BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= AC141109.8 + phase: 0
(509 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1) 287 4e-77
MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprote... 287 4e-77
MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprote... 283 7e-76
MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprote... 281 3e-75
MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprote... 276 9e-74
MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprote... 276 9e-74
MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprote... 273 8e-73
MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprote... 270 5e-72
MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein... 266 7e-71
MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprote... 266 1e-70
AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,... 262 2e-69
AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette, s... 260 7e-69
MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprote... 258 3e-68
AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,... 258 3e-68
PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1 249 2e-65
AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,... 247 6e-65
MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprote... 241 3e-63
MDR4_DROME (Q00449) Multidrug resistance protein homolog 49 (P-g... 233 1e-60
MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprote... 232 1e-60
MDR5_DROME (Q00748) Multidrug resistance protein homolog 65 (P-g... 215 2e-55
>MDR1_RAT (P43245) Multidrug resistance protein 1 (P-glycoprotein 1)
Length = 1277
Score = 287 bits (735), Expect = 4e-77
Identities = 174/519 (33%), Positives = 280/519 (53%), Gaps = 28/519 (5%)
Query: 1 MGGGDQKNVSINDKKKKNGSFKS-------IFMHADVLDWFFMAFGFFGAIGDGMMVPFV 53
+ G KN S KK K K +F +AD LD MA G AI G ++P +
Sbjct: 7 LNGRADKNFSKMGKKSKKEKEKKPAVGIFGMFRYADWLDKLCMALGTLAAIIHGTLLPLL 66
Query: 54 LFITSKIMNS------------VGSASGTSSSNFVHDVNKNAVVVLY------MACASFF 95
+ + + +S + + S +S++ V D + + +Y +
Sbjct: 67 MLVFGYMTDSFTPSRDPHSDRAITNQSEINSTHTVSDTSLEEDMAMYAYYYTGIGAGVLI 126
Query: 96 VCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDV 155
V +++ W RQ ++R ++ A++ QE+ +FD V ++ T ++ D I D
Sbjct: 127 VAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFD--VNDAGELNTRLTDDVSKINDG 184
Query: 156 LSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIRE 215
+ DK+ F + + F + I+ F W+L +V L+ + M+ ++ K +
Sbjct: 185 IGDKLGMFFQSITTFSAGFIIGFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQ 244
Query: 216 EYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGV 274
Y +AG +AE+ +++IRTV +F G+ K L ++ LE + ++G+K+ + ++IG + +
Sbjct: 245 AYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRVGIKKAITANISIGIAYLL 304
Query: 275 VYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERI 334
VYA ++L F+YG+ +V+ + G V V ++ +G + G N+ FA A A I
Sbjct: 305 VYASYALAFWYGTSLVLSNEYSIGQVLTVFFSILLGTFSIGHLAPNIEAFANARGAAYEI 364
Query: 335 MEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVAL 394
++I P+IDS + +G + ++G +EF NV F YPSR E IL LKV SG+TVAL
Sbjct: 365 FKIIDNEPSIDSFSTKGHKPDSIMGNLEFKNVYFNYPSRSEVKILKGLNLKVKSGQTVAL 424
Query: 395 VGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIK 454
VG SG GKST V LLQR YDPI GE+ +DG I + +++LR +G+VSQEP LFAT+I
Sbjct: 425 VGNSGCGKSTTVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIA 484
Query: 455 ENILFGREDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
ENI +GRE+ T +EI A K +NA++FI LP +DT V
Sbjct: 485 ENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLV 523
Score = 238 bits (606), Expect = 4e-62
Identities = 145/470 (30%), Positives = 253/470 (52%), Gaps = 8/470 (1%)
Query: 29 DVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLY 88
++ +W ++ G A+ +G + P + SKI+ + + N +++ L
Sbjct: 702 NISEWPYLVVGVLCAVINGCIQPVFAIVFSKIVGVFSRDDDHETKQ--RNCNLFSLLFLV 759
Query: 89 MACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSD 148
M SF F +G+ + + GE R+R K++LRQ++S+FD H +T + T ++SD
Sbjct: 760 MGMISFVTYFFQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDHKNTTGSLTTRLASD 819
Query: 149 SLVIQDVLSDKVPNFLVNASRFLSSNIVAFALL--WRLAIVGFPFMVLLVIPGYMYKRIS 206
+ ++ + ++ N + + I++ L+ W+L ++ + L+V+ G + ++
Sbjct: 820 ASNVKGAMGSRLAVVTQNVANLGTGIILSLVLVYGWQLTLLLVVIIPLIVLGGIIEMKLL 879
Query: 207 MRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKG 266
A K ++E +G IA +AI + RTV S E K ++ +L+ + LK+ G
Sbjct: 880 SGQALKDKKELEISGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFG 939
Query: 267 LAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFA 325
+ + ++Y ++ F +G+ +V V +V + G +A G S +A
Sbjct: 940 ITFAFTQAMIYFSYAACFRFGAYLVARELMTFENVMLVFSAVVFGAMAAGNTSSFAPDYA 999
Query: 326 EASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLK 385
+A V+ I+ +I+++P IDS + EG + G V+FN V+F YP+RP +L +
Sbjct: 1000 KAKVSASHIIGIIEKIPEIDSYSTEGLKPNWLEGNVKFNGVKFNYPTRPNIPVLQGLSFE 1059
Query: 386 VPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQE 445
V G+T+ LVG SG GKSTVV LL+RFY+P+ G + LDG I +L ++ +R+ +G+VSQE
Sbjct: 1060 VKKGQTLRLVGSSGCGKSTVVQLLERFYNPMAGTVFLDGKEIKQLNVQCVRA-LGIVSQE 1118
Query: 446 PALFATSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
P LF SI ENI +G ++EEIV AA+ +N H FI LP+ Y+T+V
Sbjct: 1119 PILFDCSIAENIAYGDNSRVVSHEEIVRAAREANIHQFIDSLPEKYNTRV 1168
>MDR1_MOUSE (P06795) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1276
Score = 287 bits (735), Expect = 4e-77
Identities = 168/508 (33%), Positives = 278/508 (54%), Gaps = 21/508 (4%)
Query: 4 GDQKNVSINDKKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI------- 56
G + +KK G F +F +AD LD M G AI G ++P ++ +
Sbjct: 19 GKKSKKEKKEKKPAVGVF-GMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDS 77
Query: 57 ----TSKIMNSVGSASGTSSSNFVHDVNKNAVVVLY------MACASFFVCFLEGYCWTR 106
+ I+ S+ + SG +S+ + + + + +Y + V +++ W
Sbjct: 78 FTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCL 137
Query: 107 TGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVN 166
RQ ++R ++ A++ QE+ +FD+H ++ T ++ D I D + DK+ F +
Sbjct: 138 AAGRQIHKIRQKFFHAIMNQEIGWFDVH--DVGELNTRLTDDVSKINDGIGDKIGMFFQS 195
Query: 167 ASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQ 226
+ FL+ I+ F W+L +V L+ + ++ ++ K + Y +AG +AE+
Sbjct: 196 ITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEE 255
Query: 227 AISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYY 285
+++IRTV +F G+ K L ++ LE + +G+K+ + ++IG + +VYA ++L F+Y
Sbjct: 256 VLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWY 315
Query: 286 GSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTID 345
G+ +V+ + G V V ++ +G + G N+ FA A A I ++I P+ID
Sbjct: 316 GTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSID 375
Query: 346 SENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTV 405
S + +G + ++G +EF NV F YPSR E IL LKV SG+TVALVG SG GKST
Sbjct: 376 SFSTKGYKPDSIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTT 435
Query: 406 VSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDAT 465
V L+QR YDP+ G + +DG I + +++LR +G+VSQEP LFAT+I ENI +GRED T
Sbjct: 436 VQLMQRLYDPLEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVT 495
Query: 466 YEEIVDAAKASNAHNFISMLPQGYDTQV 493
+EI A K +NA++FI LP +DT V
Sbjct: 496 MDEIEKAVKEANAYDFIMKLPHQFDTLV 523
Score = 251 bits (642), Expect = 2e-66
Identities = 147/471 (31%), Positives = 253/471 (53%), Gaps = 5/471 (1%)
Query: 26 MHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVV 85
++ ++ +W ++ G A+ +G + P + S+I+ + + N ++
Sbjct: 699 LNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKR--QNCNLFSLF 756
Query: 86 VLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSV 145
L M SF F +G+ + + GE R+R K++LRQ++S+FD H ST + T +
Sbjct: 757 FLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRL 816
Query: 146 SSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRI 205
+SD+ ++ + ++ N + + I++ W+L ++ + L+V+ G + ++
Sbjct: 817 ASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKL 876
Query: 206 SMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAK 265
A K +++ +G IA +AI + RT+ S E K ++ +L+ + +K+
Sbjct: 877 LSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVF 936
Query: 266 GLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYF 324
G+ + ++Y ++ F +G+ +V V +V + G +A G S +
Sbjct: 937 GITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDY 996
Query: 325 AEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCL 384
A+A V+ I+ +I++ P IDS + EG + G V+FN V+F YP+RP +L L
Sbjct: 997 AKAKVSASHIIRIIEKTPEIDSYSTEGLKPTLLEGNVKFNGVQFNYPTRPNIPVLQGLSL 1056
Query: 385 KVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQ 444
+V G+T+ALVG SG GKSTVV LL+RFYDP+ G + LDG I +L ++WLR+ +G+VSQ
Sbjct: 1057 EVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAHLGIVSQ 1116
Query: 445 EPALFATSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
EP LF SI ENI +G ++EEIV AAK +N H FI LP Y+T+V
Sbjct: 1117 EPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRV 1167
>MDR2_CRIGR (P21449) Multidrug resistance protein 2 (P-glycoprotein
2)
Length = 1276
Score = 283 bits (724), Expect = 7e-76
Identities = 167/498 (33%), Positives = 271/498 (53%), Gaps = 19/498 (3%)
Query: 13 DKKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSS 72
