BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC146745.5 + phase: 0
(1063 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein) 312 3e-84
KF5C_HUMAN (O60282) Kinesin heavy chain isoform 5C (Kinesin heav... 278 7e-74
KINN_HUMAN (Q12840) Neuronal kinesin heavy chain (NKHC) (Kinesin... 277 1e-73
KINH_LOLPE (P21613) Kinesin heavy chain 273 2e-72
KINN_MOUSE (P33175) Neuronal kinesin heavy chain (NKHC) (Kinesin... 271 5e-72
KF5C_MOUSE (P28738) Kinesin heavy chain isoform 5C (Kinesin heav... 271 5e-72
KINH_HUMAN (P33176) Kinesin heavy chain (Ubiquitous kinesin heav... 270 1e-71
KINH_MOUSE (Q61768) Kinesin heavy chain (Ubiquitous kinesin heav... 268 4e-71
KINH_DROME (P17210) Kinesin heavy chain 265 4e-70
KINH_STRPU (P35978) Kinesin heavy chain 262 3e-69
KF3A_MOUSE (P28741) Kinesin-like protein KIF3A (Microtubule plus... 256 2e-67
KINH_SYNRA (O43093) Kinesin heavy chain (Synkin) 256 2e-67
KF3A_HUMAN (Q9Y496) Kinesin-like protein KIF3A (Microtubule plus... 256 2e-67
KINH_BOTCI (Q86ZC1) Kinesin heavy chain 253 1e-66
KF4A_MOUSE (P33174) Chromosome-associated kinesin KIF4A (Chromok... 253 1e-66
KF4A_XENLA (Q91784) Chromosome-associated kinesin KLP1 (Chromoki... 248 6e-65
KF4A_HUMAN (O95239) Chromosome-associated kinesin KIF4A (Chromok... 246 3e-64
KI22_STRPU (P46872) Kinesin-II 85 kDa subunit (KRP-85/95 85 kDa ... 244 9e-64
KI21_STRPU (P46871) Kinesin-II 95 kDa subunit (KRP-85/95 95 kDa ... 243 3e-63
KF4A_CHICK (Q90640) Chromosome-associated kinesin KIF4A (Chromok... 242 3e-63
>CENE_HUMAN (Q02224) Centromeric protein E (CENP-E protein)
Length = 2663
Score = 312 bits (800), Expect = 3e-84
Identities = 285/980 (29%), Positives = 471/980 (47%), Gaps = 104/980 (10%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
+++V +R RPL+ RE G+ Y D V + + + ++ FD+VF + + VYE
Sbjct: 6 AVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEE 65
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSPGIIPLAIKDVFSSIQDTPGREF 208
A P++ +A++G NGT+FAYG T+SGKT+TM G ++ G+IP AI D+F I+ P REF
Sbjct: 66 IAAPIIDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREF 125
Query: 209 LLRVSYLEIYNEVINDLLDPTG--QNLRVREDA-QGTYVEGIKEEVVLSPGHALSFIAAG 265
LLRVSY+EIYNE I DLL T + L +RED + YV + EEVV + AL +I G
Sbjct: 126 LLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNRNVYVADLTEEVVYTSEMALKWITKG 185
Query: 266 EEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYD---GVIFSQLNLIDLAGSE-SSKT 321
E+ RH G N SSRSHTIF +++ES GE + V S LNL+DLAGSE +++T
Sbjct: 186 EKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQT 245
Query: 322 ETTGLRRKEGSYINKSLLTLGTVIGKLSEGK-SSHVPYRDSKLTRLLQSSLSGHGHVSLI 380
G+R KEG IN+SL LG VI KLS+G+ + YRDSKLTR+LQ+SL G+ +I
Sbjct: 246 GAAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNPKTRII 305
Query: 381 CTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQREISVLKLELDQLK 440
CT+TP S +ET L+FAS AK ++ N++ +++L+K+Y++EI LK +L+++
Sbjct: 306 CTITPVS--FDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEV- 362
Query: 441 KGMQFGVNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLILVSSKNANP 500
+ T Q +E+ Q + LEE++ + +I+ LT++++ SS
Sbjct: 363 ----------SLETRAQAMEKDQ--LAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQ 410
Query: 501 GYLADAPGHQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRN 560
L + + G K + +++ + + +++T LS ++ S +
Sbjct: 411 QELKAKRKRRVTWCLG---KINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCS 467
Query: 561 EELSTSNSIITESTQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRL 620
E SN++ T S + + LL ++ +I ++L+
Sbjct: 468 ESDVFSNTLDTLSE---------------IEWNPATKLLNQE------NIESELNSLRAD 506
Query: 621 TEQSVNDPESSRTQIENLEQEIQEKR--NQLRGLEQRIIESGQTSVAN-----PSLVEMQ 673
+ V D E RT+ E +E +++EK ++ LE++ + + + + +LV+ +
Sbjct: 507 YDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHR 566
Query: 674 QVTVTRLMTQCNEKAFELEIKSADNRVLQEQLNSKCSENRELQ--------EKVKLLEQQ 725
+V L + + K L K + LQE ++S+ EN ++ E K ++Q
Sbjct: 567 EVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQT 626
Query: 726 L------ATDTGGTSLLLADE-CASGEHIDEL-------KRKIQSQEIENEKLKLEQVQL 771
L A D S L E E + EL + IQ + + E K QV L
Sbjct: 627 LFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL 686
Query: 772 SEENSGLHVQNQKLSE--EASYAKELASAAAVE--LKNLAGEVTKLSLQNAKLEKELMAA 827
+E + KL+ + K+L +E + +L E+ K +N L +E++
Sbjct: 687 EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746
Query: 828 RNLANTRSAV-------------THTVNGVHRKYNDPRSGRKARVSSRANENVGPGRDEL 874
L + S V H + K +++RV E +G +D+L
Sbjct: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL-EEIGKTKDDL 805
Query: 875 ESWSLEVDDLKMELQARK----QREAALEAALAEKEIMEEEHRNRVEEAKKRESSLENDL 930
+ E Q K E + L E E M +E N +EA+K +SSL
Sbjct: 806 ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALK 865
Query: 931 ANMWVLVAKLKKEVGVVAESNIDKISGDGEAHTNDPKTNDSESNIISKEQTLDVSEPNNE 990
+ +L+++ V E + E + DS + +E+TL ++E +
Sbjct: 866 TELSYKTQELQEKTREVQER-----LNEMEQLKEQLENRDSPLQTVEREKTL-ITEKLQQ 919
Query: 991 TPKEEPLVVRLKARMQDMKE 1010
T +E + + K ++ ++E
Sbjct: 920 TLEEVKTLTQEKDDLKQLQE 939
Score = 68.2 bits (165), Expect = 1e-10
Identities = 133/696 (19%), Positives = 285/696 (40%), Gaps = 84/696 (12%)
Query: 354 SHVPYRDSKLTRLLQSSLSGHGHVSLICTVTPASSNMEETHNT----LKFASRAKRV--E 407
S V +++S++ LL+ G L T + S +E N + F + K V E
Sbjct: 782 SEVVHKESRVQGLLEEI--GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEE 839
Query: 408 IYASRNKIIDEKSLIKKYQREISVLKLELDQLKKGMQFGVNH-EEILTLKQKLEEGQVKM 466
+I++ +K+ + LK EL + +Q +E L ++L+E
Sbjct: 840 NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENR 899
Query: 467 QSRLEEEEEEKVALASRIQKLTKLILVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQD 526
S L+ E EK + ++Q+ + + ++ + D Q+SL D + D
Sbjct: 900 DSPLQTVEREKTLITEKLQQTLEEVKTLTQEKD-----DLKQLQESLQIERDQLKSDIHD 954
Query: 527 GSLLFESESQKDVSTVASDLS-HDVRHRRTSSKRNEELSTSNSIITESTQAGELISRTRI 585
++ ++Q+ + L H SK +EE+S N + E+T GE ++
Sbjct: 955 -TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR-NLHMEENT--GE--TKDEF 1008
Query: 586 PAGGVTMSDQMDLLVEQVKMLAGDIA-----------FST----STLKRLTEQSVNDPES 630
V + + DL + + L D+ FS + L+++ E + + E
Sbjct: 1009 QQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQ 1068
Query: 631 SRTQI-ENLEQEIQEKRNQLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQCNEKAF 689
+T + EN+E I E + +LR L + + + + ++ ++R + E
Sbjct: 1069 LKTDLKENIEMTI-ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE 1127
Query: 690 ELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQLATDTGGTSLLLADECASGEHIDE 749
+L+ KS + Q+QL + E E+Q+K+ I+
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKI-------------------------NEIEN 1162
Query: 750 LKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAGE 809
LK +++++E+ E ++ E+++L+++ + + + + +++E KEL + E +L G
Sbjct: 1163 LKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGY 1222
Query: 810 VTKLSLQNAKLEKELMAAR-NLANTRSAVTHTVNGVHRKYNDPRSGRKARVS-SRANENV 867
+ ++ + ++EL A +L + + V K + + S ++ E +
Sbjct: 1223 IREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEI 1282
Query: 868 GPGRDELE-----SWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRN-RVEEAKK 921
+E E E + EL+ ++ ++ + ME N + +E+++
Sbjct: 1283 PVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQE 1342
Query: 922 RESSLENDLANMWVLVAKLKKEVGVVAESNIDKISGDGEAHTNDPKTNDSESNIISKEQT 981
SL + N+ + L+ + + E + ++ K +S+S +EQ+
Sbjct: 1343 EIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA----------KIQESQS---KQEQS 1389
Query: 982 LDVSEPNNETPKEEPLVVRLKARMQDMKEKELKHLG 1017
L++ E +NET K + + K + + E++ LG
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG 1425
Score = 56.2 bits (134), Expect = 4e-07
Identities = 135/641 (21%), Positives = 251/641 (39%), Gaps = 93/641 (14%)
Query: 414 KIIDEKSLIK---KYQREISVLKLELDQLKKGMQFGVNHEEILTLKQKLEEGQVKMQSRL 470
+II+ + L K K Q EI VL E + L + E + L+ E+ K + L
Sbjct: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKKVSETQETMNELELLTEQSTTKDSTTL 1323
Query: 471 EEEEEEKVALASRIQKLTKLILVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQDGSLL 530
E E++ L + Q+ + I +SL T E D +++ +
Sbjct: 1324 ARIEMERLRLNEKFQESQEEI-------------------KSL-TKERDNLKTIKEALEV 1363
Query: 531 FESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITESTQAGELISRT-RIPAGG 589
+ ++ + + + + S E+ + + I++E Q S RI
Sbjct: 1364 KHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEM 1423
Query: 590 VTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTEQSVNDPESSRTQIENLEQEIQEKRNQL 649
+ +S ++ +++K +A + L+RL E ++ + + I+ + + E +L
Sbjct: 1424 LGLSKRLQESHDEMKSVAKE----KDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479
Query: 650 RGLEQRIIESGQTSV---ANPSLVEMQQVTVTRLMTQCNEKAFELEIKSADNRVLQEQLN 706
+ + E +T N S E + T+ + + N+K L+ K + +EQLN
Sbjct: 1480 KVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDK---LQNKIQEIYEKEEQLN 1536
Query: 707 SKCSENRELQEKVKLLEQQLATDTGGTSLLLADECASGE---HIDELKRKIQSQEIENEK 763
K + E+QE V L+Q S L + E E + E + +IQ E E+
Sbjct: 1537 IK--QISEVQENVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEE 1594
Query: 764 LKLEQVQLS------EENSGLHVQNQKLSEEASYA-KELASAAAVELKNLAGEVTKLSLQ 816
+K Q L +EN+ V K S+E Y ++ + + K E K +
Sbjct: 1595 MKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFE 1654
Query: 817 NAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRANENVGPGRDELES 876
KL E + N+ T+ +H + RS K R R+ E E+
Sbjct: 1655 TQKLNLENIETENIRLTQI--------LHENLEEMRSVTKERDDLRSVE---------ET 1697
Query: 877 WSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKRESSLENDLANMW-- 934
+E D LK L+ R+ + L + +EH+ +++ + S N+++NM
Sbjct: 1698 LKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKD 1757
Query: 935 ------VLVA---KLKKEVGVV------AESNIDKISGDGEAHTN-----DPKTNDSESN 974
L A K+++E+ + + IDK+ G T+ +S +
Sbjct: 1758 LEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAK 1817
Query: 975 IISKEQTLDVSEPN--------NETPKEEPLVVRLKARMQD 1007
