hmmpfam - search one or more sequences against HMM database HMMER 2.3.2 (Oct 2003) Copyright (C) 1992-2003 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /db/iprscan/data/Pfam.bin Sequence file: /db/iprscan/tmp/20080501/iprscan-20080501-21263467/chunk_1/iprscan-20080501-21263467.nocrc - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: KIAA0246 Accession: [none] Description: [none] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- PF02469.12.fs Fasciclin domain 416.6 6.9e-123 7 PF02469.12.ls Fasciclin domain 393.2 3.6e-115 6 PF00008.17.ls EGF-like domain 344.6 1.6e-100 22 PF00008.17.fs EGF-like domain 321.1 1.8e-93 25 PF00193.8.fs Extracellular link domain 109.9 1.2e-49 1 PF07974.3.fs EGF-like domain 129.8 6.9e-36 16 PF07974.3.ls EGF-like domain 123.1 7.5e-34 11 PF00193.8.ls Extracellular link domain 111.8 1.9e-30 1 PF07645.6.fs Calcium binding EGF domain 61.1 8.3e-18 15 PF00053.14.fs Laminin EGF-like (Domains III and V) 41.6 2.1e-11 9 PF01683.9.fs EB module 29.7 2.5e-07 7 PF01414.9.fs Delta serrate ligand 25.8 2.7e-07 7 PF00053.14.ls Laminin EGF-like (Domains III and V) 13.3 0.00095 2 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PF07974.3.ls 1/11 131 166 .. 1 37 [] 21.8 0.0022 PF00008.17.ls 4/22 255 289 .. 1 38 [] 20.0 0.0078 PF02469.12.fs 2/7 537 662 .. 1 146 [] 87.7 1.2e-25 PF02469.12.ls 1/6 537 662 .. 1 146 [] 89.5 9.2e-24 PF00008.17.ls 9/22 884 921 .. 1 38 [] 25.4 0.00019 PF00008.17.fs 9/25 884 921 .. 1 38 [] 23.5 1.2e-05 PF00008.17.ls 11/22 970 1006 .. 1 38 [] 20.0 0.0082 PF02469.12.fs 3/7 1019 1139 .. 1 146 [] 76.7 2.2e-22 PF02469.12.ls 2/6 1019 1139 .. 1 146 [] 78.5 1.9e-20 PF02469.12.ls 3/6 1159 1274 .. 1 146 [] 11.4 0.00038 PF02469.12.fs 4/7 1159 1232 .. 1 97 [. 28.4 4.2e-08 PF00008.17.ls 16/22 1520 1557 .. 1 38 [] 20.5 0.0057 PF02469.12.ls 4/6 1615 1729 .. 1 146 [] 88.7 1.7e-23 PF02469.12.fs 5/7 1625 1729 .. 16 146 .] 88.6 7e-26 PF02469.12.fs 6/7 1755 1885 .. 1 146 [] 121.8 1e-35 PF02469.12.ls 5/6 1755 1885 .. 1 146 [] 123.7 4.9e-34 PF00053.14.ls 2/2 1987 2040 .. 1 59 [] 11.7 0.0014 PF00008.17.ls 18/22 1990 2025 .. 1 38 [] 21.1 0.0037 PF00053.14.fs 7/9 2011 2040 .. 25 59 .] 22.3 8.4e-06 PF00008.17.ls 19/22 2037 2069 .. 1 38 [] 19.7 0.0094 PF00008.17.ls 21/22 2114 2149 .. 1 38 [] 20.5 0.0056 PF00008.17.ls 22/22 2155 2192 .. 1 38 [] 22.3 0.0016 PF00193.8.fs 1/1 2226 2319 .. 1 104 [] 109.9 1.2e-49 PF00193.8.ls 1/1 2226 2319 .. 1 104 [] 111.8 1.9e-30 Alignments of top-scoring domains: PF07974.3.ls: domain 1 of 11, from 131 to 166: score 21.8, E = 0.0022 *->C.......CngshGtCvspngtstpcgkCvCdsgyedkyqGadC<-* C+++ +++Cng hGtC +++ ++ g CvC + G +C KIAA0246 131 CpggaetpCNG-HGTCL-DGM-DR-NGTCVCQEN----FRGSAC 166 PF00008.17.ls: domain 4 of 22, from 255 to 289: score 20.0, E = 0.0078 *->CspnngpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C p pCs ++C +p+g +C+Cp+ ++++G C KIAA0246 255 CWPS--PCSLLAQCSVSPkGQAQCHCPEN--YHGDGMVC 289 PF02469.12.fs: