Nr search
BLASTX 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= KCC002810A_C01 KCC002810A_c01
(858 letters)
Database: nr
1,537,769 sequences; 498,525,298 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
pdb|1N0R|A Chain A, 4ank: A Designed Ankyrin Repeat Protein With... 69 1e-10
ref|XP_224620.2| similar to Hypothetical protein KIAA0379 [Rattu... 68 2e-10
ref|XP_042860.5| similar to Hypothetical ANK-repeat protein KIAA... 67 5e-10
dbj|BAC86737.1| unnamed protein product [Homo sapiens] 67 5e-10
sp|O15084|Y379_HUMAN Hypothetical ANK-repeat protein KIAA0379 gi... 67 5e-10
>pdb|1N0R|A Chain A, 4ank: A Designed Ankyrin Repeat Protein With Four
Identical Consensus Repeats
Length = 126
Score = 68.6 bits (166), Expect = 1e-10
Identities = 43/112 (38%), Positives = 61/112 (54%)
Frame = +3
Query: 369 RTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAE 548
RT LH AA G +E + LL+ G + A + NGRT +HLAAR+GH V++LLL++
Sbjct: 3 RTPLHLAARNGHLEVVKLLLEAGADVNAKDKNGRTPLHLAARNGHLEVVKLLLEAGAD-- 60
Query: 549 QEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGGRSFLN 704
VN D G TP+ LA + G LL++ G N + GR+ L+
Sbjct: 61 ----VNAKDKNGRTPLHLAARNGH--LEVVKLLLEAGADVNAKDKNGRTPLH 106
Score = 65.9 bits (159), Expect = 8e-10
Identities = 40/104 (38%), Positives = 59/104 (56%)
Frame = +3
Query: 222 AQAQQAIKDKVPDPPKNIFEAAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAG 401
A A KDK P ++ AA G + + +E + +N +DK RT LH AA G
Sbjct: 24 AGADVNAKDKNGRTPLHL--AARNGHLEVVKLLLEAGAD--VNAKDKNGRTPLHLAARNG 79
Query: 402 QVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDS 533
+E + LL+ G + A + NGRT +HLAAR+GH V++LLL++
Sbjct: 80 HLEVVKLLLEAGADVNAKDKNGRTPLHLAARNGHLEVVKLLLEA 123
Score = 48.5 bits (114), Expect = 1e-04
Identities = 31/81 (38%), Positives = 44/81 (54%)
Frame = +3
Query: 462 NGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFA 641
NGRT +HLAAR+GH V++LLL++ VN D G TP+ LA + G
Sbjct: 1 NGRTPLHLAARNGHLEVVKLLLEAGAD------VNAKDKNGRTPLHLAARNGH--LEVVK 52
Query: 642 LLMDRGGRYNQQTPGGRSFLN 704
LL++ G N + GR+ L+
Sbjct: 53 LLLEAGADVNAKDKNGRTPLH 73
>ref|XP_224620.2| similar to Hypothetical protein KIAA0379 [Rattus norvegicus]
Length = 1273
Score = 67.8 bits (164), Expect = 2e-10
Identities = 40/116 (34%), Positives = 59/116 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
NIN DK R A+HWAA G +E + L+ +G E + T +H AA SG +V++
Sbjct: 195 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 254
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGG 689
LLD +N+P+ +G TP+ +A G+D L+D G NQ+ G
Sbjct: 255 LLDLGVD------MNEPNAYGNTPLHVACYNGQDV--VVNELIDCGANVNQKNERG 302
Score = 61.2 bits (147), Expect = 2e-08
Identities = 34/94 (36%), Positives = 48/94 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
N++ +DK+ RTALH A G E + LL +G + L + GRT IHL+A GH VL
Sbjct: 894 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 953
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGED 623
LL S + + + D G T + A G +
Sbjct: 954 LLQSATSVDANPAI--VDNHGYTALHWACYNGHE 985
Score = 53.5 bits (127), Expect = 4e-06
Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 1/122 (0%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATE-CNGRTAIHLAARSGHCNVLR 518
++++R+ RT L AA G VE + L++ G L + RT IH AA +GH LR
Sbjct: 791 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYVLKRTPIHAAATNGHSECLR 850
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGGRSF 698
LL+ + AE + V+ D G TP+ L++ G + L+++G + + GR+
Sbjct: 851 LLIGN---AEPQNAVDIQDGNGQTPLMLSVLNGH--TDCVYSLLNKGANVDAKDKWGRTA 905
Query: 699 LN 704
L+
Sbjct: 906 LH 907
Score = 45.1 bits (105), Expect = 0.002
Identities = 26/62 (41%), Positives = 37/62 (58%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N RDK +T LH AA V+ AE L+ ++ GRTA+H AA SGH +++L
Sbjct: 129 DVNARDKNWQTPLHIAAANKAVKCAESLVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 188
Query: 522 LL 527
LL
Sbjct: 189 LL 190
Score = 43.1 bits (100), Expect = 0.006
Identities = 41/149 (27%), Positives = 57/149 (37%), Gaps = 36/149 (24%)
Frame = +3
Query: 282 AAERGAVGFITRAVERAIEFNIN--IRDKYQRTALHWAAEAGQVEAAECLLDYGV----- 440
+A G +G + ++ A + N I D + TALHWA G E LL+ V
Sbjct: 942 SAACGHIGVLGALLQSATSVDANPAIVDNHGYTALHWACYNGHETCVELLLEQDVFQKID 1001
Query: 441 -------------------EAL----------ATECNGRTAIHLAARSGHCNVLRLLLDS 533
E L A + GRT +H AA + H L+LLL
Sbjct: 1002 GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAPDSKGRTPLHAAAFTDHVECLQLLL-- 1059
Query: 534 RPAAEQEQLVNQPDFFGLTPVFLALQRGE 620
Q VN D G TP+ +A + G+
Sbjct: 1060 ----SQNAQVNSADSTGKTPLMMAAENGQ 1084
Score = 42.4 bits (98), Expect = 0.010
Identities = 34/148 (22%), Positives = 61/148 (40%), Gaps = 27/148 (18%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N++ K +T LH A G+ ++ ++ G + NG T +H+AAR GH ++
Sbjct: 328 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 387
Query: 522 LLDSRPAAEQEQL---------------------------VNQPDFFGLTPVFLALQRGE 620
L+ S + + ++ PD FG T + A G
Sbjct: 388 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 447
Query: 621 DARNAFALLMDRGGRYNQQTPGGRSFLN 704
LL++ G +N++ GRS L+
Sbjct: 448 --LECLNLLLNTGADFNKKDKFGRSPLH 473
Score = 42.0 bits (97), Expect = 0.013
Identities = 30/97 (30%), Positives = 45/97 (45%)
Frame = +3
Query: 339 FNINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLR 518
F+I+ D + RT LH AA G +E LL+ G + + GR+ +H AA + + L
Sbjct: 426 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLF 485
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDAR 629
L+ S + VN D G TP+ A D +
Sbjct: 486 ALVGSGAS------VNDLDERGCTPLHYAATSDTDGK 516
Score = 37.7 bits (86), Expect = 0.24
Identities = 43/150 (28%), Positives = 66/150 (43%), Gaps = 6/150 (4%)
Frame = +3
Query: 219 SAQAQQAIKDKVPDPPKNIFEAAERG---AVGFITRAVERAIEFNINIRDKYQRTALHWA 389
S AQ D P + AAE G VG T + + ++ ++DK + TALH A
Sbjct: 1060 SQNAQVNSADSTGKTP--LMMAAENGQTNTVGKETEMLVSSASADLTLQDKSKNTALHLA 1117
Query: 390 AEAGQVEAAECLLDYGVE---ALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQL 560
G +A +L+ + AT +T +H+AAR+G V++ LL +
Sbjct: 1118 CGKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGAS------ 1171
Query: 561 VNQPDFFGLTPVFLALQRGEDARNAFALLM 650