+ K Q L +E NET K+ + +LK +++D
Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Score = 34.7 bits (78), Expect = 1.4
Identities = 135/710 (19%), Positives = 271/710 (38%), Gaps = 148/710 (20%)
Query: 419 KSLIKK---YQREISVLKLELDQLKKGMQ------------------FGVNHEEIL-TLK 456
KS++K+ +R LKLE DQLK+ +Q H+E + L+
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 457 QKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLIL----------VSSKNANPGYLADA 506
+K+ E +++ ++ ++ K L +IQ+L K L +S K N
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKK 2004
Query: 507 PGHQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSK--RNEELS 564
L E D + + ES +++ VA + ++R + S K R++ ++
Sbjct: 2005 QFEPNYLCKCEMDNFQLTKK-----LHESLEEIRIVAKE-RDELRRIKESLKMERDQFIA 2058
Query: 565 TSNSIITESTQAGELISRTRIPAGG------------------VTMSDQMDLLVEQVKML 606
T +I Q ++ R+ + G + +MD E + L
Sbjct: 2059 TLREMIARDRQNHQVKPEKRLLSDGQQHLMESLREKCSRIKELLKRYSEMDDHYECLNRL 2118
Query: 607 AGD-------------IAFSTSTLKRLTEQS-----------VNDPESSR---TQIENLE 639
+ D + + S + ++ E+ +++ E + +I++L+
Sbjct: 2119 SLDLEKEIEFHRIMKKLKYVLSYVTKIKEEQHECINKFEMDFIDEVEKQKELLIKIQHLQ 2178
Query: 640 QEIQEKRNQLRGLE---------QRIIESGQTSVANPSLVEMQQVTVTRL-MTQCNEKAF 689
Q+ +LR L+ + I++ S E QQV R MTQ E+
Sbjct: 2179 QDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWL 2238
Query: 690 --ELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQLATDTGGTSLLLADECASGEHI 747
+I+ N + Q++ + C N ++ + + +T+ S ++
Sbjct: 2239 NTRFDIEKLKNGI-QKENDRICQVNNFFNNRIIAIMNE-STEFEERSATIS--------- 2287
Query: 748 DELKRKIQSQEIENEKL-KLEQVQLSEENSGLHV----QNQKLSEEASYAKELASAAAVE 802
E ++ ++S + +NEKL K Q + SG V Q+ K S A +L + E
Sbjct: 2288 KEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE 2347
Query: 803 LKNLAGEVTKLSLQN----AKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKAR 858
L+N E + ++ K++KEL ++ A H N K + + +
Sbjct: 2348 LENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDK 2407
Query: 859 VSSRANENVGPGRDELESWSLEVDDLKME-LQARKQREAALEAALAEKEIMEEEHRNRVE 917
V+ A P ++E+E +++ + +E ++ K+ E + A A E +E R E
Sbjct: 2408 VALGAK----PYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRE 2463
Query: 918 EAKKRESSLENDLANMWVLVAKLKKEVGVVAESNIDKISGDGEAHTNDPKTNDSESNIIS 977
++ + + ++ V++E + S N P T S I+
Sbjct: 2464 NLRRSQQA----------------QDTSVISEHTDPQPS-------NKPLTCGGGSGIVQ 2500
Query: 978 KEQTLDVSEPNNETPKEEPLVVRLKARMQDMKEKELKHLGNGDANSHVCK 1027
+ L + + KE + +LK + + + +++ + L N S+ K
Sbjct: 2501 NTKALILKSEHIRLEKE---ISKLKQQNEQLIKQKNELLSNNQHLSNEVK 2547
>KF5C_HUMAN (O60282) Kinesin heavy chain isoform 5C (Kinesin heavy
chain neuron-specific 2)
Length = 957
Score = 278 bits (710), Expect = 7e-74
Identities = 266/919 (28%), Positives = 425/919 (45%), Gaps = 76/919 (8%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
SI V RFRPL+E E RGD+ GD+ V Y FD+V P+T ++VY
Sbjct: 8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETV--VIGQGKPYVFDRVLPPNTTQEQVYNA 65
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQDTPG 205
AK +VK +EG NGT+FAYG TSSGKTHTM G + P GIIP D+F I
Sbjct: 66 CAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDE 125
Query: 206 R-EFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF ++VSY EIY + I DLLD + NL V ED YV+G E V SP + I
Sbjct: 126 NLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVID 185
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH+IF + I+ E + + +L L+DLAGSE SKT
Sbjct: 186 EGKANRHVAVTNMNEHSSRSHSIFLINIKQE--NVETEKKLSGKLYLVDLAGSEKVSKTG 243
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L+EG +HVPYRDSK+TR+LQ SL G+ +++
Sbjct: 244 AEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVIC 303
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------ISVL 432
+P+ N ET +TL F RAK ++ S N + + KKY++E I L
Sbjct: 304 CSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHL 363
Query: 433 KLELDQLKKGMQFGVNHEEILTLKQKLEE-----------GQVKMQSRLEEEEEEKVALA 481
++EL++ + G + E+I QK E V EE+E+ ++
Sbjct: 364 EMELNRWRNG-EAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEIS 422
Query: 482 SRIQKL-TKLILVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQD--GSLLFESESQKD 538
S ++L K ++ ++ L Q L Y+ +Q+ L E+E+ KD
Sbjct: 423 SLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKD 482
Query: 539 -VSTVASDL----------SHDVRHR-RTSSKRNEELSTSNSIIT----ESTQAGELISR 582
V V L S +V + R + + +EL+ + +T E +Q EL +
Sbjct: 483 EVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNH 542
Query: 583 TRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTE-QSVNDPE--SSRTQIENLE 639
+ A ++ ++LL++ + + G I T+ +K L + V + E +R I ++
Sbjct: 543 QKKRA-----TEILNLLLKDLGEIGGII--GTNDVKTLADVNGVIEEEFTMARLYISKMK 595
Query: 640 QEIQEKRNQLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQCNEKAFELEIKSADNR 699
E++ N+ + LE ++S + A+ + Q+ +++ + ++ R
Sbjct: 596 SEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRR 655
Query: 700 VLQEQLNSKCSENREL--QEKVKLLEQQLATDTGGTSLLLADECASG-EHIDELKRKIQS 756
L+E +S E +L QEK+ + Q T L A+E E E R+
Sbjct: 656 QLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQ 715
Query: 757 QEIENEKLKLEQVQ-----LSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAGEVT 811
+++ + ++E+ Q + + N L ++ +KLS + + K +E + ++
Sbjct: 716 KQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLK-------IEDQEREMKLE 768
Query: 812 KLSLQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRANENVGPGR 871
KL L N K E+ + L T S T++ + + + + R + N++ G
Sbjct: 769 KLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSA 828
Query: 872 DELESWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKRESSLENDLA 931
+ + S ++L+ + KQ E +E+ R E K ES+L+
Sbjct: 829 AQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKE 888
Query: 932 NMWVLVAKLKKEVGVVAES 950
N + ++EV + E+
Sbjct: 889 NAMRDRKRYQQEVDRIKEA 907
>KINN_HUMAN (Q12840) Neuronal kinesin heavy chain (NKHC) (Kinesin
heavy chain isoform 5A) (Kinesin heavy chain
neuron-specific 1)
Length = 1032
Score = 277 bits (708), Expect = 1e-73
Identities = 280/927 (30%), Positives = 415/927 (44%), Gaps = 116/927 (12%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
SI V RFRPL++ E RGD+ GD V P Y FD+VF P+T ++VY
Sbjct: 9 SIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVVIGGKP---YVFDRVFPPNTTQEQVYHA 65
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQDTPG 205
A +VK + G NGT+FAYG TSSGKTHTM G + P GIIP +D+F+ I
Sbjct: 66 CAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDE 125
Query: 206 R-EFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF ++VSY EIY + I DLLD T NL V ED +V+G E V SP L I
Sbjct: 126 NLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVID 185
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH+IF + I+ E + + +L L+DLAGSE SKT
Sbjct: 186 EGKSNRHVAVTNMNEHSSRSHSIFLINIKQE--NMETEQKLSGKLYLVDLAGSEKVSKTG 243
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L+EG S+VPYRDSK+TR+LQ SL G+ ++
Sbjct: 244 AEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFIC 303
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------ISVL 432
+P+S N ET +TL F RAK ++ AS N + + KKY++E I+ L
Sbjct: 304 CSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKL 363
Query: 433 KLELDQLKKG---------------------MQFGVNHEEILTL------KQKLEEGQVK 465
+ EL + + G + VN + + +QK EE +
Sbjct: 364 EAELSRWRNGENVPETERLAGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRR 423
Query: 466 MQSRLEEEEEEKVALASRIQKLTKL------ILVSSKNANPGYLADAPGHQQSLSTGEDD 519
+ +L+++++E + I+KL + +LVS++ N + Q +D+
Sbjct: 424 LYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDE 483
Query: 520 KYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITESTQAGEL 579
+ LQ L + QK + + S K ++T S+ +E + E+
Sbjct: 484 VKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQK----VATMLSLESELQRLQEV 539
Query: 580 ISRTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTS---------TLKRLTEQSVNDPES 630
R V DL V + G+I T+ RL +
Sbjct: 540 SGHQRKRIAEVLNGLMKDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVK 599
Query: 631 SRT----QIENLEQEIQEKRNQLRGLE----QRIIESGQTSVANPSLVE-MQQVTVTR-- 679
S Q+ENL+ E K ++ G E Q +I + + SL E MQ V + +
Sbjct: 600 SVVKRCRQLENLQVECHRKM-EVTGRELSSCQLLISQHEAKIR--SLTEYMQSVELKKRH 656
Query: 680 LMTQCNEKAFELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQLATDTGGTSLLLA- 738
L + + EL A V + L K + ++ E K LE Q+ + LA
Sbjct: 657 LEESYDSLSDELAKLQAQETVHEVALKDKEPDTQDADEVKKALELQMESHREAHHRQLAR 716
Query: 739 --DECASGEH-IDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKEL 795
DE + IDELK Q ++E EKL+ + +L E H ++ KL +E ++ E
Sbjct: 717 LRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEE---HEKSTKL-QELTFLYER 772
Query: 796 ASAAAVELKNLAGEVTKLSLQNAKLEKELMAARNLAN--TRSAVTHTVNGVHRKYNDPRS 853
+ +LK L V +EL NL + T + D
Sbjct: 773 HEQSKQDLKGLEETVA----------RELQTLHNLRKLFVQDVTTRVKKSAEMEPEDSGG 822
Query: 854 --GRKARVSSRAN--ENVGPGRDEL----ESWSLEVDDLKMELQARKQREAALEAAL--A 903
+K ++S N E + +L E+ L+ L+A +R ALE AL A
Sbjct: 823 IHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEA 882
Query: 904 EKEIMEEEHR-----NRVEEAKKRESS 925
++ M+++ R +R++EA + +SS
Sbjct: 883 KEGAMKDKRRYQQEVDRIKEAVRYKSS 909
>KINH_LOLPE (P21613) Kinesin heavy chain
Length = 967
Score = 273 bits (698), Expect = 2e-72
Identities = 248/903 (27%), Positives = 415/903 (45%), Gaps = 89/903 (9%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
+I V R RPL+E E G + D + + FDKV P+ + + VY V
Sbjct: 8 NIKVICRVRPLNEAEERAGSKFILKFPTDDSISIA---GKVFVFDKVLKPNVSQEYVYNV 64
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQDTPG 205
AKP+V + G NGT+FAYG TSSGKTHTM G + P GIIP ++D+F+ I
Sbjct: 65 GAKPIVADVLSGCNGTIFAYGQTSSGKTHTMEGVLDKPSMHGIIPRIVQDIFNYIYGMDE 124
Query: 206 R-EFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF +++SY EIY + I DLLD T NL V ED +V+G E V SP + I
Sbjct: 125 NLEFHIKISYYEIYLDKIRDLLDVTKTNLAVHEDKNRVPFVKGATERFVSSPEEVMEVID 184
