Laboratory of Chromosome Engineering
Publication
2019
- De novo formation and epigenetic maintenance of centromere chromatin.
- Ohzeki J, Larionov V, Earnshaw WC, Masumoto H.
- Curr Opin Cell Biol. 58: 15-25. (2019)
- Identification of oxidosqualene cyclases from the medicinal legume tree Bauhinia forficata: a step toward discovering preponderant α‐amyrin‐producing activity.
- Srisawat P, Fukushima EO, Yasumoto S, Robertlee J, Suzuki H, Seki H, Muranaka T.
- New Phytol. 224(1): 352-366. (2019)
- A novel assay to screen siRNA libraries identifies protein kinases required for chromosome transmission.
- Liskovykh M, Goncharov NV, Petrov N, Aksenova V, Pegoraro G, Ozbun LL, Reinhold WC, Varma S, Dasso M, Kumeiko V, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.
- Genome Res. 29(10): 1719-1732. (2019)
2018
- Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.
- Ito T, Okazaki K, Nakajima D, Shibata D, Murakami S, Schaffer S.
- Amino Acids 50(1): 117-124. (2018)
- The conserved histone variant H2A.Z illuminates meiotic recombination initiation.
- Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T.
- Current Genetics 64(5): 1015-1019. (2018)
- Generation of a Synthetic Human Chromosome with Two Centromeric Domains for Advanced Epigenetic Engineering Studies.
- Pesenti E, Kouprina N, Liskovykh M, Aurich-Costa J, Larionov V, Masumoto H, Earnshaw WC, Molina O.
- ACS Synthetic Biology 7(4): 1116-1130. (2018)
- Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.
- Kouprina N, Petrov N, Molina O, Liskovykh M, Pesenti E, Ohzeki J, Masumoto H, Earnshaw WC, Larionov V.
- ACS Synthetic Biology 7(9): 1974–1989. (2018)
- Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.
- Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.
- Cancer Research 78(21): 6282-6296. (2018)
2017
- The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast.
- Yamada, S., Kugou, K., Ding, D. Q., Fujita, Y., Hiraoka, Y., Murakami, H., Ohta, K. and Yamada, T. 2017
- Nucleic Acids Res., doi: 10.1093/nar/gkx1110.
- Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis.
- Tashiro, S., Nishihara, Y., Kugou, K., Ohta, K. and Kanoh, J. 2017
- Nucleic Acids Res., 45, 10333-10349.
- Mass spectrometry-based metabolomics to identify taurine-modified metabolites in heart.
- Ito, T., Okazaki, K., Nakajima, D., Shibata, D., Murakami, S. and Schaffer, S. 2017
- Amino Acids, doi: 10.1007/s00726-017-2498-y.
- Method to assemble genomic DNA fragments or genes on human artificial chromosome with regulated kinetochore using a multi-integrase system.
- Lee, N. C. O., Kim, J. H., Petrov, N. S., Lee, H. S., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2017
- ACS Synth Biol., doi: 10.1021/acssynbio.7b00209.
- Using human artificial chromosomes to study centromere assembly and function.
- Molina, O., Kouprina, N., Masumoto, H., Larionov, V. and Earnshaw, W. C. 2017
- Chromosoma., 126, 559-575.
- CENP-Bによるセントロメアのエピジェネティクス制御への関わり CENP-B and centromere chromatin.
- 久郷和人、大竹興一郎、舛本 寛 2017
- Medical Science Digest, Vol. 43. ニューサイエンス社, pp. 629-632.
- 人工染色体を用いたセントロメア機能獲得のエピゲノム制御解析 Analyses for epigenetic controls of functional centromere acquisition using human artificial chromosomes.
- 大関淳一郎、舛本 寛 2017
- バイオサイエンスとインダストリー (B&I), Vol. 75. バイオインダストリー協会, pp. 304-309.
2016
- Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.
- Tashiro, S., Handa, T., Matsuda, A., Ban, T., Takigawa, T., Miyasato, K., Ishii, K., Kugou, K., Ohta, K., Hiraoka, Y., Masukata, H. and Kanoh, J. 2016
- Nat Commun., 7, 10393.
- Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae.
- Mitsumori, R., Ohashi, T., Kugou, K., Ichino, A., Taniguchi, K., Ohta, K., Uchida, H. and Oki, M. 2016
- J Biochem., 160, 11-17.
- Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells.
- Kim, J. H., Lee, H. S., Lee, N. C., Goncharov, N. V., Kumeiko, V., Masumoto, H., Earnshaw, W. C., Kouprina, N. and Larionov, V. 2016
- Oncotarget., 7, 14841-14856.
- CENP-B box, a nucleotide motif involved in centromere formation, occurs in a New World monkey.
- Suntronpong, A., Kugou, K., Masumoto, H., Srikulnath, K., Ohshima, K., Hirai, H. and Koga, A. 2016
- Biol. Lett., 12, 20150817.
- KAT7/HBO1/MYST2 regulates CENP-A chromatin assembly by antagonizing Suv39h1-mediated centromere inactivation.
- Ohzeki, J., Shono, N., Otake, K., Martins, N. M. C., Kugou, K., Kimura, H., Nagase, T., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2016
- Dev Cell., 37, 413-427.
- Formation of functional CENP-B boxes at diverse locations in repeat units of centromeric DNA in New World monkeys.
- Kugou, K., Hirai, H., Masumoto, H. and Koga, A. 2016
- Sci Rep., 6, 27833.
- 3D-CLEM reveals that a major portion of mitotic chromosomes is not chromatin.
- Booth, D. G., Beckett, A. J., Molina, O., Samejima, I., Masumoto, H., Kouprina, N., Larionov, V., Prior, I. A. and Earnshaw, W. C. 2016
- Mol Cell, 64, 790-802.
- Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.
- Molina, O., Vargiu, G., Abad, M. A., Zhiteneva, A., Jeyaprakash, A. A., Masumoto, H., Kouprina, N., Larionov, V. and Earnshaw, W. C. 2016
- Nat Commun., 7, 13334.
2015
- CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
- Shono, N., Ohzeki, J., Otake, K., Martins, N. M. C., Nagase, T., Kimura, H., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2015
- J. Cell Science, 128, 4572-4587.
- Stable complex formation of CENP-B with the CENP-A nucleosome.
- Fujita, R., Otake, K., Arimura, Y., Horikoshi, N., Miya, Y., Shiga, T., Osakabe, A., Tachiwana, H., Ohzeki, J., Larionov, V., Masumoto, H. and Kurumizaka, H. 2015
- Nucleic Acids Res., 43, 4909-4922.
- Genetic and epigenetic regulation of centromeres: A look at HAC formation.
- Ohzeki, J., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2015
- Chromosome Res., 23, 87-103.
- Generation of a conditionally self-eliminating HAC gene delivery vector through incorporation of a tTAVP64 expression cassette.
- Kononenko, A. V., Lee, N. C., Liskovykh, M., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2015
- Nucleic Acids Res., 43, e57.
- Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs.
- Hasegawa, Y., Ishikura, T., Hasegawa, T., Watanabe, T., Suzuki, J., Nakayama, M., Okamura, Y., Okazaki, T., Koseki, H., Ohara, O., Ikeno, M. and Masumoto, H. 2015
- Chromosoma, 124, 107-118.
- Replication of alpha-satellite DNA arrays in endogenous human centromeric regions and in human artificial chromosome.
- Erliandri, I., Fu, H., Nakano, M., Kim, J. H., Miga, K. H., Liskovykh, M., Earnshaw, W. C., Masumoto, H., Kouprina, N., Aladjem, M. I. and Larionov, V. 2015
- Nucleic Acids Res., 42, 11502-11516.
2014 以前
- A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.
- Kononenko, A. V., Bansal, R., Lee, N. C., Grimes, B. R., Masumoto, H., Earnshaw, W. C., Larionov, V. and Kouprina, N. 2014
- Nucleic Acids Res., 42, e164.
- The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.
- Obata, Y., Furusawa, Y., Endo, T. A., Sharif, J., Takahashi, D., Atarashi, K., Nakayama, M., Onawa, S., Fujimura, Y., Takahashi, M., Ikawa, T., Otsubo, T., Kawamura, Y. I., Dohi, T., Tajima, S., Masumoto, H., Ohara, O., Honda, K., Hori, S., Ohno, H., Koseki, H. and Hase, K. 2014
- Nat Immunol., 15, 571-579.
- Human artificial chromosome based gene delivery vectors for biomedicine and biotechnology.
