Nr search
BLASTX 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= KCC000281A_C01 KCC000281A_c01
(2074 letters)
Database: nr
1,537,769 sequences; 498,525,298 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gb|AAM45881.1|AF450137_1 multicopper ferroxidase [Chlamydomonas ... 941 0.0
gb|AAQ89349.1| HEPH [Homo sapiens] 157 4e-66
ref|NP_620074.1| hephaestin isoform a [Homo sapiens] gi|12830539... 157 4e-66
dbj|BAA31673.2| KIAA0698 protein [Homo sapiens] 157 4e-66
emb|CAC35365.2| hephaestin [Homo sapiens] 157 1e-65
>gb|AAM45881.1|AF450137_1 multicopper ferroxidase [Chlamydomonas reinhardtii]
gi|25989441|gb|AAL78162.1| ferroxidase-like protein
[Chlamydomonas reinhardtii]
Length = 1142
Score = 941 bits (2431), Expect(3) = 0.0
Identities = 490/627 (78%), Positives = 506/627 (80%), Gaps = 21/627 (3%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG
Sbjct: 137 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 196
Query: 182 GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKHDN 361
GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKHDN
Sbjct: 197 GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKHDN 256
Query: 362 AGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLLFQEDTSLTAGTSYTKMA 541
AGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLLFQEDTSLTAGTSYTKMA
Sbjct: 257 AGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLLFQEDTSLTAGTSYTKMA 316
Query: 542 INGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHGHVVELNGHHVDQFTAIPT 721
INGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHGHVVELNGHHVDQFTAIPT
Sbjct: 317 INGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHGHVVELNGHHVDQFTAIPT 376
Query: 722 ATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDPAPLPTGGVERVYYV------- 880
ATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDPAPLPTGGVERVYYV
Sbjct: 377 ATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDPAPLPTGGVERVYYVRAQEVEW 436
Query: 881 -------LRAGG*VELQRPQQHPGLRRCPS---CSSPASPAVRR*TAMCSWRVPPPTPCA 1030
+A ELQ + PG P++ VR + T +
Sbjct: 437 SYSGPNNTQACAVPELQFSSE-PGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDAS 495
Query: 1031 WDTSTPRRC*SSTRTRASPPSSRWPADEQYLGLLVCRSCGPTW----GTPSRWC*RTTPR 1198
+ T PR PADEQYLGLL GP G + + +
Sbjct: 496 FTTVKPR-----------------PADEQYLGLL-----GPVMRANVGDTIKVVLKNDAK 533
Query: 1199 ST*ACTLTVCATARPTRARCTRTAPAGCRQG*RLWWLPGTTYTYVWNVPDRAGPGPCDPS 1378
+ ++ +G + + PGTTYTYVWNVPDRAGPGPCDPS
Sbjct: 534 IDVSLHPHGVRYSKANEGTLYEDGTSGADKADDV-VAPGTTYTYVWNVPDRAGPGPCDPS 592
Query: 1379 SMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTADLTPKDVDREIVIFFTVVDEIKSS 1558
SMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTADLTPKDVDREIVIFFTVVDEIKSS
Sbjct: 593 SMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTADLTPKDVDREIVIFFTVVDEIKSS 652
Query: 1559 NFMENLANKLGDGGALAAQLAANATEMTALVTDPVFMEHMLKHGINGHMYCHMPRLTFEQ 1738
NFMENLANKLGDGGALAAQLAANATEMTALVTDPVFMEHMLKHGINGHMYCHMPRLTFEQ
Sbjct: 653 NFMENLANKLGDGGALAAQLAANATEMTALVTDPVFMEHMLKHGINGHMYCHMPRLTFEQ 712
Query: 1739 GDKVRLHVMVLGTLEDMHTPNMGGPRF 1819
GDKVRLHVMVLGTLEDMHTPNMGGPRF
Sbjct: 713 GDKVRLHVMVLGTLEDMHTPNMGGPRF 739
Score = 199 bits (505), Expect = 2e-49
Identities = 101/122 (82%), Positives = 104/122 (84%)
Frame = +1
Query: 910 AAPTTPRPAPLPELQFSSEPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTT 1089
+ P + +PELQFSSEPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTT
Sbjct: 439 SGPNNTQACAVPELQFSSEPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTT 498
Query: 1090 VKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDG 1269
VKP G G PVMRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDG
Sbjct: 499 VKPRPADEQYLGLLG-PVMRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDG 557
Query: 1270 TS 1275
TS
Sbjct: 558 TS 559
Score = 164 bits (415), Expect = 6e-39
Identities = 108/330 (32%), Positives = 157/330 (46%), Gaps = 37/330 (11%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ K + YTD+SF T+ PA+ Q+LG +GPVM VG I+VV KN+ V++ P G
Sbjct: 483 YTKTLLIEYTDASFTTVKPRPADEQYLGLLGPVMRANVGDTIKVVLKNDAKIDVSLHPHG 542
Query: 182 --------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSS 337
G + DG D V PG T TY+W +P+ AGP +S LW+Y S
Sbjct: 543 VRYSKANEGTLYEDGTSGADKADDVVAPGTTYTYVWNVPDRAGP-GPCDPSSMLWMYHSH 601
Query: 338 VDPQKHDNAGLVGPIIVTSA--ANADANGRARDVDRDVVAIFQLVQERASPLLFQ----- 496
+D AG+ G IIVT+ A + A+ +DVDR++V F +V E S +
Sbjct: 602 IDETAETYAGVAGGIIVTAKDMARSTADLTPKDVDREIVIFFTVVDEIKSSNFMENLANK 661
Query: 497 ----------------EDTSLTAGTSYT----KMAINGYTWCNMPDGAITIKTGERVRWH 616
E T+L + K ING+ +C+MP +T + G++VR H
Sbjct: 662 LGDGGALAAQLAANATEMTALVTDPVFMEHMLKHGINGHMYCHMP--RLTFEQGDKVRLH 719
Query: 617 VASIGSSESLHNFHWHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHM 796
V +G+ E +H + G + NG H D P S ++ PG + C V H+
Sbjct: 720 VMVLGTLEDMHTPNMGGPRFDYNGMHTDSIQISPGGMVSADVQMTSPGDYELQCRVADHV 779
Query: 797 DGGMVALYTVTGDPAPLPT--GGVERVYYV 880
GM A YTVT + + + GV R YY+
Sbjct: 780 MAGMRAKYTVTANASRMVVNPSGVTRTYYI 809
Score = 141 bits (356), Expect = 4e-32
Identities = 93/300 (31%), Positives = 149/300 (49%), Gaps = 24/300 (8%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNL----DFPVNM 169
+ KA+YRAYTD++F+T TPA + G +GP++ VG I V FKN + ++P+N+
Sbjct: 850 YRKAVYRAYTDATFSTRVPTPA---YYGTMGPMIIAEVGDRIVVHFKNAVTDLEEYPLNI 906