+K+ N +F +AD LD +M G A+ G +P ++ + + +S A +
Sbjct: 28 EKENPNVGIFGMFRYADWLDKLYMVLGTLAAVLHGTSLPLLMLVFGNMTDSFTKAETSIW 87
Query: 73 SNFVHDVNKNAVVVLY------MACASFF----------VCFLEGYCWTRTGERQAARMR 116
N + N V+ MA +++ V +++ W RQ ++R
Sbjct: 88 PNMTNQSEINNTEVISGSLEEDMATYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQINKIR 147
Query: 117 VRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIV 176
++ A++ QE+ +FD+H ++ T ++ D I D + DK+ F + + FL++ IV
Sbjct: 148 QKFFHAIMNQEIGWFDVH--DIGELNTRLTDDVSKINDGIGDKIGMFFQSIATFLAAFIV 205
Query: 177 AFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYS 236
F W+L +V L+ + M+ ++ K + Y +AG +AE+ +++IRTV +
Sbjct: 206 GFISGWKLTLVILAVSPLIGLSSAMWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIA 265
Query: 237 FVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGA 295
F G++K L ++ LE + +G+K+ + ++IG + +VYA ++L F+YG+ +V+ +
Sbjct: 266 FGGQNKELERYNKNLEEAKNVGIKKAVTANISIGIAYLLVYASYALAFWYGTSLVLSNEY 325
Query: 296 KGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIE 355
G V V ++ G + G N+ FA A A I ++I P+IDS + +G +
Sbjct: 326 SVGQVLTVFFSILFGTFSIGHIAPNIEVFANARGAAYEIFKIIDNEPSIDSFSTQGHKPD 385
Query: 356 KVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDP 415
V+G +EF NV F YPSR IL LKV SG+TVALVG SG GKST V LLQR YDP
Sbjct: 386 SVMGNLEFKNVHFSYPSRSGIKILKGLNLKVQSGQTVALVGKSGCGKSTTVQLLQRLYDP 445
Query: 416 IGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIVDAAKA 475
G + +DG I + +++LR +G+VSQEP LFAT+I ENI +GRE+ T +EI A K
Sbjct: 446 TEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 505
Query: 476 SNAHNFISMLPQGYDTQV 493
+NA++FI LP +DT V
Sbjct: 506 ANAYDFIMKLPHKFDTLV 523
Score = 253 bits (645), Expect = 1e-66
Identities = 153/498 (30%), Positives = 263/498 (52%), Gaps = 8/498 (1%)
Query: 2 GGGDQ-KNVSINDKKKKNGSFKSIF--MHADVLDWFFMAFGFFGAIGDGMMVPFVLFITS 58
G DQ + VS+ + + ++ S + + ++ +W ++ G A+ +G M P + S
Sbjct: 672 GSQDQERRVSVKEAQDEDVPLVSFWGILKLNITEWPYLVVGVLCAVINGCMQPVFSIVFS 731
Query: 59 KIMNSVGSASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVR 118
I+ + + N ++ L M F F +G+ + + GE R+R
Sbjct: 732 GIIGVFTRDDDPKTKQ--QNCNLFSLFFLVMGMICFVTYFFQGFTFGKAGEILTKRLRYM 789
Query: 119 YLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAF 178
K++LRQ++S+FD H ST + T ++SD+ ++ +S ++ N + + I++
Sbjct: 790 VFKSMLRQDISWFDDHRNSTGALTTRLASDAANVKGAMSSRLAGITQNVANLGTGIIISL 849
Query: 179 ALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFV 238
W+L ++ L+++ G M ++ A K ++E +G IA +AI + RTV S
Sbjct: 850 VYGWQLTLLLVVIAPLIILSGMMEMKVLSGQALKDKKELEVSGKIATEAIENFRTVVSLT 909
Query: 239 GESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKG 297
E K ++ +L+ + LK+ G+ + ++Y ++ F +G+ +V +
Sbjct: 910 REQKFENMYAQSLQIPYRNALKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVAHQIMTF 969
Query: 298 GTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKV 357
V +V + G +A G S +A+A V+ I+ +++++P+IDS + G +
Sbjct: 970 ENVMLVFSAVVFGAIAAGNASSFAPDYAKAKVSASHIIRIMEKIPSIDSYSTRGLKPNWL 1029
Query: 358 LGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIG 417
G V+FN V F YP+RP+ +L L+V G+T+ALVG SG GKSTVV LL+RFYDP+
Sbjct: 1030 EGNVKFNEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA 1089
Query: 418 GEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGRED--ATYEEIVDAAKA 475
G + LDG I +L ++WLR+ +G+VSQEP LF SI ENI +G + +EI AAK
Sbjct: 1090 GTVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKE 1149
Query: 476 SNAHNFISMLPQGYDTQV 493
+N H FI LP Y+T+V
Sbjct: 1150 ANIHQFIESLPDKYNTRV 1167
>MDR3_MOUSE (P21447) Multidrug resistance protein 3 (P-glycoprotein
3) (MDR1A)
Length = 1276
Score = 281 bits (719), Expect = 3e-75
Identities = 165/503 (32%), Positives = 270/503 (52%), Gaps = 17/503 (3%)
Query: 6 QKNVSINDKKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVG 65
+K+ +KK S ++F +A LD +M G AI G+ +P ++ I + +S
Sbjct: 20 KKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFA 79
Query: 66 SASGTS-SSNFVHDVNKNAVVVLY-------------MACASFFVCFLEGYCWTRTGERQ 111
S S +S + + +K A+ + V +++ W RQ
Sbjct: 80 SVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQ 139
Query: 112 AARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFL 171
++R ++ A++ QE+ +FD+H ++ T ++ D I + + DK+ F + F
Sbjct: 140 IHKIRQKFFHAIMNQEIGWFDVH--DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFF 197
Query: 172 SSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSI 231
I+ F W+L +V +L + ++ +I K Y +AG +AE+ +++I
Sbjct: 198 GGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAI 257
Query: 232 RTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNGV-VYAIWSLIFYYGSIMV 290
RTV +F G+ K L ++N LE + +LG+K+ + +++G+ + +YA ++L F+YG+ +V
Sbjct: 258 RTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLV 317
Query: 291 MYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENME 350
+ G V V ++ IG + G N+ FA A A + ++I P+IDS +
Sbjct: 318 ISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKS 377
Query: 351 GEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQ 410
G + + G +EF N+ F YPSR E IL LKV SG+TVALVG SG GKST V L+Q
Sbjct: 378 GHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQ 437
Query: 411 RFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIV 470
R YDP+ G + +DG I + +++LR +G+VSQEP LFAT+I ENI +GRED T +EI
Sbjct: 438 RLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIE 497
Query: 471 DAAKASNAHNFISMLPQGYDTQV 493
A K +NA++FI LP +DT V
Sbjct: 498 KAVKEANAYDFIMKLPHQFDTLV 520
Score = 248 bits (634), Expect = 2e-65
Identities = 148/465 (31%), Positives = 249/465 (52%), Gaps = 5/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W + G F AI +G + P I SK++ + + + N +++ L +
Sbjct: 703 EWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQR--QNSNLFSLLFLILGI 760
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
SF FL+G+ + + GE R+R K++LRQ+VS+FD +T + T +++D+
Sbjct: 761 ISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQ 820
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
++ ++ N + + I++ W+L ++ + ++ I G + ++ A
Sbjct: 821 VKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL 880
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
K ++E +G IA +AI + RTV S E K ++ +L+ + +K+ G+
Sbjct: 881 KDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFFF 940
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
+ ++Y ++ F +G+ +V V +V + G +A G S +A+A+V+
Sbjct: 941 TQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVS 1000
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
I+ +I++ P IDS + +G + G V+F+ F YP+RP +L L+V G+
Sbjct: 1001 ASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGFVFNYPTRPSIPVLQGLSLEVKKGQ 1060
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+ALVG SG GKSTVV LL+RFYDP+ G + LDG I +L ++WLR+Q+G+VSQEP LF
Sbjct: 1061 TLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFD 1120
Query: 451 TSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI ENI +G +YEEIV AAK +N H FI LP Y+T+V
Sbjct: 1121 CSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRV 1165
>MDR1_HUMAN (P08183) Multidrug resistance protein 1 (P-glycoprotein
1) (CD243 antigen)
Length = 1280
Score = 276 bits (706), Expect = 9e-74
Identities = 167/518 (32%), Positives = 278/518 (53%), Gaps = 28/518 (5%)
Query: 2 GGGDQKNV------SINDKKKKNGSFK--SIFMHADVLDWFFMAFGFFGAIGDGMMVPFV 53
GG +KN S DKK+K + S+F +++ LD +M G AI G +P +
Sbjct: 9 GGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLM 68
Query: 54 LFITSK-------------IMNSVGSASGTSSSNFVHDVNKNAVVVLY----MACASFFV 96
+ + + +M+++ + S + + F ++ ++ Y +
Sbjct: 69 MLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVA 128
Query: 97 CFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVL 156
+++ W RQ ++R ++ A++RQE+ +FD+H ++ T ++ D I + +
Sbjct: 129 AYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVH--DVGELNTRLTDDVSKINEGI 186
Query: 157 SDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREE 216
DK+ F + + F + IV F W+L +V +L + ++ +I K
Sbjct: 187 GDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLA 246
Query: 217 YNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNGV-V 275
Y +AG +AE+ +++IRTV +F G+ K L ++ LE + ++G+K+ + ++IG+ + +
Sbjct: 247 YAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLI 306
Query: 276 YAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIM 335
YA ++L F+YG+ +V+ G V V ++ IG + G ++ FA A A I
Sbjct: 307 YASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIF 366
Query: 336 EVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALV 395
++I P+IDS + G + + G +EF NV F YPSR E IL LKV SG+TVALV
Sbjct: 367 KIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALV 426
Query: 396 GGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKE 455
G SG GKST V L+QR YDP G + +DG I + +++LR +G+VSQEP LFAT+I E
Sbjct: 427 GNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAE 486
Query: 456 NILFGREDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
NI +GRE+ T +EI A K +NA++FI LP +DT V
Sbjct: 487 NIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLV 524
Score = 250 bits (639), Expect = 5e-66
Identities = 153/473 (32%), Positives = 253/473 (53%), Gaps = 9/473 (1%)
Query: 26 MHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVV 85
M ++ +W + G F AI +G + P I SKI+ + N N