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH++F + ++ E + +L L+DLAGSE SKT
Sbjct: 185 EGKNNRHVAVTNMNEHSSRSHSVFLINVKQE--NVETQKKLSGKLYLVDLAGSEKVSKTG 242
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L++G SHVPYRDSKLTR+LQ SL G+ +++
Sbjct: 243 AEGAVLDEAKNINKSLSALGNVISALADGNKSHVPYRDSKLTRILQESLGGNARTTMVIC 302
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE---ISVLKLELDQL 439
+PAS N ET +TL F RAK ++ S N+ + ++Y++E ++ LK + +L
Sbjct: 303 CSPASYNESETKSTLLFGQRAKTIKNVVSVNEELTADEWKRRYEKEKERVTKLKATMAKL 362
Query: 440 KKGMQ-----FGVNHEEILTLKQ----------------------------KLEEGQVKM 466
+ +Q V+ EE + LK+ +LEE ++K+
Sbjct: 363 EAELQRWRTGQAVSVEEQVDLKEDVPAESPATSTTSLAGGLIASMNEGDRTQLEEERLKL 422
Query: 467 QSRLEEEEEEKVALASRIQKLTKL------ILVSSKNANPGYLADAPGHQQSLSTGEDDK 520
+L+++++E + I+KL + ++ S+ D Q + +D+
Sbjct: 423 YQQLDDKDDEINNQSQLIEKLKEQMMEQEDLIAQSRRDYENLQQDMSRIQADNESAKDEV 482
Query: 521 YDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITESTQAGELI 580
+ LQ L + QK S D + + + S + N++LST NS+ E Q +
Sbjct: 483 KEVLQALEELAMNYDQK--SQEVEDKNKE--NENLSEELNQKLSTLNSLQNELDQLKDSS 538
Query: 581 SRTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTEQSVNDPESSRTQIENLEQ 640
R + ++ DL + + G A T E+ + +R I ++
Sbjct: 539 MHHRKRVTDMMINLLKDL--GDIGTIVGGNAAETKPTAGSGEKIEEEFTVARLYISKMKS 596
Query: 641 EIQ---EKRNQLRGLEQ---RIIESGQTSVANPSLVEMQQVTVTRLMTQCNEKAFELEIK 694
E++ + NQL +Q + IE+ + ++N L+ Q + + + IK
Sbjct: 597 EVKTLVSRNNQLENTQQDNFKKIETHEKDLSNCKLLIQQH--------EAKMASLQEAIK 648
Query: 695 SADN--RVLQEQLNSKCSENREL--QEKVKL--LEQQLATDTGGTSLLLADECASGEHID 748
++N R+L++ ++S E +L QE++ L L ++ + + E H +
Sbjct: 649 DSENKKRMLEDNVDSLNEEYAKLKAQEQMHLAALSEREKETSQASETREVLEKQMEMHRE 708
Query: 749 ELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAG 808
+ ++++QS E + + L ++N L + +KL + K+ E A
Sbjct: 709 QHQKQLQSLRDEISEKQATVDNLKDDNQRLSLALEKLQADYDKLKQ-------EEVEKAA 761
Query: 809 EVTKLSLQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRA---NE 865
++ LSLQ + E+ + L T + T++ + + + + + S+ +E
Sbjct: 762 KLADLSLQIDRREQAKQDLKGLEETVAKELQTLHNLRKLFVQDLQNKVKKSCSKTEEEDE 821
Query: 866 NVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKRESS 925
+ G + + S ++L+ + KQ E +E+ R +E K ES+
Sbjct: 822 DTGGNAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATMERVKSLESA 881
Query: 926 LEN 928
L++
Sbjct: 882 LKD 884
>KINN_MOUSE (P33175) Neuronal kinesin heavy chain (NKHC) (Kinesin
heavy chain isoform 5A) (Kinesin heavy chain
neuron-specific 1)
Length = 1027
Score = 271 bits (694), Expect = 5e-72
Identities = 275/929 (29%), Positives = 412/929 (43%), Gaps = 120/929 (12%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
SI V RFRPL++ E RGD+ GD V P Y FD+VF P+T ++VY
Sbjct: 9 SIKVLCRFRPLNQAEILRGDKFIPIFQGDDSVIIGGKP---YVFDRVFPPNTTQEQVYHA 65
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQDTPG 205
A +VK + G NGT+FAYG TSSGKTHTM G + P GIIP +D+F+ I
Sbjct: 66 CAMQIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDE 125
Query: 206 R-EFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF ++VSY EIY + I DLLD T NL V ED +V+G E V SP L I
Sbjct: 126 NLEFHIKVSYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVID 185
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH+IF + I+ E + + +L L+DLAGSE SKT
Sbjct: 186 EGKSNRHVAVTNMNEHSSRSHSIFLINIKQE--NVETEQKLSGKLYLVDLAGSEKVSKTG 243
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L+EG S+VPYRD+K+TR+LQ SL G+ ++
Sbjct: 244 AEGAVLDEAKNINKSLSALGNVISALAEGTKSYVPYRDTKMTRILQDSLGGNCRTTMFIC 303
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------ISVL 432
+P+S N ET +TL F RAK ++ AS N + + KKY++E I+ +
Sbjct: 304 CSPSSYNDAETKSTLMFGQRAKTIKNTASVNLELTAEQWKKKYEKEKEKTKAQKETIANV 363
Query: 433 KLELDQLKKG---------------------MQFGVNHEEILTL------KQKLEEGQVK 465
+ EL + + G + VN + + +QK EE +
Sbjct: 364 EAELSRWRNGENVPETERLAGEDSALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRR 423
Query: 466 MQSRLEEEEEEKVALASRIQKLTKL------ILVSSKNANPGYLADAPGHQQSLSTGEDD 519
+ +L+++++E + I+KL + +LVS++ N + Q +D+
Sbjct: 424 LYKQLDDKDDEINQQSQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDE 483
Query: 520 KYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITESTQAGEL 579
+ LQ L + QK + + S K ++T S+ +E + E+
Sbjct: 484 VKEVLQALEELAVNYDQKSQEVEEKSQQNQLLVDELSQK----VATMLSLESELQRLQEV 539
Query: 580 ISRTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTS---------TLKRLTEQSVNDPES 630
R V DL V + G+I T+ RL +
Sbjct: 540 SGHQRKRIAEVLNGLMRDLSEFSVIVGNGEIKLPVEISGAIEEEFTVARLYISKIKSEVK 599
Query: 631 SRT----QIENLEQEIQEKRNQLRGLE----QRIIESGQTSVANPSLVEMQQVTVTR--- 679
S Q+ENL+ E K ++ G E Q +I + + SL E Q +
Sbjct: 600 SVVKRCRQLENLQVECHRKM-EVTGRELSSCQLLISQHEAKIR--SLTEYMQTVELKKRH 656
Query: 680 LMTQCNEKAFELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQLATDTGGTSLLLA- 738
L + + EL A V + L K + ++ +E K LE Q+ LA
Sbjct: 657 LEESYDSLSDELARLQAHETVHEVALKDKEPDTQDAEEVKKALELQMENHREAHHRQLAR 716
Query: 739 --DECASGEH-IDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLS--EEASYAK 793
DE + IDELK Q ++E EKL+ + +L E +N+K + +E ++
Sbjct: 717 LRDEINEKQKTIDELKDLNQKLQLELEKLQADYERLKNE------ENEKSAKLQELTFLY 770
Query: 794 ELASAAAVELKNLAGEVTKLSLQNAKLEKELMAARNLAN--TRSAVTHTVNGVHRKYNDP 851
E + +LK L V +EL NL + T + D
Sbjct: 771 ERHEQSKQDLKGLEETVA----------RELQTLHNLRKLFVQDVTTRVKKSAEMEPEDS 820
Query: 852 RS--GRKARVSSRAN--ENVGPGRDEL----ESWSLEVDDLKMELQARKQREAALEAAL- 902
+K ++S N E + +L E+ L+ L+A +R ALE AL
Sbjct: 821 GGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALK 880
Query: 903 -AEKEIMEEEHR-----NRVEEAKKRESS 925
A++ M+++ R +R++EA + +SS
Sbjct: 881 EAKEGAMKDKRRYQQEVDRIKEAVRYKSS 909
>KF5C_MOUSE (P28738) Kinesin heavy chain isoform 5C (Kinesin heavy
chain neuron-specific 2)
Length = 956
Score = 271 bits (694), Expect = 5e-72
Identities = 258/933 (27%), Positives = 424/933 (44%), Gaps = 105/933 (11%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
SI V RFRPL+E E RGD+ G++ V Y FD+V P+T ++VY
Sbjct: 8 SIKVMCRFRPLNEAEILRGDKFIPKFKGEETV--VIGQGKPYVFDRVLPPNTTQEQVYNA 65
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQDTPG 205
AK +VK +EG NGT+FAYG TSSGKTHTM G + P GIIP D+F I
Sbjct: 66 CAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDE 125
Query: 206 R-EFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF ++VSY EIY + I DLLD + NL V ED YV+G E V SP + I
Sbjct: 126 NLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVID 185
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH+IF + I+ E + + +L L+DLAGSE SKT
Sbjct: 186 EGKANRHVAVTNMNEHSSRSHSIFLINIKQE--NVETEKKLSGKLYLVDLAGSEKVSKTG 243
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L+EG +HVPYRDSK+TR+LQ SL G+ +++
Sbjct: 244 AEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVIC 303
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------ISVL 432
+P+ N ET +TL F RAK ++ S N + + KKY++E + L
Sbjct: 304 CSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKALKSVLQHL 363
Query: 433 KLELDQLKKGMQFGVNH--------------------------EEILTLKQKLEEGQVKM 466
++EL++ + G + + I K+K +E +
Sbjct: 364 EMELNRWRNGEAVPEDEQISAKDHKSLEPCDNTPIIDNITPVVDGISAEKEKYDEEITSL 423
Query: 467 QSRLEEEEEEKVALASRIQKLTKLILVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQD 526
+L+++++E + +KL + +L Q L Y+ +Q+
Sbjct: 424 YRQLDDKDDEINQQSQLAEKLKQQML----------------DQDELLASTRRDYEKIQE 467
Query: 527 --GSLLFESESQKD-VSTVASDL----------SHDVRHR-RTSSKRNEELSTSNSIIT- 571
L E+E+ KD V V L S +V + R + + +EL+ + +T
Sbjct: 468 ELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTT 527
Query: 572 ---ESTQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTE-QSVND 627
E +Q EL + + A ++ ++LL++ + + G I T+ +K L + V +
Sbjct: 528 TQRELSQLQELSNHQKKRA-----TEILNLLLKDLGEIGGII--GTNDVKTLADVNGVIE 580
Query: 628 PE--SSRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQCN 685
E +R I ++ E++ N+ + LE ++S + A+ + Q+ +++ +
Sbjct: 581 EEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIK 640
Query: 686 EKAFELEIKSADNRVLQEQLNSKCSENREL--QEKVKLLEQQLATDTGGTSLLLADECAS 743
++ R L+E +S E +L QEK+ + Q T L A+E
Sbjct: 641 SLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEVKK 700
Query: 744 G-EHIDELKRKIQSQEIENEKLKLEQVQ-----LSEENSGLHVQNQKLSEEASYAKELAS 797
E E R+ +++ + ++E+ Q + + N L ++ ++LS + + K
Sbjct: 701 ALEQQMESHREAHQKQLSRLRDEIEEKQRIIDEIRDLNQKLQLEQERLSSDYNKLK---- 756
Query: 798 AAAVELKNLAGEVTKLSLQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKA 857
+E + ++ KL L N K E+ + L T S T++ + + + + R
Sbjct: 757 ---IEDQEREVKLEKLLLLNDKREQAREDLKGLEETVSIELQTLHNLRKLFVQDLTTRVK 813
Query: 858 RVSSRANENVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVE 917
+ +++ G + + S ++L+ + KQ E +E+ R E
Sbjct: 814 KSVELDSDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAE 873
Query: 918 EAKKRESSLENDLANMWVLVAKLKKEVGVVAES 950
K ES+L+ N + ++EV + E+
Sbjct: 874 RVKALESALKEAKENAMRDRKRYQQEVDRIKEA 906
>KINH_HUMAN (P33176) Kinesin heavy chain (Ubiquitous kinesin heavy
chain) (UKHC)
Length = 963
Score = 270 bits (691), Expect = 1e-71
Identities = 262/915 (28%), Positives = 418/915 (45%), Gaps = 102/915 (11%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
+I V RFRPL+E E +RGD+ G+ V P YAFD+VF T+ ++VY
Sbjct: 8 NIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKP---YAFDRVFQSSTSQEQVYND 64
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQD-TP 204
AK +VK +EG NGT+FAYG TSSGKTHTM G + P GIIP ++D+F+ I
Sbjct: 65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDE 124
Query: 205 GREFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF ++VSY EIY + I DLLD + NL V ED YV+G E V SP + I
Sbjct: 125 NLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTID 184
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH+IF +I + + + +L L+DLAGSE SKT
Sbjct: 185 EGKSNRHVAVTNMNEHSSRSHSIF--LINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTG 242
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L+EG S++VPYRDSK+TR+LQ SL G+ +++
