hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/shimazu/full/sf/sf00012/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: sf00012 2651 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Filamin Filamin/ABP280 repeat 3155.6 0 24 CH Calponin homology (CH) domain 206.5 4e-58 2 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- CH 1/2 57 161 .. 1 121 [] 107.2 3.2e-28 CH 2/2 180 281 .. 1 121 [] 99.2 8.3e-26 Filamin 1/24 290 383 .. 1 101 [] 167.5 2.2e-46 Filamin 2/24 390 483 .. 1 101 [] 170.6 2.6e-47 Filamin 3/24 489 579 .. 1 101 [] 158.0 1.6e-43 Filamin 4/24 585 672 .. 1 101 [] 147.1 3.1e-40 Filamin 5/24 681 772 .. 1 101 [] 163.2 4.3e-45 Filamin 6/24 778 875 .. 1 101 [] 150.8 2.4e-41 Filamin 7/24 881 974 .. 1 101 [] 167.7 1.9e-46 Filamin 8/24 980 1070 .. 1 101 [] 117.3 3e-31 Filamin 9/24 1076 1163 .. 1 101 [] 175.8 7e-49 Filamin 10/24 1169 1258 .. 1 101 [] 157.2 2.8e-43 Filamin 11/24 1264 1358 .. 1 101 [] 151.7 1.3e-41 Filamin 12/24 1364 1451 .. 1 101 [] 173.8 2.8e-48 Filamin 13/24 1457 1548 .. 1 101 [] 176.0 6.1e-49 Filamin 14/24 1554 1645 .. 1 101 [] 173.4 3.6e-48 Filamin 15/24 1651 1741 .. 1 101 [] 92.0 1.2e-23 Filamin 16/24 1774 1861 .. 1 101 [] 4.6 0.00056 Filamin 17/24 1866 1953 .. 1 101 [] 176.6 4e-49 Filamin 18/24 1965 2040 .. 1 101 [] 8.1 0.00028 Filamin 19/24 2048 2135 .. 1 101 [] 171.1 1.9e-47 Filamin 20/24 2161 2231 .. 1 101 [] 11.5 0.00014 Filamin 21/24 2239 2326 .. 1 101 [] 167.2 2.8e-46 Filamin 22/24 2333 2421 .. 1 101 [] 122.0 1.1e-32 Filamin 23/24 2430 2517 .. 1 101 [] 143.0 5.2e-39 Filamin 24/24 2558 2647 .. 1 101 [] 147.8 2e-40 Alignments of top-scoring domains: CH: domain 1 of 2, from 57 to 161: score 107.2, E = 3.2e-28 *->qekellrWvnsvlagypgkkdtlPippvritnfftdwlkDGlaLcaL q+++++rW+n++l++ + k ri n+ td++ DGl L+aL sf00012 57 QQNTFTRWCNEHLKC-VSK---------RIANLQTDLS-DGLRLIAL 92 lnklrPglvdkkkv.pslsrfdkleNlnlaldaaekeGlgiilvlidpeD l++l+ +++ k+ ++++ r+ +leN++ al+++++e ++ lv id++ sf00012 93 LEVLSQKKMHRKHNqRPTFRQMQLENVSVALEFLDRES-IK-LVSIDSKA 140 ivegnpdPDeklvltllwqLirrfq<-* iv+gn kl+l+l+w+Li++++ sf00012 141 IVDGNL----KLILGLIWTLILHYS 161 CH: domain 2 of 2, from 180 to 281: score 99.2, E = 8.3e-26 *->qekellrWvnsvlagypgkkdtlPippvritnfftdwlkDGlaLcaL +++ ll W++++l ++itnf+ dw +G+aL aL sf00012 180 PKQRLLGWIQNKLPQ------------LPITNFSRDWQ-SGRALGAL 213 lnklrPglvdkkkvpslsrfdkleNlnlaldaaekeGlgiilvlidpeDi +++++Pgl++ + s+++ +++ N++ a++ a+++ lgi ++ i+pe+i sf00012 214 VDSCAPGLCPDWD--SWDASKPVTNAREAMQQADDW-LGI-PQVITPEEI 259 vegnpdPDeklvltllwqLirrfq<-* v+ ++ +De++v+t+l+q+ ++ sf00012 260 VD-PN-VDEHSVMTYLSQFPKAKL 281 Filamin: domain 1 of 24, from 290 to 383: score 167.5, E = 2.2e-46 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +++ K +AyGPG+e++G++v+k aeFtV+t ++AG+G++ sf00012 290 KLNPKKARAYGPGIEPTGNMVKKRAEFTVET-------RSAGQGEVL 329 VkVeGPsGaeAvvevkvtDngD..GtYtVsYtPtepGdYtvnVtygGehI V+Ve+P+G+ ++e+kvt+n+D+++t++V+Y+P+++G++ v+V+++G+hI sf00012 330 VYVEDPAGH--QEEAKVTANNDknRTFSVWYVPEVTGTHKVTVLFAGQHI 377 PgSPFk<-* ++SPF+ sf00012 378 AKSPFE 383 Filamin: domain 2 of 24, from 390 to 483: score 170.6, E = 2.6e-47 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +gDasKV+A+GPGLe+ G+ ++k+++F ++t +gAG+G+++ sf00012 390 QGDASKVTAQGPGLEPSGNIANKTTYFEIFT-------AGAGTGEVE 429 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg V +++P+G++++ve++++++gD tY++sY+Pt++G++tv+Vt++G++IP+ sf00012 