Sbjct: 701 MKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKR----QNSNLFS 756
Query: 86 VLYMACA--SFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVIT 143
+L++A SF FL+G+ + + GE R+R +++LRQ+VS+FD +T + T
Sbjct: 757 LLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTT 816
Query: 144 SVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYK 203
+++D+ ++ + ++ N + + I++F W+L ++ + ++ I G +
Sbjct: 817 RLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEM 876
Query: 204 RISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGL 263
++ A K ++E AG IA +AI + RTV S E K ++ +L+ + L++
Sbjct: 877 KMLSGQALKDKKELEGAGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAH 936
Query: 264 AKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVR 322
G+ + ++Y ++ F +G+ +V + V +V + G +A G S
Sbjct: 937 IFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAP 996
Query: 323 YFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDF 382
+A+A ++ I+ +I++ P IDS + EG + + G V F V F YP+RP+ +L
Sbjct: 997 DYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGL 1056
Query: 383 CLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLV 442
L+V G+T+ALVG SG GKSTVV LL+RFYDP+ G++LLDG I +L ++WLR+ +G+V
Sbjct: 1057 SLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIV 1116
Query: 443 SQEPALFATSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SQEP LF SI ENI +G + EEIV AAK +N H FI LP Y T+V
Sbjct: 1117 SQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKV 1169
>MDR1_CRIGR (P21448) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1276
Score = 276 bits (706), Expect = 9e-74
Identities = 165/504 (32%), Positives = 270/504 (52%), Gaps = 18/504 (3%)
Query: 6 QKNVSINDKKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVG 65
+K+ +KK S ++F +A LD +M G AI G+ +P ++ + + +S
Sbjct: 20 RKSKKEKKEKKPVVSVFTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLVFGDMTDSFA 79
Query: 66 SASG--TSSSNFVHDVNKNAV-------VVLY------MACASFFVCFLEGYCWTRTGER 110
S T+++N VN + + + Y + V +++ W R
Sbjct: 80 SVGNIPTNATNNATQVNASDIFGKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGR 139
Query: 111 QAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRF 170
Q ++R ++ A++ QE+ +FD+H ++ T ++ D I + + DK+ F + F
Sbjct: 140 QIHKIRQKFFHAIMNQEIGWFDVH--DVGELNTRLTDDVSKINEGIGDKIGMFFQAMATF 197
Query: 171 LSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISS 230
I+ F W+L +V +L + ++ +I K + Y +AG +AE+ +++
Sbjct: 198 FGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVAEEVLAA 257
Query: 231 IRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNGV-VYAIWSLIFYYGSIM 289
IRTV +F G+ K L ++N LE + +LG+K+ + +++G+ + +YA ++L F+YG+ +
Sbjct: 258 IRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSL 317
Query: 290 VMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENM 349
V+ G V V + IG + G N+ FA A A I +I P+IDS +
Sbjct: 318 VISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSK 377
Query: 350 EGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLL 409
G + + G +EF N+ F YPSR + IL LKV SG+TVALVG SG GKST V LL
Sbjct: 378 NGYKPDNIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLL 437
Query: 410 QRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEI 469
QR YDP G + +DG I + +++LR +G+VSQEP LFAT+I ENI +GRE+ T +EI
Sbjct: 438 QRLYDPTEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEI 497
Query: 470 VDAAKASNAHNFISMLPQGYDTQV 493
A K +NA++FI LP +DT V
Sbjct: 498 EKAVKEANAYDFIMKLPHKFDTLV 521
Score = 249 bits (635), Expect = 2e-65
Identities = 150/465 (32%), Positives = 249/465 (53%), Gaps = 5/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W + G F AI +G + P I SK++ T HD N +++ L +
Sbjct: 704 EWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVF--TRNTDDETKRHDSNLFSLLFLILGV 761
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
SF FL+G+ + + GE R+R K++LRQ+VS+FD +T + T +++D+
Sbjct: 762 ISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQ 821
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
++ ++ N + + I++ W+L ++ + ++ I G + ++ A
Sbjct: 822 VKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQAL 881
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
K ++E +G IA +AI + RTV S E K ++ +L+ + LK+ G+
Sbjct: 882 KDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQIPYRNALKKAHVFGITFSF 941
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
+ ++Y ++ F +G+ +V V +V + G +A G S +A+A V+
Sbjct: 942 TQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVS 1001
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
I+ +I++VP+IDS + G + G V+FN V F YP+RP+ +L L+V G+
Sbjct: 1002 ASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQ 1061
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+ALVG SG GKSTVV LL+RFYDP+ G + LDG +++L ++WLR+ +G+VSQEP LF
Sbjct: 1062 TLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFD 1121
Query: 451 TSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI ENI +G + +EI AAK +N H FI LP Y+T+V
Sbjct: 1122 CSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRV 1166
>MDR3_HUMAN (P21439) Multidrug resistance protein 3 (P-glycoprotein
3)
Length = 1279
Score = 273 bits (698), Expect = 8e-73
Identities = 169/510 (33%), Positives = 271/510 (53%), Gaps = 21/510 (4%)
Query: 3 GGDQKNVSINDKKKKNGSFKSI-----FMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI- 56
G + +S K+KK + K I F ++D D FM+ G AI G +P ++ +
Sbjct: 19 GDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVF 78
Query: 57 ---TSKIMNSVGSASGTSSSNFV---------HDVNKNAVVVLYMACASFFVCFLEGYCW 104
T K +++ G+ S + + ++ + A + +++ W
Sbjct: 79 GEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFW 138
Query: 105 TRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFL 164
T RQ ++R ++ A+LRQE+ +FD++ TT++ T ++ D I + + DKV F
Sbjct: 139 TLAAGRQIRKIRQKFFHAILRQEIGWFDIN--DTTELNTRLTDDISKISEGIGDKVGMFF 196
Query: 165 VNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIA 224
+ F + IV F W+L +V +L + ++ +I + K Y +AG +A
Sbjct: 197 QAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVA 256
Query: 225 EQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIF 283
E+A+ +IRTV +F G++K L + LE + ++G+K+ ++ +++G + ++YA ++L F
Sbjct: 257 EEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAF 316
Query: 284 YYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPT 343
+YGS +V+ G V ++ IG + G + FA A A I ++I P
Sbjct: 317 WYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPK 376
Query: 344 IDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKS 403
IDS + G + + G +EFN+V F YPSR IL LKV SG+TVALVG SG GKS
Sbjct: 377 IDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKS 436
Query: 404 TVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGRED 463
T V L+QR YDP G I +DG I + +LR +G+VSQEP LF+T+I ENI +GR +
Sbjct: 437 TTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN 496
Query: 464 ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
T +EI A K +NA+ FI LPQ +DT V
Sbjct: 497 VTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
Score = 255 bits (651), Expect = 2e-67
Identities = 153/465 (32%), Positives = 249/465 (52%), Gaps = 6/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W + G AI +G + P I S+I+ G N +++ L++
Sbjct: 707 EWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQ---KCNIFSLIFLFLGI 763
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
SFF FL+G+ + + GE R+R KA+LRQ++S+FD H ST + T +++D+
Sbjct: 764 ISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQ 823
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
+Q ++ N + + I++F W+L ++ + ++ + G + ++ A+
Sbjct: 824 VQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAK 883
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
+ ++E AG IA +AI +IRTV S E K + + L G + +++ G+
Sbjct: 884 RDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSI 943
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
S +Y ++ F +G+ +++ + V +V + G +A G S +A+A ++
Sbjct: 944 SQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLS 1003
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
+ + +R P IDS + EG +K G + FN V F YP+R +L L+V G+
Sbjct: 1004 AAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1063
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+ALVG SG GKSTVV LL+RFYDP+ G +LLDG KL ++WLR+Q+G+VSQEP LF
Sbjct: 1064 TLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1123
Query: 451 TSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI ENI +G + +EIV AAKA+N H FI LP Y+T+V
Sbjct: 1124 CSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1168
>MDR3_CRIGR (P23174) Multidrug resistance protein 3 (P-glycoprotein
3)
Length = 1281
Score = 270 bits (691), Expect = 5e-72
Identities = 173/508 (34%), Positives = 272/508 (53%), Gaps = 23/508 (4%)
Query: 4 GDQKNVSINDKKKKN--GSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI----T 57
G N N KKK N G ++F ++D D FM G AI G +P ++ + T
Sbjct: 24 GSISNQGRNKKKKVNLIGPL-TLFRYSDWQDKLFMLLGTIMAIAHGSGLPLMMIVFGEMT 82
Query: 58 SKIMNSVGSASGTSSSNF-VHDVNKNAVVVLYMACASFF----------VCFLEGYCWTR 106
K +N+ G+ S NF + +N ++ M +++ +++ WT
Sbjct: 83 DKFVNNAGNFS--LPVNFSLSMINPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTL 140
Query: 107 TGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVN 166
