: 4640 init1: 4640 opt: 4640  Z-score: 5577.7  bits: 1042.6 E():    0
Smith-Waterman score: 4640;  98.729% identity (99.576% similar) in 708 aa overlap (1-708:2-709)

                10        20        30        40        50         
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
               10        20        30        40        50        60

      60        70        80        90       100       110         
KIAA02 GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
       :::::::::::::::::.::::::::::::::::::::::: ::: ::::::::::::::
gi|109 GCQSSISGDTGVIHVVEREEDLQWVLTDGPNPPYMVLLESKLFTRHLMEKLKGRTSRIAG
               70        80        90       100       110       120

     120       130       140       150       160       170         
KIAA02 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
       ::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 LAVSLTKPNPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
              130       140       150       160       170       180

     180       190       200       210       220       230         
KIAA02 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
              190       200       210       220       230       240

     240       250       260       270       280       290         
KIAA02 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
              250       260       270       280       290       300

     300       310       320       330       340       350         
KIAA02 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
              310       320       330       340       350       360

     360       370       380       390       400       410         
KIAA02 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
       :::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
gi|109 SFVELGQVALRTSLELWMHTDPVSQKNDSVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
              370       380       390       400       410       420

     420       430       440       450       460       470         
KIAA02 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
              430       440       450       460       470       480

     480       490       500       510       520       530         
KIAA02 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
              490       500       510       520       530       540

     540       550       560       570       580       590         
KIAA02 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
              550       560       570       580       590       600

     600       610       620       630       640       650         
KIAA02 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
       :::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::
gi|109 EYSWVQGPLNSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
              610       620       630       640       650       660

     660       670       680       690       700        
KIAA02 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       :::::::::.::: ::::::.::::::::::::::::::::::::::::
gi|109 FLIASKELEFITLIVGFGILVFSLIVTYCINAKADVLFIAPREPGAVSY
              670       680       690       700         

>>gi|55959864|emb|CAI15010.1| nicastrin [Homo sapiens]    (689 aa)
 initn: 4525 init1: 4525 opt: 4525  Z-score: 5439.5  bits: 1017.0 E():    0
Smith-Waterman score: 4525;  98.984% identity (99.710% similar) in 689 aa overlap (20-708:1-689)

               10        20        30        40        50        60
KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG
                          ..: ..: .::::::::::::::::::::::::::::::::
gi|559                    MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG
                                  10        20        30        40 

               70        80        90       100       110       120
KIAA02 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL
              50        60        70        80        90       100 

              130       140       150       160       170       180
KIAA02 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF
             110       120       130       140       150       160 

              190       200       210       220       230       240
KIAA02 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS
             170       180       190       200       210       220 

              250       260       270       280       290       300
KIAA02 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS
             230       240       250       260       270       280 

              310       320       330       340       350       360
KIAA02 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS
             290       300       310       320       330       340 

              370       380       390       400       410       420
KIAA02 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP
             350       360       370       380       390       400 

              430       440       450       460       470       480
KIAA02 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT
             410       420       430       440       450       460 

              490       500       510       520       530       540
KIAA02 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD
             470       480       490       500       510       520 

              550       560       570       580       590       600
KIAA02 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE
             530       540       550       560       570       580 

              610       620       630       640       650       660
KIAA02 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF
             590       600       610       620       630       640 

              670       680       690       700        
KIAA02 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       ::::::::::::::::::::::::::::::::::::::::::::::::
gi|559 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
             650       660       670       680         

>>gi|28839464|gb|AAH47621.1| NCSTN protein [Homo sapiens  (689 aa)
 initn: 4518 init1: 4518 opt: 4518  Z-score: 5431.0  bits: 1015.4 E():    0
Smith-Waterman score: 4518;  98.839% identity (99.710% similar) in 689 aa overlap (20-708:1-689)

               10        20        30        40        50        60
KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG
                          ..: ..: .::::::::::::::::::::::::::::::::
gi|288                    MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG
                                  10        20        30        40 

               70        80        90       100       110       120
KIAA02 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL
              50        60        70        80        90       100 

              130       140       150       160       170       180
KIAA02 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF
             110       120       130       140       150       160 

              190       200       210       220       230       240
KIAA02 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS
             170       180       190       200       210       220 

              250       260       270       280       290       300
KIAA02 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS
             230       240       250       260       270       280 

              310       320       330       340       350       360
KIAA02 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS
             290       300       310       320       330       340 

              370       380       390       400       410       420
KIAA02 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP
             350       360       370       380       390       400 

              430       440       450       460       470       480
KIAA02 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT
             410       420       430       440       450       460 

              490       500       510       520       530       540
KIAA02 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD
             470       480       490       500       510       520 