430 VVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPR 479 SPFk<-* SP++ sf00012 480 SPYT 483 Filamin: domain 3 of 24, from 489 to 579: score 158.0, E = 1.6e-43 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs a+++s ++A G GL++ GV+v+++a+F+V+t kgAG+G+L+ sf00012 489 ACNPSACRAVGRGLQPKGVRVKETADFKVYT-------KGAGSGELK 528 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg V+V+GP+G + vk +D gDG Y+ +Y+P++pG+Y+v++t+gG++I++ sf00012 529 VTVKGPKGE---ERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGR 575 SPFk<-* SPF+ sf00012 576 SPFE 579 Filamin: domain 4 of 24, from 585 to 672: score 147.1, E = 3.1e-40 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +++ +KV+A+GPGLegg +vgk+a+F+V++ g+ +G L+ sf00012 585 ECGNQKVRAWGPGLEGG--VVGKSADFVVEA-------IGDDVGTLG 622 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg +VeGPs+a ++++ D gDG+++V+Y+P+e+G+Y v+V+++ e I sf00012 623 FSVEGPSQA----KIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRL 668 SPFk<-* SPF+ sf00012 669 SPFM 672 Filamin: domain 5 of 24, from 681 to 772: score 163.2, E = 4.3e-45 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +++ +VkA GPGLe++GV v+kPae tVd+ k++G+++L sf00012 681 DFHPDRVKARGPGLEKTGVAVNKPAELTVDA-------KHGGKAPLR 720 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg V+V++ +G+ +ve+ v+Dng+GtY++sY+P++p +t +V +gG+ IP+ sf00012 721 VQVQDNEGC--PVEALVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPN 768 SPFk<-* SPF+ sf00012 769 SPFR 772 Filamin: domain 6 of 24, from 778 to 875: score 150.8, E = 2.4e-41 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +++++KVk+yGPG+ ++G+k+++P++FtVd+ ++AG+G++s sf00012 778 GSHPNKVKVYGPGVAKTGLKAHEPTYFTVDC-------AEAGQGDVS 817 VkVeGPsGa....eAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGe ++++++ G+ ++ eA+++++++ n+++t+tV+YtP+ +G+Yt++V+++++ sf00012 818 IGIKCAPGVvgpaEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQ 867 hIPgSPFk<-* + P SP++ sf00012 868 ATPTSPIR 875 Filamin: domain 7 of 24, from 881 to 974: score 167.7, E = 1.9e-46 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++DasKVkA+GPGL+++GV+ gkP++FtV++ k+AG+G+L+ sf00012 881 SHDASKVKAEGPGLSRTGVELGKPTHFTVNA-------KAAGKGKLD 920 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg V+ +G + +Av++v+++D++D tYtV+YtP ++G+ vnVtygG++IP+ sf00012 921 VQFSGLTKGDAVRDVDIIDHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPK 970 SPFk<-* SPF+ sf00012 971 SPFS 974 Filamin: domain 8 of 24, from 980 to 1070: score 117.3, E = 3e-31 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++D sK+k++G+G+ vgk +eFtV++ + ++G+G+++ sf00012 980 SLDLSKIKVSGLGEKVD---VGKDQEFTVKS------KGAGGQGKVA 1017 VkVeGPsGaeAvvevkvtDngD.GtYtVsYtPtepGdYtvnVtygGehIP k++GPsGa +v++kv+ + V+++P+e+G+Y+v+Vty+G+++P sf00012 1018 SKIVGPSGA--AVPCKVEPGLGaDNSVVRFLPREEGPYEVEVTYDGVPVP 1065 gSPFk<-* gSPF sf00012 1066 GSPFP 1070 Filamin: domain 9 of 24, from 1076 to 1163: score 175.8, E = 7e-49 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++ +sKVkA GPGL+gg +g Pa Ft+dt kgAG+GgL+ sf00012 1076 PTKPSKVKAFGPGLQGG--SAGSPARFTIDT-------KGAGTGGLG 1113 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg ++VeGP++a + ++ DngDGt++VsY+PtepGdY++n++++++hIPg sf00012 1114 LTVEGPCEA----QLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPG 1159 SPFk<-* SPFk sf00012 1160 SPFK 1163 Filamin: domain 10 of 24, from 1169 to 1258: score 157.2, E = 2.8e-43 