RQ ++R + A+LRQE+ +FD + TT++ T ++ D I + + DKV F
Sbjct: 141 AAGRQIKKIRQNFFHAILRQEMGWFD--IKGTTELNTRLTDDISKISEGIGDKVGMFFQA 198
Query: 167 ASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQ 226
+ F + IV F W+L +V +L + ++ +I + K Y +AG +AE+
Sbjct: 199 VATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSTFSDKELAAYAKAGAVAEE 258
Query: 227 AISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYY 285
A+ +IRTV +F G++K L + LE + K+G+K+ ++ +++G + ++YA ++L F+Y
Sbjct: 259 ALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWY 318
Query: 286 GSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTID 345
GS +V+ G V ++ IG + G + FA A A I ++I P ID
Sbjct: 319 GSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKID 378
Query: 346 SENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTV 405
S + G + + G ++F++V F YPSR IL LKV SG+TVALVG SG GK+T
Sbjct: 379 SFSERGHKPDSIKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTT 438
Query: 406 VSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDAT 465
+ LLQR YDP G I +DG I +++LR +G+VSQEP LF+T+I ENI +GR + T
Sbjct: 439 LQLLQRLYDPTEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYGRGNVT 498
Query: 466 YEEIVDAAKASNAHNFISMLPQGYDTQV 493
EEI A K +NA+ FI LPQ +DT V
Sbjct: 499 MEEIKKAVKEANAYEFIMKLPQKFDTLV 526
Score = 247 bits (631), Expect = 5e-65
Identities = 152/465 (32%), Positives = 244/465 (51%), Gaps = 6/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W + G AI +G + P + I S+++ G N ++V L +
Sbjct: 709 EWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQ---KCNLFSLVFLGLGV 765
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
SFF FL+G+ + + GE R+R KA+LRQ++S+FD + ST + T +++D
Sbjct: 766 LSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQ 825
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
+Q ++ N + + I++F W+L ++ + + + G + ++ A+
Sbjct: 826 VQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAK 885
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
+ ++ AG IA +AI +IRTV S E K + + L + ++ G+
Sbjct: 886 RDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHEPYRNSVQMAHIYGITFSI 945
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
S +Y ++ F +G+ +++ + V +V + G +A G S +A+A ++
Sbjct: 946 SQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLS 1005
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
+ + +R P IDS + EG +K G V FN V F YP+R +L L+V G+
Sbjct: 1006 AAHLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQ 1065
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+ALVG SG GKSTVV LL+RFYDP+ G +LLDG KL ++WLR+Q+G+VSQEP LF
Sbjct: 1066 TLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFD 1125
Query: 451 TSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI ENI +G + +EIV AAKA+N H FI LPQ Y T+V
Sbjct: 1126 CSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRV 1170
>MDR2_RAT (Q08201) Multidrug resistance protein 2 (P-glycoprotein 2)
(P-glycoprotein 3)
Length = 1278
Score = 266 bits (681), Expect = 7e-71
Identities = 172/506 (33%), Positives = 268/506 (51%), Gaps = 19/506 (3%)
Query: 4 GDQKNVSINDKKKKN--GSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI----T 57
G N S KKK N G ++F ++D D FM G AI G +P ++ + T
Sbjct: 21 GSISNQSREKKKKVNLIGPL-TLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMT 79
Query: 58 SKIMNSVGSAS-----GTSSSN----FVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTG 108
K +++ G+ S S N ++ + A + +++ WT
Sbjct: 80 DKFVDNAGNFSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLLAAYIQVSFWTLAA 139
Query: 109 ERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNAS 168
RQ ++R ++ A+LRQE+ +FD + TT++ T ++ D I + + DKV F +
Sbjct: 140 GRQIRKIRQKFFHAILRQEMGWFD--IKGTTELNTRLTDDISKISEGIGDKVGMFFQAIA 197
Query: 169 RFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAI 228
F + IV F W+L +V +L + ++ +I + K Y +AG +AE+A+
Sbjct: 198 TFFAGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAL 257
Query: 229 SSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGS 287
+IRTV +F G++K L + LE + K+G+K+ ++ +++G + ++YA ++L F+YGS
Sbjct: 258 GAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGS 317
Query: 288 IMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSE 347
+V+ G V ++ IG + G + F A A I ++I P IDS
Sbjct: 318 TLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSF 377
Query: 348 NMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVS 407
+ G + + G +EF++V F YPSR IL LKV SG+TVALVG SG GKST V
Sbjct: 378 SERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQ 437
Query: 408 LLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYE 467
LLQR YDP G I +DG I ++ LR +G+VSQEP LF+T+I ENI +GR + T +
Sbjct: 438 LLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMD 497
Query: 468 EIVDAAKASNAHNFISMLPQGYDTQV 493
EI A K +NA++FI LPQ +DT V
Sbjct: 498 EIKKAVKEANAYDFIMKLPQKFDTLV 523
Score = 257 bits (657), Expect = 4e-68
Identities = 155/465 (33%), Positives = 249/465 (53%), Gaps = 6/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W + G AI +G + P I S+++ G T N ++V L +
Sbjct: 706 EWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDTVKQQ---KCNMFSLVFLGLGV 762
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
SFF FL+G+ + + GE R+R KA+LRQ++S+FD H ST + T +++D+
Sbjct: 763 HSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQ 822
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
+Q ++ N + + I++F W+L ++ + + + G + ++ A+
Sbjct: 823 VQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAK 882
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
+ ++E AG IA +AI +IRTV S E K + + L G + +++ G+
Sbjct: 883 RDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSI 942
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
S +Y ++ F +GS +++ + V +V + +G +A G S +A+A ++
Sbjct: 943 SQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLS 1002
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
+ + +R P IDS + EG +K G V FN V F YP+R +L L+V G+
Sbjct: 1003 AAYLFSLFERQPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1062
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+ALVG SG GKSTVV LL+RFYDP+ G +LLDG KL ++WLR+Q+G+VSQEP LF
Sbjct: 1063 TLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1122
Query: 451 TSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI +NI +G + +EIV AAK +N H FI LPQ Y+T+V
Sbjct: 1123 CSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRV 1167
>MDR2_MOUSE (P21440) Multidrug resistance protein 2 (P-glycoprotein
2)
Length = 1276
Score = 266 bits (679), Expect = 1e-70
Identities = 169/497 (34%), Positives = 266/497 (53%), Gaps = 18/497 (3%)
Query: 13 DKKKKNG--SFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI----TSKIMNSVGS 66
+KKKK ++F ++D D FM G AI G +P ++ + T K +++ G+
Sbjct: 29 EKKKKVNLIGLLTLFRYSDWQDKLFMFLGTLMAIAHGSGLPLMMIVFGEMTDKFVDNTGN 88
Query: 67 AS-----GTSSSN----FVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRV 117
S S N ++ + A + +++ WT RQ ++R
Sbjct: 89 FSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVLVAAYIQVSFWTLAAGRQIKKIRQ 148
Query: 118 RYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVA 177
++ A+LRQE+ +FD + TT++ T ++ D I + + DKV F + F + IV
Sbjct: 149 KFFHAILRQEMGWFD--IKGTTELNTRLTDDVSKISEGIGDKVGMFFQAIATFFAGFIVG 206
Query: 178 FALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSF 237
F W+L +V +L + ++ +I + K Y +AG +AE+A +IRTV +F
Sbjct: 207 FIRGWKLTLVIMAISPILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEAPGAIRTVIAF 266
Query: 238 VGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAK 296
G++K L + LE + K+G+K+ ++ +++G + ++YA ++L F+YGS +V+
Sbjct: 267 GGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYT 326
Query: 297 GGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEK 356
G V ++ IG + G + FA A A I ++I P IDS + G +
Sbjct: 327 IGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDN 386
Query: 357 VLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPI 416
+ G +EF++V F YPSR IL LKV SG+TVALVG SG GKST V LLQR YDP
Sbjct: 387 IKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPT 446
Query: 417 GGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIVDAAKAS 476
G+I +DG I ++ LR +G+VSQEP LF+T+I ENI +GR + T +EI A K +
Sbjct: 447 EGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIEKAVKEA 506
Query: 477 NAHNFISMLPQGYDTQV 493
NA++FI LPQ +DT V
Sbjct: 507 NAYDFIMKLPQKFDTLV 523
Score = 257 bits (657), Expect = 4e-68
Identities = 156/465 (33%), Positives = 248/465 (52%), Gaps = 6/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W + G AI +G + P I S+++ G N ++V L +
Sbjct: 704 EWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQ---KCNMFSLVFLGLGV 760
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
SFF FL+G+ + + GE R+R KA+LRQ++S+FD H ST + T +++D+
Sbjct: 761 LSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQ 820
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
+Q K+ N + + I++F W+L ++ + + + G + ++ A+
Sbjct: 821 VQGATGTKLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAK 880
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
+ ++E AG IA +AI +IRTV S E K + + L G + +++ G+
Sbjct: 881 RDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSI 940
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
S +Y ++ F +GS +++ + V +V + +G +A G S +A+A ++