domain 2 of 7, from 537 to 662: score 87.7, E = 1.2e-25 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld fs f ++l+ gL + L +gpGpfTvFAP+neA++ l g l KIAA0246 537 AFSRFETILENCGLPSIL---DGPGPFTVFAPSNEAVDSL-RDGRLI 579 aLlke.lpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlq L+ +l +L+++++yH+ ++g + l+ + L++ ++++t ++ KIAA0246 580 YLFTAgL----SKLQELVRYHIYNHG----Q--LTVEKLISKGRILT-MA 618 GsplrvnvsvngggegdvvvndgvnnArvvqaDieatNGViHvIDkVLlP ++ l vn+s++g + + + ++ + D++a NGViH +D +LlP KIAA0246 619 NQVLAVNISEEGR----ILLGP--EGVPLQRVDVMAANGVIHMLDGILLP 662 <-* KIAA0246 - - PF02469.12.ls: domain 1 of 6, from 537 to 662: score 89.5, E = 9.2e-24 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld fs f ++l+ gL + L +gpGpfTvFAP+neA++ l g l KIAA0246 537 AFSRFETILENCGLPSIL---DGPGPFTVFAPSNEAVDSL-RDGRLI 579 aLlke.lpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlq L+ +l +L+++++yH+ ++g + l+ + L++ ++++t ++ KIAA0246 580 YLFTAgL----SKLQELVRYHIYNHG----Q--LTVEKLISKGRILT-MA 618 GsplrvnvsvngggegdvvvndgvnnArvvqaDieatNGViHvIDkVLlP ++ l vn+s++g + + + ++ + D++a NGViH +D +LlP KIAA0246 619 NQVLAVNISEEGR----ILLGP--EGVPLQRVDVMAANGVIHMLDGILLP 662 <-* KIAA0246 - - PF00008.17.ls: domain 9 of 22, from 884 to 921: score 25.4, E = 0.00019 *->Cspnn.gpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* Cs ++g+Cs +++Cv++ g+++C C++G +++G+ C KIAA0246 884 CSHPDrGGCSENAECVPGSlGTHHCTCHKG--WSGDGRVC 921 PF00008.17.fs: domain 9 of 25, from 884 to 921: score 23.5, E = 1.2e-05 *->Cspnn.gpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* Cs ++g+Cs +++Cv++ g+++C C++G +++G+ C KIAA0246 884 CSHPDrGGCSENAECVPGSlGTHHCTCHKG--WSGDGRVC 921 PF00008.17.ls: domain 11 of 22, from 970 to 1006: score 20.0, E = 0.0082 *->CspnngpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C ng+C++ +tC+ +++g C CppG ++++G C KIAA0246 970 CRAGNGGCHGLATCRAVGgGQRVCTCPPG--FGGDGFSC 1006 PF02469.12.fs: domain 3 of 7, from 1019 to 1139: score 76.7, E = 2.2e-22 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld +fs+f+++lk+ag++ ++ ++T ++P+ +A+ +l p++ + KIAA0246 1019 HFSIFYQWLKSAGITLPA---DR--RVTALVPSEAAVRQLSPEDRAF 1060 aLlkelpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlqG +L + L n+++ H + g + + + + l+G KIAA0246 1061 WLQP------RTLPNLVRAHFLQGA----L--FEEE-------LAR-LGG 1090 splrvnvsvngggegdvvvnd.gvnnArvvqaDieatNGViHvIDkVLlP +++ ++ ++ +e++ ++ +v+nA+v aD atNGV H++ +VLlP KIAA0246 1091 QEVA-TLNPTTRWEIRNISGRvWVQNASVDVADLLATNGVLHILSQVLLP 1139 <-* KIAA0246 - - PF02469.12.ls: domain 2 of 6, from 1019 to 1139: score 78.5, E = 1.9e-20 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld +fs+f+++lk+ag++ ++ ++T ++P+ +A+ +l p++ + KIAA0246 1019 HFSIFYQWLKSAGITLPA---DR--RVTALVPSEAAVRQLSPEDRAF 1060 aLlkelpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlqG +L + L n+++ H + g + + + + l+G KIAA0246 1061 WLQP------RTLPNLVRAHFLQGA----L--FEEE-------LAR-LGG 1090 splrvnvsvngggegdvvvnd.gvnnArvvqaDieatNGViHvIDkVLlP +++ ++ ++ +e++ ++ +v+nA+v aD atNGV