              550       560       570       580       590       600
KIAA02 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE
             530       540       550       560       570       580 

              610       620       630       640       650       660
KIAA02 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
gi|288 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIHARIF
             590       600       610       620       630       640 

              670       680       690       700        
KIAA02 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       ::::::::::::::::::::::::::::::::::::::::::::::::
gi|288 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
             650       660       670       680         

>>gi|114560649|ref|XP_001171706.1| PREDICTED: nicastrin   (689 aa)
 initn: 4514 init1: 4514 opt: 4514  Z-score: 5426.2  bits: 1014.5 E():    0
Smith-Waterman score: 4514;  98.839% identity (99.565% similar) in 689 aa overlap (20-708:1-689)

               10        20        30        40        50        60
KIAA02 ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG
                          ..: ..: .::::::::::::::::::::::::::::::::
gi|114                    MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIG
                                  10        20        30        40 

               70        80        90       100       110       120
KIAA02 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 CQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGL
              50        60        70        80        90       100 

              130       140       150       160       170       180
KIAA02 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 AVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIF
             110       120       130       140       150       160 

              190       200       210       220       230       240
KIAA02 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 LLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFS
             170       180       190       200       210       220 

              250       260       270       280       290       300
KIAA02 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 INPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVAS
             230       240       250       260       270       280 

              310       320       330       340       350       360
KIAA02 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 FVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDS
             290       300       310       320       330       340 

              370       380       390       400       410       420
KIAA02 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQP
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
gi|114 FVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRTNQSQP
             350       360       370       380       390       400 

              430       440       450       460       470       480
KIAA02 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 LPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVT
             410       420       430       440       450       460 

              490       500       510       520       530       540
KIAA02 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 DTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQD
             470       480       490       500       510       520 

              550       560       570       580       590       600
KIAA02 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 LRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYE
             530       540       550       560       570       580 

              610       620       630       640       650       660
KIAA02 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 YSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIF
             590       600       610       620       630       640 

              670       680       690       700        
KIAA02 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
       ::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 LIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
             650       660       670       680         

>>gi|114560633|ref|XP_001171686.1| PREDICTED: nicastrin   (742 aa)
 initn: 4506 init1: 4506 opt: 4506  Z-score: 5416.1  bits: 1012.7 E():    0
Smith-Waterman score: 4594;  95.277% identity (95.277% similar) in 741 aa overlap (1-708:2-742)

                10        20                                       
KIAA02  ATAGGGSGADPGSRGLLRLLSFCVLLAGL------------------------------
        ::::::: :::::::::::::::::::::                              
gi|114 MATAGGGSVADPGSRGLLRLLSFCVLLAGLFLDFEPDPLPLCPDVSFFPQPQPPTPQSKG
               10        20        30        40        50        60

         30        40        50        60        70        80      
KIAA02 ---CRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLT
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 TGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLT
               70        80        90       100       110       120

         90       100       110       120       130       140      
KIAA02 DGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 DGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGV
              130       140       150       160       170       180

        150       160       170       180       190       200      
KIAA02 YSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 YSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSA
              190       200       210       220       230       240

        210       220       230       240       250       260      
KIAA02 PTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 PTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTG
              250       260       270       280       290       300

        270       280       290       300       310       320      
KIAA02 TLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 TLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMF
              310       320       330       340       350       360

        330       340       350       360       370       380      
KIAA02 VFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 VFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKN
              370       380       390       400       410       420

        390       400       410       420       430       440      
KIAA02 ESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGA
       :::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::
gi|114 ESVRNQVEDLLATLEKSGAGVPAVILRRTNQSQPLPPSSLQRFLRARNISGVVLADHSGA
              430       440       450       460       470       480

        450       460       470       480       490       500      
KIAA02 FHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 FHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNF
              490       500       510       520       530       540

        510       520       530       540       550       560      
KIAA02 SDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 SDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVV
              550       560       570       580       590       600

        570       580       590       600       610       620      
KIAA02 QYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 QYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARL
              610       620       630       640       650       660

        630       640       650       660       670       680      
KIAA02 ARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
gi|114 ARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVT
              670       680       690       700       710       720

        690       700        
KIAA02 YCINAKADVLFIAPREPGAVSY
       ::::::::::::::::::::::
gi|114 YCINAKADVLFIAPREPGAVSY
              730       740  




708 residues in 1 query   sequences
2693465022 residues in 7827732 library sequences
 Tcomplib [34.26] (8 proc)
 start: Wed Mar  4 07:50:02 2009 done: Wed Mar  4 07:53:39 2009
 Total Scan time: 1538.420 Total Display time:  0.410

Function used was FASTA [version 34.26.5 April 26, 2007]