Query: 170 APSGGLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQ 349
+P GGL+ G V G+T Y W +P+ +GP A + ++ Y SSVD
Sbjct: 907 SPGGGLLV---EGAADENCAEVAAGETCVYRWIVPDSSGP-GTADFNTAVYGYTSSVDVA 962
Query: 350 KHDNAGLVGPIIVTS----AANADANGRARDVDRDVVAIFQLVQERASPLL--------- 490
+AGL G ++V A D + R VD V +Q+V E +SP L
Sbjct: 963 TAPSAGLAGALVVAGRGQLVAGPDGSLLPRGVDLMVPLYWQVVDENSSPFLDLNVEAAQL 1022
Query: 491 ----FQEDTSLTA--GTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHN 652
F+ D L+A +INGY +CN P +TI G+++RW + + G+ H+
Sbjct: 1023 NVTKFENDAVLSADFDEGNRMHSINGYVYCNQP--LVTIAKGKKLRWVLVAYGTEGDFHS 1080
Query: 653 FHWHGHVVELNGHHVDQFTAI-PTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVT 829
+ G +E + ++ P+ +M + GTW+ +C V+ H GM++ + VT
Sbjct: 1081 PQFTGQSLEADKSGYSTLASLMPSIARVADMTAADVGTWLLYCDVHDHYMAGMMSQFAVT 1140
Score = 102 bits (253), Expect(3) = 0.0
Identities = 48/48 (100%), Positives = 48/48 (100%)
Frame = +1
Query: 1930 ADHVMAGMRAKYTVTANASRMVVNPSGVTRTYYIQAEAVNWDYAPAGY 2073
ADHVMAGMRAKYTVTANASRMVVNPSGVTRTYYIQAEAVNWDYAPAGY
Sbjct: 776 ADHVMAGMRAKYTVTANASRMVVNPSGVTRTYYIQAEAVNWDYAPAGY 823
Score = 88.6 bits (218), Expect(3) = 7e-21
Identities = 57/168 (33%), Positives = 86/168 (50%), Gaps = 2/168 (1%)
Frame = +2
Query: 1313 GTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKD--MARSTA 1486
G T Y W VPD +GPG D ++ ++ Y S +D AG+AG ++V + +A
Sbjct: 928 GETCVYRWIVPDSSGPGTADFNTAVYGYTSSVDVATAPSAGLAGALVVAGRGQLVAGPDG 987
Query: 1487 DLTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVF 1666
L P+ VD + +++ VVDE SS F+ D AAQL E A+++ F
Sbjct: 988 SLLPRGVDLMVPLYWQVVDE-NSSPFL--------DLNVEAAQLNVTKFENDAVLSAD-F 1037
Query: 1667 MEHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHTPNMGG 1810
E H ING++YC+ P +T +G K+R ++ GT D H+P G
Sbjct: 1038 DEGNRMHSINGYVYCNQPLVTIAKGKKLRWVLVAYGTEGDFHSPQFTG 1085
Score = 81.6 bits (200), Expect(3) = 6e-25
Identities = 59/186 (31%), Positives = 87/186 (46%), Gaps = 3/186 (1%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGP-GPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTA 1486
PG T TY+W +P+ AGP +S LW+Y S +D AG+ G IIVT+ A + A
Sbjct: 216 PGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKHDNAGLVGPIIVTSA--ANADA 273
Query: 1487 DLTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVF 1666
+ +DVDR++V F +V E S + E T+L +
Sbjct: 274 NGRARDVDRDVVAIFQLVQERASPLLFQ---------------------EDTSLTAGTSY 312
Query: 1667 MEHMLKHGINGHMYCHMP--RLTFEQGDKVRLHVMVLGTLEDMHTPNMGGPRF*LQRHAH 1840
K ING+ +C+MP +T + G++VR HV +G+ E +H + G L H
Sbjct: 313 T----KMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHGHVVELNGH-- 366
Query: 1841 RLHPDQ 1858
H DQ
Sbjct: 367 --HVDQ 370
Score = 79.0 bits (193), Expect(3) = 0.0
Identities = 36/36 (100%), Positives = 36/36 (100%)
Frame = +3
Query: 1821 DYNGMHTDSIQISPGGMVSADVQMTSPGDYELQCRV 1928
DYNGMHTDSIQISPGGMVSADVQMTSPGDYELQCRV
Sbjct: 740 DYNGMHTDSIQISPGGMVSADVQMTSPGDYELQCRV 775
Score = 45.1 bits (105), Expect = 0.005
Identities = 21/34 (61%), Positives = 21/34 (61%)
Frame = +3
Query: 837 PRPCPPAAWSGCTTCCAQEVEWSYSGPNNTQACA 938
P P P AQEVEWSYSGPNNTQACA
Sbjct: 415 PAPLPTGGVERVYYVRAQEVEWSYSGPNNTQACA 448
Score = 40.4 bits (93), Expect(3) = 6e-25
Identities = 24/66 (36%), Positives = 33/66 (49%)
Frame = +1
Query: 1027 RLGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDV 1206
R+G + K + YTD+SF T+ G G PVM VG I+VV KN+ V
Sbjct: 132 RVGGTFAKAIYRAYTDSSFNTLATTPAEWQHLGNVG-PVMYGAVGQVIRVVFKNNLDFPV 190
Query: 1207 SLHPHG 1224
++ P G
Sbjct: 191 NMAPSG 196
Score = 36.6 bits (83), Expect(3) = 6e-25
Identities = 17/42 (40%), Positives = 25/42 (59%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNPSGVTRTYYIQAEAVNWDYA 2061
H+ GM A YTVT + + + GV R YY++A+ V W Y+
Sbjct: 400 HMDGGMVALYTVTGDPAPLPTG--GVERVYYVRAQEVEWSYS 439
Score = 32.3 bits (72), Expect(3) = 7e-21
Identities = 25/63 (39%), Positives = 33/63 (51%)
Frame = +1
Query: 1030 LGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDVS 1209
+G Y K + YTDA+F+T P A G G P++ A VGD I V KN A D+
Sbjct: 846 IGSRYRKAVYRAYTDATFSTRVPTP---AYYGTMG-PMIIAEVGDRIVVHFKN-AVTDLE 900
Query: 1210 LHP 1218
+P
Sbjct: 901 EYP 903
Score = 23.9 bits (50), Expect(3) = 7e-21
Identities = 9/15 (60%), Positives = 12/15 (80%)
Frame = +1
Query: 1933 DHVMAGMRAKYTVTA 1977
DH MAGM +++ VTA
Sbjct: 1127 DHYMAGMMSQFAVTA 1141
>gb|AAQ89349.1| HEPH [Homo sapiens]
Length = 1160
Score = 157 bits (398), Expect = 5e-37
Identities = 98/296 (33%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ KA++R YTD +F +HLG +GP++ G VG ++ VVFKNN P ++ G
Sbjct: 784 YKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHG 843
Query: 182 GLIAWDGNGRRSARIDPV--KPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKH 355
L S + P+ +PG+ VTY W IPE +GP N + W+Y S+VDP K
Sbjct: 844 VL--------ESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVS-WIYYSAVDPIKD 894
Query: 356 DNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLL--------------- 490
+GLVGP+ + + +G D+DR+ +F + E S L
Sbjct: 895 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 954
Query: 491 -FQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHG 667
Q++T L + + AING + N+ +T+ GERV W++ ++G LH H+H
Sbjct: 955 NLQDETFLESNKMH---AINGKLYANL--RGLTMYQGERVAWYMLAMGQDVDLHTIHFHA 1009
Query: 668 H-VVELNG--HHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV 826
+ NG + D P V MV PGTW+ HCHV H+ GM L+TV