V D G TP LA +D + AL++
Sbjct: 1172 VLAVDENGYTPA-LACAPNKDVADCLALIL 1200
Score = 36.2 bits (82), Expect = 0.71
Identities = 36/135 (26%), Positives = 53/135 (38%)
Frame = +3
Query: 228 AQQAIKDKVPDPPKNIFEAAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAGQV 407
A+ KDK P + AA G + + ++ ++ +N + Y T LH A GQ
Sbjct: 227 AEVTCKDKKSYTP--LHAAASSGMISVVKYLLDLGVD--MNEPNAYGNTPLHVACYNGQD 282
Query: 408 EAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGL 587
L+D G G T +H AA S H + LL A VN G
Sbjct: 283 VVVNELIDCGANVNQKNERGFTPLHFAAASTHGALCLELLVGNGAD-----VNMKSKDGK 337
Query: 588 TPVFLALQRGEDARN 632
TP+ + G +R+
Sbjct: 338 TPLHMTALHGRFSRS 352
Score = 35.8 bits (81), Expect = 0.92
Identities = 25/76 (32%), Positives = 36/76 (46%)
Frame = +3
Query: 378 LHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQ 557
LH AA +G + LL G + + GRT +H AA G+ L LLL++
Sbjct: 406 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD----- 460
Query: 558 LVNQPDFFGLTPVFLA 605
N+ D FG +P+ A
Sbjct: 461 -FNKKDKFGRSPLHYA 475
Score = 33.9 bits (76), Expect = 3.5
Identities = 21/67 (31%), Positives = 33/67 (48%), Gaps = 3/67 (4%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAI---HLAARSGHCNV 512
N IRDK A+H++A G + L++ + ++ + R I HLAA GH
Sbjct: 722 NPGIRDKQGYNAVHYSAAYGHRLCLQLLMETSGTDMLSDSDNRATISPLHLAAYHGHHQA 781
Query: 513 LRLLLDS 533
L +L+ S
Sbjct: 782 LEVLVQS 788
>ref|XP_042860.5| similar to Hypothetical ANK-repeat protein KIAA0379 [Homo sapiens]
Length = 1127
Score = 66.6 bits (161), Expect = 5e-10
Identities = 40/116 (34%), Positives = 59/116 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
NIN DK R A+HWAA G +E + L+ +G E + T +H AA SG +V++
Sbjct: 239 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 298
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGG 689
LLD +N+P+ +G TP+ +A G+D L+D G NQ+ G
Sbjct: 299 LLDLGVD------MNEPNAYGNTPLHVACYNGQDV--VVNELIDCGAIVNQKNEKG 346
Score = 61.6 bits (148), Expect = 2e-08
Identities = 36/94 (38%), Positives = 48/94 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
N++ +DK+ RTALH A G E + LL +G + L + GRT IHL+A GH VL
Sbjct: 752 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 811
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGED 623
LL S AA + D G T + A G +
Sbjct: 812 LLQS--AASMDANPATADNHGYTALHWACYNGHE 843
Score = 53.5 bits (127), Expect = 4e-06
Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 1/122 (0%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATE-CNGRTAIHLAARSGHCNVLR 518
++++R+ RT L AA G VE + L++ G L + RT IH AA +GH LR
Sbjct: 649 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 708
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGGRSF 698
LL+ + AE + V+ D G TP+ L++ G + L+++G + + GR+
Sbjct: 709 LLIGN---AEPQNAVDIQDGNGQTPLMLSVLNGH--TDCVYSLLNKGANVDAKDKWGRTA 763
Query: 699 LN 704
L+
Sbjct: 764 LH 765
Score = 45.4 bits (106), Expect = 0.001
Identities = 26/62 (41%), Positives = 37/62 (58%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N RDK +T LH AA V+ AE L+ ++ GRTA+H AA SGH +++L
