hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna/full/aisin/as00018/interpro/cnk_1/seq.in
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Query:  as00018  1430

Scores for sequence family classification (score includes all domains):
Model      Description                                  Score    E-value  N 
--------   -----------                                  -----    ------- ---
RhoGEF     RhoGEF domain                                129.7    5.4e-35   1
PH         PH domain                                     33.1    6.2e-06   1
Extensin_2 Extensin-like region                        -126.7       0.15   1

Parsed for domains:
Model      Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------   ------- ----- -----    ----- -----      -----  -------
RhoGEF       1/1     150   326 ..     1   207 []   129.7  5.4e-35
PH           1/1     352   455 ..     1    92 []    33.1  6.2e-06
Extensin_2   1/1    1037  1387 ..     1   385 []  -126.7     0.15

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 150 to 326: score 129.7, E = 5.4e-35
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v++E++eTE++YvrdL+ ++ +y+ pL++        l+ +++ t+F
     as00018   150    VAREIVETERAYVRDLRSIVEDYLGPLLDGGVLG---LSVEQVGTLF 193  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                   +Niediyef +e+L   Le+  s+                +++ +F ++ 
     as00018   194 ANIEDIYEFSSELLE-DLENSSSAG---------------GIAECFVQR- 226  

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                   ++ +++Y+ Yc n+p++  ll+ l   +  + + ++ +    +       
     as00018   227 SEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRH------- 269  

                   davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkaldl
                       l Lqs+LlkPvqRil+Y+LLL+eL kh  eg +  +re+ ++a+  
     as00018   270 ---SLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVS 316  

                   lqdlaksiNe<-*
                   +  +a +iN+   
     as00018   317 MTAVAWYIND    326  

PH: domain 1 of 1, from 352 to 455: score 33.1, E = 6.2e-06
                   *->vikeGwLlkkg.........gkkswkkRyfvLfndvLlyykdkk..k
                      +   G+L + g  +++++++ + +  +R ++Lf++ Ll  k ++ ++
     as00018   352    LSAFGELVLEGafrggggggPRLRGGERLLFLFSRMLLVAKRRGleY 398  

                   kpkgsipLsgiqvekvpdnkrkncFeirt.dr..etlllqaeseeerkeW
                   ++kg i   +++v + p+  ++ +F+++  + ++ ++llqa+++ee++ W
     as00018   399 TYKGHIFCCNLSVSESPR--DPLGFKVSDlTIpkHRHLLQAKNQEEKRLW 446  

                   vkaiqsair<-*
                   ++++q++ +   
     as00018   447 IHCLQRLFF    455  

Extensin_2: domain 1 of 1, from 1037 to 1387: score -126.7, E = 0.15
                   *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy
                        ++++a+     p + ++        P  ++ +       s   v 
     as00018  1037    SHMVIPAPSTAFCPEQGHCADIHVPTTPALPKEIC------SDFTVS 1077 

                   kSPPPpkkpYvYsSPPPPsyvykSPPPPkp..........yvYkSPPpPk
                      P pk++ +  S  P        P  k++++++ +++++v + P +P 
     as00018  1078 VTTPVPKQEGHLDSESPT-----NIPLTKQggsrdvqgpdPVCSQPIQPL 1122 

                   yvYkSPPpPv.ykYkSPPPPthsppPpyvykSPPPPpkkyvykSpPpptP
                       S   P ++    PP P h p  +    SP P   +   +  P  +P
     as00018  1123 SWHGSSLDPQgPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAP 1172 

                   vYkYkSPPPPpyvYkspPpPvkkripyvYkSPPPPpPYvYkSpPppvkky
                       +   P   v    P P ++  + ++    P +P +  S P      
     as00018  1173 -LSLSQELPDTQVPATTPLPLPQVLTDIWVQALPTSP-KQGSLPDIQ--- 1217 

                   iyksppppephkYvYkSPPPPpP.YvyesvpeqkikYvYkSPPPPkksYk
                        p+          PP P+P+    +v +  +    kS    + +  
     as00018  1218 ----GPAA--------APPLPEPsLTDTQVQKLTPSLEQKSLIDAHVPAA 1255 

                   spsp....pkyVYkSpPpPvipykYkSPPPPkkkyspaPrkpyvYkSPPP
                    p p++++   +    P Pv   +  S P      s a ++    +S   
     as00018  1256 TPLPerggSLDIQGLSPTPVQTTMVLSKPGG----SLASHVARLESSDLT 1301 

                   PtyvYkSpPpPykpptppkiyksPPPPtPvyvYkspPpippik.....ss
                   P+    SpPp ++    p         +  y  +s  +    ++++++  
     as00018  1302 PP---HSPPPSSRQLLGPNAAALSRYLAASYISQSLAR----RqgpggGA 1344 

                   sppPvyvYkSpPppvysPPPPyvYssPPPPvyvynsaPvykksPPkhhYi
                   +      + S+P    s PPP     PPPP+                  +
     as00018  1345 PAASRGSWSSAPTSRASSPPP--QPQPPPPA--------------ARRLS 1378 

                   YsSPPPphh<-*
                   Y+     h    
     as00018  1379 YATTVNIHV    1387 

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