Sbjct: 1010 ESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 1065
Score = 150 bits (379), Expect(3) = 4e-66
Identities = 104/319 (32%), Positives = 143/319 (44%), Gaps = 26/319 (8%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ K IY+ Y D S+ PA W LG +GPV+ VG VI + KN P + P G
Sbjct: 76 YKKTIYKEYKDDSYTDEVAQPA-W--LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHG 132
Query: 182 --------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSS 337
G + DG+ D V PG + Y W IPE P +A W+Y S
Sbjct: 133 VFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPT-DADPACLTWIYHSH 191
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANG--RARDVDRDVVAIFQLVQERASPLLFQEDTSL 511
VD + GL+GP+I D N + +DVD D +F +V E S L + +
Sbjct: 192 VDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATY 251
Query: 512 ------------TAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNF 655
T S AING+ + N+P+ + + +RV WH+ +G+ +H
Sbjct: 252 CSDPASVDKEDETFQESNRMHAINGFVFGNLPE--LNMCAQKRVAWHLFGMGNEIDVHTA 309
Query: 656 HWHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV--- 826
+HG ++ GHH D P + MVP EPGTW+ C VN H GM ALY V
Sbjct: 310 FFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC 369
Query: 827 -TGDPAPLPTGGVERVYYV 880
P L TG V R Y++
Sbjct: 370 SMAPPVDLLTGKV-RQYFI 387
Score = 137 bits (344), Expect = 1e-30
Identities = 96/319 (30%), Positives = 144/319 (45%), Gaps = 27/319 (8%)
Frame = +2
Query: 8 KAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG-- 181
K Y A+ D +F + +HLG +GPV+ VG I+VVF N P +M P G
Sbjct: 433 KVRYEAFQDETFQEKMHLEED-RHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVF 491
Query: 182 ------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVAN--ATVTSRLWLYRSS 337
G + DG+ KP + VTY W +P AGP A A +T W+Y S+
Sbjct: 492 YEKDYEGTVYNDGSSYPGL---VAKPFEKVTYRWTVPPHAGPTAQDPACLT---WMYFSA 545
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPL---------- 487
DP + N+GLVGP++V A A+G+ + VD++ +F ++ E S
Sbjct: 546 ADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAML 605
Query: 488 ---LFQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFH 658
L ED S AING+ + N+P + + G+ V WH+ +G+ +H
Sbjct: 606 DFRLLSEDIE-GFQDSNRMHAINGFLFSNLP--RLDMCKGDTVAWHLLGLGTETDVHGVM 662
Query: 659 WHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDP 838
+ G+ V+L G P M PD GT+ +C H + GM A+Y V+ P
Sbjct: 663 FQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCP 722
Query: 839 ----APLPTGGVERVYYVL 883
P R+YY++
Sbjct: 723 GHQATPRQRYQAARIYYIM 741
Score = 99.4 bits (246), Expect(4) = 9e-29
Identities = 57/183 (31%), Positives = 92/183 (50%), Gaps = 1/183 (0%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG TY WN+P+R+GPGP D + + W+Y+S +D + Y+G+ G + + K +
Sbjct: 857 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 916
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLA-NKLGDGGALAAQLAANATEMTALVTDPVF 1666
+ D+DRE + F + DE KS EN+A + D G++ Q D F
Sbjct: 917 RS--DMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQ-------------DETF 961
Query: 1667 MEHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHTPNMGGPRF*LQRHAHRL 1846
+E H ING +Y ++ LT QG++V +++ +G D+HT + F L R+
Sbjct: 962 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESF-LYRNGENY 1020
Query: 1847 HPD 1855
D
Sbjct: 1021 RAD 1023
Score = 85.5 bits (210), Expect(4) = 3e-36
Identities = 45/162 (27%), Positives = 75/162 (45%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG ++ Y W +P+ P DP+ + W+YHSH+D + G+ G +I + +
Sbjct: 160 PGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSP 219
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
+DVD + + F+VVDE S + EN+A D ++ + D F
Sbjct: 220 PQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKE-------------DETFQ 266
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHT 1795
E H ING ++ ++P L +V H+ +G D+HT
Sbjct: 267 ESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHT 308
Score = 85.1 bits (209), Expect(3) = 4e-66
Identities = 54/161 (33%), Positives = 76/161 (46%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
P TY W VP AGP DP+ + WMY S D +T +G+ G ++V AD
Sbjct: 514 PFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCR--AGALGAD 571
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
K VD+E + FTV+DE KS N A + D L+ + F
Sbjct: 572 GKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG-------------FQ 618
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMH 1792
+ H ING ++ ++PRL +GD V H++ LGT D+H
Sbjct: 619 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVH 659
Score = 68.2 bits (165), Expect(4) = 3e-36
Identities = 44/116 (37%), Positives = 63/116 (53%), Gaps = 2/116 (1%)
Frame = +1
Query: 934 APLPELQFSSEPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGR 1113
AP +++P ++ + FL+ +D R+G Y KT+ EY D S+T
Sbjct: 43 APKGRNVITNQPLDSDIVASSFLK---SDKNRIGGTYKKTIYKEYKDDSYTDEV------ 93
Query: 1114 AVPGAAGV--PVMRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTS 1275
A P G PV++A VGD I + LKN A ++HPHGV Y K +EG+LY DG+S
Sbjct: 94 AQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSS 149
Score = 62.0 bits (149), Expect(3) = 4e-66
Identities = 43/105 (40%), Positives = 56/105 (52%)
Frame = +1
Query: 964 EPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPV 1143
EPGS ++ F + S R+G Y K + D +F L R + G G PV
Sbjct: 411 EPGS--ISDKFFQKSSS----RIGGTYWKVRYEAFQDETFQEKMHLEEDRHL-GILG-PV 462
