Nr search
BLASTX 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= KCC000120A_C02 KCC000120A_c02
(1288 letters)
Database: nr
1,537,769 sequences; 498,525,298 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
emb|CAC84639.1| mixed lineage kinase 4alpha [Homo sapiens] 74 4e-12
emb|CAC17571.1| dJ862P8.3 (Similar to MAP3K10 (mitogen-activated... 74 4e-12
ref|NP_115811.1| mixed lineage kinase 4 [Homo sapiens] gi|177367... 74 4e-12
ref|NP_663583.1| cDNA sequence BC021891; mixed lineage kinase 4 ... 72 2e-11
gb|AAF73281.1|AF155142_1 mixed lineage kinase 3 [Mus musculus] 72 2e-11
>emb|CAC84639.1| mixed lineage kinase 4alpha [Homo sapiens]
Length = 570
Score = 74.3 bits (181), Expect = 4e-12
Identities = 86/327 (26%), Positives = 127/327 (38%), Gaps = 38/327 (11%)
Frame = +2
Query: 407 RNAAGQGPTGSFIALGAGGGSITGINRRTPVGLKSGAHVSADLN---------------- 538
R AAG T A GA GGS + + + +GA + A L
Sbjct: 4 RGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQ 63
Query: 539 ---------AIVDDQGTINALVSRQLSVM--SHYSVKSEAGSVILQPEVAHGPNALGFT- 682
A+ D+G V R+L + ++ + A S P P + F
Sbjct: 64 LVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFER 123
Query: 683 --LHKLIGRGGFGNVYLGEWEGRKVAVKVVTGNNNETASDQPEDKEWEARKEKMAQMEAI 856
L +LIG GGFG VY W+G++VAVK + + A+ E EAR
Sbjct: 124 LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREAR---------- 173
Query: 857 LMASVNHPNIVHTLKVIAHQGDAMDPELAAIERELFTEKEDQHPPSFEWHIIMEYCDRGS 1036
L A + HPNI+ V Q P L +++E+ G+
Sbjct: 174 LFAMLRHPNIIELRGVCLQQ-----PHLC---------------------LVLEFARGGA 207
Query: 1037 LSRALAAMRFHEFVETQG---YVRWDAWACLQTLKEVTKALMFLHENR---ILHGDLKAA 1198
L+RALAA G R + ++ + +++LHE ILH DLK++
Sbjct: 208 LNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSS 267
Query: 1199 NVLL--SSSETDRRGFVAKVSDFGLSR 1273
N+LL D K++DFGL+R
Sbjct: 268 NILLLEEIEHDDICNKTLKITDFGLAR 294
>emb|CAC17571.1| dJ862P8.3 (Similar to MAP3K10 (mitogen-activated protein kinase
kinase kinase 10)) [Homo sapiens]
Length = 564
Score = 74.3 bits (181), Expect = 4e-12
Identities = 86/327 (26%), Positives = 127/327 (38%), Gaps = 38/327 (11%)
Frame = +2
Query: 407 RNAAGQGPTGSFIALGAGGGSITGINRRTPVGLKSGAHVSADLN---------------- 538
R AAG T A GA GGS + + + +GA + A L
Sbjct: 4 RGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQ 63
Query: 539 ---------AIVDDQGTINALVSRQLSVM--SHYSVKSEAGSVILQPEVAHGPNALGFT- 682
A+ D+G V R+L + ++ + A S P P + F
Sbjct: 64 LVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFER 123
Query: 683 --LHKLIGRGGFGNVYLGEWEGRKVAVKVVTGNNNETASDQPEDKEWEARKEKMAQMEAI 856
L +LIG GGFG VY W+G++VAVK + + A+ E EAR
Sbjct: 124 LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREAR---------- 173
Query: 857 LMASVNHPNIVHTLKVIAHQGDAMDPELAAIERELFTEKEDQHPPSFEWHIIMEYCDRGS 1036
L A + HPNI+ V Q P L +++E+ G+
Sbjct: 174 LFAMLRHPNIIELRGVCLQQ-----PHLC---------------------LVLEFARGGA 207
Query: 1037 LSRALAAMRFHEFVETQG---YVRWDAWACLQTLKEVTKALMFLHENR---ILHGDLKAA 1198
L+RALAA G R + ++ + +++LHE ILH DLK++
Sbjct: 208 LNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSS 267
Query: 1199 NVLL--SSSETDRRGFVAKVSDFGLSR 1273
N+LL D K++DFGL+R
Sbjct: 268 NILLLEKIEHDDICNKTLKITDFGLAR 294
>ref|NP_115811.1| mixed lineage kinase 4 [Homo sapiens] gi|17736731|emb|CAC84640.1|
mixed lineage kinase 4beta [Homo sapiens]
Length = 1036
Score = 74.3 bits (181), Expect = 4e-12