Sbjct: 243 AEGAVLDEAKNINKSLSALGNVISALAEG-STYVPYRDSKMTRILQDSLGGNCRTTIVIC 301
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------ISVL 432
+P+S N ET +TL F RAK ++ N + + KKY++E I L
Sbjct: 302 CSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWL 361
Query: 433 KLELDQLKKGMQFGVNHE--------EILTL-------------------------KQKL 459
+ EL++ + G ++ + E T+ ++K
Sbjct: 362 ENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKC 421
Query: 460 EEGQVKMQSRLEEEEEEKVALASRIQKL------TKLILVSSKNANPGYLADAPGHQQSL 513
EE K+ +L++++EE + ++KL + +L S++ A+ Q
Sbjct: 422 EEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAEN 481
Query: 514 STGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITES 573
+++ + LQ L + QK S D + + + S + N++ +T SI E
Sbjct: 482 DASKEEVKEVLQALEELAVNYDQK--SQEVEDKTKE--YELLSDELNQKSATLASIDAEL 537
Query: 574 TQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAG-DIAFSTSTLKRLTEQSVNDPE--S 630
+ E+ + + A +++ +K LA IA + +K+ + D E
Sbjct: 538 QKLKEMTNHQKKRAA--------EMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTV 589
Query: 631 SRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQCNEKAFE 690
+R I ++ E++ + + LE ES + N + Q+ +++ +
Sbjct: 590 ARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEY 649
Query: 691 LEIKSADNRVLQEQLNSKCSENREL--QEKVKLLEQQ-LATDTGGTSLLLADECASGEHI 747
L+ R L+E +++ E +L QEKV +E++ L + A E H
Sbjct: 650 LQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHR 709
Query: 748 DELKRKIQS--QEIE------------NEKLKLEQVQLSEENSGLHVQNQKLS---EEAS 790
+ +++I S E+E N+K+ LEQ +L E+ L +Q+ S E +
Sbjct: 710 ETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELT 769
Query: 791 YAKELASAAAVELKNLAGEVTK--LSLQN-AKLEKELMAARNLANTRSAVTHTVNGVHRK 847
++ A +LK L V K +L N KL + +A R + T +K
Sbjct: 770 VMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQK 829
Query: 848 YNDPRSGRKARVSSRANENVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEI 907
++ ++ + +L E+ L+ L+A +R ALE+AL E +
Sbjct: 830 QKISFLENNLEQLTKVHKQLVRDNADLR---CELPKLEKRLRATAERVKALESALKEAKE 886
Query: 908 MEEEHRNRVEEAKKR 922
R R ++ R
Sbjct: 887 NASRDRKRYQQEVDR 901
>KINH_MOUSE (Q61768) Kinesin heavy chain (Ubiquitous kinesin heavy
chain) (UKHC)
Length = 963
Score = 268 bits (686), Expect = 4e-71
Identities = 261/915 (28%), Positives = 417/915 (45%), Gaps = 102/915 (11%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
+I V RFRPL+E E +RGD+ G+ V P YAFD+VF T+ ++VY
Sbjct: 8 NIKVMCRFRPLNESEVNRGDKYVAKFQGEDTVVIASKP---YAFDRVFQSSTSQEQVYND 64
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSIQD-TP 204
AK +VK +EG NGT+FAYG TSSGKTHTM G + P GIIP ++D+F+ I
Sbjct: 65 CAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDE 124
Query: 205 GREFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFIA 263
EF ++VSY EIY + I DLLD + NL V ED YV+G E V SP + I
Sbjct: 125 NLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTID 184
Query: 264 AGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKTE 322
G+ +RHV N N SSRSH+IF +I + + + +L L+DLAGSE SKT
Sbjct: 185 EGKSNRHVAVTNMNEHSSRSHSIF--LINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTG 242
Query: 323 TTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLICT 382
G E INKSL LG VI L+EG S++VPYRDSK+TR+LQ SL G+ +++
Sbjct: 243 AEGAVLDEAKNINKSLSALGNVISALAEG-STYVPYRDSKMTRILQDSLGGNCRTTIVIC 301
Query: 383 VTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------ISVL 432
+P+S N ET +TL F RAK ++ N + + KKY++E I L
Sbjct: 302 CSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWL 361
Query: 433 KLELDQLKKGMQFGVNHE--------EILTL-------------------------KQKL 459
+ EL++ + G ++ + E T ++K
Sbjct: 362 ENELNRWRNGETVPIDEQFDKEKANLEAFTADKDIAITSDKGAAAVGMAGSFTDAERRKC 421
Query: 460 EEGQVKMQSRLEEEEEEKVALASRIQKL------TKLILVSSKNANPGYLADAPGHQQSL 513
EE K+ +L++++EE + ++KL + +L S++ A+ Q
Sbjct: 422 EEELAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAEN 481
Query: 514 STGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITES 573
+++ + LQ L + QK S D + + + + + N++ +T SI E
Sbjct: 482 DASKEEVKEVLQALEELAVNYDQK--SQEVEDKTKE--YELLTDEFNQKSATLASIDAEL 537
Query: 574 TQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAG-DIAFSTSTLKRLTEQSVNDPE--S 630
+ E+ + + A +++ +K LA IA + +K+ + D E
Sbjct: 538 QKLKEMTNHQKKRAA--------EMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTV 589
Query: 631 SRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQCNEKAFE 690
+R I ++ E++ + + LE ES + N + Q+ +++ +
Sbjct: 590 ARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEY 649
Query: 691 LEIKSADNRVLQEQLNSKCSENREL--QEKVKLLEQQ-LATDTGGTSLLLADECASGEH- 746
L+ R L+E L+S E +L QEKV +E++ L + A E H
Sbjct: 650 LQNDEQKKRQLEESLDSLGEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHR 709
Query: 747 ------IDELKRKIQSQE-------IENEKLKLEQVQLSEENSGLHVQNQKLS---EEAS 790
I L+ +++++E +N+K+ LE +L E+ L +Q+ S E +
Sbjct: 710 ETHQKQISSLRDEVEAKEKLITDLQDQNQKMVLETERLRVEHERLKATDQEKSRKLHELT 769
Query: 791 YAKELASAAAVELKNLAGEVTK--LSLQN-AKLEKELMAARNLANTRSAVTHTVNGVHRK 847
++ A +LK L V K +L N KL + +A R + T +K
Sbjct: 770 VMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEVDSDDTGGSAAQK 829
Query: 848 YNDPRSGRKARVSSRANENVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEI 907
++ ++ + +L E+ L+ L+A +R ALE+AL E +
Sbjct: 830 QKISFLENNLEQLTKVHKQLVRDNADLR---CELPKLEFRLRATAERVKALESALKEAKE 886
Query: 908 MEEEHRNRVEEAKKR 922
R R ++ R
Sbjct: 887 NASRDRKRYQQEVDR 901
>KINH_DROME (P17210) Kinesin heavy chain
Length = 975
Score = 265 bits (678), Expect = 4e-70
Identities = 269/980 (27%), Positives = 425/980 (42%), Gaps = 145/980 (14%)
Query: 88 DSISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPA-TAYAFDKVFGPHTNSDEVY 146
DSI V RFRPL++ E G + + + N + A Y FDKVF P+ + ++VY
Sbjct: 11 DSIKVVCRFRPLNDSEEKAGSKFV-VKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVY 69
Query: 147 EVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHG---DQNSPGIIPLAIKDVFSSIQDT 203
AAK +V + G NGT+FAYG TSSGKTHTM G D GIIP + D+F+ I
Sbjct: 70 NEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAM 129
Query: 204 P-GREFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSF 261
EF ++VSY EIY + I DLLD + NL V ED YV+G E V SP
Sbjct: 130 EVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEV 189
Query: 262 IAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SK 320
I G+ +RH+ N N SSRSH++F + ++ E + +L L+DLAGSE SK
Sbjct: 190 IEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQE--NLENQKKLSGKLYLVDLAGSEKVSK 247
Query: 321 TETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLI 380
T G E INKSL LG VI L++G +H+PYRDSKLTR+LQ SL G+ +++
Sbjct: 248 TGAEGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIV 307
Query: 381 CTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQRE----------IS 430
+PAS N ET +TL F RAK V+ N+ + + ++Y++E +
Sbjct: 308 ICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVE 367
Query: 431 VLKLELDQLKKGMQFGVNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKL 490
L++EL + + G V EE + ++ +E ++ + + ALA++ L +
Sbjct: 368 KLEIELARWRAGET--VKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANM 425
Query: 491 ILVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDV 550
+ N Q L+T + Y L D + E S A L V
Sbjct: 426 SASVAVN-----------EQARLATECERLYQQLDD-----KDEEINQQSQYAEQLKEQV 469
Query: 551 RHRRTSSKRNEELSTSNSIITESTQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAGDI 610
+ EEL +N+ T E+ + + + E+VK
Sbjct: 470 MEQ-------EEL-IANARREYETLQSEM----------ARIQQENESAKEEVK------ 505
Query: 611 AFSTSTLKRLTEQSVNDPESSRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVANPSLV 670
L+ L E +VN + S QEI K + L + + + + SV N +
Sbjct: 506 ----EVLQALEELAVNYDQKS--------QEIDNKNKDIDALNEELQQ--KQSVFNAAST 551
Query: 671 EMQQVTVTRLMTQCNEKAFELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQLATDT 730
E+QQ+ ++ S + + E L + + E+ + A
Sbjct: 552 ELQQLK---------------DMSSHQKKRITEMLTNLLRDLGEVGQ---------AIAP 587
Query: 731 GGTSLLLADECASGEHIDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQ----NQKLS 786
G +S+ L +G +++ + K+K E +++ S + Q N+K+S
Sbjct: 588 GESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKIS 647
Query: 787 EEASYAKELA------SAAAVELKNLAGEVTKLSLQNAKLEKELMAARNLANTRSAVTHT 840
E Y K+L S +K+L + + + LE+++ + R A H
Sbjct: 648 E---YEKDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEH- 703
Query: 841 VNGVHRKYNDPRSGRKARVSSRANE-------NVGPGRDELESWSLEVDDLK----MELQ 889
V+ V+ + ++ S+ +E V RDE+ + E+D++K L
Sbjct: 704 VSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLL 763
Query: 890 ARKQREAALEAALAEKEIMEEEHRN------RVEEAKKRESSLENDLANMWVLVAKLKKE 943
A +Q A E E E +N R E+A+K LE+ +A + L+K
Sbjct: 764 AHQQMTADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKL 823
Query: 944 VGVVAESNI------DKISGDGEAHTNDPKTNDSESNI-----ISKEQTLDVSEPNNETP 992
+ I ++ DG + K + E+N+ + K+ D ++ E P
Sbjct: 824 FVQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELP 883
Query: 993 KEEPLVVRLKARMQDMKEKE 1012
K E RL+ M+ +K E
Sbjct: 884 KLEK---RLRCTMERVKALE 900
>KINH_STRPU (P35978) Kinesin heavy chain
Length = 1031
Score = 262 bits (670), Expect = 3e-69
Identities = 254/935 (27%), Positives = 432/935 (46%), Gaps = 125/935 (13%)
Query: 89 SISVTIRFRPLSEREYHRGDEIAWYADGDKI-VRNEFNPATAYAFDKVFGPHTNSDEVYE 147
+I V R RP++ E + + +++ + + N FD++F P+T +EVY
Sbjct: 8 NIKVVCRVRPMNATEQNTSHICTKFISEEQVQIGGKLN-----MFDRIFKPNTTQEEVYN 62
Query: 148 VAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAIKDVFSSI-QDT 203
AA+ +VK ++G NGT+FAYG TSSGKT TM G +P GIIP ++D+F+ I Q
Sbjct: 63 KAARQIVKDVLDGYNGTIFAYGQTSSGKTFTMEGVMGNPQYMGIIPRIVQDIFNHIYQMD 122
Query: 204 PGREFLLRVSYLEIYNEVINDLLDPTGQNLRVREDAQGT-YVEGIKEEVVLSPGHALSFI 262
EF ++VSY EIY + I DLLD + NL V ED +V+G E SP + I
Sbjct: 123 ESLEFHIKVSYFEIYMDRIRDLLDVSKTNLSVHEDKNRVPFVKGATERFASSPEEVMDVI 182
Query: 263 AAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-SKT 321