Query: 1144 MRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTSW 1278
+RA VGDTI+VV N A S+ PHGV Y K EGT+Y DG+S+
Sbjct: 463 IRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSY 507
Score = 50.4 bits (119), Expect(4) = 9e-29
Identities = 27/66 (40%), Positives = 36/66 (53%)
Frame = +1
Query: 1030 LGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDVS 1209
LG Y K + EYTD +F +P G G G P+++ VGD + VV KN+A S
Sbjct: 780 LGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILG-PLIKGEVGDILTVVFKNNASRPYS 838
Query: 1210 LHPHGV 1227
+H HGV
Sbjct: 839 VHAHGV 844
Score = 35.0 bits (79), Expect(4) = 3e-36
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNP-SGVTRTYYIQAEAVNWDYAPAGY 2073
H GM+A Y V + + V+ +G R Y+I+A + WDY P G+
Sbjct: 355 HFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGH 401
Score = 34.3 bits (77), Expect = 8.9
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNPSG--VTRTYYIQAEAVNWDYAP 2064
H AGMRA Y V+ R YYI AE V WDY P
Sbjct: 707 HREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCP 751
Score = 28.1 bits (61), Expect(4) = 3e-36
Identities = 16/43 (37%), Positives = 22/43 (50%), Gaps = 1/43 (2%)
Frame = +3
Query: 1830 GMHTDSIQISPGGMVSADVQMTSPGDYELQCRVCGP-RDGGHA 1955
G HTD I P V+A++ PG + + C+V RDG A
Sbjct: 320 GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQA 362
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 8/20 (40%), Positives = 11/20 (55%)
Frame = +1
Query: 1933 DHVMAGMRAKYTVTANASRM 1992
DHV AGM +TV + +
Sbjct: 1053 DHVHAGMETLFTVFSRTEHL 1072
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 7/29 (24%), Positives = 15/29 (51%)
Frame = +3
Query: 1842 DSIQISPGGMVSADVQMTSPGDYELQCRV 1928
D + + PG ++ ++PG + + C V
Sbjct: 1023 DVVDLFPGTFEVVEMVASNPGTWLMHCHV 1051
>ref|NP_620074.1| hephaestin isoform a [Homo sapiens]
gi|12830539|gb|AAK08131.1|AF148860_1 hephaestin [Homo
sapiens] gi|15079445|gb|AAH11561.1| Hephaestin, isoform a
[Homo sapiens]
Length = 1158
Score = 157 bits (398), Expect = 5e-37
Identities = 98/296 (33%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ KA++R YTD +F +HLG +GP++ G VG ++ VVFKNN P ++ G
Sbjct: 781 YKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHG 840
Query: 182 GLIAWDGNGRRSARIDPV--KPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKH 355
L S + P+ +PG+ VTY W IPE +GP N + W+Y S+VDP K
Sbjct: 841 VL--------ESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVS-WIYYSAVDPIKD 891
Query: 356 DNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLL--------------- 490
+GLVGP+ + + +G D+DR+ +F + E S L
Sbjct: 892 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 951
Query: 491 -FQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHG 667
Q++T L + + AING + N+ +T+ GERV W++ ++G LH H+H
Sbjct: 952 NLQDETFLESNKMH---AINGKLYANL--RGLTMYQGERVAWYMLAMGQDVDLHTIHFHA 1006
Query: 668 H-VVELNG--HHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV 826
+ NG + D P V MV PGTW+ HCHV H+ GM L+TV
Sbjct: 1007 ESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 1062
Score = 150 bits (379), Expect(3) = 4e-66
Identities = 104/319 (32%), Positives = 143/319 (44%), Gaps = 26/319 (8%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ K IY+ Y D S+ PA W LG +GPV+ VG VI + KN P + P G
Sbjct: 73 YKKTIYKEYKDDSYTDEVAQPA-W--LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHG 129
Query: 182 --------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSS 337
G + DG+ D V PG + Y W IPE P +A W+Y S
Sbjct: 130 VFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPT-DADPACLTWIYHSH 188
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANG--RARDVDRDVVAIFQLVQERASPLLFQEDTSL 511
VD + GL+GP+I D N + +DVD D +F +V E S L + +
Sbjct: 189 VDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATY 248
Query: 512 ------------TAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNF 655
T S AING+ + N+P+ + + +RV WH+ +G+ +H
Sbjct: 249 CSDPASVDKEDETFQESNRMHAINGFVFGNLPE--LNMCAQKRVAWHLFGMGNEIDVHTA 306
Query: 656 HWHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV--- 826
+HG ++ GHH D P + MVP EPGTW+ C VN H GM ALY V
Sbjct: 307 FFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC 366
Query: 827 -TGDPAPLPTGGVERVYYV 880
P L TG V R Y++
Sbjct: 367 SMAPPVDLLTGKV-RQYFI 384
Score = 137 bits (344), Expect = 1e-30
Identities = 96/319 (30%), Positives = 144/319 (45%), Gaps = 27/319 (8%)
Frame = +2
Query: 8 KAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG-- 181
K Y A+ D +F + +HLG +GPV+ VG I+VVF N P +M P G
Sbjct: 430 KVRYEAFQDETFQEKMHLEED-RHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVF 488
Query: 182 ------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVAN--ATVTSRLWLYRSS 337
G + DG+ KP + VTY W +P AGP A A +T W+Y S+
Sbjct: 489 YEKDYEGTVYNDGSSYPGL---VAKPFEKVTYRWTVPPHAGPTAQDPACLT---WMYFSA 542
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPL---------- 487
DP + N+GLVGP++V A A+G+ + VD++ +F ++ E S
Sbjct: 543 ADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAML 602
Query: 488 ---LFQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFH 658
L ED S AING+ + N+P + + G+ V WH+ +G+ +H
Sbjct: 603 DFRLLSEDIE-GFQDSNRMHAINGFLFSNLP--RLDMCKGDTVAWHLLGLGTETDVHGVM 659
Query: 659 WHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDP 838
+ G+ V+L G P M PD GT+ +C H + GM A+Y V+ P