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++DasKVk++GPGLe++ ++g+ +F+Vd+ ++AG+++L+ sf00012 1169 CFDASKVKCSGPGLERA--TAGEVGQFQVDC-------SSAGSAELT 1206 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg + +++ +G+ + ev+++D+gDGt+t++Y+P +pG Ytv+++ygG+++P+ sf00012 1207 IEICSEAGL--PAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPN 1254 SPFk<-* +P k sf00012 1255 FPSK 1258 Filamin: domain 11 of 24, from 1264 to 1358: score 151.7, E = 1.3e-41 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs a+D s V++yGPG+eg+GV+ +++eF+Vd+ +++ + Gg +++ sf00012 1264 AVDTSGVQCYGPGIEGQGVFREATTEFSVDA----RALTQTGGPHVK 1306 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg + V +PsG+ ++e++v+D+gDG+Y V+YtP+e+G ++v+Vty+G ++P sf00012 1307 ARVANPSGN--LTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPS 1354 SPFk<-* SPF+ sf00012 1355 SPFQ 1358 Filamin: domain 12 of 24, from 1364 to 1451: score 173.8, E = 2.8e-48 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++D+s+V+++GPG++ g +++kP +FtV+t +gAG+GgL+ sf00012 1364 GCDPSRVRVHGPGIQSG--TTNKPNKFTVET-------RGAGTGGLG 1401 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg ++VeGPs+a +++++Dn+DG+++V+Y+P+e+G+Y+ nVtygG+++Pg sf00012 1402 LAVEGPSEA----KMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPG 1447 SPFk<-* SPFk sf00012 1448 SPFK 1451 Filamin: domain 13 of 24, from 1457 to 1548: score 176.0, E = 6.1e-49 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +DasKVk++GPGL++g+V+++ P++F+Vdt ++AG+++L+ sf00012 1457 VTDASKVKCSGPGLSPGMVRANLPQSFQVDT-------SKAGVAPLQ 1496 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg VkV+GP+G+ v++v+v+Dn DGt tV Y+P +G+Y+++V+yg+e++P+ sf00012 1497 VKVQGPKGL--VEPVDVVDNADGTQTVNYVPSREGPYSISVLYGDEEVPR 1544 SPFk<-* SPFk sf00012 1545 SPFK 1548 Filamin: domain 14 of 24, from 1554 to 1645: score 173.4, E = 3.6e-48 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++DasKVkA+GPGL +GV + P eFt+d+ k+AG+G L+ sf00012 1554 THDASKVKASGPGLNTTGVPASLPVEFTIDA-------KDAGEGLLA 1593 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg V++ +P+G +++++++Dn+DGtYtV+Y+P ++G Yt+ ++ygG++IP sf00012 1594 VQITDPEGK--PKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPF 1641 SPFk<-* SP++ sf00012 1642 SPYR 1645 Filamin: domain 15 of 24, from 1651 to 1741: score 92.0, E = 1.2e-23 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +gDasK+++ G G+ ++ + g+ + tVdt k+AG+G+++ sf00012 1651 TGDASKCTVTGAGIGPT-IQIGEETVITVDT-------KAAGKGKVT 1689 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg +V+ P+G +v+v+v++n DGt+++ Yt+ +pG Y + V +gGeh+P+ sf00012 1690 CTVCTPDGS--EVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPN 1737 SPFk<-* SPF+ sf00012 1738 SPFQ 1741 Filamin: domain 16 of 24, from 1774 to 1861: score 4.6, E = 0.00056 *->agDasKVkAyGPGLeggGVkvg.kPaeFtVdtVdkdGepkgAGgGgL + +++ + GL + ++ ++ Ft++ G+ sf00012 1774 TWAPERPLVGVNGLDVTSLRPFdLVIPFTIKK------------GEI 1808 sVkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIP + V PsG v ++ +tDn+DGt tV+Y P e+G ++ ++ y+ hIP sf00012 1809 TGEVRMPSGK--VAQPTITDNKDGTVTVRYAPSEAGLHEMDIRYDNMHIP 1856 gSPFk<-* gSP + sf00012 1857 GSPLQ 1861 Filamin: domain 17 of 24, from 1866 to 1953: score 176.6, E = 4e-49 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +++ +V+AyGPGL +g +v+kPa FtV+t k+AG+GgLs sf00012 1866 YVNCGHVTAYGPGLTHG--VVNKPATFTVNT-------KDAGEGGLS 1903 