G+ +RH+ N N SSRSH+IF + ++ E + +L L+DLAGSE SKT
Sbjct: 183 EEGKSNRHIAVTNMNEHSSRSHSIFLIQVKQE--NMETKKKLSGKLYLVDLAGSEKVSKT 240
Query: 322 ETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSLIC 381
G E INKSL LG VI L++GK SH+PYRDSK+TR+LQ SL G+ +++
Sbjct: 241 GAEGTVLDEAKNINKSLSALGNVISALADGKKSHIPYRDSKMTRILQESLGGNARTTIVI 300
Query: 382 TVTPASSNMEETHNTLKFASRAKRV--------EIYAS--RNKIIDEKSLIKKYQREISV 431
+P+S N E+ +TL F RAK + E+ A RN+ EK + + ++ +
Sbjct: 301 CCSPSSFNESESKSTLMFGQRAKTIKNTVTVNMELTAEEWRNRYEKEKEKNGRLKAQLLI 360
Query: 432 LKLELDQLKKG-----MQFGVNHEEIL---------------TLKQKLEEGQVKMQSRLE 471
L+ EL + + G + G ++EIL K K EE +VK+ +L+
Sbjct: 361 LENELQRWRAGESVPVKEQGNKNDEILKEMMKPKQMTVHVSEEEKNKWEEEKVKLYEQLD 420
Query: 472 EEEEE-----KVALASRIQKLTKLILVSSKNANPGYLADAPGHQQSLSTGEDDK----YD 522
E++ E ++ + Q L + L+SS + L G ++ + ++
Sbjct: 421 EKDSEIDNQSRLTEKLKQQMLEQEELLSSMQRDYELLQSQMGRLEAENAAAKEEAKEVLQ 480
Query: 523 ALQDGSLLFESESQ--KDVSTVASDLSHDVRHRRTS--------SKRNEELSTSNSIITE 572
AL++ ++ ++ +S+ +D + + LS +V + T+ K E ITE
Sbjct: 481 ALEEMAVNYDEKSKEVEDKNRMNETLSEEVNEKMTALHTTSTELQKLQELEQHQRRRITE 540
Query: 573 STQA-----GELISRTRIPAGGVTMSDQMD-------------LLVEQVKMLAGDIAFST 614
+ GE+ T + M ++ L V ++K ++
Sbjct: 541 MMASLLKDLGEI--GTALGGNAADMKPNVENIEKVDEEFTMARLFVSKMKTEVKTMSQRC 598
Query: 615 STLKRLTEQSVNDPESSRTQIENLEQEIQEKRNQLRGLEQRIIES--------GQTSVAN 666
L+ ++ +S ++++ IQ+ +++ L + I E+ + N
Sbjct: 599 KILEASNAENETKIRTSEDELDSCRMTIQQHEAKMKSLSENIRETEGKKRHLEDSLDMLN 658
Query: 667 PSLVEMQQVTVTRLMTQCNEKAFELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQL 726
+V+++ RL Q +K E E K +Q ++ + +R+ +K QL
Sbjct: 659 EEIVKLRAAEEIRLTDQ-EDKKREEEDKMQSATEMQASMSEQMESHRDAHQK------QL 711
Query: 727 ATDTGGTSLLLADECASGEH-IDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKL 785
A L E EH ++ELK Q +++EKL+L+ +L E + + ++L
Sbjct: 712 AN--------LRTEINEKEHQMEELKDVNQRMTLQHEKLQLDYEKLKIEEAEKAAKLREL 763
Query: 786 SEEASYAKELASAAAVELKNLAGEVTKLSLQNAKLEKELMAARNLANTRSAVTHTVNGVH 845
S++ ++ A +LK L V K LQ ++L +++ ++ V + G
Sbjct: 764 SQQFDRREQ----AKQDLKGLEETVAK-ELQTLHNLRKLF----VSDLQNRVKKALEGGD 814
Query: 846 RKYNDPRS-GRKARVSSRAN--ENVGPGRDEL----ESWSLEVDDLKMELQARKQREAAL 898
R + S +K ++S N E + +L E+ L+ L+A +R AL
Sbjct: 815 RDDDSGGSQAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLERRLRATSERVKAL 874
Query: 899 EAALAEKE--IMEEEHRNRVEEAKKRESSLENDLA 931
E +L E + M + R + E + RE+ + + A
Sbjct: 875 EMSLKETKEGAMRDRKRYQQEVDRIREAVRQRNFA 909
>KF3A_MOUSE (P28741) Kinesin-like protein KIF3A (Microtubule plus
end-directed kinesin motor 3A)
Length = 701
Score = 256 bits (655), Expect = 2e-67
Identities = 200/638 (31%), Positives = 322/638 (50%), Gaps = 79/638 (12%)
Query: 77 PVEEVDSSTPRDSISVTIRFRPLSERE----YHRG---DEIAWYADGDKIVRNEFNPATA 129
P+ + + D++ V +R RPL+ERE Y + DE+ K + P T
Sbjct: 2 PINKSEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKT- 60
Query: 130 YAFDKVFGPHTNSDEVYEVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSPG-- 187
+ FD VFGP + +VY + A+P++ + +EG NGT+FAYG T +GKT TM G + PG
Sbjct: 61 FTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLR 120
Query: 188 -IIPLAIKDVFSSIQDTPG-REFLLRVSYLEIYNEVINDLL--DPTGQNLRVREDAQ-GT 242
+IP + +F I G FL+RVSYLEIYNE + DLL D T Q L V+E G
Sbjct: 121 GVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQT-QRLEVKERPDVGV 179
Query: 243 YVEGIKEEVVLSPGHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYD- 301
Y++ + VV + + G ++R VG+ N N SSRSH IFT+ IE S G + +
Sbjct: 180 YIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNM 239
Query: 302 GVIFSQLNLIDLAGSE-SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRD 360
V +L+L+DLAGSE +KT TG R KE + IN SL TLG VI L +GKS+HVPYR+
Sbjct: 240 HVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRN 299
Query: 361 SKLTRLLQSSLSGHGHVSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEK- 419
SKLTRLLQ SL G+ + + PA N +ET +TL++A+RAK ++ A N+ D K
Sbjct: 300 SKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINE--DPKD 357
Query: 420 SLIKKYQREISVLKLELDQ----------------------------LKKGMQFG---VN 448
+L++++Q+EI LK +L++ K+ Q G V+
Sbjct: 358 ALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKRKKRRDQAGKKKVS 417
Query: 449 HEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLILVSSKNANPGYLADAPG 508
++++ ++ K++E + ++++L+ EEEE+ + +++ K +L + +
Sbjct: 418 PDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQE----------- 466
Query: 509 HQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNS 568
HQ L + + G L +++ S++ + R RR R E
Sbjct: 467 HQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKE------- 519
Query: 569 IITESTQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTEQSVNDP 628
+ E Q R I ++ ++ +++K + + + S + L ++ +
Sbjct: 520 -LEEKEQ-----ERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREI 573
Query: 629 ESSRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVAN 666
E +EN+ Q +E R Q+ ++ I + Q + N
Sbjct: 574 EG---LLENIRQLSRELRLQMLIIDNFIPQDYQEMIEN 608
Score = 38.1 bits (87), Expect = 0.13
Identities = 45/221 (20%), Positives = 92/221 (41%), Gaps = 18/221 (8%)
Query: 745 EHIDELKRKIQS-QEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVEL 803
+ I+ELK+K++ +E+ + + E G + +K + + K+++ VE+
Sbjct: 365 KEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKRKKRRDQAGKKKVSPDKMVEM 424
Query: 804 KNLAGEVTKLSLQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRA 863
+ K+ + LE +L N A K ++S+
Sbjct: 425 Q------AKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALE 478
Query: 864 NENVGPGRDEL---ESWSLEVDDLKMELQARKQREAALEAALAEKE----IMEEEHRNRV 916
+ + G D L E +++ MEL+ R++R L L EKE +EE++ +
Sbjct: 479 KKVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQ 538
Query: 917 EEAKKRESSLENDLANMWVLVAKLKKEVGVVAESNIDKISG 957
EEA+ + L+ +W ++ K E+ + + + +I G
Sbjct: 539 EEAQGKTKKLK----KVWTMLMAAKSEMADLQQEHQREIEG 575
Score = 33.5 bits (75), Expect = 3.1
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 7/165 (4%)
Query: 763 KLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAGEVTKLSLQNAKLEK 822
KL L + SE + Q+L E L++ V + G+ T + +N+KL +
Sbjct: 245 KLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTR 304
Query: 823 ELMAARNLANTRSAVTHTVNGVHRKYNDPRS-----GRKARVSSRANENVGPGRDELESW 877
L + N+++ + + Y++ S R + ++A N P L +
Sbjct: 305 LLQDSLG-GNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQF 363
Query: 878 SLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKR 922
E+++LK +L+ ++ + + + +E++ E E E+ KKR
Sbjct: 364 QKEIEELKKKLEEGEEVSGS-DISGSEEDDEEGELGEDGEKRKKR 407
>KINH_SYNRA (O43093) Kinesin heavy chain (Synkin)
Length = 935
Score = 256 bits (654), Expect = 2e-67
Identities = 268/960 (27%), Positives = 435/960 (44%), Gaps = 110/960 (11%)
Query: 88 DSISVTIRFRPLSEREYHRGDE--IAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEV 145
++I V RFRP + E G I +G ++ + FDKVFG +T +V
Sbjct: 4 NNIKVVCRFRPQNSLEIREGGTPIIDIDPEGTQLELKGKEFKGNFNFDKVFGMNTAQKDV 63
Query: 146 YEVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHG----DQNSPGIIPLAIKDVFSSIQ 201
++ + K +V G NGTVFAYG T SGKT TM G D+ + GIIP ++ +F SI
Sbjct: 64 FDYSIKTIVDDVTAGYNGTVFAYGQTGSGKTFTMMGADIDDEKTKGIIPRIVEQIFDSIM 123
Query: 202 DTPGR-EFLLRVSYLEIYNEVINDLLDPTGQNLRVRED-AQGTYVEGIKEEVVLSPGHAL 259
+P EF ++VSY+EIY E + DLL+P+ +NL + ED +G YV+G+ E V S
Sbjct: 124 ASPSNLEFTVKVSYMEIYMEKVRDLLNPSSENLPIHEDKTKGVYVKGLLEVYVGSTDEVY 183
Query: 260 SFIAAGEEHRHVGSNNFNLFSSRSHTI--FTLMIESSAHGEEYDGVIFSQLNLIDLAGSE 317
+ G +R V N N SSRSH+I FT+ ++ G G ++ L+DLAGSE
Sbjct: 184 EVMRRGSNNRVVAYTNMNAESSRSHSIVMFTITQKNVDTGAAKSGKLY----LVDLAGSE 239
Query: 318 S-SKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGH 376
KT +G +E INKSL LG VI L++GKSSHVPYRDSKLTR+LQ SL G+
Sbjct: 240 KVGKTGASGQTLEEAKKINKSLTALGMVINALTDGKSSHVPYRDSKLTRILQESLGGNSR 299
Query: 377 VSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKII---DEKSLIKK-------YQ 426
+LI +P+S N ET +TL+F +RAK ++ A N + + K+L+KK YQ
Sbjct: 300 TTLIINCSPSSYNEAETLSTLRFGARAKSIKNKAKVNADLSPAELKALLKKVKSEAVTYQ 359
Query: 427 REISVLKLELDQLKKGMQFGVNHEEILTLKQKLEEGQVK-------MQSRLEEEEEEKVA 479
I+ L+ E++ + G G E K+ +G +S + +E
Sbjct: 360 TYIAALEGEVNVWRTG---GTVPEGKWVTMDKVSKGDFAGLPPAPGFKSPVSDEGSRPAT 416
Query: 480 LASRIQKLTKLILVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQDGSLLFESESQ--- 536
++K + + +N L D +++ T + ++L++ ++ + Q
Sbjct: 417 PVPTLEKDEREEFIKRENE----LMDQISEKETELTNREKLLESLREEMGYYKEQEQSVT 472
Query: 537 KDVSTVASDLSH-DVRHRRTSSKRNEELSTSNS-------IITESTQAGELISRTRIPAG 588
K+ + S+LS ++ ++ S + E T +S ++ E + + +S R
Sbjct: 473 KENQQMTSELSELRLQLQKVSYESKENAITVDSLKEANQDLMAELEELKKNLSEMRQAHK 532
Query: 589 GVTMSDQMDLLVEQV-KMLAGDIAFSTSTLKRLTEQSVNDPESSRTQIENLEQEIQEKRN 647
T SD+ E++ +M++G F S + +ND E QI N ++ ++
Sbjct: 533 DATDSDKEKRKAEKMAQMMSG---FDPSGI-------LNDKE---RQIRNALSKLDGEQQ 579
Query: 648 QLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQ---CNEKAFELEIKSADNRVLQEQ 704
Q +E ++ + + LVE T++ L K ELE + E+
Sbjct: 580 QTLTVED-LVSLRRELAESKMLVEQHTKTISDLSADKDAMEAKKIELEGRLGALEKEYEE 638
Query: 705 LNSKCSENRELQEKVKLLEQQLATDTGGTSLLLADECASGEHIDELKRKIQSQEIENEKL 764
L K E + ++ A T + + + ID+LKR++ ++ +EKL
Sbjct: 639 LLDKTIAEEEANMQNADVDNLSALKTKLEAQYAEKKEVQQKEIDDLKRELDRKQSGHEKL 698
Query: 765 KLEQVQLSEENSGLHV-----------QNQKLSEEASYAKELASAAAVELKNLAGEVTKL 813
L N L N ++E+ + + A +L + EV K
Sbjct: 699 SAAMTDLRAANDQLQAALSEQPFQAPQDNSDMTEKEKDIERTRKSMAQQLADF--EVMKK 756
Query: 814 SLQ---NAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRANENVGPG 870
+L + EK + +L TR N V R N+ +K R E +
Sbjct: 757 ALMRDLQNRCEKVVELEMSLDETR----EQYNNVLRASNNKAQQKKMAFLERNLEQLTNV 812
Query: 871 RDEL----ESWSLEVDDLKMELQARKQREAALEAAL--AEKEIMEEEH---------RNR 915
+ +L S EV + +L AR +R +LE L A+ +++ + R R
Sbjct: 813 QKQLVEQNASLKKEVALAERKLIARNERIQSLETLLHNAQDKLLNQNKKFEQQLATVRER 872
Query: 916 VEEAKKRESSLENDLANM-WVLVAKLKKEVGVVAESNIDKISGDGEAHTNDPKTNDSESN 974
+E+A+ ++S +N LA + + +AK + G ID S DG T+ D S+