Sbjct: 941 SQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLS 1000
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
+ + +R P IDS + EG +K G V FN V F YP+R +L L+V G+
Sbjct: 1001 AAYLFSLFERQPLIDSYSGEGLWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQ 1060
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+ALVG SG GKSTVV LL+RFYDP+ G +LLDG KL ++WLR+Q+G+VSQEP LF
Sbjct: 1061 TLALVGSSGCGKSTVVQLLERFYDPMAGSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFD 1120
Query: 451 TSIKENILFGRED--ATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI ENI +G ++EIV AAK +N H FI LPQ Y+T+V
Sbjct: 1121 CSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRV 1165
>AB11_MOUSE (Q9QY30) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 262 bits (669), Expect = 2e-69
Identities = 152/443 (34%), Positives = 247/443 (55%), Gaps = 4/443 (0%)
Query: 53 VLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQA 112
+++I S ++ + + + +V K + + + A + + + W TG RQ
Sbjct: 112 IVWINSSFNQNMTNGTSCGLVDINSEVIKFSGIYAGVGVAVLILGYFQIRLWVITGARQI 171
Query: 113 ARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLS 172
+MR Y + ++R E+ +FD TS ++ + S D I + ++D++ FL S LS
Sbjct: 172 RKMRKFYFRRIMRMEIGWFDC--TSVGELNSRFSDDINKIDEAIADQMALFLQRLSTALS 229
Query: 173 SNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIR 232
++ F W+L +V L+ I + + + Y +AG+IA++ +SSIR
Sbjct: 230 GLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYAKAGSIADEVLSSIR 289
Query: 233 TVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNG-VVYAIWSLIFYYGSIMVM 291
TV +F GE+K + + L + + G+ +G+ G G +++ ++L F+YGS +V+
Sbjct: 290 TVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSRLVL 349
Query: 292 YHGA-KGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENME 350
G GT+ + + + I + G S + F+ A I + I R P +D + +
Sbjct: 350 DEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGD 409
Query: 351 GEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQ 410
G ++++ GE+EF+NV F YPSRPE ILN+ + + G+T A VG SG+GKST + L+Q
Sbjct: 410 GYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQ 469
Query: 411 RFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIV 470
RFYDP G + LDG I L ++WLR Q+G+V QEP LF+T+I ENI GRE+AT E+IV
Sbjct: 470 RFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATMEDIV 529
Query: 471 DAAKASNAHNFISMLPQGYDTQV 493
AAK +NA+NFI LPQ +DT V
Sbjct: 530 QAAKDANAYNFIMALPQQFDTLV 552
Score = 244 bits (622), Expect = 5e-64
Identities = 146/502 (29%), Positives = 262/502 (52%), Gaps = 14/502 (2%)
Query: 4 GDQKNVSINDKKKKNGSFKSI-------FMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI 56
GD K+ S D+K + + + + ++ +W ++ G A +G + P +
Sbjct: 717 GDHKS-SYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLL 775
Query: 57 TSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMR 116
S+I+ + + ++ + + + + C S F FL+GY + ++GE R+R
Sbjct: 776 FSQILKTFSLVDKEQQRSEIYSM---CLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLR 832
Query: 117 VRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIV 176
KA+LRQ++ +FD + + T +++D+ +Q +V + + + + ++
Sbjct: 833 KFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLI 892
Query: 177 AFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYS 236
AF W+L++V F L + G + ++ A + +E +AG I +A+S+IRTV
Sbjct: 893 AFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAG 952
Query: 237 FVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGA 295
E + + AF LE S K +++ GL S G+ + S + YG +++Y
Sbjct: 953 IGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDL 1012
Query: 296 KGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIE 355
VF V ++A+ A G FS +A+A ++ R +++ R P ID + GE +
Sbjct: 1013 NFSYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWD 1072
Query: 356 KVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDP 415
G+++F + +F YPSRP+ +LN + V G+T+A VG SG GKST + LL+RFYDP
Sbjct: 1073 NFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDP 1132
Query: 416 IGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFG--REDATYEEIVDAA 473
G +++DG K+ +++LRS +G+VSQEP LF SI +NI +G ++ + E + AA
Sbjct: 1133 DQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAA 1192
Query: 474 KASNAHNFISMLPQGYDTQVSV 495
K + H+F+ LP+ Y+T V +
Sbjct: 1193 KQAQLHDFVMSLPEKYETNVGI 1214
>AB11_RAT (O70127) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 260 bits (664), Expect = 7e-69
Identities = 146/392 (37%), Positives = 228/392 (57%), Gaps = 4/392 (1%)
Query: 104 WTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNF 163
W TG RQ RMR Y + ++R E+ +FD TS ++ + + D I D ++D++ +F
Sbjct: 163 WVITGARQIRRMRKIYFRRIMRMEIGWFDC--TSVGELNSRFADDIEKINDAIADQLAHF 220
Query: 164 LVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTI 223
L S + ++ F W+L +V L+ I + + + Y +AG+I
Sbjct: 221 LQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSI 280
Query: 224 AEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNG-VVYAIWSLI 282
A++ +SSIRTV +F GE+K + + L + + G+ +G+ G G +++ ++L
Sbjct: 281 ADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALA 340
Query: 283 FYYGSIMVMYHGA-KGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRV 341
F+YGS +V+ GT+ + + + + + G S + F+ A I + I R
Sbjct: 341 FWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQ 400
Query: 342 PTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSG 401
P ID + +G ++++ GE+EF+NV F YPSRP+ IL++ + + G+T ALVG SG+G
Sbjct: 401 PVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAG 460
Query: 402 KSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGR 461
KST + L+QRFYDP G + LDG I L ++WLR Q+G+V QEP LF+T+I ENI FGR
Sbjct: 461 KSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGR 520
Query: 462 EDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
EDAT E+IV AAK +NA+NFI LPQ +DT V
Sbjct: 521 EDATMEDIVQAAKDANAYNFIMALPQQFDTLV 552
Score = 244 bits (622), Expect = 5e-64
Identities = 136/470 (28%), Positives = 251/470 (52%), Gaps = 6/470 (1%)
Query: 29 DVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLY 88
++ +W ++ G A +G + P + S+++ + + +H + + +
Sbjct: 748 NIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSM---CLFFVI 804
Query: 89 MACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSD 148
+ C S F FL+GY + ++GE R+R KA+L Q++ +FD + + T +++D
Sbjct: 805 LGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATD 864
Query: 149 SLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMR 208
+ +Q +V + + + +++ ++AF W+L+++ F L + G + ++
Sbjct: 865 ASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTG 924
Query: 209 LARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLA 268
A + ++ +AG I +A+S+IRTV E + + AF L+ S K +++ GL
Sbjct: 925 FASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLC 984
Query: 269 IG-SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEA 327
S G+ + S + YG ++ Y G VF V ++A+ A G FS +A+A
Sbjct: 985 FAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKA 1044
Query: 328 SVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVP 387
++ R +++ R P I+ + GE + G+++F + +F YPSRP+ +LN + V
Sbjct: 1045 KISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVN 1104
Query: 388 SGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPA 447
G+T+A VG SG GKST + LL+RFYDP G +++DG K+ +++LRS +G+VSQEP
Sbjct: 1105 PGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPV 1164
Query: 448 LFATSIKENILFG--REDATYEEIVDAAKASNAHNFISMLPQGYDTQVSV 495
LF SI +NI +G ++ + E + AAK + H+F+ LP+ Y+T V +
Sbjct: 1165 LFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGI 1214
>MDR1_LEIEN (Q06034) Multidrug resistance protein 1 (P-glycoprotein
1)
Length = 1280
Score = 258 bits (658), Expect = 3e-68
Identities = 153/475 (32%), Positives = 253/475 (53%), Gaps = 16/475 (3%)
Query: 24 IFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKI----MNSVGSASGTSSSNFVHDV 79
IF +AD D M G A+ G +P FI +I M+ VGSA ++
Sbjct: 60 IFRYADATDRVLMIAGTAFAVACGAGMPVFSFIFGRIAMDLMSGVGSAEEKAA------- 112
Query: 80 NKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTT 139
K +++++Y+ A C CWT RQ AR+R+ + +AVLRQ++ + D H S
Sbjct: 113 -KTSLIMVYVGIAMLIACAGHVMCWTVAACRQVARIRLLFFRAVLRQDIGWHDEH--SPG 169
Query: 140 DVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPG 199
+ ++ D+ VIQ+ ++DK+ ++N S + I F W L ++ M +++
Sbjct: 170 ALTARMTGDTRVIQNGINDKLSQGIMNGSMGVIGYIAGFVFSWELTLMMIGMMPFIIVMA 229
Query: 200 YMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGL 259
+ I ++ R+ + +AG++A + + +IRTV +F E L F+ A+ + G+
Sbjct: 230 AIIGSIVSKITESSRKYFAKAGSLATEVMENIRTVQAFGREDYELERFTKAVLYAQGRGI 289
Query: 260 KQGLAKGLAIGS-NGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCF 318
++ LA L+ ++Y +++ F++GS +V + + + + +G G
Sbjct: 290 RKELASNLSAAVIMALMYVSYTVAFFFGSYLVEWGRRDMADIISTFLAVLMGSFGLGFVA 349
Query: 319 SNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVI 378
+ F E+ A I + I RVP +D + G + +EF NV F YP+RP ++
Sbjct: 350 PSRTAFTESRAAAYEIFKAIDRVPPVDID-AGGVPVPGFKESIEFRNVRFAYPTRPGMIL 408
Query: 379 LNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQ 438
D LK+ G+ VA G SG GKS+V+ L+QRFYDPIGG +L+DGV + +L L+ R Q
Sbjct: 409 FRDLSLKIKCGQKVAFSGASGCGKSSVIGLIQRFYDPIGGAVLVDGVRMRELCLREWRDQ 468
Query: 439 MGLVSQEPALFATSIKENILFGREDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