Sbjct: 173 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 232
Query: 522 LL 527
LL
Sbjct: 233 LL 234
Score = 42.4 bits (98), Expect = 0.010
Identities = 34/148 (22%), Positives = 61/148 (40%), Gaps = 27/148 (18%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N++ K +T LH A G+ ++ ++ G + NG T +H+AAR GH ++
Sbjct: 372 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 431
Query: 522 LLDSRPAAEQEQL---------------------------VNQPDFFGLTPVFLALQRGE 620
L+ S + + ++ PD FG T + A G
Sbjct: 432 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 491
Query: 621 DARNAFALLMDRGGRYNQQTPGGRSFLN 704
LL++ G +N++ GRS L+
Sbjct: 492 --LECLNLLLNTGADFNKKDKFGRSPLH 517
Score = 42.0 bits (97), Expect = 0.013
Identities = 30/97 (30%), Positives = 45/97 (45%)
Frame = +3
Query: 339 FNINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLR 518
F+I+ D + RT LH AA G +E LL+ G + + GR+ +H AA + + L
Sbjct: 470 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLF 529
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDAR 629
L+ S + VN D G TP+ A D +
Sbjct: 530 ALVGSGAS------VNDLDERGCTPLHYAATSDTDGK 560
Score = 42.0 bits (97), Expect = 0.013
Identities = 40/149 (26%), Positives = 56/149 (36%), Gaps = 36/149 (24%)
Frame = +3
Query: 282 AAERGAVGFITRAVERAIEFNIN--IRDKYQRTALHWAAEAGQVEAAECLLDYGV----- 440
+A G +G + ++ A + N D + TALHWA G E LL+ V
Sbjct: 800 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 859
Query: 441 -------------------EAL----------ATECNGRTAIHLAARSGHCNVLRLLLDS 533
E L AT+ GRT +H AA + H L+LLL
Sbjct: 860 GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL-- 917
Query: 534 RPAAEQEQLVNQPDFFGLTPVFLALQRGE 620
VN D G TP+ +A + G+
Sbjct: 918 ----SHNAQVNSVDSTGKTPLMMAAENGQ 942
Score = 35.8 bits (81), Expect = 0.92
Identities = 36/126 (28%), Positives = 56/126 (43%), Gaps = 3/126 (2%)
Frame = +3
Query: 282 AAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEAL---A 452
AAE G + V A + ++D + TALH A G +A +L+ + A
Sbjct: 937 AAENGQTNTVEMLVSSA-SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA 995
Query: 453 TECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARN 632
T +T +H+AAR+G V++ LL + V D G TP LA +D +
Sbjct: 996 TNAALQTPLHVAARNGLTMVVQELLGKGAS------VLAVDENGYTPA-LACAPNKDVAD 1048
Query: 633 AFALLM 650
AL++
Sbjct: 1049 CLALIL 1054
Score = 35.8 bits (81), Expect = 0.92
Identities = 25/76 (32%), Positives = 36/76 (46%)
Frame = +3
Query: 378 LHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQ 557
LH AA +G + LL G + + GRT +H AA G+ L LLL++
Sbjct: 450 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD----- 504
Query: 558 LVNQPDFFGLTPVFLA 605
N+ D FG +P+ A
Sbjct: 505 -FNKKDKFGRSPLHYA 519
Score = 35.0 bits (79), Expect = 1.6
Identities = 36/135 (26%), Positives = 53/135 (38%)
Frame = +3
Query: 228 AQQAIKDKVPDPPKNIFEAAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAGQV 407
A+ KDK P + AA G + + ++ ++ +N + Y T LH A GQ
Sbjct: 271 AEVTCKDKKSYTP--LHAAASSGMISVVKYLLDLGVD--MNEPNAYGNTPLHVACYNGQD 326
Query: 408 EAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGL 587
L+D G G T +H AA S H + LL A VN G