Sbjct: 873 LEQARSQKS--QNSLAALNFSRIAKPLRGNGAA----IDNGSDDGSLPTSPTDKRDKRSS 926
>KF3A_HUMAN (Q9Y496) Kinesin-like protein KIF3A (Microtubule plus
end-directed kinesin motor 3A)
Length = 702
Score = 256 bits (654), Expect = 2e-67
Identities = 186/536 (34%), Positives = 282/536 (51%), Gaps = 68/536 (12%)
Query: 77 PVEEVDSSTPRDSISVTIRFRPLSERE----YHRG---DEIAWYADGDKIVRNEFNPATA 129
P+ + + D++ V +R RPL+ERE Y + DE+ K + P T
Sbjct: 2 PINKSEKPESCDNVKVVVRCRPLNEREKSMCYKQAVSVDEMRGTITVHKTDSSNEPPKT- 60
Query: 130 YAFDKVFGPHTNSDEVYEVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP--- 186
+ FD VFGP + +VY + A+P++ + +EG NGT+FAYG T +GKT TM G + P
Sbjct: 61 FTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAIPELR 120
Query: 187 GIIPLAIKDVFSSIQDTPG-REFLLRVSYLEIYNEVINDLL--DPTGQNLRVREDAQ-GT 242
GIIP + +F I G FL+RVSYLEIYNE + DLL D T Q L V+E G
Sbjct: 121 GIIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQT-QRLEVKERPDVGV 179
Query: 243 YVEGIKEEVVLSPGHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDG 302
Y++ + VV + + G ++R VG+ N N SSRSH IFT+ IE S G DG
Sbjct: 180 YIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKG--IDG 237
Query: 303 ---VIFSQLNLIDLAGSE-SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPY 358
V +L+L+DLAGSE +KT TG R KE + IN SL TLG VI L +GKS+HVPY
Sbjct: 238 NMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPY 297
Query: 359 RDSKLTRLLQSSLSGHGHVSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDE 418
R+SKLTRLLQ SL G+ + + PA N +ET +TL++A+RAK ++ A N+ D
Sbjct: 298 RNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINE--DP 355
Query: 419 K-SLIKKYQREISVLKLELDQ-----------------------------LKKGMQFG-- 446
K +L++++Q+EI LK +L++ K+ Q G
Sbjct: 356 KDALLRQFQKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRDQTGKK 415
Query: 447 -VNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLILVSSKNANPGYLAD 505
V+ ++++ ++ K++E + ++++L+ EEEE+ + ++K K +L + +
Sbjct: 416 KVSPDKMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQE-------- 467
Query: 506 APGHQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNE 561
HQ L + + G L +++ S++ + R +R R E
Sbjct: 468 ---HQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRE 520
Score = 37.7 bits (86), Expect = 0.17
Identities = 45/220 (20%), Positives = 89/220 (40%), Gaps = 15/220 (6%)
Query: 745 EHIDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELK 804
+ I+ELK+K++ E E++ + SEE+ + + E+ ++ V
Sbjct: 365 KEIEELKKKLE----EGEEISGSDISGSEEDDDEEGEVGEDGEKRKKRRDQTGKKKVSPD 420
Query: 805 NLAGEVTKLSLQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRAN 864
+ K+ + LE +L N A K ++S+
Sbjct: 421 KMIEMQAKIDEERKALETKLDMEEEERNKARAELEKREKDLLKAQQEHQSLLEKLSALEK 480
Query: 865 ENVGPGRDEL---ESWSLEVDDLKMELQARKQREAALEAALAEKE----IMEEEHRNRVE 917
+ + G D L E +++ MEL+ R++R L L EKE +EE++ + E
Sbjct: 481 KVIVGGVDLLAKAEEQEKLLEESNMELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQE 540
Query: 918 EAKKRESSLENDLANMWVLVAKLKKEVGVVAESNIDKISG 957
EA+ + L+ +W ++ K E+ + + + +I G
Sbjct: 541 EAQGKTKKLK----KVWTMLMAAKSEMADLQQEHQREIEG 576
Score = 34.3 bits (77), Expect = 1.8
Identities = 35/165 (21%), Positives = 69/165 (41%), Gaps = 6/165 (3%)
Query: 763 KLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAGEVTKLSLQNAKLEK 822
KL L + SE + Q+L E L++ V + G+ T + +N+KL +
Sbjct: 245 KLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTR 304
Query: 823 ELMAARNLANTRSAVTHTVNGVHRKYNDPRS-----GRKARVSSRANENVGPGRDELESW 877
L + N+++ + + Y++ S R + ++A N P L +
Sbjct: 305 LLQDSLG-GNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQF 363
Query: 878 SLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKR 922
E+++LK +L+ ++ + + E + E E E+ KKR
Sbjct: 364 QKEIEELKKKLEEGEEISGSDISGSEEDDDEEGEVGEDGEKRKKR 408
>KINH_BOTCI (Q86ZC1) Kinesin heavy chain
Length = 880
Score = 253 bits (647), Expect = 1e-66
Identities = 239/883 (27%), Positives = 401/883 (45%), Gaps = 93/883 (10%)
Query: 88 DSISVTIRFRPLSEREYHRGDE-IAWYADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVY 146
+SI V RFRP + E +G + + + D + A ++ FD+VFG + +++
Sbjct: 3 NSIKVVCRFRPQNRIENEQGAQPVVKFEADDTCALDSNGAAGSFTFDRVFGMSSRQKDIF 62
Query: 147 EVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHG----DQNSPGIIPLAIKDVFSSIQD 202
+ + KP V + G NGTVFAYG T +GK++TM G + + G+IP ++ +F+SI
Sbjct: 63 DFSIKPTVDDILNGYNGTVFAYGQTGAGKSYTMMGTNLDNDDGRGVIPRIVEQIFASILS 122
Query: 203 TPGR-EFLLRVSYLEIYNEVINDLLDPTGQNLRVREDA-QGTYVEGIKEEVVLSPGHALS 260
+PG E+ +RVSY+EIY E I DLL P NL + E+ +G YV+G+ E V S
Sbjct: 123 SPGTIEYTVRVSYMEIYMERIRDLLQPQNDNLPIHEEKNRGVYVKGLLEVYVSSVQEVYE 182
Query: 261 FIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSES-S 319
+ G + R V S N N SSRSH+IF + I E QL L+DLAGSE
Sbjct: 183 VLKRGGDARVVASTNMNAESSRSHSIFVITITQK--NVETGSAKSGQLFLVDLAGSEKVG 240
Query: 320 KTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQSSLSGHGHVSL 379
KT +G +E INKSL LG VI L++GKSSH+PYRDSKLTR+LQ SL G+ +L
Sbjct: 241 KTGASGQTLEEAKKINKSLSALGMVINNLTDGKSSHIPYRDSKLTRILQESLGGNSRTTL 300
Query: 380 ICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKII---DEKSLIKKYQREISVLKLEL 436
I +P+S N EET +TL+F RAK ++ A N + + K+L++K Q +++ + +
Sbjct: 301 IINCSPSSYNAEETLSTLRFGMRAKAIKNKAKVNAELSPAELKALLRKAQSQVTTFETYV 360
Query: 437 DQLKKGMQF-----GVNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLI 491
L+ +Q V E+ + + ++A SR +
Sbjct: 361 STLEGEVQLWRKGESVPKEQWAPPLAGVSGAKAAAAQTPRPSTPSRLATESRAE-----T 415
Query: 492 LVSSKNANPGYLADAPGHQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLS-HDV 550
V+ ++A PG D +D++ + L+ + L + ++K+ A++ + D
Sbjct: 416 PVAERSATPGIPID-----------KDEREEFLRRENELQDQITEKETQIAAAEKTLRDT 464
Query: 551 RHRRTSSK-RNEELSTSNSIITESTQAGEL-ISRTRIPAGGVTMSDQMDLLVEQVKMLAG 608
+ T K R+ +++ N +T ++A E + R+ MD L E L
Sbjct: 465 KEELTYLKERDTKVNKDNEKLT--SEANEFKMQLERLAFESKEAQITMDSLKEANAEL-- 520
Query: 609 DIAFSTSTLKRLTEQSVNDPESSRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVANPS 668
T+ L L +Q +N S++ L+++ + K ++ + G N +
Sbjct: 521 -----TAELDELKQQLLNVKMSAKESTAALDEKEKRKAEKMAQMMAGFDLGGDVFSENEA 575
Query: 669 LVEMQQVTVTRLMTQCN-------EKAFELEIKSADNRVLQEQL----------NSKCSE 711
++ + L Q + ++ EL+ K + + + Q ++
Sbjct: 576 TIKKVIDHIDSLHEQSSAGEAIPPDEFEELKAKLVETQGIVRQAELSMFGSSSNDANVKR 635
Query: 712 NRELQEKVKLLEQQLATDTGGTSLLLADECASGEHIDELKRKIQSQEIENEKLKLEQV-- 769
EL++++++LEQ+ LL G+ + E+K +++ N+ +K+E V
Sbjct: 636 REELEQRLQVLEQEYED-------LLERNLGEGD-VAEIKERLEKAYSNNQDIKVELVED 687
Query: 770 ------QLSEENSGLHVQNQKLSEEA-------SYAKELASAAAVELKNLAGEVTKLSLQ 816
Q S E N+ L + A AS V+ + +V K SL
Sbjct: 688 LKKEVAQKSAEIEKFKAVNEDLQQRVKSGSASNGTAPGSASGKTVQQQIAEFDVMKKSLM 747
Query: 817 NAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRANENVGPGRDEL-- 874
L+ L + N V R N+ +K R E + + +L
Sbjct: 748 R-DLQNRCERVVELEISLDETREQYNNVLRSSNNRAQQKKMAFLERNLEQLTHVQRQLVE 806
Query: 875 --ESWSLEVDDLKMELQARKQREAALEAAL--AEKEIMEEEHR 913
S EV + +L AR +R +LE+ L +++++ HR
Sbjct: 807 QNGSLKKEVAIAERKLIARNERIQSLESLLQDSQEKLTTASHR 849
>KF4A_MOUSE (P33174) Chromosome-associated kinesin KIF4A
(Chromokinesin)
Length = 1231
Score = 253 bits (647), Expect = 1e-66
Identities = 264/978 (26%), Positives = 444/978 (44%), Gaps = 90/978 (9%)
Query: 90 ISVTIRFRPLSEREYHRGDEIAW-YADGDK--IVRNEFNPATAYAFDKVFGPHTNSDEVY 146
+ V +R RPL +E G + + G+ +V N+ ++ +D VF P T +EV+
Sbjct: 10 VRVALRCRPLVSKEIKEGCQTCLSFVPGEPQVVVGND----KSFTYDFVFDPSTEQEEVF 65
Query: 147 EVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHG-------DQNSPGIIPLAIKDVFSS 199
A P++K +G N TV AYG T SGKT++M G ++ G+IP I+ +F
Sbjct: 66 NTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKE 125
Query: 200 IQDTPGREFLLRVSYLEIYNEVINDLLDPTGQN---LRVREDA-QGTYVEGIKEEVVLSP 255
I EF L+VSYLEIYNE I DLL + + + +RED +G + G+ E+ VL
Sbjct: 126 INKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVLVA 185
Query: 256 GHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAG 315
+S + G R V S N SSRSH IFT+ IE ++ + S+L+L+DLAG
Sbjct: 186 SDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDK-NSSFRSKLHLVDLAG 244
Query: 316 SE-SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSH-VPYRDSKLTRLLQSSLSG 373
SE KT+ G R +EG IN+ LL LG VI L + K + VPYRDSKLTRLLQ SL G
Sbjct: 245 SERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGG 304
Query: 374 HGHVSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQREISVLK 433
+ H +I V+PA SN+EET NTL++A RA++++ N I + + + ++++ L+
Sbjct: 305 NSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIIN-IDPQAAELNHLKQQVQQLQ 363
Query: 434 LELDQLKKGMQFG-VNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLIL 492
+ L Q G G +N E L+ +E+ Q ++ + A Q L ++IL
Sbjct: 364 ILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIIL 423
Query: 493 VSSKNANPGYLADAPGHQQSLSTGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRH 552
N + + + L+D L E ++ V + LS +
Sbjct: 424 TEQANEKMNAKLEELRRHAACKVDLQKLVETLEDQELKENIEIICNLQQVIAQLSDEAAA 483
Query: 553 RRTSS-KRNEELSTSNSIITESTQAGELISRTRIPAGGVTMSDQMDLLVEQVKMLAGDIA 611
T++ E T +++++ ++ S T+ MS + L+E K L A
Sbjct: 484 CMTATIDTAGEADTQVQSSPDTSRSSDVFS-TQHALRQAQMSKE---LIELNKAL----A 535
Query: 612 FSTSTLKRLTEQSVNDPESSRTQ------IENLEQEI----QEKRNQLRGLEQRIIESGQ 661
+ K++T+ ND + Q I+NLE E+ +EK + L+ ++ Q
Sbjct: 536 LKEALAKKMTQ---NDNQLQPIQFQYQDNIKNLESEVLSLQREKEELVLELQTAKKDANQ 592
Query: 662 TSVANPSLVEMQQV--TVTRLMTQCNEKAFELEIKSAD-------NRVLQEQLNSKCSEN 712
++ +Q++ + L + E++ L++K + N+ ++ N +
Sbjct: 593 AKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQLM 652
Query: 713 RELQEKVKLLEQQLATDTGGTSLLLADECASGEHIDELKRKIQSQEIENEKLKLEQVQLS 772
R+++E + Q L + + +L+R Q Q + L+ + + +
Sbjct: 653 RQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERNFQKQ---SNVLRRKTEEAA 709
Query: 773 EENSGLHVQNQKLSEEASYAKELAS----AAAVELKNLAGEVTKLSLQNAKLEKELMAAR 828
N L QK E A KE S + A +KN G ++ + + ++ L
Sbjct: 710 AANKRLKDALQKQKEVAEKRKETQSRGMESTAARMKNWLGNEIEVMVSTEEAKRHL---N 766