+G+VSQEP LFA ++ EN+ G+ +AT EE+V+A + +N H+ I LP YDT V
Sbjct: 469 IGIVSQEPNLFAGTMMENVRMGKPNATDEEVVEACRQANIHDTIMALPDRYDTPV 523
Score = 187 bits (474), Expect = 7e-47
Identities = 135/499 (27%), Positives = 243/499 (48%), Gaps = 20/499 (4%)
Query: 6 QKNVSIND------KKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSK 59
++NV I++ K K G + + M+ D + +A G ++ G P +
Sbjct: 679 RQNVPIDELAKWEVKHAKVGFLRLMRMNKDKA--WAVALGILSSVVIGSARPASSIVMGH 736
Query: 60 IMNSVGSASGTSSSNFVHD-VNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVR 118
++ +G S T + N A + + A A+F L G+ + GE ++RV
Sbjct: 737 MLRVLGEYSATKDVEALRSGTNLYAPLFIVFAVANFSGWILHGF-YGYAGEHLTTKIRVL 795
Query: 119 YLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAF 178
+ ++RQ++++FD+ + +S D + + + + S +V F
Sbjct: 796 LFRQIMRQDINFFDIPGRDAGTLAGMLSGDCEAVHQLWGPSIGLKVQTMCIIASGLVVGF 855
Query: 179 ALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFV 238
W+LA+V M L+ I + +R+ + K RE + TI +A+S++RTV S
Sbjct: 856 IYQWKLALVALACMPLM-IGCSLTRRLMINGYTKSREG-DTDDTIVTEALSNVRTVTSLN 913
Query: 239 GESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKG 297
+ + AF AL +++G+ G G + + Y +++L F+YGS ++ A+
Sbjct: 914 MKEDCVEAFQAALREEAPRSVRKGIIAGGIYGITQFIFYGVYALCFWYGSKLIDKGEAEF 973
Query: 298 GTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKV 357
V + +++ G G + A+A + +R+ VI RVP +D E K
Sbjct: 974 KDVMIASMSILFGAQNAGEAGAFATKLADAEASAKRVFSVIDRVPDVDIEQAGN----KD 1029
Query: 358 LGE---VEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYD 414
LGE +E+ NV+F+Y +RP+ V+L ++ + L+G +G GKSTV+ +L RFY+
Sbjct: 1030 LGEGCDIEYRNVQFIYSARPKQVVLASVNMRFGDATSNGLIGQTGCGKSTVIQMLARFYE 1089
Query: 415 PIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIVDAAK 474
G I ++G + L + R + +V QEP LF+ +++ENI + RE AT EE+ +AA+
Sbjct: 1090 RRSGLISVNGRDLSSLDIAEWRRNISIVLQEPNLFSGTVRENIRYAREGATDEEVEEAAR 1149
Query: 475 ASNAHNFISMLPQGYDTQV 493
++ H+ I GYDT+V
Sbjct: 1150 LAHIHHEIIKWTDGYDTEV 1168
>AB11_HUMAN (O95342) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11)
Length = 1321
Score = 258 bits (658), Expect = 3e-68
Identities = 149/443 (33%), Positives = 244/443 (54%), Gaps = 4/443 (0%)
Query: 53 VLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQA 112
+++ S + ++ + + N ++ K A +A A +++ W RQ
Sbjct: 112 IVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQI 171
Query: 113 ARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLS 172
+MR Y + ++R E+ +FD + S ++ T S D I D ++D++ F+ + +
Sbjct: 172 QKMRKFYFRRIMRMEIGWFDCN--SVGELNTRFSDDINKINDAIADQMALFIQRMTSTIC 229
Query: 173 SNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIR 232
++ F W+L +V L+ I + + Y +AG +A++ ISS+R
Sbjct: 230 GFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMR 289
Query: 233 TVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNG-VVYAIWSLIFYYGSIMVM 291
TV +F GE + + + L + + G+++G+ G G +++ +++ F+YGS +V+
Sbjct: 290 TVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYAVAFWYGSTLVL 349
Query: 292 YHGA-KGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENME 350
G GT+ + +++ +G L G + FA A I E I R P ID + +
Sbjct: 350 DEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSED 409
Query: 351 GEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQ 410
G ++++ GE+EF+NV F YPSRPE ILND + + G+ ALVG SG+GKST + L+Q
Sbjct: 410 GYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQ 469
Query: 411 RFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIV 470
RFYDP G + +DG I L ++WLR Q+G+V QEP LF+T+I ENI +GREDAT E+IV
Sbjct: 470 RFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIV 529
Query: 471 DAAKASNAHNFISMLPQGYDTQV 493
AAK +NA+NFI LPQ +DT V
Sbjct: 530 QAAKEANAYNFIMDLPQQFDTLV 552
Score = 244 bits (624), Expect = 3e-64
Identities = 140/465 (30%), Positives = 244/465 (52%), Gaps = 6/465 (1%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMAC 91
+W +M G GA +G + P F+ S+I+ G+ S +N ++ + M C
Sbjct: 751 EWPYMLVGSVGAAVNGTVTPLYAFLFSQIL---GTFSIPDKEEQRSQINGVCLLFVAMGC 807
Query: 92 ASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLV 151
S F FL+GY + ++GE R+R +A+L Q++++FD S + T +++D+
Sbjct: 808 VSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQ 867
Query: 152 IQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLAR 211
+Q ++ + + + + I+AF+ W+L++V F L + G R+ A
Sbjct: 868 VQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFAS 927
Query: 212 KIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG- 270
+ ++ G I +A+S+IRTV E + + A LE K +++ G
Sbjct: 928 RDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAF 987
Query: 271 SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVA 330
+ +++ S + YG ++ G VF V + + A G FS +A+A ++
Sbjct: 988 AQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKIS 1047
Query: 331 GERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGK 390
R +++ R P I N GE + G+++F + +F YPSRP+S +LN + + G+
Sbjct: 1048 AARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQ 1107
Query: 391 TVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFA 450
T+A VG SG GKST + LL+RFYDP G++++DG K+ +++LRS +G+VSQEP LFA
Sbjct: 1108 TLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFA 1167
Query: 451 TSIKENILFG--REDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
SI +NI +G ++ E ++ AAK + H+F+ LP+ Y+T V
Sbjct: 1168 CSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNV 1212
>PMD1_SCHPO (P36619) Leptomycin B resistance protein pmd1
Length = 1362
Score = 249 bits (635), Expect = 2e-65
Identities = 159/507 (31%), Positives = 265/507 (51%), Gaps = 29/507 (5%)
Query: 11 INDKKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGS-ASG 69
IND K + I +AD D G IG G+ +P + ++ ++ + ASG
Sbjct: 70 INDTPAKLSGYPRILSYADKWDIMLQLAGTITGIGAGLGMPLMSLVSGQLAQAFTDLASG 129
Query: 70 TSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVS 129
+S+F H V+ + +Y+A F ++ + GER A R+R YL A+L Q +
Sbjct: 130 KGASSFQHTVDHFCLYFIYIAIGVFGCSYIYTVTFIIAGERIARRIRQDYLHAILSQNIG 189
Query: 130 YFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIV-- 187
YFD ++ T +++D+ IQD L +KV + F+S ++AF W+ ++
Sbjct: 190 YFDR--LGAGEITTRITTDTNFIQDGLGEKVGLVFFAIATFVSGFVIAFIRHWKFTLILS 247
Query: 188 -GFPFM---VLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKT 243
FP + + L +P ++ K ++A ++ T E+ S+IR ++F +
Sbjct: 248 SMFPAICGGIGLGVP-FITKNTKGQIA-----VVAESSTFVEEVFSNIRNAFAFGTQDIL 301
Query: 244 LAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFV 302
++ L + + G+ + +A GL +G V Y ++ L F+ G ++ H +
Sbjct: 302 AKLYNKYLITAQRFGINKAIAMGLMVGWMFFVAYGVYGLAFWEGGRLL--HAGDLDVSKL 359
Query: 303 VGVTLA--IGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGE 360
+G A I + ++ F + A ++I + I RV I++ G++++ + GE
Sbjct: 360 IGCFFAVLIASYSLANISPKMQSFVSCASAAKKIFDTIDRVSPINAFTPTGDVVKDIKGE 419
Query: 361 VEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEI 420
+E N+ FVYP+RPE ++L++F L PSGK ALVG SGSGKST++ L++RFYDPIGG++
Sbjct: 420 IELKNIRFVYPTRPEVLVLDNFSLVCPSGKITALVGASGSGKSTIIGLVERFYDPIGGQV 479
Query: 421 LLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDA-----TYEE----IVD 471
LDG + L + LR+Q+ LV QEP LFAT++ ENI +G D + EE + D
Sbjct: 480 FLDGKDLRTLNVASLRNQISLVQQEPVLFATTVFENITYGLPDTIKGTLSKEELERRVYD 539
Query: 472 AAKASNAHNFISMLPQGYDTQVSVNYF 498
AAK +NA++FI LP+ + T V F
Sbjct: 540 AAKLANAYDFIMTLPEQFSTNVGQRGF 566
Score = 206 bits (524), Expect = 1e-52
Identities = 143/490 (29%), Positives = 235/490 (47%), Gaps = 19/490 (3%)
Query: 15 KKKNGSFKSI----FMHADV---LDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSA 67
KK N S+ F+H+ V ++ + G ++ G P + ++ +N
Sbjct: 767 KKNNHEINSLTALWFIHSFVRTMIEIICLLIGILASMICGAAYPVQAAVFARFLNIF--- 823
Query: 68 SGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQE 127
+ SS++F+H VN AV L +A FF + + T E R+R + +LRQ+
Sbjct: 824 TDLSSTDFLHKVNVFAVYWLILAIVQFFAYAISNFAMTYAMEAVLQRIRYHLFRTLLRQD 883
Query: 128 VSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIV 187
V +FD + + TS+S+ ++ + + F + +S I++ A W+L +V
Sbjct: 884 VEFFDRSENTVGAITTSLSTKIQSLEGLSGPTLGTFFQILTNIISVTILSLATGWKLGLV 943
Query: 188 GFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAF 247
+++ GY R ++ K+ Y ++ A ++ S+IRTV S E A +
Sbjct: 944 TLSTSPVIITAGYYRVRALDQVQEKLSAAYKESAAFACESTSAIRTVASLNREENVFAEY 1003
Query: 248 SNAL----EGSVKLGLKQGLAKGLAIGSNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVV 303
++L S LK GL A GV + I +L F+YGS ++ +
Sbjct: 1004 CDSLIKPGRESAIASLKSGLFFSAA---QGVTFLINALTFWYGSTLMRKGEYNIVQFYTC 1060
Query: 304 GVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGE-VE 362
+ + G G F +A A I + + P ID+ + EG+ +E + +E
Sbjct: 1061 FIAIVFGIQQAGQFFGYSADVTKAKAAAGEIKYLSESKPKIDTWSTEGKKVESLQSAAIE 1120
Query: 363 FNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILL 422
F VEF YP+R +L L V G+ VA VG SG GKST + L++RFYD G +L+
Sbjct: 1121 FRQVEFSYPTRRHIKVLRGLNLTVKPGQFVAFVGSSGCGKSTTIGLIERFYDCDNGAVLV 1180
Query: 423 DGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFG-REDATYEEIVDAAKASNAHNF 481
DGV + + R Q+ LVSQEP L+ +++ENI+ G +D + EE+++A K +N H F
Sbjct: 1181 DGVNVRDYNINDYRKQIALVSQEPTLYQGTVRENIVLGASKDVSEEEMIEACKKANIHEF 1240
Query: 482 ISMLPQGYDT 491
I LP GY+T
Sbjct: 1241 ILGLPNGYNT 1250
>AB11_RABIT (Q9N0V3) Bile salt export pump (ATP-binding cassette,
sub-family B, member 11) (Sister of P-glycoprotein)
Length = 1321
