BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0282.7
(463 letters)
Database: uniref100
2,790,947 sequences; 848,049,833 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
UniRef100_Q9M6U1 Homogentisate 1,2-dioxygenase [Lycopersicon esc... 785 0.0
UniRef100_Q9ZRA2 Homogentisate 1,2-dioxygenase [Arabidopsis thal... 761 0.0
UniRef100_Q5VRH4 Putative homogentisate 1,2-dioxygenase [Oryza s... 719 0.0
UniRef100_Q68F23 MGC82288 protein [Xenopus laevis] 528 e-148
UniRef100_UPI0000437F69 UPI0000437F69 UniRef100 entry 523 e-147
UniRef100_Q6P2V4 Hgd protein [Brachydanio rerio] 522 e-147
UniRef100_Q7PMI7 ENSANGP00000021048 [Anopheles gambiae str. PEST] 521 e-146
UniRef100_Q9GU65 Homogentisate 1,2-dioxygenase [Dictyostelium di... 515 e-144
UniRef100_UPI00003A9B30 UPI00003A9B30 UniRef100 entry 504 e-141
UniRef100_UPI00003A9B2F UPI00003A9B2F UniRef100 entry 504 e-141
UniRef100_UPI000035F164 UPI000035F164 UniRef100 entry 504 e-141
UniRef100_Q7TPP2 Homogentisate 1, 2-dioxygenase [Mus musculus] 503 e-141
UniRef100_Q9VKJ0 Homogentisate 1,2-dioxygenase [Drosophila melan... 503 e-141
UniRef100_O09173 Homogentisate 1,2-dioxygenase [Mus musculus] 501 e-140
UniRef100_Q8CI38 Homogentisate 1, 2-dioxygenase [Mus musculus] 501 e-140
UniRef100_UPI000036B6DA UPI000036B6DA UniRef100 entry 501 e-140
UniRef100_Q93099 Homogentisate 1,2-dioxygenase [Homo sapiens] 501 e-140
UniRef100_UPI00002DA81C UPI00002DA81C UniRef100 entry 500 e-140
UniRef100_Q6AYR0 Hypothetical protein [Rattus norvegicus] 499 e-140
UniRef100_Q5RF05 Hypothetical protein DKFZp469K2032 [Pongo pygma... 495 e-138
>UniRef100_Q9M6U1 Homogentisate 1,2-dioxygenase [Lycopersicon esculentum]
Length = 477
Score = 785 bits (2027), Expect = 0.0
Identities = 356/432 (82%), Positives = 395/432 (91%)
Query: 9 DFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRV 68
D Y +GFGNHFSSEA+ GALP+ QNSPLICP+GLYAEQISGTSFTSPR LN SW YR+
Sbjct: 10 DLEYQTGFGNHFSSEAIVGALPQGQNSPLICPFGLYAEQISGTSFTSPRKLNQRSWLYRI 69
Query: 69 KPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSG 128
KPSVTHEPF+PR+P + +++SEFN SNSS PTQLRWKP++ P++PTDFIDGL T+CG+G
Sbjct: 70 KPSVTHEPFRPRMPRHEKLVSEFNQSNSSATPTQLRWKPVEIPETPTDFIDGLYTICGAG 129
Query: 129 SSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLP 188
SS++RHG+AIHMYTANKSM N AFCNADGDFLIVPQ+GRL+ITTECGRL+V PGEI +LP
Sbjct: 130 SSYLRHGFAIHMYTANKSMENSAFCNADGDFLIVPQKGRLWITTECGRLQVCPGEIVILP 189
Query: 189 QGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGY 248
QG+RF VDLPDGPSRGYVAE FGTH QLPDLGPIGANGLAAPRDFLVP AW+ D S PGY
Sbjct: 190 QGYRFAVDLPDGPSRGYVAETFGTHLQLPDLGPIGANGLAAPRDFLVPVAWYGDGSRPGY 249