H++ +VLlP KIAA0246 1091 QEVA-TLNPTTRWEIRNISGRvWVQNASVDVADLLATNGVLHILSQVLLP 1139 <-* KIAA0246 - - PF02469.12.ls: domain 3 of 6, from 1159 to 1274: score 11.4, E = 0.00038 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld fs f+ ll++ gLv++++ a +T+F+Ptn ++ + KIAA0246 1159 AFSLFRELLQHHGLVPQIEAAT---AYTIFVPTNRSLEAQ-GNSS-- 1199 aLlkelpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlqG + ++ +++Hvv g ls ++L++g+ +++l G KIAA0246 1200 ----------HLDADTVRHHVVLGE----A--LSMETLRKGG-HRNSLLG 1232 splrvnvsvngggegdvvvndgvnnArvvqaDieatNGViHvIDkVLlP< p v n++g vn+ ++ + ea ++ VL KIAA0246 1233 -PAHWIVFYNHSG--QPEVNH----VPLEGPMLEAPGRSLIGLSGVLTV 1274 -* KIAA0246 - - PF02469.12.fs: domain 4 of 7, from 1159 to 1232: score 28.4, E = 4.2e-08 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld fs f+ ll++ gLv++++ a +T+F+Ptn ++ + KIAA0246 1159 AFSLFRELLQHHGLVPQIEAAT---AYTIFVPTNRSLEAQ-GNSS-- 1199 aLlkelpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlqG + ++ +++Hvv g ls ++L++g+ +++l G KIAA0246 1200 ----------HLDADTVRHHVVLGE----A--LSMETLRKGG-HRNSLLG 1232 <-* KIAA0246 - - PF00008.17.ls: domain 16 of 22, from 1520 to 1557: score 20.5, E = 0.0057 *->CspnngpCsngGtCvdtp.ggytCeCppGyfllytG...krC<-* C ++g+C+ +++C++t+++ +C C +G y+G++ ++C KIAA0246 1520 CLIHHGGCHIHAECIPTGpQQVSCSCREG----YSGdgiRTC 1557 PF02469.12.ls: domain 4 of 6, from 1615 to 1729: score 88.7, E = 1.7e-23 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld f ++ ll+ +L +g+GpfT+F+P + +++l ++ l+ KIAA0246 1615 SFFSLR-LLEYKEL-------KGDGPFTIFVPHADLMSNL-SQDELA 1652 aLlkelpenkeqLkniLkyHvvpggvyslkrslssadLkngsnvtttlqG ++ + + + +yHvv ++ + l s+dL +++t l+G KIAA0246 1653 RIRA-------HRQLVFRYHVVGCR----R--LRSEDLLEQGYATA-LSG 1688 splrvnvsvngggegdvvvndgvnnArvvqaDieatNGViHvIDkVLlP< plr++ + +g+ ++ nd Arvv++D+ea NG+ H ID+VLlP KIAA0246 1689 HPLRFSER--EGS---IYLND---FARVVSSDHEAVNGILHFIDRVLLP 1729 -* KIAA0246 - - PF02469.12.fs: domain 5 of 7, from 1625 to 1729: score 88.6, E = 7e-26 *->dtLndangpGpfTvFAPtneAFaklpppgtldaLlkelpenkeqLkn ++L +g+GpfT+F+P + +++l ++ l+++ + + KIAA0246 1625 KEL---KGDGPFTIFVPHADLMSNL-SQDELARIRA-------HRQL 1660 iLkyHvvpggvyslkrslssadLkngsnvtttlqGsplrvnvsvngggeg + +yHvv ++ + l s+dL +++t l+G plr++ + +g+ KIAA0246 1661 VFRYHVVGCR----R--LRSEDLLEQGYATA-LSGHPLRFSER--EGS-- 1699 dvvvndgvnnArvvqaDieatNGViHvIDkVLlP<-* ++ nd Arvv++D+ea NG+ H ID+VLlP KIAA0246 1700 -IYLND---FARVVSSDHEAVNGILHFIDRVLLP 1729 PF02469.12.fs: domain 6 of 7, from 1755 to 1885: score 121.8, E = 1e-35 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld g+++f +llk agL++ L++a++ pfT ++Pt++AF +l pp+ ++ KIAA0246 1755 GYKIFSGLLKVAGLLPLLREASHR-PFTMLWPTDAAFRAL-PPDRQA 1799 aLlkelpenk.eqLkniLkyHvvpggvyslkrslssadLkngsnvtttlq +L e+++++L++iL+ H++ + ++dL n+++++t ++ KIAA0246 1800 WLYH---EDHrDKLAAILRGHMIRNV----E--ALASDLPNLGPLRT-MH 1839 GsplrvnvsvngggegdvvvndgvnnArvvqaDieatNGViHvIDkVLlP G+p+++++s+++ ge +v d Ar+vq+ + G ++ID++L P KIAA0246 1840 GTPISFSCSRTRPGELMVGEDD----ARIVQRHLPFEGGLAYGIDQLLEP 