Score = 247 bits (630), Expect = 6e-65
Identities = 150/501 (29%), Positives = 258/501 (50%), Gaps = 16/501 (3%)
Query: 5 DQKNVSINDKKKKN---------GSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLF 55
D K+ D+K K+ S + I M + +W +M G GA +G + P F
Sbjct: 716 DHKSTHEEDRKDKDLPAQEDIEPASVRRI-MKLNAPEWPYMLLGSMGAAVNGAVTPLYAF 774
Query: 56 ITSKIMNSVGSASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARM 115
+ S+I+ G+ S +N ++ + + C SFF FL+GY + ++GE R+
Sbjct: 775 LFSQIL---GTFSLPDKEEQRSQINGICLLFVTLGCVSFFTQFLQGYTFAKSGELLTKRL 831
Query: 116 RVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNI 175
R +A+L Q++ +FD S + T +++D+ +Q ++ + + + + I
Sbjct: 832 RKFGFRAMLGQDIGWFDDLRNSPGALTTRLATDASQVQGATGSQIGMMVNSFTNVTVAMI 891
Query: 176 VAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVY 235
+AF W+L + F L + G + ++ A + ++ +AG I +A+S+IRTV
Sbjct: 892 IAFLFSWKLTLGIVCFFPFLALSGALQTKMLTGFASRDKQALEKAGQITSEALSNIRTVA 951
Query: 236 SFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHG 294
E K + F LE K+ +K+ GL G S + + S + YG ++ G
Sbjct: 952 GIGKERKFIETFEAELEKPYKMAIKKANVYGLCFGFSQCITFIANSASYRYGGYLISNEG 1011
Query: 295 AKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEII 354
VF V + + A G S +A+A ++ R +++ R P I+ + GE
Sbjct: 1012 LHFSYVFRVISAVVLSATALGRASSYTPSYAKAKISAARFFQLLDRQPPINVYSSAGEKW 1071
Query: 355 EKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYD 414
+ G+++F + +F YPSRP+ +LN + + +T+A VG SG GKST + LL+RFYD
Sbjct: 1072 DNFQGKIDFVDCKFTYPSRPDIQVLNGLSVSMSPRQTLAFVGSSGCGKSTSIQLLERFYD 1131
Query: 415 PIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFG--REDATYEEIVDA 472
P G++++DG K+ +++LRS +G+VSQEP LFA SIK+NI +G ++ E I+ A
Sbjct: 1132 PDHGKVMIDGHDSRKVNIQFLRSNIGIVSQEPVLFACSIKDNIKYGDNTQEIPMERIIAA 1191
Query: 473 AKASNAHNFISMLPQGYDTQV 493
AK + H+F+ LP+ Y+T V
Sbjct: 1192 AKKAQVHDFVMSLPEKYETNV 1212
Score = 230 bits (587), Expect = 6e-60
Identities = 135/400 (33%), Positives = 218/400 (53%), Gaps = 9/400 (2%)
Query: 96 VCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDV 155
+CF W Q +MR Y + ++R + + D + S + T S D I D
Sbjct: 160 ICF-----WGIAAAHQIQKMRKSYFRKIMRMGIGWVDCN--SVGKLNTPFSVDFNKINDS 212
Query: 156 LSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIRE 215
+D++ F+ + + +V F+ W+L +V L+ + + + +
Sbjct: 213 SADQLAIFIQGMTSPIFGFLVGFSQWWKLTLVIISVSPLIGLGAAIIGLSVSKFTDYELK 272
Query: 216 EYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNG-V 274
Y +AG++A++ ISS+RTV +F GE K + + L + + G+++G+ G G +
Sbjct: 273 AYAKAGSVADEVISSMRTVAAFGGEKKEVERYEKNLVFAQRWGIRKGIVMGFFTGYMWCL 332
Query: 275 VYAIWSLIFYYGSIMVMYHGAKG-GTVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGER 333
++ ++L F+YGS +V+ G G + + +++ IG L G + FA A
Sbjct: 333 IFFCYALAFWYGSKLVLEEGEYSPGALVQIFLSVIIGALNLGNASPCLEAFAAGRAAASS 392
Query: 334 IMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVA 393
I E I R P ID + +G +E++ GE+EF+NV F YPSRPE ILN+ + + G+ A
Sbjct: 393 IFETIDRKPIIDCMSEDGYKLERIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGEMTA 452
Query: 394 LVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSI 453
LVG SG+GKST + L+ RFY P G + ++ I ++WLR+Q+G+V QEP LF +I
Sbjct: 453 LVGPSGAGKSTALQLIHRFYGPTEGMVTVESHDIRSSHIQWLRNQIGIVEQEPVLFFHTI 512
Query: 454 KENILFGREDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
E I +GREDAT E+++ AAK +NA+NFI LPQ +DT V
Sbjct: 513 AEKIRYGREDATMEDLIQAAKEANAYNFIMDLPQQFDTLV 552
>MDR1_CAEEL (P34712) Multidrug resistance protein 1 (P-glycoprotein
A)
Length = 1321
Score = 241 bits (615), Expect = 3e-63
Identities = 156/490 (31%), Positives = 248/490 (49%), Gaps = 18/490 (3%)
Query: 20 SFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKI----------MNSVGSA-- 67
S ++ + L+ + G A+ G +P + + K+ +N+ GS
Sbjct: 61 SIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMSILQGKVSQAFINEQIVINNNGSTFL 120
Query: 68 ---SGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVL 124
+ ++F HDV M + + C+ E+ R+R ++K++L
Sbjct: 121 PTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMNNRLRREFVKSIL 180
Query: 125 RQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRL 184
RQE+S+FD + + T + T + + +++ DK+ S+F++ IVAF W+L
Sbjct: 181 RQEISWFDTNHSGT--LATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQL 238
Query: 185 AIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTL 244
+V + + G+ + A + Y +AG + E+ ISSIRTV S G L
Sbjct: 239 TLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLNGLRYEL 298
Query: 245 AAFSNALEGSVKLGLKQGLAKGLAIGS-NGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVV 303
+S A+E + K G+ +GL G++ G+ + ++L FY G V G +
Sbjct: 299 ERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTT 358
Query: 304 GVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEF 363
++ +G +A G + A A I EV+ R P IDS + G K+ G++
Sbjct: 359 FSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITV 418
Query: 364 NNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLD 423
NV F YPSRP+ IL L+V +G+TVALVG SG GKST++SLL R+YD + G+I +D
Sbjct: 419 ENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVLKGKITID 478
Query: 424 GVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIVDAAKASNAHNFIS 483
GV + + L++LR + +VSQEPALF +I+ENI G+E T EE+V A K +NA FI
Sbjct: 479 GVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAACKMANAEKFIK 538
Query: 484 MLPQGYDTQV 493
LP GY+T V
Sbjct: 539 TLPNGYNTLV 548
Score = 199 bits (506), Expect = 1e-50
Identities = 129/418 (30%), Positives = 221/418 (52%), Gaps = 10/418 (2%)
Query: 83 AVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVI 142
A++ L +A A FL + E +R + + VL Q + +FD ++ +
Sbjct: 797 ALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKIS 856
Query: 143 TSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMY 202
T +++D ++ + + + ++ +AF W++A++ + ++ Y+
Sbjct: 857 TRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLR 916
Query: 203 KRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQG 262
R K E+ +G IA +AI ++RTV + E F L+ K +K+
Sbjct: 917 GRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEAIKEA 976
Query: 263 LAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKGGTVFVV----GVTLAIGGLAFGTC 317
+GL+ G ++ V+Y + + + G +++ + V+ +T++ L F T
Sbjct: 977 FIQGLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATS 1036
Query: 318 FSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESV 377
+ +A+A+ AG I +++++ IDS ++ GE +K+ G+V F NV F YP RPE
Sbjct: 1037 Y--FPEYAKATFAGGIIFGMLRKISKIDSLSLAGEK-KKLYGKVIFKNVRFAYPERPEIE 1093
Query: 378 ILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRS 437
IL V G+T+ALVG SG GKSTVV+LL+RFYD +GGEI +DG I L + RS
Sbjct: 1094 ILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRS 1153
Query: 438 QMGLVSQEPALFATSIKENILFGRE--DATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
Q+ +VSQEP LF SI ENI++G + T ++ +AA+ +N HNFI+ LP+G++T+V
Sbjct: 1154 QIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRV 1211
>MDR4_DROME (Q00449) Multidrug resistance protein homolog 49
(P-glycoprotein 49)
Length = 1302
Score = 233 bits (593), Expect = 1e-60
Identities = 154/520 (29%), Positives = 257/520 (48%), Gaps = 36/520 (6%)
Query: 7 KNVSINDKKKKNGSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFI----TSKIMN 62
K S+ D +K F +F ++ + F + A +P+ + I TS +++
Sbjct: 18 KEGSVVDATRKYSYF-DLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVD 76
Query: 63 ---SVGSAS----------GTSSSNFVHDVNKNAVV---------VLYMACASFFVCFLE 100
VG++S G +N + N A++ L + A F + L
Sbjct: 77 RTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLA 136
Query: 101 GYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKV 160
R Q R+R +L+A+LRQ+++++D +S ++ + ++ D +++ + +K+
Sbjct: 137 IDLANRIALNQIDRIRKLFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGEKI 194
Query: 161 PNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQA 220
+ F+ + AF W+L +V + ++ + R+ LA K + Y+ A
Sbjct: 195 VIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDA 254
Query: 221 GTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLAIGSNG-VVYAIW 279
+ E+ S IRTV++F G+ K F L + G K+GL G+ + ++Y
Sbjct: 255 ANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCM 314
Query: 280 SLIFYYGSIMVMYHGAKGGTVFVVGVTLAI------GGLAFGTCFSNVRYFAEASVAGER 333
+L +YG +++ V+ V + + G G +V A A+ AG+
Sbjct: 315 ALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQT 374
Query: 334 IMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVA 393
+ +I R +D + +G E G + F + F YP+RP+ IL + V G+TVA
Sbjct: 375 LFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVA 434
Query: 394 LVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSI 453
VG SG GKST++ L+QRFYDP G + LDG + L + WLRSQ+G+V QEP LFAT+I
Sbjct: 435 FVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTI 494
Query: 454 KENILFGREDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
ENI +GR AT +I AA+A+N H+FI+ LP+GYDTQV
Sbjct: 495 GENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQV 534
Score = 210 bits (535), Expect = 6e-54
Identities = 146/499 (29%), Positives = 238/499 (47%), Gaps = 15/499 (3%)
Query: 6 QKNVSINDKKKKNGSFKSIFMHADVL-----DWFFMAFGFFGAIGDGMMVP-FVLFITSK 59
+K S KKKK+ S ++ +W F+ G ++ G P + LF
Sbjct: 700 RKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFG-- 757