Sbjct: 660 FQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCP 719
Query: 839 ----APLPTGGVERVYYVL 883
P R+YY++
Sbjct: 720 GHQATPRQRYQAARIYYIM 738
Score = 99.4 bits (246), Expect(4) = 9e-29
Identities = 57/183 (31%), Positives = 92/183 (50%), Gaps = 1/183 (0%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG TY WN+P+R+GPGP D + + W+Y+S +D + Y+G+ G + + K +
Sbjct: 854 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 913
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLA-NKLGDGGALAAQLAANATEMTALVTDPVF 1666
+ D+DRE + F + DE KS EN+A + D G++ Q D F
Sbjct: 914 RS--DMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQ-------------DETF 958
Query: 1667 MEHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHTPNMGGPRF*LQRHAHRL 1846
+E H ING +Y ++ LT QG++V +++ +G D+HT + F L R+
Sbjct: 959 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESF-LYRNGENY 1017
Query: 1847 HPD 1855
D
Sbjct: 1018 RAD 1020
Score = 85.5 bits (210), Expect(4) = 3e-36
Identities = 45/162 (27%), Positives = 75/162 (45%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG ++ Y W +P+ P DP+ + W+YHSH+D + G+ G +I + +
Sbjct: 157 PGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSP 216
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
+DVD + + F+VVDE S + EN+A D ++ + D F
Sbjct: 217 PQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKE-------------DETFQ 263
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHT 1795
E H ING ++ ++P L +V H+ +G D+HT
Sbjct: 264 ESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHT 305
Score = 85.1 bits (209), Expect(3) = 4e-66
Identities = 54/161 (33%), Positives = 76/161 (46%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
P TY W VP AGP DP+ + WMY S D +T +G+ G ++V AD
Sbjct: 511 PFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCR--AGALGAD 568
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
K VD+E + FTV+DE KS N A + D L+ + F
Sbjct: 569 GKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG-------------FQ 615
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMH 1792
+ H ING ++ ++PRL +GD V H++ LGT D+H
Sbjct: 616 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVH 656
Score = 68.2 bits (165), Expect(4) = 3e-36
Identities = 44/116 (37%), Positives = 63/116 (53%), Gaps = 2/116 (1%)
Frame = +1
Query: 934 APLPELQFSSEPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGR 1113
AP +++P ++ + FL+ +D R+G Y KT+ EY D S+T
Sbjct: 40 APKGRNVITNQPLDSDIVASSFLK---SDKNRIGGTYKKTIYKEYKDDSYTDEV------ 90
Query: 1114 AVPGAAGV--PVMRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTS 1275
A P G PV++A VGD I + LKN A ++HPHGV Y K +EG+LY DG+S
Sbjct: 91 AQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSS 146
Score = 62.0 bits (149), Expect(3) = 4e-66
Identities = 43/105 (40%), Positives = 56/105 (52%)
Frame = +1
Query: 964 EPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPV 1143
EPGS ++ F + S R+G Y K + D +F L R + G G PV
Sbjct: 408 EPGS--ISDKFFQKSSS----RIGGTYWKVRYEAFQDETFQEKMHLEEDRHL-GILG-PV 459
Query: 1144 MRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTSW 1278
+RA VGDTI+VV N A S+ PHGV Y K EGT+Y DG+S+
Sbjct: 460 IRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSY 504
Score = 50.4 bits (119), Expect(4) = 9e-29
Identities = 27/66 (40%), Positives = 36/66 (53%)
Frame = +1
Query: 1030 LGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDVS 1209
LG Y K + EYTD +F +P G G G P+++ VGD + VV KN+A S
Sbjct: 777 LGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILG-PLIKGEVGDILTVVFKNNASRPYS 835
Query: 1210 LHPHGV 1227
+H HGV
Sbjct: 836 VHAHGV 841
Score = 35.0 bits (79), Expect(4) = 3e-36
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNP-SGVTRTYYIQAEAVNWDYAPAGY 2073
H GM+A Y V + + V+ +G R Y+I+A + WDY P G+
Sbjct: 352 HFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGH 398
Score = 34.3 bits (77), Expect = 8.9
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNPSG--VTRTYYIQAEAVNWDYAP 2064
H AGMRA Y V+ R YYI AE V WDY P
Sbjct: 704 HREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCP 748
Score = 28.1 bits (61), Expect(4) = 3e-36
Identities = 16/43 (37%), Positives = 22/43 (50%), Gaps = 1/43 (2%)
Frame = +3
Query: 1830 GMHTDSIQISPGGMVSADVQMTSPGDYELQCRVCGP-RDGGHA 1955
G HTD I P V+A++ PG + + C+V RDG A
Sbjct: 317 GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQA 359
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 8/20 (40%), Positives = 11/20 (55%)
Frame = +1
Query: 1933 DHVMAGMRAKYTVTANASRM 1992
DHV AGM +TV + +
Sbjct: 1050 DHVHAGMETLFTVFSRTEHL 1069
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 7/29 (24%), Positives = 15/29 (51%)
Frame = +3
Query: 1842 DSIQISPGGMVSADVQMTSPGDYELQCRV 1928
D + + PG ++ ++PG + + C V
Sbjct: 1020 DVVDLFPGTFEVVEMVASNPGTWLMHCHV 1048
>dbj|BAA31673.2| KIAA0698 protein [Homo sapiens]
Length = 1104
Score = 157 bits (398), Expect = 5e-37
Identities = 98/296 (33%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ KA++R YTD +F +HLG +GP++ G VG ++ VVFKNN P ++ G
Sbjct: 727 YKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHG 786
Query: 182 GLIAWDGNGRRSARIDPV--KPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKH 355
L S + P+ +PG+ VTY W IPE +GP N + W+Y S+VDP K
Sbjct: 787 VL--------ESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVS-WIYYSAVDPIKD 837