Identities = 86/327 (26%), Positives = 127/327 (38%), Gaps = 38/327 (11%)
Frame = +2
Query: 407 RNAAGQGPTGSFIALGAGGGSITGINRRTPVGLKSGAHVSADLN---------------- 538
R AAG T A GA GGS + + + +GA + A L
Sbjct: 4 RGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQ 63
Query: 539 ---------AIVDDQGTINALVSRQLSVM--SHYSVKSEAGSVILQPEVAHGPNALGFT- 682
A+ D+G V R+L + ++ + A S P P + F
Sbjct: 64 LVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFER 123
Query: 683 --LHKLIGRGGFGNVYLGEWEGRKVAVKVVTGNNNETASDQPEDKEWEARKEKMAQMEAI 856
L +LIG GGFG VY W+G++VAVK + + A+ E EAR
Sbjct: 124 LELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREAR---------- 173
Query: 857 LMASVNHPNIVHTLKVIAHQGDAMDPELAAIERELFTEKEDQHPPSFEWHIIMEYCDRGS 1036
L A + HPNI+ V Q P L +++E+ G+
Sbjct: 174 LFAMLRHPNIIELRGVCLQQ-----PHLC---------------------LVLEFARGGA 207
Query: 1037 LSRALAAMRFHEFVETQG---YVRWDAWACLQTLKEVTKALMFLHENR---ILHGDLKAA 1198
L+RALAA G R + ++ + +++LHE ILH DLK++
Sbjct: 208 LNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSS 267
Query: 1199 NVLL--SSSETDRRGFVAKVSDFGLSR 1273
N+LL D K++DFGL+R
Sbjct: 268 NILLLEEIEHDDICNKTLKITDFGLAR 294
>ref|NP_663583.1| cDNA sequence BC021891; mixed lineage kinase 4 [Mus musculus]
gi|18257338|gb|AAH21891.1| CDNA sequence BC021891 [Mus
musculus]
Length = 1001
Score = 72.4 bits (176), Expect = 2e-11
Identities = 62/211 (29%), Positives = 90/211 (42%), Gaps = 14/211 (6%)
Frame = +2
Query: 683 LHKLIGRGGFGNVYLGEWEGRKVAVKVVTGNNNETASDQPEDKEWEARKEKMAQMEAILM 862
L +LIG GGFG VY W+G++VAVK + + A+ E EAR L
Sbjct: 112 LKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRREAR----------LF 161
Query: 863 ASVNHPNIVHTLKVIAHQGDAMDPELAAIERELFTEKEDQHPPSFEWHIIMEYCDRGSLS 1042
A + HPNI+ V Q P L +++E+ G+L+
Sbjct: 162 AMLRHPNIIQLRGVCLRQ-----PHLC---------------------LVLEFARGGALN 195
Query: 1043 RALAAM---------RFHEFVETQGYVRWDAWACLQTLKEVTKALMFLHENR---ILHGD 1186
RALAA R + Q V W ++ + +++LHE ILH D
Sbjct: 196 RALAAAASDPRAPGPRRARRIPPQVLVNWAV--------QIARGMLYLHEEAVVPILHRD 247
Query: 1187 LKAANVLL--SSSETDRRGFVAKVSDFGLSR 1273
LK++N+LL D K++DFGL+R
Sbjct: 248 LKSSNILLLEKIEHDDICNKTLKITDFGLAR 278
>gb|AAF73281.1|AF155142_1 mixed lineage kinase 3 [Mus musculus]
Length = 850
Score = 72.0 bits (175), Expect = 2e-11
Identities = 88/323 (27%), Positives = 124/323 (38%), Gaps = 34/323 (10%)
Frame = +2
Query: 407 RNAAGQGPTGSFIALGAGGGSITG--------------------------INRRTPVGLK 508
+N + P GS+ G+GGG TG N + + L+
Sbjct: 5 KNLFLKSPLGSWNGSGSGGGGGTGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALR 64
Query: 509 SGAHV---SADLNAIVDDQGTINALVSRQLSVMSHYSVKSEAGSVILQPEVAHGPNALGF 679
G V S D AI D+G V Q+ + V G P +
Sbjct: 65 KGDRVEVLSRDA-AISGDEGWWAGQVGGQVGIFPSNYVSRGGG-----PPPCEVASFQEL 118
Query: 680 TLHKLIGRGGFGNVYLGEWEGRKVAVKVVTGNNNETASDQPEDKEWEARKEKMAQMEAIL 859
L ++IG GGFG VY G W G VAVK A+ Q D++ E + Q EA L
Sbjct: 119 RLEEVIGIGGFGKVYRGSWRGELVAVK---------AARQDPDEDISVTAESVRQ-EARL 168
Query: 860 MASVNHPNIVHTLKVIAHQGDAMDPELAAIERELFTEKEDQHPPSFEWHIIMEYCDRGSL 1039
A + HPNI+ LK + + +P L ++MEY G L
Sbjct: 169 FAMLAHPNII-ALKAVCLE----EPNLC---------------------LVMEYAAGGPL 202
Query: 1040 SRALAAMRFHEFVETQGYVRWDAWACLQTLKEVTKALMFLHENR---ILHGDLKAANVLL 1210
SRALA R V V W ++ + + +LH ++H DLK+ N+LL
Sbjct: 203 SRALAGRR----VPPHVLVNWAV--------QIARGMHYLHCEALVPVIHRDLKSNNILL 250
Query: 1211 SS--SETDRRGFVAKVSDFGLSR 1273
D K++DFGL+R
Sbjct: 251 LQPIEGDDMEHKTLKITDFGLAR 273