Query: 249 TIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTA 308
TIVQK+GGELF+A QDFSPFNVVAW GNYVPYKYDLSKFCPYNTVL DHSDPSINTVLTA
Sbjct: 250 TIVQKYGGELFTAKQDFSPFNVVAWHGNYVPYKYDLSKFCPYNTVLMDHSDPSINTVLTA 309
Query: 309 PTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGAS 368
PTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLI+GGYEAK DGF PGGAS
Sbjct: 310 PTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIYGGYEAKADGFHPGGAS 369
Query: 369 LHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDY 428
LHSCMTPHGPDTK++EATIA GN+ GP++I DTMAFMFESCL+PR+ WALESPF+DHDY
Sbjct: 370 LHSCMTPHGPDTKTFEATIALGNEAGPHRIADTMAFMFESCLVPRVCPWALESPFMDHDY 429
Query: 429 YQCWIGLRSHFN 440
YQCWIGL+SHF+
Sbjct: 430 YQCWIGLKSHFS 441
>UniRef100_Q9ZRA2 Homogentisate 1,2-dioxygenase [Arabidopsis thaliana]
Length = 461
Score = 761 bits (1965), Expect = 0.0
Identities = 351/433 (81%), Positives = 384/433 (88%)
Query: 8 DDFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYR 67
++ Y SGFGNHFSSEA+AGALP QNSPL+CPYGLYAEQISGTSFTSPR LN SW YR
Sbjct: 9 EELKYQSGFGNHFSSEAIAGALPLDQNSPLLCPYGLYAEQISGTSFTSPRKLNQRSWLYR 68
Query: 68 VKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGS 127
VKPSVTHEPFKPRVP + +++SEF+ SNS TNPTQLRW+P D PDS DF+DGL T+CG+
Sbjct: 69 VKPSVTHEPFKPRVPAHKKLVSEFDASNSRTNPTQLRWRPEDIPDSEIDFVDGLFTICGA 128
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
GSSF+RHG+AIHMY AN M + AFCNADGDFL+VPQ GRL+I TECGRL V+PGEIA++
Sbjct: 129 GSSFLRHGFAIHMYVANTGMKDSAFCNADGDFLLVPQTGRLWIETECGRLLVTPGEIAVI 188
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
PQGFRF++DLPDG SRGYVAEI+G HFQLPDLGPIGANGLAA RDFL PTAWFED P
Sbjct: 189 PQGFRFSIDLPDGKSRGYVAEIYGAHFQLPDLGPIGANGLAASRDFLAPTAWFEDGLRPE 248
Query: 248 YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLT 307
YTIVQKFGGELF+A QDFSPFNVVAW GNYVPYKYDL KFCPYNTVL DH DPSINTVLT
Sbjct: 249 YTIVQKFGGELFTAKQDFSPFNVVAWHGNYVPYKYDLKKFCPYNTVLLDHGDPSINTVLT 308
Query: 308 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGA 367
APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLI+G YEAK DGFLPGGA
Sbjct: 309 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIYGAYEAKADGFLPGGA 368
Query: 368 SLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHD 427
SLHSCMTPHGPDT +YEATIAR N + P+K+T TMAFMFES LIPR+ WALESPFLDHD
Sbjct: 369 SLHSCMTPHGPDTTTYEATIARVNAMAPSKLTGTMAFMFESALIPRVCHWALESPFLDHD 428
Query: 428 YYQCWIGLRSHFN 440
YYQCWIGL+SHF+
Sbjct: 429 YYQCWIGLKSHFS 441
>UniRef100_Q5VRH4 Putative homogentisate 1,2-dioxygenase [Oryza sativa]
Length = 470
Score = 719 bits (1856), Expect = 0.0
Identities = 333/443 (75%), Positives = 379/443 (85%), Gaps = 4/443 (0%)