Query: 356 DNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLL--------------- 490
+GLVGP+ + + +G D+DR+ +F + E S L
Sbjct: 838 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 897
Query: 491 -FQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHG 667
Q++T L + + AING + N+ +T+ GERV W++ ++G LH H+H
Sbjct: 898 NLQDETFLESNKMH---AINGKLYANL--RGLTMYQGERVAWYMLAMGQDVDLHTIHFHA 952
Query: 668 H-VVELNG--HHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV 826
+ NG + D P V MV PGTW+ HCHV H+ GM L+TV
Sbjct: 953 ESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 1008
Score = 150 bits (379), Expect(3) = 4e-66
Identities = 104/319 (32%), Positives = 143/319 (44%), Gaps = 26/319 (8%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ K IY+ Y D S+ PA W LG +GPV+ VG VI + KN P + P G
Sbjct: 19 YKKTIYKEYKDDSYTDEVAQPA-W--LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHG 75
Query: 182 --------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSS 337
G + DG+ D V PG + Y W IPE P +A W+Y S
Sbjct: 76 VFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPT-DADPACLTWIYHSH 134
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANG--RARDVDRDVVAIFQLVQERASPLLFQEDTSL 511
VD + GL+GP+I D N + +DVD D +F +V E S L + +
Sbjct: 135 VDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATY 194
Query: 512 ------------TAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNF 655
T S AING+ + N+P+ + + +RV WH+ +G+ +H
Sbjct: 195 CSDPASVDKEDETFQESNRMHAINGFVFGNLPE--LNMCAQKRVAWHLFGMGNEIDVHTA 252
Query: 656 HWHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV--- 826
+HG ++ GHH D P + MVP EPGTW+ C VN H GM ALY V
Sbjct: 253 FFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC 312
Query: 827 -TGDPAPLPTGGVERVYYV 880
P L TG V R Y++
Sbjct: 313 SMAPPVDLLTGKV-RQYFI 330
Score = 137 bits (344), Expect = 1e-30
Identities = 96/319 (30%), Positives = 144/319 (45%), Gaps = 27/319 (8%)
Frame = +2
Query: 8 KAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG-- 181
K Y A+ D +F + +HLG +GPV+ VG I+VVF N P +M P G
Sbjct: 376 KVRYEAFQDETFQEKMHLEED-RHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVF 434
Query: 182 ------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVAN--ATVTSRLWLYRSS 337
G + DG+ KP + VTY W +P AGP A A +T W+Y S+
Sbjct: 435 YEKDYEGTVYNDGSSYPGL---VAKPFEKVTYRWTVPPHAGPTAQDPACLT---WMYFSA 488
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPL---------- 487
DP + N+GLVGP++V A A+G+ + VD++ +F ++ E S
Sbjct: 489 ADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAML 548
Query: 488 ---LFQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFH 658
L ED S AING+ + N+P + + G+ V WH+ +G+ +H
Sbjct: 549 DFRLLSEDIE-GFQDSNRMHAINGFLFSNLP--RLDMCKGDTVAWHLLGLGTETDVHGVM 605
Query: 659 WHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDP 838
+ G+ V+L G P M PD GT+ +C H + GM A+Y V+ P
Sbjct: 606 FQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCP 665
Query: 839 ----APLPTGGVERVYYVL 883
P R+YY++
Sbjct: 666 GHQATPRQRYQAARIYYIM 684
Score = 99.4 bits (246), Expect(4) = 9e-29
Identities = 57/183 (31%), Positives = 92/183 (50%), Gaps = 1/183 (0%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG TY WN+P+R+GPGP D + + W+Y+S +D + Y+G+ G + + K +
Sbjct: 800 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 859
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLA-NKLGDGGALAAQLAANATEMTALVTDPVF 1666
+ D+DRE + F + DE KS EN+A + D G++ Q D F
Sbjct: 860 RS--DMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQ-------------DETF 904
Query: 1667 MEHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHTPNMGGPRF*LQRHAHRL 1846
+E H ING +Y ++ LT QG++V +++ +G D+HT + F L R+
Sbjct: 905 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESF-LYRNGENY 963
Query: 1847 HPD 1855
D
Sbjct: 964 RAD 966
Score = 85.5 bits (210), Expect(4) = 2e-35
Identities = 45/162 (27%), Positives = 75/162 (45%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG ++ Y W +P+ P DP+ + W+YHSH+D + G+ G +I + +
Sbjct: 103 PGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSP 162
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
+DVD + + F+VVDE S + EN+A D ++ + D F
Sbjct: 163 PQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKE-------------DETFQ 209
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHT 1795
E H ING ++ ++P L +V H+ +G D+HT
Sbjct: 210 ESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHT 251
Score = 85.1 bits (209), Expect(3) = 4e-66
Identities = 54/161 (33%), Positives = 76/161 (46%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
P TY W VP AGP DP+ + WMY S D +T +G+ G ++V AD
Sbjct: 457 PFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCR--AGALGAD 514
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
K VD+E + FTV+DE KS N A + D L+ + F
Sbjct: 515 GKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG-------------FQ 561
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMH 1792
+ H ING ++ ++PRL +GD V H++ LGT D+H
Sbjct: 562 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVH 602
Score = 65.5 bits (158), Expect(4) = 2e-35
Identities = 39/89 (43%), Positives = 51/89 (56%), Gaps = 2/89 (2%)
Frame = +1
Query: 1015 TDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGV--PVMRANVGDTIKVVLKN 1188
+D R+G Y KT+ EY D S+T A P G PV++A VGD I + LKN
Sbjct: 10 SDKNRIGGTYKKTIYKEYKDDSYTDEV------AQPAWLGFLGPVLQAEVGDVILIHLKN 63