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg +++eGPs+a e+++tDn+DGt++VsY+P pGdY++ V+y+++h+Pg sf00012 1904 LAIEGPSKA----EISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPG 1949 SPFk<-* SPF+ sf00012 1950 SPFT 1953 Filamin: domain 18 of 24, from 1965 to 2040: score 8.1, E = 0.00028 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++ kvg a+ ++ ++ L+ sf00012 1965 --------------SHL--KVGSAADIPINI-------SETDLSLLT 1988 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg ++V+ PsG ++++ ++ +G ++s++P+e+G++ v+V+ +G+h++ sf00012 1989 ATVVPPSGR--EEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVAS 2036 SPFk<-* SP+ sf00012 2037 SPIP 2040 Filamin: domain 19 of 24, from 2048 to 2135: score 171.1, E = 1.9e-47 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs gDas+V+++G GL+ g ++++PaeF +dt ++AG GgLs sf00012 2048 IGDASRVRVSGQGLHEG--HTFEPAEFIIDT-------RDAGYGGLS 2085 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg +++eGPs++ ++ +D DGt++V+Y+PtepG+Y++n++++++h+Pg sf00012 2086 LSIEGPSKV----DINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPG 2131 SPFk<-* SPF+ sf00012 2132 SPFS 2135 Filamin: domain 20 of 24, from 2161 to 2231: score 11.5, E = 0.00014 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++++ + L + + + sf00012 2161 GSHCDLS------LKIP----------EISI------------QDMT 2179 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg ++V +PsG + e+++++ + tY ++++P e G++tv+V+y G+h+Pg sf00012 2180 AQVTSPSGK--THEAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPG 2227 SPFk<-* SPF+ sf00012 2228 SPFQ 2231 Filamin: domain 21 of 24, from 2239 to 2326: score 167.2, E = 2.8e-46 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +g+a+KV+A GPGLe++ ++g+PaeF+++t ++AG+GgL+ sf00012 2239 EGGAHKVRAGGPGLERA--EAGVPAEFSIWT-------REAGAGGLA 2276 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg ++VeGPs+a e++ +D++DG+++V+Y+ +epGdY+v+V++++ehIP+ sf00012 2277 IAVEGPSKA----EISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPD 2322 SPFk<-* SPF sf00012 2323 SPFV 2326 Filamin: domain 22 of 24, from 2333 to 2421: score 122.0, E = 1.1e-32 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +gDa + +++ + ++g kv++Pa+F V ++ +G+ + sf00012 2333 SGDARRLTVSSLRESGL--KVNQPASFAVSL--------NGAKGAID 2369 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg +kV++PsGa ++e++vt+ +++ Y V+++P+e+G+Y ++V+++G+hIPg sf00012 2370 AKVHSPSGA--LEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPG 2417 SPFk<-* SPFk sf00012 2418 SPFK 2421 Filamin: domain 23 of 24, from 2430 to 2517: score 143.0, E = 5.2e-39 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs +gD+ V AyG GLegg ++g PaeF+V+t ++AG+G+Ls sf00012 2430 GGDPGLVSAYGAGLEGG--VTGNPAEFVVNT-------SNAGAGALS 2467 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGe.hIP V++ GPs++ +++++++ G Y+V+YtP+ pG+Y ++++ygG hI+ sf00012 2468 VTIDGPSKV----KMDCQECPEG-YRVTYTPMAPGSYLISIKYGGPyHIG 2512 gSPFk<-* gSPFk sf00012 2513 GSPFK 2517 Filamin: domain 24 of 24, from 2558 to 2647: score 147.8, E = 2e-40 *->agDasKVkAyGPGLeggGVkvgkPaeFtVdtVdkdGepkgAGgGgLs ++DasKV A G+GL+++ +vg+ ++FtVd+ ++AG+++L sf00012 2558 PADASKVVAKGLGLSKA--YVGQKSSFTVDC-------SKAGNNMLL 2595 VkVeGPsGaeAvvevkvtDngDGtYtVsYtPtepGdYtvnVtygGehIPg V+V+GP + ++e+ v++ g + Y+VsY+ + G+Yt +V++g+ehIPg sf00012 2596 VGVHGPRTP--CEEILVKHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPG 2643 SPFk<-* SP++ sf00012 2644 SPYR 2647 //