Query: 829 NLANTRSAVTHTVNGVHRK----YNDPRSGRKARVSSRANENVGPGRDELESWSLEVDDL 884
L R + V + K N P R+ S +E G +S + +++ L
Sbjct: 767 GLLEERKILAQDVAQLKEKRESGENPPLKLRRRTFS--YDEIHGQDSGAEDSIAKQIESL 824
Query: 885 KMELQARKQREAALEAALAEKEIMEEEHRNRVE------EAKKRESSLENDLANMWVLVA 938
+ EL+ R + A L+ L + E E+ + R E EAK L +L + +LV+
Sbjct: 825 ETELELRSAQIADLQQKLLDAE-SEDRPKQRWESIATILEAKCAIKYLVGELVSSKILVS 883
Query: 939 KLKKEVGVVAESNID--KISGDGEAHTNDPKTNDSESNIISKEQTLDVSEPNNETPKEEP 996
KL+ + S ID K+ + + H +T KE+ + V + + +E+
Sbjct: 884 KLESSLNQSKASCIDVQKMLFEEQNHFAKIETE-------LKEELVKVEQQH----QEKV 932
Query: 997 LVVRLKARMQDMKEKELK 1014
L + + + M EK+L+
Sbjct: 933 LYLLSQLQQSQMTEKQLE 950
>KF4A_XENLA (Q91784) Chromosome-associated kinesin KLP1
(Chromokinesin)
Length = 1226
Score = 248 bits (633), Expect = 6e-65
Identities = 262/929 (28%), Positives = 418/929 (44%), Gaps = 121/929 (13%)
Query: 90 ISVTIRFRPLSEREYHRGDEIAW-YADGDK--IVRNEFNPATAYAFDKVFGPHTNSDEVY 146
+ V +R RPL +E + G ++ + G++ IV E ++ +D VF P +EVY
Sbjct: 9 VRVALRCRPLVPKENNEGCKMCLTFVPGEQQVIVGTE----KSFTYDYVFDPSAEQEEVY 64
Query: 147 EVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTM-----HGDQNSP--GIIPLAIKDVFSS 199
A P++K +G N TV AYG T SGKT++M H +N P G+IP + +F
Sbjct: 65 NSAVAPLIKGLFKGYNATVLAYGQTGSGKTYSMGGAYTHNQENEPTVGVIPRTVIALFRE 124
Query: 200 IQDTPGREFLLRVSYLEIYNEVINDLL----DPTGQNLRVREDA-QGTYVEGIKEEVVLS 254
I P EF L+VSYLEIYNE I DLL D T + +RED +G + G+ E V +
Sbjct: 125 IHQRPEWEFNLKVSYLEIYNEEILDLLYAARDKTN-TISIREDPKEGIKICGLTERDVKT 183
Query: 255 PGHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLA 314
LS + G R V S N SSRSH IFT+ IE G++ + S+L+L+DLA
Sbjct: 184 ALDTLSCLEQGNSSRTVASTAMNSQSSRSHAIFTISIEQRKEGDKNNS-FRSKLHLVDLA 242
Query: 315 GSE-SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEG--KSSHVPYRDSKLTRLLQSSL 371
GSE KT+ G R KEG IN+ LL LG VI L + K VPYRDSKLTRLLQ SL
Sbjct: 243 GSERQKKTKAEGDRLKEGISINRGLLCLGNVISALGDESKKGGFVPYRDSKLTRLLQDSL 302
Query: 372 SGHGHVSLICTVTPASSNMEETHNTLKFASRAKRV--EIYASRNKIIDEKSLIKKYQREI 429
G+ H +I V+PA SNMEET NTL++A RA+++ + + + E +K +E+
Sbjct: 303 GGNSHTLMIACVSPADSNMEETLNTLRYADRARKIKNKPIVNTDPQAAELQRLKLQVQEL 362
Query: 430 SVLKLELD----QLKKGMQFGVNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQ 485
VL L+ + M+ N + ++ + LE+ K+ L E A Q
Sbjct: 363 QVLLLQAHGGTLPVLNSMEPSENLQSLMERNKNLEKENGKLSRELGE------AAVQTAQ 416
Query: 486 KLTKLILVSSKNANPG--------YLADAPGHQQSLSTGED----DKYDALQDGSLLFES 533
L K+I+ +N G + A Q+ + T ED D + +Q+ +
Sbjct: 417 FLEKIIMTEQQNEKLGSKMEELKQHAACKVNLQRLVETLEDQELKDNVEVIQNLQQVI-V 475
Query: 534 ESQKDVSTVASDL--------SHDVRHRRTSSKRNEELSTSNSIITESTQAGELISRTRI 585
+ Q + S +A + S V + KR+ + T+N + ++ + ELI
Sbjct: 476 QLQDESSGIAGSIEAMDEEAASFPVPEEDSGEKRSSDGFTTNHALRQAQLSKELI----- 530
Query: 586 PAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTEQSVNDPESSRTQIENLEQEIQE- 644
+++ + + LA +A + L+ + + +N+ + +++ L++E +E
Sbjct: 531 ---------ELNKALVMKEALAKKMAQNDRQLEPIQSEYLNNIKHLESEVGVLQKEKEEL 581
Query: 645 --------KRNQLRGLEQRIIE-----SGQTSVANPSLVEMQQVTVTRLMTQCNEKAFEL 691
K N L +R + GQ + L E ++ R T+
Sbjct: 582 ILALHSAKKDNNQAKLSERRRKRLQELEGQMTELKKKLGEQSKLLKLRESTEKTVAKMNQ 641
Query: 692 EIKSADNRVLQEQLNSKCSENRE-----LQEKVKLLEQQLATDTGGTSLLLADECASGEH 746
EI+ ++ + QL + E+ E Q+K K + Q D LL E +
Sbjct: 642 EIQGM--KMQRVQLMRQMKEDAEKFRTWKQQKTKEVIQLKEKDRKRQYELLKLERDFQKQ 699
Query: 747 IDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKN- 805
+ L+RK + N++LK L Q + + + + AA +KN
Sbjct: 700 ANVLRRKTEEAASANKRLK----------EALQRQKEAMEKRKDSQSKGMEGAASRVKNW 749
Query: 806 LAGEVTKLSLQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYND----PRSGRKARVSS 861
LA EV L E+ +L R + + + +K + P R+ +
Sbjct: 750 LANEVEVL----VSTEEAQRHLNDLLEDRKILAQDIAQLKQKTDAGERIPTKIRRRTYTV 805
Query: 862 RANENVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVE---- 917
EN+ +E S + +++ L+ E++ R + A L+ L + + EE + R E
Sbjct: 806 AELENL----EEEASVTKQIESLETEMELRSAQIADLQQKLLDADGEEEMVKRRWETISN 861
Query: 918 --EAKKRESSLENDLANMWVLVAKLKKEV 944
EAK L +L + V +KL+ V
Sbjct: 862 IMEAKCALKYLITELVSSKVAGSKLESSV 890
Score = 39.7 bits (91), Expect = 0.043
Identities = 76/411 (18%), Positives = 166/411 (39%), Gaps = 32/411 (7%)
Query: 398 KFASRAKRVEIYASRNKIIDEKSLIKKYQREISVLKLELDQLKKGMQFGVNHEEILTLKQ 457
K ++K +++ S K + K +EI +K++ QL + M+ + E+ T KQ
Sbjct: 618 KLGEQSKLLKLRESTEKTV------AKMNQEIQGMKMQRVQLMRQMK--EDAEKFRTWKQ 669
Query: 458 KLEEGQVKMQSRLEEEEEEKVALASRIQKLTKLILVSSK---NANPGYLADAPGHQQSLS 514
+ + ++++ + + + E + L QK ++ ++ +AN ++++
Sbjct: 670 QKTKEVIQLKEKDRKRQYELLKLERDFQKQANVLRRKTEEAASANKRLKEALQRQKEAME 729
Query: 515 TGEDDKYDALQDGSLLFESESQKDVSTVASDLSHDVRHRRTSSKRNEELSTSNSIITEST 574
+D + ++ + ++ +V + S RH + + L+ + + + T
Sbjct: 730 KRKDSQSKGMEGAASRVKNWLANEVEVLVST-EEAQRHLNDLLEDRKILAQDIAQLKQKT 788
Query: 575 QAGELISRTRIPAGGVTMSDQMDL-----LVEQVKMLAGDIAFSTSTLKRLTEQSVNDPE 629
AGE I T+I T+++ +L + +Q++ L ++ ++ + L +Q + D +
Sbjct: 789 DAGERIP-TKIRRRTYTVAELENLEEEASVTKQIESLETEMELRSAQIADL-QQKLLDAD 846
Query: 630 SSRTQIENLEQEIQEKRNQLRGLEQRIIESGQTSVANPSL---VEMQQVTVTRLMTQCNE 686
++ + I L+ I E + VA L V+ + V L E
Sbjct: 847 GEEEMVKRRWETISNIMEAKCALKYLITELVSSKVAGSKLESSVKQNRAHVADLQKNIFE 906
Query: 687 KAFELEIKSADNRVLQEQLNSKCSENRELQEKVKLLEQQLATDTGGTSLLL----ADECA 742
+ ++ +++ QL + QEK+ L QL + + A+E
Sbjct: 907 ERNQMAEMETEHQSQLMQLE------QHHQEKILYLLSQLQQKQASVPVTIEELPAEEIT 960
Query: 743 SGEHIDELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAK 793
E + K Q +EIE K E+ Q + + ++ Q L AS K
Sbjct: 961 EREKQLMERLKFQDEEIEKMKALCEKNQQLLQENDMYKQKLALLHVASGKK 1011
>KF4A_HUMAN (O95239) Chromosome-associated kinesin KIF4A
(Chromokinesin)
Length = 1232
Score = 246 bits (627), Expect = 3e-64
Identities = 248/907 (27%), Positives = 416/907 (45%), Gaps = 80/907 (8%)
Query: 90 ISVTIRFRPLSEREYHRGDEIAW-YADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEV 148
+ V +R RPL +E G ++ + G+ V ++ +D VF P T +EV+
Sbjct: 10 VRVALRCRPLVPKEISEGCQMCLSFVPGEPQV--VVGTDKSFTYDFVFDPSTEQEEVFNT 67
Query: 149 AAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHG-----DQNSP--GIIPLAIKDVFSSIQ 201
A P++K +G N TV AYG T SGKT++M G +N P G+IP I+ +F I
Sbjct: 68 AVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEID 127
Query: 202 DTPGREFLLRVSYLEIYNEVINDLLDPTGQN--LRVREDA-QGTYVEGIKEEVVLSPGHA 258
EF L+VSYLEIYNE I DLL P+ + + +RED +G + G+ E+ VL
Sbjct: 128 KKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDT 187
Query: 259 LSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSE- 317
+S + G R V S N SSRSH IFT+ +E ++ + S+L+L+DLAGSE
Sbjct: 188 VSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDK-NSSFRSKLHLVDLAGSER 246
Query: 318 SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSS-HVPYRDSKLTRLLQSSLSGHGH 376
KT+ G R KEG IN+ LL LG VI L + K VPYRDSKLTRLLQ SL G+ H
Sbjct: 247 QKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSH 306
Query: 377 VSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEKSLIKKYQREISVLKLEL 436
+I V+PA SN+EET NTL++A RA++++ N I + + + ++++ L++ L
Sbjct: 307 TLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVN-IDPQTAELNHLKQQVQQLQVLL 365
Query: 437 DQLKKGMQFGVNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALA----SRIQKLTKLIL 492
Q G G E Q L E K QS +EE E+ L+ Q L ++IL
Sbjct: 366 LQAHGGTLPGSITVEPSENLQSLME---KNQSLVEENEKLSRGLSEAAGQTAQMLERIIL 422
Query: 493 VSSKNAN-PGYLADAPGH-------QQSLSTGED----DKYDALQDGSLLFESESQKDVS 540
N L + H Q+ + T ED + + + + L S + V+
Sbjct: 423 TEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVA 482
Query: 541 TVASDLSHDVRHRRTSSKRNEELSTSNSIITESTQAGELISRTRIPAGGVTMSDQMDLLV 600
+A+ + V E +S++ T+ +S+ + +++ +
Sbjct: 483 CMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELV---------ELNKAL 533
Query: 601 EQVKMLAGDIAFSTSTLKRLTEQSVNDPESSRTQIENLEQEIQEKRNQLRGLEQRIIESG 660
+ LA + + S L+ + Q ++ + ++ NL++E +E +L+ ++ ++
Sbjct: 534 ALKEALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKK---DAN 590
Query: 661 QTSVANPSLVEMQQV--TVTRLMTQCNEKAFELEIKSADNRVLQE-------QLNSKCSE 711
Q ++ +Q++ + L + NE++ L++K + R + + N +
Sbjct: 591 QAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQL 650
Query: 712 NRELQEKVKLLEQQLATDTGGTSLLLADECASGEHIDELKRKIQSQEIENEKLKLEQVQL 771
R+++E + Q L + + +L+R Q Q + L+ + +
Sbjct: 651 MRQMKEDAEKFRQWKQKRDKEVIQLKERDRKRQYELLKLERNFQKQ---SNVLRRKTEEA 707
Query: 772 SEENSGLHVQNQKLSEEASYAKELAS----AAAVELKNLAGEVTKLSLQNAKLEKELMAA 827
+ N L QK E A KE S A +KN G ++ + + ++ L
Sbjct: 708 AAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHL--- 764
Query: 828 RNLANTRSAVTHTVNGVHRK----YNDPRSGRKARVSSRANENVGPGRDELESWSLEVDD 883
+L R + V + K N P R+ S E G + +S + +++
Sbjct: 765 NDLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFS--LTEVRGQVSESEDSITKQIES 822
Query: 884 LKMELQARKQREAALEAALAEKEIMEEEHRNRVE------EAKKRESSLENDLANMWVLV 937
L+ E++ R + A L+ L + E E+ + R E EAK L +L + + V
Sbjct: 823 LETEMEFRSAQIADLQQKLLDAE-SEDRPKQRWENIATILEAKCALKYLIGELVSSKIQV 881
Query: 938 AKLKKEV 944
+KL+ +
Sbjct: 882 SKLESSL 888
>KI22_STRPU (P46872) Kinesin-II 85 kDa subunit (KRP-85/95 85 kDa
subunit)
Length = 699
Score = 244 bits (623), Expect = 9e-64
Identities = 154/376 (40%), Positives = 223/376 (58%), Gaps = 18/376 (4%)
Query: 84 STPRDSISVTIRFRPLSEREYHRGDEIAWYAD---GDKIVRN----EFNPATAYAFDKVF 136
S+ D++ V +R RPL+ +E +G + D G V N P ++ FD VF
Sbjct: 5 SSGNDNVRVVVRCRPLNSKETGQGFKSVVKMDEMRGTVQVTNPNAPSGEPPKSFTFDTVF 64
Query: 137 GPHTNSDEVYEVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLAI 193
P +VY A+P+V A +EG NGT+FAYG T +GKT TM G ++ P GIIP +
Sbjct: 65 APGAKQTDVYNQTARPIVDAIIEGYNGTIFAYGQTGTGKTFTMEGVRSQPELRGIIPNSF 124
Query: 194 KDVFSSI-QDTPGREFLLRVSYLEIYNEVINDLLDPTGQN-LRVREDAQ-GTYVEGIKEE 250
+F I ++ FL+RVSYLEIYNE + DLL Q+ L V+E G YV+ +
Sbjct: 125 AHIFGHIAKEQENVRFLVRVSYLEIYNEEVKDLLGKDQQHRLEVKERPDVGVYVKDLSAF 184
Query: 251 VVLSPGHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHG-EEYDGVIFSQLN 309