Query: 1189 DAKIDVSLHPHGVRYSKANEGTLYEDGTS 1275
A ++HPHGV Y K +EG+LY DG+S
Sbjct: 64 FATRPYTIHPHGVFYEKDSEGSLYPDGSS 92
Score = 62.0 bits (149), Expect(3) = 4e-66
Identities = 43/105 (40%), Positives = 56/105 (52%)
Frame = +1
Query: 964 EPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPV 1143
EPGS ++ F + S R+G Y K + D +F L R + G G PV
Sbjct: 354 EPGS--ISDKFFQKSSS----RIGGTYWKVRYEAFQDETFQEKMHLEEDRHL-GILG-PV 405
Query: 1144 MRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTSW 1278
+RA VGDTI+VV N A S+ PHGV Y K EGT+Y DG+S+
Sbjct: 406 IRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSY 450
Score = 50.4 bits (119), Expect(4) = 9e-29
Identities = 27/66 (40%), Positives = 36/66 (53%)
Frame = +1
Query: 1030 LGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDVS 1209
LG Y K + EYTD +F +P G G G P+++ VGD + VV KN+A S
Sbjct: 723 LGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILG-PLIKGEVGDILTVVFKNNASRPYS 781
Query: 1210 LHPHGV 1227
+H HGV
Sbjct: 782 VHAHGV 787
Score = 35.0 bits (79), Expect(4) = 2e-35
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNP-SGVTRTYYIQAEAVNWDYAPAGY 2073
H GM+A Y V + + V+ +G R Y+I+A + WDY P G+
Sbjct: 298 HFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGH 344
Score = 34.3 bits (77), Expect = 8.9
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNPSG--VTRTYYIQAEAVNWDYAP 2064
H AGMRA Y V+ R YYI AE V WDY P
Sbjct: 650 HREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCP 694
Score = 28.1 bits (61), Expect(4) = 2e-35
Identities = 16/43 (37%), Positives = 22/43 (50%), Gaps = 1/43 (2%)
Frame = +3
Query: 1830 GMHTDSIQISPGGMVSADVQMTSPGDYELQCRVCGP-RDGGHA 1955
G HTD I P V+A++ PG + + C+V RDG A
Sbjct: 263 GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQA 305
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 8/20 (40%), Positives = 11/20 (55%)
Frame = +1
Query: 1933 DHVMAGMRAKYTVTANASRM 1992
DHV AGM +TV + +
Sbjct: 996 DHVHAGMETLFTVFSRTEHL 1015
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 7/29 (24%), Positives = 15/29 (51%)
Frame = +3
Query: 1842 DSIQISPGGMVSADVQMTSPGDYELQCRV 1928
D + + PG ++ ++PG + + C V
Sbjct: 966 DVVDLFPGTFEVVEMVASNPGTWLMHCHV 994
>emb|CAC35365.2| hephaestin [Homo sapiens]
Length = 1158
Score = 157 bits (398), Expect = 5e-37
Identities = 98/296 (33%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ KA++R YTD +F +HLG +GP++ G VG ++ VVFKNN P ++ G
Sbjct: 781 YKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHG 840
Query: 182 GLIAWDGNGRRSARIDPV--KPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSSVDPQKH 355
L S + P+ +PG+ VTY W IPE +GP N + W+Y S+VDP K
Sbjct: 841 VL--------ESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVS-WIYYSAVDPIKD 891
Query: 356 DNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPLL--------------- 490
+GLVGP+ + + +G D+DR+ +F + E S L
Sbjct: 892 MYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSI 951
Query: 491 -FQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFHWHG 667
Q++T L + + AING + N+ +T+ GERV W++ ++G LH H+H
Sbjct: 952 NLQDETFLESNKMH---AINGKLYANL--RGLTMYQGERVAWYMLAMGQDVDLHTIHFHA 1006
Query: 668 H-VVELNG--HHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV 826
+ NG + D P V MV PGTW+ HCHV H+ GM L+TV
Sbjct: 1007 ESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTV 1062
Score = 149 bits (375), Expect(3) = 1e-65
Identities = 103/319 (32%), Positives = 142/319 (44%), Gaps = 26/319 (8%)
Frame = +2
Query: 2 FAKAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG 181
+ K IY+ Y D S+ PA W LG +GPV+ VG VI + KN P + P G
Sbjct: 73 YKKTIYKEYKDDSYTDEVAQPA-W--LGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHG 129
Query: 182 --------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVANATVTSRLWLYRSS 337
G + DG+ D V PG + Y W IPE P +A W+Y S
Sbjct: 130 VFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPT-DADPACLTWIYHSH 188
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANG--RARDVDRDVVAIFQLVQERASPLLFQEDTSL 511
VD + GL+GP+I D N + +D D D +F +V E S L + +
Sbjct: 189 VDAPRDIATGLIGPLITCKRGALDGNSPPQRQDTDHDFFLLFSVVDENLSWHLNENIATY 248
Query: 512 ------------TAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNF 655
T S AING+ + N+P+ + + +RV WH+ +G+ +H
Sbjct: 249 CSDPASVDKEDETFQESNRMHAINGFVFGNLPE--LNMCAQKRVAWHLFGMGNEIDVHTA 306
Query: 656 HWHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTV--- 826
+HG ++ GHH D P + MVP EPGTW+ C VN H GM ALY V
Sbjct: 307 FFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSC 366
Query: 827 -TGDPAPLPTGGVERVYYV 880
P L TG V R Y++
Sbjct: 367 SMAPPVDLLTGKV-RQYFI 384
Score = 137 bits (344), Expect = 1e-30
Identities = 96/319 (30%), Positives = 144/319 (45%), Gaps = 27/319 (8%)
Frame = +2
Query: 8 KAIYRAYTDSSFNTLATTPAEWQHLGNVGPVMYGAVGQVIRVVFKNNLDFPVNMAPSG-- 181
K Y A+ D +F + +HLG +GPV+ VG I+VVF N P +M P G
Sbjct: 430 KVRYEAFQDETFQEKMHLEED-RHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVF 488
Query: 182 ------GLIAWDGNGRRSARIDPVKPGQTVTYLWQIPEDAGPVAN--ATVTSRLWLYRSS 337
G + DG+ KP + VTY W +P AGP A A +T W+Y S+
Sbjct: 489 YEKDYEGTVYNDGSSYPGL---VAKPFEKVTYRWTVPPHAGPTAQDPACLT---WMYFSA 542
Query: 338 VDPQKHDNAGLVGPIIVTSAANADANGRARDVDRDVVAIFQLVQERASPL---------- 487
DP + N+GLVGP++V A A+G+ + VD++ +F ++ E S
Sbjct: 543 ADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAML 602