- Kouprina, N., Tomilin, A. N., Masumoto, H., Earnshaw, W. C. and Larionov, V. 2014
- Expert Opin. Drug Deliv., 11, 517-35.
- Identification of novel α-n-methylation of CENP-B that regulates its binding to the centromeric DNA
- Dai, X., Otake, K., You, C., Cai, Q., Wang, Z., Masumoto, H. and Wang, Y. 2013
- J Proteome Res., 12, 4167-4175.
- A new generation of human artificial chromosomes for functional genomics and gene therapy.
- Kouprina, N., Earnshaw, W. C., Masumoto, H. and Larionov, V. 2013
- Cell Mol Life Sci., 70, 1135-1148.
- A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cells.
- Lee, H. S., Lee, N. C., Grimes, B. R., Samoshkin, A., Kononenko, A. V., Bansal, R., Masumoto, H., Earnshaw, W. C., Kouprina, N. and Larionov, V. 2013
- BMC Cancer, 13, 252.
- Protecting a transgene expression from the HAC-based vector by different chromatin insulators.
- Lee, N. C., Kononenko, A. V., Lee, H. S., Tolkunova, E. N., Liskovykh, M. A., Masumoto, H., Earnshaw, W. C., Tomilin, A. N., Larionov, V. and Kouprina, N. 2013
- Cell Mol Life Sci., 70, 3723-3737.
- Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
- Earnshaw, W. C., Allshire, R. C., Black, B. E., Bloom, K., Brinkley, B. R., Brown, W., Cheeseman, I. M., Choo, K. H., Copenhaver, G. P., Deluca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D. W., Glover, D. M., Gorbsky, G. J., Harrison, S. C., Heun, P., Hirota, T., Jansen, L. E., Karpen, G., Kops, G. J., Lampson, M. A., Lens, S. M., Losada, A., Luger, K., Maiato, H., Maddox, P. S., Margolis, R. L., Masumoto, H., McAinsh, A. D, Mellone, B. G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R. J., Salmon, E. D., Scott, K. C., Straight, A. F., Stukenberg, P. T., Sullivan, B. A., Sullivan, K. F., Sunkel, C. E., Swedlow, J. R., Walczak, C. E., Warburton, P. E., Westermann, S., Willard, H. F., Wordeman, L., Yanagida, M., Yen, T. J., Yoda, K. and Cleveland, D. W. 2013
- Chromosome Res., 21, 101-106.
- Nap1 regulates proper CENP-B binding to nucleosomes.
- Tachiwana, H., Miya, Y., Shono, N., Ohzeki, J., Osakabe, A., Otake, K., Larionov, V., Earnshaw, W. C., Kimura, H., Masumoto, H. and Kurumizaka, H. 2013
- Nucleic Acids Res., 41, 2869-2880.
- Breaking the HAC Barrier: histone H3K9 acetyl/methyl balance regulates CENP-A assembly.
- Ohzeki, J., Bergmann, J. H., Kouprina, N., Noskov, V. N., Nakano, M., Kimura, H., Earnshaw, W. C., Larionov, V., Masumoto, H. 2012
- EMBO J., 31, 2391-2402.
- Inactivation of a human kinetochore by specific targeting of chromatin modifiers.
- Nakano, M., Cardinale, S., Noskov, V., Gassmann, R., Vagnarelli, P., Kandels-Lewis, S., Larionov, V., Earnshaw, W. C. and Masumoto, H. 2008
- Developmental Cell, 14, 507-522.
- CENP-B controls centromere formation depending on the chromatin context.
- Okada, T., Ohzeki, J., Nakano, M., Yoda, K., Brinkley, W. R., Larionov, V. and Masumoto, H. 2007
- Cell, 131, 1287-1300.
- A minimal CENP-A core is required for nucleation and maintenance of a functional human centromere.
- Okamoto, Y., Nakano, M., Ohzeki, J., Larionov, V. and Masumoto, H. 2007
- EMBO J., 26, 1279-1291.
- Construction of YAC based Mammalian Artificial Chromosomes.
- Ikeno, M., Grimes, B., Okazaki T., Nakano, M., Saitoh, K., Hoshino, H., McGill, N., Cooke, H. and Masumoto H.1998
- Nature Biotech., 16, 431-439.