Query: 2 EHSTAGDDFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNL 61
+ G ++ YLSG GN SSEA+AG LP QNSPL+CP GLYAEQ+SGT FT+PR NL
Sbjct: 14 QQEKGGLEYVYLSGLGNSLSSEAVAGTLPRGQNSPLVCPLGLYAEQLSGTPFTAPRARNL 73
Query: 62 FSWFYRVKPSVTHEPFKPRVPCNGRILSEFNHSNSST--NPTQLRWKPMDSPDS--PTDF 117
+W YR+KPSVTHEPF PR P + R++ +F+ + + T PTQLRW+P D P P DF
Sbjct: 74 RTWLYRIKPSVTHEPFHPRRPAHPRLIGDFDRTTTDTVATPTQLRWRPADVPPHHPPLDF 133
Query: 118 IDGLSTVCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRL 177
IDGL TVCG+GSSF+RHGYAIHMY ANKSM+ CAFCNADGDFLIVPQQG+L ITTECG+L
Sbjct: 134 IDGLYTVCGAGSSFLRHGYAIHMYAANKSMDGCAFCNADGDFLIVPQQGKLLITTECGKL 193
Query: 178 KVSPGEIAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPT 237
V PGEI ++PQGFRF VDLPDGPSRGYV+EIFGTHFQLPDLGPIGANGLA+ RDFL PT
Sbjct: 194 LVPPGEIVVIPQGFRFAVDLPDGPSRGYVSEIFGTHFQLPDLGPIGANGLASARDFLSPT 253
Query: 238 AWFEDKSYPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDH 297
AWFE PGYTIVQK+GGELF+A QDFSPFNVVAW GNYVPYKYDLSKFCP+NTVLFDH
Sbjct: 254 AWFEQVHRPGYTIVQKYGGELFTATQDFSPFNVVAWHGNYVPYKYDLSKFCPFNTVLFDH 313
Query: 298 SDPSINTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEA 357
+DPS+NTVLTAPTDKPGVALLDFVIFPPRWLVAE+TFRPPYYHRNCMSEFMGLI+G YEA
Sbjct: 314 ADPSVNTVLTAPTDKPGVALLDFVIFPPRWLVAENTFRPPYYHRNCMSEFMGLIYGIYEA 373
Query: 358 KVDGFLPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRW 417
K DGFLPGGASLHSCMTPHGPDTK+YEATI+R + P++++ T+AFMFES LIPR+ +W
Sbjct: 374 KADGFLPGGASLHSCMTPHGPDTKTYEATISRPDANEPSRLSGTLAFMFESALIPRVCQW 433
Query: 418 ALESPFLDHDYYQCWIGLRSHFN 440
AL+SP D DYYQCWIGL+SHF+
Sbjct: 434 ALDSPSRDLDYYQCWIGLKSHFS 456
>UniRef100_Q68F23 MGC82288 protein [Xenopus laevis]
Length = 443
Score = 528 bits (1359), Expect = e-148
Identities = 262/440 (59%), Positives = 323/440 (72%), Gaps = 15/440 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ YLSGFGN FSSE GALPE QN+P +CPYGLYAEQ+SG++FT PR+ N SWFY
Sbjct: 3 ELKYLSGFGNEFSSEDPRCPGALPEGQNNPQVCPYGLYAEQLSGSAFTCPRSTNKRSWFY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPT---DFIDGLST 123
R+ P V H+PF VP + L+ N +P Q+RWKP P + DFIDGL T
Sbjct: 63 RILPPVQHKPF---VPYEQKNLTH-NWDEVEPDPNQMRWKPYHIPTAAAQKQDFIDGLHT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G + R+G AIH++TAN SM + N+DGDFLIVPQQG+L I TE G++ V P E
Sbjct: 119 LCGAGDARSRNGIAIHIFTANTSMIDRCLYNSDGDFLIVPQQGKLLILTEFGKMLVEPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ QG RF+V++ G +RGYV E+FG HF+LPDLGPIGANGLA PRDFL P AW+ED+
Sbjct: 179 ICVIQQGMRFSVEV-FGETRGYVLEVFGVHFELPDLGPIGANGLANPRDFLTPVAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
+ G YT++ K+ G+LF+++QDFSPFNVVAW GNY PYKY+L F N V FDH+DPSI