Query: 488 ---LFQEDTSLTAGTSYTKMAINGYTWCNMPDGAITIKTGERVRWHVASIGSSESLHNFH 658
L ED S AING+ + N+P + + G+ V WH+ +G+ +H
Sbjct: 603 DFRLLSEDIE-GFQDSNRMHAINGFLFSNLP--RLDMCKGDTVAWHLLGLGTETDVHGVM 659
Query: 659 WHGHVVELNGHHVDQFTAIPTATYSVNMVPDEPGTWMFHCHVNFHMDGGMVALYTVTGDP 838
+ G+ V+L G P M PD GT+ +C H + GM A+Y V+ P
Sbjct: 660 FQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCP 719
Query: 839 ----APLPTGGVERVYYVL 883
P R+YY++
Sbjct: 720 GHQATPRQRYQAARIYYIM 738
Score = 99.4 bits (246), Expect(4) = 9e-29
Identities = 57/183 (31%), Positives = 92/183 (50%), Gaps = 1/183 (0%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG TY WN+P+R+GPGP D + + W+Y+S +D + Y+G+ G + + K +
Sbjct: 854 PGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGG 913
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLA-NKLGDGGALAAQLAANATEMTALVTDPVF 1666
+ D+DRE + F + DE KS EN+A + D G++ Q D F
Sbjct: 914 RS--DMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQ-------------DETF 958
Query: 1667 MEHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHTPNMGGPRF*LQRHAHRL 1846
+E H ING +Y ++ LT QG++V +++ +G D+HT + F L R+
Sbjct: 959 LESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESF-LYRNGENY 1017
Query: 1847 HPD 1855
D
Sbjct: 1018 RAD 1020
Score = 85.1 bits (209), Expect(3) = 1e-65
Identities = 54/161 (33%), Positives = 76/161 (46%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
P TY W VP AGP DP+ + WMY S D +T +G+ G ++V AD
Sbjct: 511 PFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCR--AGALGAD 568
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
K VD+E + FTV+DE KS N A + D L+ + F
Sbjct: 569 GKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEG-------------FQ 615
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMH 1792
+ H ING ++ ++PRL +GD V H++ LGT D+H
Sbjct: 616 DSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVH 656
Score = 84.0 bits (206), Expect(4) = 1e-35
Identities = 44/162 (27%), Positives = 74/162 (45%)
Frame = +2
Query: 1310 PGTTYTYVWNVPDRAGPGPCDPSSMLWMYHSHIDETAETYAGVAGGIIVTAKDMARSTAD 1489
PG ++ Y W +P+ P DP+ + W+YHSH+D + G+ G +I + +
Sbjct: 157 PGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSP 216
Query: 1490 LTPKDVDREIVIFFTVVDEIKSSNFMENLANKLGDGGALAAQLAANATEMTALVTDPVFM 1669
+D D + + F+VVDE S + EN+A D ++ + D F
Sbjct: 217 PQRQDTDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKE-------------DETFQ 263
Query: 1670 EHMLKHGINGHMYCHMPRLTFEQGDKVRLHVMVLGTLEDMHT 1795
E H ING ++ ++P L +V H+ +G D+HT
Sbjct: 264 ESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHT 305
Score = 68.2 bits (165), Expect(4) = 1e-35
Identities = 44/116 (37%), Positives = 63/116 (53%), Gaps = 2/116 (1%)
Frame = +1
Query: 934 APLPELQFSSEPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGR 1113
AP +++P ++ + FL+ +D R+G Y KT+ EY D S+T
Sbjct: 40 APKGRNVITNQPLDSDIVASSFLK---SDKNRIGGTYKKTIYKEYKDDSYTDEV------ 90
Query: 1114 AVPGAAGV--PVMRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTS 1275
A P G PV++A VGD I + LKN A ++HPHGV Y K +EG+LY DG+S
Sbjct: 91 AQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSS 146
Score = 62.0 bits (149), Expect(3) = 1e-65
Identities = 43/105 (40%), Positives = 56/105 (52%)
Frame = +1
Query: 964 EPGSEEVNGNVFLEGPSTDPVRLGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPV 1143
EPGS ++ F + S R+G Y K + D +F L R + G G PV
Sbjct: 408 EPGS--ISDKFFQKSSS----RIGGTYWKVRYEAFQDETFQEKMHLEEDRHL-GILG-PV 459
Query: 1144 MRANVGDTIKVVLKNDAKIDVSLHPHGVRYSKANEGTLYEDGTSW 1278
+RA VGDTI+VV N A S+ PHGV Y K EGT+Y DG+S+
Sbjct: 460 IRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSY 504
Score = 50.4 bits (119), Expect(4) = 9e-29
Identities = 27/66 (40%), Positives = 36/66 (53%)
Frame = +1
Query: 1030 LGHIYTKTLLIEYTDASFTTVKPLAGGRAVPGAAGVPVMRANVGDTIKVVLKNDAKIDVS 1209
LG Y K + EYTD +F +P G G G P+++ VGD + VV KN+A S
Sbjct: 777 LGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILG-PLIKGEVGDILTVVFKNNASRPYS 835
Query: 1210 LHPHGV 1227
+H HGV
Sbjct: 836 VHAHGV 841
Score = 35.0 bits (79), Expect(4) = 1e-35
Identities = 17/47 (36%), Positives = 26/47 (55%), Gaps = 1/47 (2%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNP-SGVTRTYYIQAEAVNWDYAPAGY 2073
H GM+A Y V + + V+ +G R Y+I+A + WDY P G+
Sbjct: 352 HFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGH 398
Score = 34.3 bits (77), Expect = 8.9
Identities = 19/45 (42%), Positives = 20/45 (44%), Gaps = 2/45 (4%)
Frame = +1
Query: 1936 HVMAGMRAKYTVTANASRMVVNPSG--VTRTYYIQAEAVNWDYAP 2064
H AGMRA Y V+ R YYI AE V WDY P
Sbjct: 704 HREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCP 748
Score = 28.1 bits (61), Expect(4) = 1e-35
Identities = 16/43 (37%), Positives = 22/43 (50%), Gaps = 1/43 (2%)
Frame = +3
Query: 1830 GMHTDSIQISPGGMVSADVQMTSPGDYELQCRVCGP-RDGGHA 1955
G HTD I P V+A++ PG + + C+V RDG A
Sbjct: 317 GHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQA 359
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 8/20 (40%), Positives = 11/20 (55%)
Frame = +1
Query: 1933 DHVMAGMRAKYTVTANASRM 1992
DHV AGM +TV + +
Sbjct: 1050 DHVHAGMETLFTVFSRTEHL 1069
Score = 20.8 bits (42), Expect(4) = 9e-29
Identities = 7/29 (24%), Positives = 15/29 (51%)
Frame = +3
Query: 1842 DSIQISPGGMVSADVQMTSPGDYELQCRV 1928
D + + PG ++ ++PG + + C V
Sbjct: 1020 DVVDLFPGTFEVVEMVASNPGTWLMHCHV 1048