Sbjct: 327 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD-----VNMKSKDGK 381
Query: 588 TPVFLALQRGEDARN 632
TP+ + G +R+
Sbjct: 382 TPLHMTALHGRFSRS 396
Score = 32.7 bits (73), Expect = 7.8
Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 12/76 (15%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAG-----QVEAAECLLDY-----GVEALATECNGRTA--IHL 485
N IRDK A+H++A G Q+ A+E LD G + L+ N T +HL
Sbjct: 571 NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHL 630
Query: 486 AARSGHCNVLRLLLDS 533
AA GH L +L+ S
Sbjct: 631 AAYHGHHQALEVLVQS 646
>dbj|BAC86737.1| unnamed protein product [Homo sapiens]
Length = 687
Score = 66.6 bits (161), Expect = 5e-10
Identities = 40/116 (34%), Positives = 59/116 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
NIN DK R A+HWAA G +E + L+ +G E + T +H AA SG +V++
Sbjct: 198 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 257
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGG 689
LLD +N+P+ +G TP+ +A G+D L+D G NQ+ G
Sbjct: 258 LLDLGVD------MNEPNAYGNTPLHVACYNGQDV--VVNELIDCGAIVNQKNEKG 305
Score = 45.4 bits (106), Expect = 0.001
Identities = 26/62 (41%), Positives = 37/62 (58%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N RDK +T LH AA V+ AE L+ ++ GRTA+H AA SGH +++L
Sbjct: 132 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 191
Query: 522 LL 527
LL
Sbjct: 192 LL 193
Score = 42.4 bits (98), Expect = 0.010
Identities = 28/79 (35%), Positives = 42/79 (52%), Gaps = 1/79 (1%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATE-CNGRTAIHLAARSGHCNVLR 518
++++R+ RT L AA G VE + L++ G L + RT IH AA +GH LR
Sbjct: 608 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 667
Query: 519 LLLDSRPAAEQEQLVNQPD 575
LL+ + AE + V+ D
Sbjct: 668 LLIGN---AEPQNAVDIQD 683
Score = 42.4 bits (98), Expect = 0.010
Identities = 34/148 (22%), Positives = 61/148 (40%), Gaps = 27/148 (18%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N++ K +T LH A G+ ++ ++ G + NG T +H+AAR GH ++
Sbjct: 331 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 390
Query: 522 LLDSRPAAEQEQL---------------------------VNQPDFFGLTPVFLALQRGE 620
L+ S + + ++ PD FG T + A G
Sbjct: 391 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 450
Query: 621 DARNAFALLMDRGGRYNQQTPGGRSFLN 704
LL++ G +N++ GRS L+
Sbjct: 451 --LECLNLLLNTGADFNKKDKFGRSPLH 476
Score = 42.4 bits (98), Expect = 0.010
Identities = 36/118 (30%), Positives = 51/118 (42%)
Frame = +3
Query: 339 FNINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLR 518
F+I+ D + RT LH AA G +E LL+ G + + GR+ +H AA + + L
Sbjct: 429 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLF 488
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGGR 692
L+ S + VN D G TP+ A D + LL N PG R
Sbjct: 489 ALVGSGAS------VNDLDERGCTPLHYAATSDTDGKCLEYLLR------NDANPGVR 534
Score = 35.8 bits (81), Expect = 0.92
Identities = 25/76 (32%), Positives = 36/76 (46%)
Frame = +3
Query: 378 LHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQ 557
LH AA +G + LL G + + GRT +H AA G+ L LLL++
Sbjct: 409 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD----- 463