Sbjct: 238 TVEGGYTVISKYQGKLFASLQDFSPFNVVAWHGNYTPYKYNLDNFMVINCVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+HTFRPPYYHRNCMSEFMGLI G YEAK +GF
Sbjct: 298 FTVLTAKSLRPGVAIADFVIFPPRWGVADHTFRPPYYHRNCMSEFMGLIKGHYEAKEEGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES 421
PGG SLHS MTPHGPDT+ +E AR + P ++ + TMAFMFES L +++W LE+
Sbjct: 358 QPGGGSLHSVMTPHGPDTECFEK--ARKAKLEPERVAEGTMAFMFESSLSMAVTKWGLET 415
Query: 422 -PFLDHDYYQCWIGLRSHFN 440
LD +YYQCW LRSHFN
Sbjct: 416 CQRLDKNYYQCWESLRSHFN 435
>UniRef100_UPI0000437F69 UPI0000437F69 UniRef100 entry
Length = 432
Score = 523 bits (1346), Expect = e-147
Identities = 262/437 (59%), Positives = 316/437 (71%), Gaps = 15/437 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN FSSE G+LPE QN+P +CPYGLYAEQ+SG++FT PR+ N SW YR+
Sbjct: 1 YMSGFGNEFSSEDPRCPGSLPEGQNNPQVCPYGLYAEQLSGSAFTCPRSSNKRSWLYRIL 60
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLSTVCG 126
PSV H+PF R+ C L+E N + +P QLRWKP + P S DF+ GL TVCG
Sbjct: 61 PSVRHKPFT-RMSCGD--LTE-NWNEVEPDPNQLRWKPFNIPKSSEKKVDFVSGLHTVCG 116
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+G S R+G AIHMY+ N SM + F NADGDFLIVPQQG + ITTE G++ V P EI +
Sbjct: 117 AGDSKSRNGIAIHMYSCNTSMTDKCFQNADGDFLIVPQQGEILITTEFGKMMVEPNEICV 176
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+ QG RF+VD+ G +RGY+ E+FG HF+LPDLGPIGANGLA PRDF P AW+ED++
Sbjct: 177 IQQGMRFSVDV-FGETRGYILEVFGAHFELPDLGPIGANGLANPRDFQTPVAWYEDRTIA 235
Query: 247 -GYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTV 305
GYTIV K+ G+LFS QDFSPFNVVAW GNY PYKY+L F N V FDH+DPSI TV
Sbjct: 236 TGYTIVNKYQGKLFSCQQDFSPFNVVAWHGNYAPYKYNLENFMVINCVAFDHADPSIFTV 295
Query: 306 LTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPG 365
LTA + +PGVA+ DFVIFPPRW VA+HTFRPPYYHRNCMSEFMGLI G YEAK +GF PG
Sbjct: 296 LTAKSTRPGVAIADFVIFPPRWGVADHTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQPG 355
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES-PF 423
G SLHS MTPHGPD +E + + P K+ + TMAFMFES ++ W LE+
Sbjct: 356 GGSLHSIMTPHGPDVDCFEKNSSA--LLKPEKVAEGTMAFMFESSFSMAVTEWGLETCQR 413
Query: 424 LDHDYYQCWIGLRSHFN 440
LD +YY+CW L+SHFN
Sbjct: 414 LDKNYYKCWEALKSHFN 430
>UniRef100_Q6P2V4 Hgd protein [Brachydanio rerio]
Length = 443
Score = 522 bits (1344), Expect = e-147
Identities = 261/437 (59%), Positives = 316/437 (71%), Gaps = 15/437 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN FSSE G+LPE QN+P +CPYGLYAEQ+SG++FT PR+ N SW YR+
Sbjct: 6 YMSGFGNEFSSEDPRCPGSLPEGQNNPQVCPYGLYAEQLSGSAFTCPRSSNKRSWLYRIL 65
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLSTVCG 126
PSV H+PF R+ C L+E N + +P QLRWKP + P S DF+ GL TVCG
Sbjct: 66 PSVRHKPFT-RMSCGD--LTE-NWNEVEPDPNQLRWKPFNIPKSSEKKVDFVSGLHTVCG 121