Query: 60 IMNSVGSASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRY 119
+ G S +V K +++ + + + L+ Y +T G + R+R R
Sbjct: 758 --DFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRA 815
Query: 120 LKAVLRQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFA 179
++ Q+++YFD S + + ++SD +Q +V L + + +V F
Sbjct: 816 FGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFV 875
Query: 180 LLWRLAIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVG 239
W+ ++ + L+ + Y+ R M+ A+K + +A +A +AI++IRTV
Sbjct: 876 FSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCL 935
Query: 240 ESKTLAAFSNALEGSVKLGLKQGLAKGLAIG-SNGVVYAIWSLIFYYGSIMVMYHGAKGG 298
E + L + ++ ++ +GL + + + YYG I+V
Sbjct: 936 ERQVLDQYVQQIDRVDVACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYE 995
Query: 299 TVFVVGVTLAIGGLAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEG-EIIEKV 357
+ V L G G + +A ++ R+M++ KR T + +EK
Sbjct: 996 DIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKS 1055
Query: 358 LGEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIG 417
G++ + NV F YP+R + IL L + TVALVG SGSGKST V LL R+YDP+
Sbjct: 1056 EGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVS 1115
Query: 418 GEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFG---REDATYEEIVDAAK 474
G + L GV + L LRS++GLVSQEP LF +I ENI +G R+D + +EI++AAK
Sbjct: 1116 GSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAK 1175
Query: 475 ASNAHNFISMLPQGYDTQV 493
SN HNFIS LPQGYDT++
Sbjct: 1176 KSNIHNFISALPQGYDTRL 1194
>MDR3_CAEEL (P34713) Multidrug resistance protein 3 (P-glycoprotein
C)
Length = 1268
Score = 232 bits (592), Expect = 1e-60
Identities = 145/482 (30%), Positives = 240/482 (49%), Gaps = 9/482 (1%)
Query: 19 GSFKSIFMHADVLDWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSN---- 74
G+F +F AD D+ + G + +G +VPF I I N++ +
Sbjct: 29 GNFFDVFRDADYKDYILFSGGLILSAVNGALVPFNSLIFEGIANALMEGESQYQNGTINM 88
Query: 75 --FVHDVNKNAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFD 132
F ++ + Y+ A F + C ER+ +R +YLK+VLRQ+ +FD
Sbjct: 89 PWFSSEIKMFCLRYFYLGVALFLCSYFANSCLYTLCERRLHCIRKKYLKSVLRQDAKWFD 148
Query: 133 LHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFM 192
T+ + +SS I+D + DKV + + F+S + F + W+L +V +
Sbjct: 149 --ETTIGGLTQKMSSGIEKIKDGIGDKVGVLVGGVATFISGVSIGFYMCWQLTLVMMITV 206
Query: 193 VLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALE 252
L + Y+ + R + Y+ AG +A + I+ IRTV +F + + +++ L
Sbjct: 207 PLQLGSMYLSAKHLNRATKNEMSAYSNAGGMANEVIAGIRTVMAFNAQPFEINRYAHQLN 266
Query: 253 GSVKLGLKQGLAKGLAIGSN-GVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGG 311
+ ++G+++ + + +++ ++ F+YG+ + G VF V + IG
Sbjct: 267 EARRMGIRKAIILAICTAFPLMLMFTCMAVAFWYGATLAAAGAVSSGAVFAVFWAVLIGT 326
Query: 312 LAFGTCFSNVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYP 371
G ++ A +A I +VI P I + EG+I EK+ G++ F+ +EF YP
Sbjct: 327 RRLGEAAPHLGAITGARLAIHDIFKVIDHEPEIKCTSSEGKIPEKIQGKLTFDGIEFTYP 386
Query: 372 SRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQ 431
+RPE IL +V G+TVALVG SG GKST + LL RFY+ G I LDG+ I +
Sbjct: 387 TRPELKILKGVSFEVNPGETVALVGHSGCGKSTSIGLLMRFYNQCAGMIKLDGIPIQEYN 446
Query: 432 LKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIVDAAKASNAHNFISMLPQGYDT 491
++WLRS +G+V QEP +F ++ ENI G T ++I +A K +NAH FI L YDT
Sbjct: 447 IRWLRSTIGIVQQEPIIFVATVAENIRMGDVLITDQDIEEACKMANAHEFICKLSDRYDT 506
Query: 492 QV 493
+
Sbjct: 507 VI 508
Score = 174 bits (441), Expect = 5e-43
Identities = 107/417 (25%), Positives = 205/417 (48%), Gaps = 4/417 (0%)
Query: 82 NAVVVLYMACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDV 141
N++ + +A + G + GE + R+R+ + +++Q+ SYFD + +
Sbjct: 750 NSLWFILLAFTGGISTLISGSLLGKAGETMSGRLRMDVFRNIMQQDASYFDDSRHNVGSL 809
Query: 142 ITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYM 201
+ +++D+ +Q + ++ L VAF W +A +G +LLV+
Sbjct: 810 TSRLATDAPNVQAAIDQRLAEVLTGIVSLFCGVGVAFYYGWNMAPIGLATALLLVVVQSS 869
Query: 202 YKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQ 261
+ ++ + +A + ++IS+ +TV + + AF+ A + + + +
Sbjct: 870 VAQYLKFRGQRDMDSAIEASRLVTESISNWKTVQALTKQEYMYDAFTAASKSPHRRAIVR 929
Query: 262 GLAKGLAIGSNGVVYAIWS--LIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFS 319
GL + L+ G + +W+ + + +G ++ + + TVF V L + ++ S
Sbjct: 930 GLWQSLSFALAGS-FVMWNFAIAYMFGLWLISNNWSTPYTVFQVIEALNMASMSVMLAAS 988
Query: 320 NVRYFAEASVAGERIMEVIKRVPTIDSENMEGEIIEKVLGEVEFNNVEFVYPSRPESVIL 379
+ A ++ + +I++ ID+ + G+ + G + V F YP+R ++L
Sbjct: 989 YFPEYVRARISAGIMFTMIRQKSVIDNRGLTGDT-PTIKGNINMRGVYFAYPNRRRQLVL 1047
Query: 380 NDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAIHKLQLKWLRSQM 439
+ F + G+TVALVG SG GKST + L++R+YD + G + +D I L +K LR +
Sbjct: 1048 DGFNMSANFGQTVALVGPSGCGKSTTIQLIERYYDALCGSVKIDDSDIRDLSVKHLRDNI 1107
Query: 440 GLVSQEPALFATSIKENILFGREDATYEEIVDAAKASNAHNFISMLPQGYDTQVSVN 496
LV QEP LF +I+ENI +G E+ T +++ AA +N H F+ LP GYDT V +
Sbjct: 1108 ALVGQEPTLFNLTIRENITYGLENITQDQVEKAATLANIHTFVMGLPDGYDTSVGAS 1164
>MDR5_DROME (Q00748) Multidrug resistance protein homolog 65
(P-glycoprotein 65)
Length = 1302
Score = 215 bits (548), Expect = 2e-55
Identities = 138/439 (31%), Positives = 235/439 (53%), Gaps = 15/439 (3%)
Query: 66 SASGTSSSNFVHDVNKNAVVVLYMACASFFVCFLEGY-CWTRTGERQAARMRVRYLKAVL 124
+AS ++ ++D + + ++L +A F+ + + RQ RMR++ +V+
Sbjct: 103 NASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVI 162
Query: 125 RQEVSYFDLHVTSTTDVITSVSSDSLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRL 184
RQ++ + DL S + S+ D I+D +S+KV +F+ F+ + ++F+ W+L
Sbjct: 163 RQDIGWHDL--ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKL 220
Query: 185 AIVGFPFMVLLVIPGYMYKRISMRLARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTL 244
+ ++ L+++ Y + +L + +E Y AG +AE+ +SSIRTV SF GE +
Sbjct: 221 TLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEV 280
Query: 245 AAFSNALEGSVKLGLKQGLAKGLAIGS-NGVVYAIWSLIFYYG-SIMVMYHGAKGGTVFV 302
+ N L + K +G GL+ ++Y + F+YG ++++ +
Sbjct: 281 QRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTP 340
Query: 303 VGVTLAIGGLAFGTCFSNV-------RYFAEASVAGERIMEVIKRVPTIDSENMEGEIIE 355
+ +A G+ G N+ FA A + +VI ID + +G+++
Sbjct: 341 AILMIAFFGIIVGA--DNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLN 398
Query: 356 KVL-GEVEFNNVEFVYPSRPESVILNDFCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYD 414
L G+VEF +V F YPSRPE ++ +++ +G+TVALVG SG GKST V LLQRFYD
Sbjct: 399 YGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYD 458
Query: 415 PIGGEILLDGVAIHKLQLKWLRSQMGLVSQEPALFATSIKENILFGREDATYEEIVDAAK 474
P+ G +LLD + I K ++WLRS + +V QEP LF +I +NI +G+ AT +EI AA
Sbjct: 459 PVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAAT 518
Query: 475 ASNAHNFISMLPQGYDTQV 493
+ AH FI+ LP+ Y + +
Sbjct: 519 QAGAHEFITNLPESYRSMI 537
Score = 198 bits (504), Expect = 2e-50
Identities = 141/475 (29%), Positives = 237/475 (49%), Gaps = 21/475 (4%)
Query: 32 DWFFMAFGFFGAIGDGMMVPFVLFITSKIMNSVGSASGTSSSNFVHDVNKNAVV---VLY 88
+W ++ G A+ G + P I + ++ + + + AV+ L
Sbjct: 728 EWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDA------LRRTAVLSWACLG 781
Query: 89 MACASFFVCFLEGYCWTRTGERQAARMRVRYLKAVLRQEVSYFDLHVTSTTDVITSVSSD 148
+A + VCFL+ Y + G RMR A++ QEV +FD S + +S +
Sbjct: 782 LAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGE 841
Query: 149 SLVIQDVLSDKVPNFLVNASRFLSSNIVAFALLWRLAIVGFPFMVLLVIPGYMYKRISMR 208
++ IQ + + + S F+SS VA W+LA++ ++V + ++
Sbjct: 842 AVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSN 901
Query: 209 LARKIREEYNQAGTIAEQAISSIRTVYSFVGESKTLAAFSNALEGSVKLGLKQGLAKGLA 268
+ ++ +A IA ++I++IRTV E+ + ++ ++ V++ ++Q L
Sbjct: 902 AVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQ-RVEVLIRQKLRWRGV 960
Query: 269 IGSN--GVVYAIWSLIFYYGSIMVMYHGAKGGTVFVVGVTLAIGGLAFGTCFSNVRYFAE 326
+ S + +++ YG ++V + V TL G + + F+
Sbjct: 961 LNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSA 1020
Query: 327 ASVAGERIMEVIKRVPTIDS-----ENMEGEIIEKVLGEVEFNNVEFVYPSRPESVILND 381
A +AG R+ +++ R P I S +N + + G V + ++F YP+RP++ ILN
Sbjct: 1021 ALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNG 1079
Query: 382 FCLKVPSGKTVALVGGSGSGKSTVVSLLQRFYDPIGGEILLDGVAI-HKLQLKWLRSQMG 440
L+V G+TVALVG SG GKST V LLQR+YDP G I +D I H L L +R+++G
Sbjct: 1080 LDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLG 1139
Query: 441 LVSQEPALFATSIKENILFG--REDATYEEIVDAAKASNAHNFISMLPQGYDTQV 493
+VSQEP LF SI ENI +G R + EI+ AAK++NAH+FI LP GYDT++
Sbjct: 1140 IVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRM 1194
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.323 0.138 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,995,306
Number of Sequences: 164201
Number of extensions: 2219012
Number of successful extensions: 9571
Number of sequences better than 10.0: 862
Number of HSP's better than 10.0 without gapping: 653
Number of HSP's successfully gapped in prelim test: 209
Number of HSP's that attempted gapping in prelim test: 8339
Number of HSP's gapped (non-prelim): 1043
length of query: 509
length of database: 59,974,054
effective HSP length: 115
effective length of query: 394
effective length of database: 41,090,939
effective search space: 16189829966
effective search space used: 16189829966
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 68 (30.8 bits)
Medicago: description of AC141109.8