Query: 558 LVNQPDFFGLTPVFLA 605
N+ D FG +P+ A
Sbjct: 464 -FNKKDKFGRSPLHYA 478
Score = 35.0 bits (79), Expect = 1.6
Identities = 36/135 (26%), Positives = 53/135 (38%)
Frame = +3
Query: 228 AQQAIKDKVPDPPKNIFEAAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAGQV 407
A+ KDK P + AA G + + ++ ++ +N + Y T LH A GQ
Sbjct: 230 AEVTCKDKKSYTP--LHAAASSGMISVVKYLLDLGVD--MNEPNAYGNTPLHVACYNGQD 285
Query: 408 EAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGL 587
L+D G G T +H AA S H + LL A VN G
Sbjct: 286 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD-----VNMKSKDGK 340
Query: 588 TPVFLALQRGEDARN 632
TP+ + G +R+
Sbjct: 341 TPLHMTALHGRFSRS 355
>sp|O15084|Y379_HUMAN Hypothetical ANK-repeat protein KIAA0379 gi|6634025|dbj|BAA20833.2|
KIAA0379 protein [Homo sapiens]
Length = 1059
Score = 66.6 bits (161), Expect = 5e-10
Identities = 40/116 (34%), Positives = 59/116 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
NIN DK R A+HWAA G +E + L+ +G E + T +H AA SG +V++
Sbjct: 171 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 230
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGG 689
LLD +N+P+ +G TP+ +A G+D L+D G NQ+ G
Sbjct: 231 LLDLGVD------MNEPNAYGNTPLHVACYNGQDV--VVNELIDCGAIVNQKNEKG 278
Score = 61.6 bits (148), Expect = 2e-08
Identities = 36/94 (38%), Positives = 48/94 (50%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
N++ +DK+ RTALH A G E + LL +G + L + GRT IHL+A GH VL
Sbjct: 684 NVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGA 743
Query: 522 LLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGED 623
LL S AA + D G T + A G +
Sbjct: 744 LLQS--AASMDANPATADNHGYTALHWACYNGHE 775
Score = 53.5 bits (127), Expect = 4e-06
Identities = 38/122 (31%), Positives = 63/122 (51%), Gaps = 1/122 (0%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATE-CNGRTAIHLAARSGHCNVLR 518
++++R+ RT L AA G VE + L++ G L + RT IH AA +GH LR
Sbjct: 581 DLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLR 640
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARNAFALLMDRGGRYNQQTPGGRSF 698
LL+ + AE + V+ D G TP+ L++ G + L+++G + + GR+
Sbjct: 641 LLIGN---AEPQNAVDIQDGNGQTPLMLSVLNGH--TDCVYSLLNKGANVDAKDKWGRTA 695
Query: 699 LN 704
L+
Sbjct: 696 LH 697
Score = 45.4 bits (106), Expect = 0.001
Identities = 26/62 (41%), Positives = 37/62 (58%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N RDK +T LH AA V+ AE L+ ++ GRTA+H AA SGH +++L
Sbjct: 105 DVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKL 164
Query: 522 LL 527
LL
Sbjct: 165 LL 166
Score = 42.4 bits (98), Expect = 0.010
Identities = 34/148 (22%), Positives = 61/148 (40%), Gaps = 27/148 (18%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRL 521
++N++ K +T LH A G+ ++ ++ G + NG T +H+AAR GH ++
Sbjct: 304 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 363
Query: 522 LLDSRPAAEQEQL---------------------------VNQPDFFGLTPVFLALQRGE 620
L+ S + + ++ PD FG T + A G
Sbjct: 364 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 423
Query: 621 DARNAFALLMDRGGRYNQQTPGGRSFLN 704
LL++ G +N++ GRS L+