VV + + G ++R VG+ N N SSRSH IFT+ +E S G ++ V +L+
Sbjct: 185 VVNNADDMDRIMTLGNKNRSVGATNMNESSSRSHAIFTITLERSDMGLDKEQHVRVGKLH 244
Query: 310 LIDLAGSE-SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLLQ 368
++DLAGSE +KT TG R KE + IN SL TLG VI L +GKS+H+PYR+SKLTRLLQ
Sbjct: 245 MVDLAGSERQTKTGATGQRLKEATKINLSLSTLGNVISSLVDGKSTHIPYRNSKLTRLLQ 304
Query: 369 SSLSGHGHVSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEK-SLIKKYQR 427
SL G+ + + PA N +ET +TL++A+RAK ++ A N+ D K +L++++Q+
Sbjct: 305 DSLGGNAKTVMCANIGPAEYNYDETISTLRYANRAKNIKNKAKINE--DPKDALLREFQK 362
Query: 428 EISVLKLELDQLKKGM 443
EI LK ++ + +G+
Sbjct: 363 EIEELKKQISESGEGL 378
Score = 35.0 bits (79), Expect = 1.1
Identities = 41/233 (17%), Positives = 89/233 (37%), Gaps = 6/233 (2%)
Query: 755 QSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAGEVTKLS 814
+ Q + KL + + SE + Q+L E L++ V + G+ T +
Sbjct: 234 KEQHVRVGKLHMVDLAGSERQTKTGATGQRLKEATKINLSLSTLGNVISSLVDGKSTHIP 293
Query: 815 LQNAKLEKELMAARNLANTRSAVTHTVNGVHRKYNDPRS-----GRKARVSSRANENVGP 869
+N+KL + L + N ++ + + Y++ S R + ++A N P
Sbjct: 294 YRNSKLTRLLQDSLG-GNAKTVMCANIGPAEYNYDETISTLRYANRAKNIKNKAKINEDP 352
Query: 870 GRDELESWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKRESSLEND 929
L + E+++LK ++ + E + +E+ EE V++ +K ++
Sbjct: 353 KDALLREFQKEIEELKKQISESGEGLDDDEESGSEESGDEEAGEGGVKKKRKGKNPKRKL 412
Query: 930 LANMWVLVAKLKKEVGVVAESNIDKISGDGEAHTNDPKTNDSESNIISKEQTL 982
+ + K E E D + D + + +SE + +Q +
Sbjct: 413 SPEIMAAMQKKIDEEKKALEEKKDMVEEDRNTVHRELQRRESELHKAQDDQKI 465
Score = 33.5 bits (75), Expect = 3.1
Identities = 53/223 (23%), Positives = 90/223 (39%), Gaps = 44/223 (19%)
Query: 748 DELKRKIQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLA 807
D L R+ Q + E +K Q+SE GL + SEE+ E A V+ K
Sbjct: 354 DALLREFQKEIEELKK------QISESGEGLDDDEESGSEESG--DEEAGEGGVKKKR-- 403
Query: 808 GEVTKLSLQNAKLEKELMAA---------RNLANTRSAVTHTVNGVHR----------KY 848
K KL E+MAA + L + V N VHR K
Sbjct: 404 ----KGKNPKRKLSPEIMAAMQKKIDEEKKALEEKKDMVEEDRNTVHRELQRRESELHKA 459
Query: 849 NDPRSGRKARVSSRANENVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEIM 908
D + ++++ + + G D L + L+ K+R A E+ +++M
Sbjct: 460 QDDQKILNEKLNAIQKKLIVGGVDLLAKSEEQEQLLEQSALEMKERMAKQESM---RKMM 516
Query: 909 EEEHRNRVEEAKKRESSLEND-------LANMWVLVAKLKKEV 944
EE + R++ +++ SSL+++ L +W ++ + K EV
Sbjct: 517 EEREQERMD-IEEKYSSLQDEAHGKTKKLKKVWTMLMQAKSEV 558
>KI21_STRPU (P46871) Kinesin-II 95 kDa subunit (KRP-85/95 95 kDa
subunit)
Length = 742
Score = 243 bits (619), Expect = 3e-63
Identities = 166/447 (37%), Positives = 245/447 (54%), Gaps = 46/447 (10%)
Query: 83 SSTPRDSISVTIRFRPLSEREYHRGDEIAWYADGDKIVRNEFNPA-------TAYAFDKV 135
S +++ V +R RP++ +E +G + D + + NP ++ FD V
Sbjct: 2 SKKSAETVKVVVRCRPMNSKEISQGHKRIVEMDNKRGLVEVTNPKGPPGEPNKSFTFDTV 61
Query: 136 FGPHTNSDEVYEVAAKPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQNSP---GIIPLA 192
+ ++ ++Y+ + +V++ ++G NGT+FAYG T +GKT TM G +++P G+IP +
Sbjct: 62 YDWNSKQIDLYDETFRSLVESVLQGFNGTIFAYGQTGTGKTFTMEGVRSNPELRGVIPNS 121
Query: 193 IKDVFSSIQDTPGREFLLRVSYLEIYNEVINDLLDPTGQ---NLRVREDAQGTYVEGIKE 249
+ +F+ I T ++FL+R SYLEIY E I DLL + +L+ R D G YV+ +
Sbjct: 122 FEHIFTHIARTQNQQFLVRASYLEIYQEEIRDLLAKDQKKRLDLKERPDT-GVYVKDLSS 180
Query: 250 EVVLSPGHALSFIAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVI-FSQL 308
V S + G +R VGS N N SSRSH IF + IE S G + + I +L
Sbjct: 181 FVTKSVKEIEHVMTVGNNNRSVGSTNMNEHSSRSHAIFIITIECSELGVDGENHIRVGKL 240
Query: 309 NLIDLAGSE-SSKTETTGLRRKEGSYINKSLLTLGTVIGKLSEGKSSHVPYRDSKLTRLL 367
NL+DLAGSE +KT TG R KE + IN SL LG VI L +GKSSH+PYRDSKLTRLL
Sbjct: 241 NLVDLAGSERQAKTGATGDRLKEATKINLSLSALGNVISALVDGKSSHIPYRDSKLTRLL 300
Query: 368 QSSLSGHGHVSLICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKIIDEK-SLIKKYQ 426
Q SL G+ ++ + PAS N +ET TL++A+RAK ++ N+ D K +L++++Q
Sbjct: 301 QDSLGGNAKTVMVANMGPASYNFDETITTLRYANRAKNIKNKPKINE--DPKDALLREFQ 358
Query: 427 REISVLKLELDQL------------KKGMQFG--------------VNHEEILT-LKQKL 459
EIS LK LD+ K G Q G ++ EE+ +QKL
Sbjct: 359 EEISRLKQALDKKGPSDGRKKGKKRKPGEQGGDDDIEDETEEEGDEMDEEEMYKESQQKL 418
Query: 460 EEGQVKMQSRLEEEEEEKVALASRIQK 486
EE + K+ + EEK L S +QK
Sbjct: 419 EEEKEKIMANQSMIAEEKQKLLSEVQK 445
Score = 42.7 bits (99), Expect = 0.005
Identities = 37/177 (20%), Positives = 78/177 (43%), Gaps = 19/177 (10%)
Query: 851 PRSGRKARVSSRANENVGPG--RDELESWSLEVDDLKMELQARKQREAALEAALAEKEIM 908
P GRK + E G DE E E+D+ +M +++++ E E +A + ++
Sbjct: 373 PSDGRKKGKKRKPGEQGGDDDIEDETEEEGDEMDEEEMYKESQQKLEEEKEKIMANQSMI 432
Query: 909 EEEHRNRVEEAKKRESSLENDLANMWVLVAKLK---KEVGVVAESNIDKISGDGEAHTND 965
EE + + E +KR+ ++ + +L K+K ++ V +S +D HTN+
Sbjct: 433 AEEKQKLLSEVQKRQGEIKKEHQQKEMLEGKIKAMESKLLVGGKSIVD--------HTNE 484
Query: 966 PKTNDSESNIISKEQTLDVSEPNNETPKEEPLVVRLKARMQ------DMKEKELKHL 1016
+ E ++ E+ + + +++ V ++ ++K K+LK L
Sbjct: 485 QQRKIEEQRLLLAEEKNRERDMERKLKEQDDKTVEIEGTFSSLQQEVEVKTKKLKKL 541
Score = 36.6 bits (83), Expect = 0.37
Identities = 56/259 (21%), Positives = 104/259 (39%), Gaps = 57/259 (22%)
Query: 713 RELQEKVKLLEQQLAT----------------DTGGTSLLLADECASGEHIDE---LKRK 753
RE QE++ L+Q L + GG + + G+ +DE K
Sbjct: 355 REFQEEISRLKQALDKKGPSDGRKKGKKRKPGEQGGDDDIEDETEEEGDEMDEEEMYKES 414
Query: 754 IQSQEIENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAGEVTKL 813
Q E E EK+ Q ++EE QKL E++ GE+ K
Sbjct: 415 QQKLEEEKEKIMANQSMIAEE-------KQKLLS--------------EVQKRQGEIKKE 453
Query: 814 SLQNAKLEKEL--MAARNLANTRSAVTHTVNGVHRKYNDPR------SGRKARVSSRANE 865
Q LE ++ M ++ L +S V HT N RK + R R+ + + E
Sbjct: 454 HQQKEMLEGKIKAMESKLLVGGKSIVDHT-NEQQRKIEEQRLLLAEEKNRERDMERKLKE 512
Query: 866 NVGPGRDELESWSLEVDDLKMELQARKQREAALEAALAEKEIMEEEHRNRVEEAKKRESS 925
+ ++S +++++ + K+ A L++ ++ + +++EH +E ++ ++
Sbjct: 513 QDDKTVEIEGTFSSLQQEVEVKTKKLKKLFAKLQSYKSDIQDLQDEHARERQELEQTQNE 572
Query: 926 LENDLANMWVLVAKLKKEV 944
L +L KLKK +
Sbjct: 573 LIREL--------KLKKVI 583
>KF4A_CHICK (Q90640) Chromosome-associated kinesin KIF4A
(Chromokinesin)
Length = 1225
Score = 242 bits (618), Expect = 3e-63
Identities = 250/907 (27%), Positives = 417/907 (45%), Gaps = 90/907 (9%)
Query: 94 IRFRPLSEREYHRGDEIAW-YADGDKIVRNEFNPATAYAFDKVFGPHTNSDEVYEVAAKP 152
+R RPL +E G ++ + G+ V A+ +D VF P +EV+ A P
Sbjct: 14 VRCRPLVPKETSEGCQMCLSFVPGEPQVI--VGSDKAFTYDYVFDPSVEQEEVFNTAVAP 71
Query: 153 VVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQN-------SPGIIPLAIKDVFSSIQDTPG 205
+++ +G N TV AYG T SGKT++M G S G+IP IK +F +
Sbjct: 72 LIRGIFKGYNATVLAYGQTGSGKTYSMGGTYTASQEHDPSMGVIPRVIKLLFKEKEQRQD 131
Query: 206 REFLLRVSYLEIYNEVINDLLDPTGQN---LRVREDA-QGTYVEGIKEEVVLSPGHALSF 261
EF+L+VSYLEIYNE I DLL + + + +RED +G + G+ E V S +S
Sbjct: 132 WEFVLKVSYLEIYNEDILDLLCSSRERSSQISIREDPKEGIKIVGLTERNVASARDTVSC 191
Query: 262 IAAGEEHRHVGSNNFNLFSSRSHTIFTLMIESSAHGEEYDGVIFSQLNLIDLAGSE-SSK 320
+ G R V S N SSRSH IFT+ I+ ++ + S+L+L+DLAGSE K
Sbjct: 192 LEQGNNCRTVASTAMNSQSSRSHAIFTICIDQKKKNDK-NSSFHSKLHLVDLAGSERQKK 250
Query: 321 TETTGLRRKEGSYINKSLLTLGTVIGKLSEG--KSSHVPYRDSKLTRLLQSSLSGHGHVS 378
T+ G R KEG IN+ LL LG VI L E K VPYRDSKLTRLLQ SL G+ H
Sbjct: 251 TKAEGDRLKEGININRGLLCLGNVISALGEENKKGGFVPYRDSKLTRLLQDSLGGNSHTL 310
Query: 379 LICTVTPASSNMEETHNTLKFASRAKRVEIYASRNKII-------DEKSLIKKYQREISV 431
+I V+PA SN+EET NTL++A RA+++ +NK I E + +K+ +++ V
Sbjct: 311 MIACVSPADSNLEETLNTLRYADRARKI-----KNKPIVNVDPQAAELNHLKQQVQQLQV 365
Query: 432 LKLE-----LDQLKKGMQFGVNHEEILTLKQKLEEGQVKMQSRLEEEEEEKVALASRIQK 486
L L+ L M N + ++ Q L E K+ L E A Q
Sbjct: 366 LLLQAHGGTLPVSINSMAPSENLQSLMEKNQSLMEENEKLSRGLSE------AAGQTAQM 419
Query: 487 LTKLILVSSKNAN-PGYLADAPGH-------QQSLSTGEDDKYDA-------LQDGSLLF 531
L ++I+ +N L H Q+ L T ED++ LQ F
Sbjct: 420 LERIIVTEQENEKMNAKLEQLQQHAVCKLDLQKLLETVEDEELKENVEVIRNLQQVLAQF 479
Query: 532 ESES--QKDVSTVASDLSHDVRHRRTS---SKRNEELSTSNSIITESTQAGELIS----- 581
+SES + +T ++ D + +KR+ + T+ + ++ + EL+
Sbjct: 480 QSESAAAAEAATEMANAEQDAAGEAETGQVTKRSSDDFTTQHALRQAQMSKELVELNKAL 539
Query: 582 --RTRIPAGGVTMSDQMDLLVEQVKMLAGDIAFSTSTLKRLTEQSVNDPESSRTQIENLE 639
+ + + Q++ + Q + D+ S L++ E+ + ++ + N
Sbjct: 540 ALKEALAKKMIQNDSQLEPIQSQYQTNIKDLELEVSNLQKEKEELILALSMAKKDV-NQA 598
Query: 640 QEIQEKRNQLRGLEQRIIESGQTSVANPSLVEMQQVTVTRLMTQCNEKAFELEIKSADNR 699
+ + +R +L+ LE +I E + L+++++ T R +++ N++ E++ +
Sbjct: 599 KLSERRRKRLQELEGQINELKKKLNEQAKLLKLKEST-ERTVSKLNQEIREMKNQRVQ-- 655
Query: 700 VLQEQLNSKCSENRE-LQEKVKLLEQQLATDTGGTSLLLADECASGEHIDELKRKIQSQE 758
L Q+ + R+ Q+K K + Q D LL E + L+RK +
Sbjct: 656 -LMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQYELLKLERDFQKQASVLRRKTEEAA 714
Query: 759 IENEKLKLEQVQLSEENSGLHVQNQKLSEEASYAKELASAAAVELKNLAG-EVTKLSLQN 817
N++LK + +Q E + ++Q E A + S A E++ L E + L +
Sbjct: 715 AANKRLK-DALQKQREAADKRKESQNRGME-GVAARVKSWLANEVEVLVSTEEARRHLAD 772
Query: 818 AKLEKELMAAR--NLANTRSAVTHTVNGVHRKYNDPRSGRKARVSSRANENVGPGRDELE 875
+++++A L + + + + + R+ + + + ++ + E+E
Sbjct: 773 LLEDRKILAQELLQLKEKKESGENPPSKLRRRTYSITDLQASEMDLSLSKQIESLETEME 832
Query: 876 SWSLEVDDLKMEL------QARKQR----EAALEAALAEKEIMEEEHRNRVEEAKKRESS 925
S ++ DL+ +L KQR LEA A K ++ E ++V+E+ K ESS
Sbjct: 833 LRSAQIADLQQKLLDADNGDRVKQRWDNIATILEAKCALKYLLGELVSSKVQES-KLESS 891
Query: 926 LENDLAN 932
L+ N
Sbjct: 892 LQQSKTN 898
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.309 0.126 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,675,617
Number of Sequences: 164201
Number of extensions: 4967499
Number of successful extensions: 24695
Number of sequences better than 10.0: 1190
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 936
Number of HSP's that attempted gapping in prelim test: 19038
Number of HSP's gapped (non-prelim): 3574
length of query: 1063
length of database: 59,974,054
effective HSP length: 121
effective length of query: 942
effective length of database: 40,105,733
effective search space: 37779600486
effective search space used: 37779600486
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Medicago: description of AC146745.5