1885 <-* KIAA0246 - - PF02469.12.ls: domain 5 of 6, from 1755 to 1885: score 123.7, E = 4.9e-34 *->gfstfvallkaagLvdtLndangpGpfTvFAPtneAFaklpppgtld g+++f +llk agL++ L++a++ pfT ++Pt++AF +l pp+ ++ KIAA0246 1755 GYKIFSGLLKVAGLLPLLREASHR-PFTMLWPTDAAFRAL-PPDRQA 1799 aLlkelpenk.eqLkniLkyHvvpggvyslkrslssadLkngsnvtttlq +L e+++++L++iL+ H++ + ++dL n+++++t ++ KIAA0246 1800 WLYH---EDHrDKLAAILRGHMIRNV----E--ALASDLPNLGPLRT-MH 1839 GsplrvnvsvngggegdvvvndgvnnArvvqaDieatNGViHvIDkVLlP G+p+++++s+++ ge +v d Ar+vq+ + G ++ID++L P KIAA0246 1840 GTPISFSCSRTRPGELMVGEDD----ARIVQRHLPFEGGLAYGIDQLLEP 1885 <-* KIAA0246 - - PF00053.14.ls: domain 2 of 2, from 1987 to 2040: score 11.7, E = 0.0014 *->Cd.CnphGslsddtCdsddelf...geetGqClkCkpnvtGrrCdrC C+ C++ s + C sd +++ ++ +GqCl C+ +++G+ C+ C KIAA0246 1987 CQaCPGGP--S-SPC-SDRGVCmdgMSGSGQCL-CRSGFAGTACELC 2028 kpGyyglpsgdpgqgC<-* +pG +g +q C KIAA0246 2029 APGAFG----PHCQAC 2040 PF00008.17.ls: domain 18 of 22, from 1990 to 2025: score 21.1, E = 0.0037 *->Cspnn.gpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C+ ++ pCs +G C+d+ +g+ +C C G ++G C KIAA0246 1990 CPGGPsSPCSDRGVCMDGMsGSGQCLCRSG----FAGTAC 2025 PF00053.14.fs: domain 7 of 9, from 2011 to 2040: score 22.3, E = 8.4e-06 *->tGqClkCkpnvtGrrCdrCkpGyyglpsgdpgqgC<-* +GqCl C+ +++G+ C+ C+pG +g +q C KIAA0246 2011 SGQCL-CRSGFAGTACELCAPGAFG----PHCQAC 2040 PF00008.17.ls: domain 19 of 22, from 2037 to 2069: score 19.7, E = 0.0094 *->CspnngpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C+ C +G+C ++ +g+ +C+C++G +tG+rC KIAA0246 2037 CQAC--RCTVHGRCDEGLgGSGSCFCDEG----WTGPRC 2069 PF00008.17.ls: domain 21 of 22, from 2114 to 2149: score 20.5, E = 0.0056 *->CspnngpCsngGtCvdtpggytCeCppGyfllytGkrC<-* C++ +g+Cs ++ C +++++ tC C p ++++G C KIAA0246 2114 CQDGHGGCSEHANCSQVGTMVTCTCLPD--YEGDGWSC 2149 PF00008.17.ls: domain 22 of 22, from 2155 to 2192: score 22.3, E = 0.0016 *->Cspnn.gpCsngGtCvdtp.ggytCeCppGyfllytGkrC<-* C++ ++g+Cs ++ C++t+ ++ +CeC+ G + ++G +C KIAA0246 2155 CTDGHrGGCSEHANCLSTGlNTRRCECHAG--YVGDGLQC 2192 PF00193.8.fs: domain 1 of 1, from 2226 to 2319: score 109.9, E = 1.2e-49 *->GeVFhyrapsgRYkltFeEAqaaClrqgAriATtgQLyAAwkgGfdq ++VFh+ a sg Y l+F EA aaC++qgA++A++ QL AA + Gf+ KIAA0246 2226 AGVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHL 2272 CdAGWLADgsVRYPIvkPRenCgGdkdgfpGVRtyYlfpNQTGfpddpss C GWLA gs +P+v P + Cg + G+ + G + + s+ KIAA0246 2273 CLMGWLANGSTAHPVVFPVADCGNGR---VGIVSL-------GARKNLSE 2312 rYDvYCF<-* r+D+YCF KIAA0246 2313 RWDAYCF 2319 PF00193.8.ls: domain 1 of 1, from 2226 to 2319: score 111.8, E = 1.9e-30 *->GeVFhyrapsgRYkltFeEAqaaClrqgAriATtgQLyAAwkgGfdq ++VFh+ a sg Y l+F EA aaC++qgA++A++ QL AA + Gf+ KIAA0246 2226 AGVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHL 2272 CdAGWLADgsVRYPIvkPRenCgGdkdgfpGVRtyYlfpNQTGfpddpss C GWLA gs +P+v P + Cg + G+ + G + + s+ KIAA0246 2273 CLMGWLANGSTAHPVVFPVADCGNGR---VGIVSL-------GARKNLSE 2312 rYDvYCF<-* r+D+YCF KIAA0246 2313 RWDAYCF 2319 //