Sbjct: 424 --LECLNLLLNTGADFNKKDKFGRSPLH 449
Score = 42.0 bits (97), Expect = 0.013
Identities = 30/97 (30%), Positives = 45/97 (45%)
Frame = +3
Query: 339 FNINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLR 518
F+I+ D + RT LH AA G +E LL+ G + + GR+ +H AA + + L
Sbjct: 402 FDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLF 461
Query: 519 LLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDAR 629
L+ S + VN D G TP+ A D +
Sbjct: 462 ALVGSGAS------VNDLDERGCTPLHYAATSDTDGK 492
Score = 42.0 bits (97), Expect = 0.013
Identities = 40/149 (26%), Positives = 56/149 (36%), Gaps = 36/149 (24%)
Frame = +3
Query: 282 AAERGAVGFITRAVERAIEFNIN--IRDKYQRTALHWAAEAGQVEAAECLLDYGV----- 440
+A G +G + ++ A + N D + TALHWA G E LL+ V
Sbjct: 732 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 791
Query: 441 -------------------EAL----------ATECNGRTAIHLAARSGHCNVLRLLLDS 533
E L AT+ GRT +H AA + H L+LLL
Sbjct: 792 GNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL-- 849
Query: 534 RPAAEQEQLVNQPDFFGLTPVFLALQRGE 620
VN D G TP+ +A + G+
Sbjct: 850 ----SHNAQVNSVDSTGKTPLMMAAENGQ 874
Score = 35.8 bits (81), Expect = 0.92
Identities = 36/126 (28%), Positives = 56/126 (43%), Gaps = 3/126 (2%)
Frame = +3
Query: 282 AAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAGQVEAAECLLDYGVEAL---A 452
AAE G + V A + ++D + TALH A G +A +L+ + A
Sbjct: 869 AAENGQTNTVEMLVSSA-SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA 927
Query: 453 TECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGLTPVFLALQRGEDARN 632
T +T +H+AAR+G V++ LL + V D G TP LA +D +
Sbjct: 928 TNAALQTPLHVAARNGLTMVVQELLGKGAS------VLAVDENGYTPA-LACAPNKDVAD 980
Query: 633 AFALLM 650
AL++
Sbjct: 981 CLALIL 986
Score = 35.8 bits (81), Expect = 0.92
Identities = 25/76 (32%), Positives = 36/76 (46%)
Frame = +3
Query: 378 LHWAAEAGQVEAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQ 557
LH AA +G + LL G + + GRT +H AA G+ L LLL++
Sbjct: 382 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGAD----- 436
Query: 558 LVNQPDFFGLTPVFLA 605
N+ D FG +P+ A
Sbjct: 437 -FNKKDKFGRSPLHYA 451
Score = 35.0 bits (79), Expect = 1.6
Identities = 36/135 (26%), Positives = 53/135 (38%)
Frame = +3
Query: 228 AQQAIKDKVPDPPKNIFEAAERGAVGFITRAVERAIEFNINIRDKYQRTALHWAAEAGQV 407
A+ KDK P + AA G + + ++ ++ +N + Y T LH A GQ
Sbjct: 203 AEVTCKDKKSYTP--LHAAASSGMISVVKYLLDLGVD--MNEPNAYGNTPLHVACYNGQD 258
Query: 408 EAAECLLDYGVEALATECNGRTAIHLAARSGHCNVLRLLLDSRPAAEQEQLVNQPDFFGL 587
L+D G G T +H AA S H + LL A VN G
Sbjct: 259 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGAD-----VNMKSKDGK 313
Query: 588 TPVFLALQRGEDARN 632
TP+ + G +R+
Sbjct: 314 TPLHMTALHGRFSRS 328
Score = 32.7 bits (73), Expect = 7.8
Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 12/76 (15%)
Frame = +3
Query: 342 NINIRDKYQRTALHWAAEAG-----QVEAAECLLDY-----GVEALATECNGRTA--IHL 485
N IRDK A+H++A G Q+ A+E LD G + L+ N T +HL
Sbjct: 503 NPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHL 562
Query: 486 AARSGHCNVLRLLLDS 533
AA GH L +L+ S
Sbjct: 563 AAYHGHHQALEVLVQS 578