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+G S R+G AIHMY+ N SM + F NADGDFLIVPQQG + ITTE G++ V P EI +
Sbjct: 122 AGDSKSRNGIAIHMYSCNTSMTDKCFQNADGDFLIVPQQGEILITTEFGKMMVEPNEICV 181
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+ QG RF+VD+ G +RGY+ E+FG HF+LPDLGPIGANGLA PRDF P AW+ED++
Sbjct: 182 IQQGMRFSVDV-FGETRGYILEVFGAHFELPDLGPIGANGLANPRDFQTPVAWYEDRTIA 240
Query: 247 -GYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTV 305
GYTIV K+ G+LFS QDFSPFNVVAW GNY PYKY+L F N V FDH+DPSI TV
Sbjct: 241 TGYTIVNKYQGKLFSCQQDFSPFNVVAWHGNYAPYKYNLENFMVINCVAFDHADPSIFTV 300
Query: 306 LTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPG 365
LTA + +PGVA+ DFVIFPPRW VA+HTFRPPYYHRNCMSEFMGLI G YEAK +GF PG
Sbjct: 301 LTAKSTRPGVAIADFVIFPPRWGVADHTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQPG 360
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES-PF 423
G SLHS MTPHGPD +E + P ++ + TMAFMFES +++W LE+
Sbjct: 361 GGSLHSIMTPHGPDVDCFEKNSTA--LLKPERVAEGTMAFMFESSFSMAVTKWGLETCQR 418
Query: 424 LDHDYYQCWIGLRSHFN 440
LD +YY+CW L+SHFN
Sbjct: 419 LDKNYYKCWEALKSHFN 435
>UniRef100_Q7PMI7 ENSANGP00000021048 [Anopheles gambiae str. PEST]
Length = 434
Score = 521 bits (1343), Expect = e-146
Identities = 263/436 (60%), Positives = 309/436 (70%), Gaps = 10/436 (2%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
YLSGFG+HFSSE ALP QNSP CP+GLYAEQ+SG++FT+PR N SW YR++
Sbjct: 3 YLSGFGSHFSSEDARFPNALPVGQNSPQKCPHGLYAEQLSGSAFTAPRTENTRSWLYRIR 62
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP--DSPTDFIDGLSTVCGS 127
PSV H+PFK R L NP Q+RW P D P S DF+ GL TVCG+
Sbjct: 63 PSVVHQPFK-RFEGVAPFLRGTGWEEQHPNPNQMRWNPFDLPAAGSEVDFVAGLHTVCGA 121
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
G R+G A+H+Y AN SM + AF N+DGD LIVPQQG L ITTE GRL V P EI ++
Sbjct: 122 GDVRARNGLAVHVYLANCSMKDTAFYNSDGDMLIVPQQGPLDITTEFGRLYVKPNEICVI 181
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
PQG RF+V L +GPSRGY+ E++ HF+LPDLGPIGANGLA PRDFL PTA FED+S G
Sbjct: 182 PQGIRFSVAL-EGPSRGYILEVYDGHFRLPDLGPIGANGLANPRDFLTPTAHFEDRSVEG 240
Query: 248 YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLT 307
Y IV KF G LF A Q SPF+VVAW GNYVPYKYDL++F N+V FDH DPSI TVLT
Sbjct: 241 YRIVSKFQGALFVATQGHSPFDVVAWHGNYVPYKYDLARFMVINSVSFDHCDPSIFTVLT 300
Query: 308 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGA 367
P+++PG A+ DFVIFPPRW V EHTFRPPYYHRNCMSEFMGLI G YEAK GF+PGGA
Sbjct: 301 CPSNRPGTAIADFVIFPPRWSVQEHTFRPPYYHRNCMSEFMGLIFGRYEAKEGGFMPGGA 360
Query: 368 SLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES-PFLD 425
SLHS MTPHGPD + +E A D+ P ++ D T AFMFES L ++RW E+ LD
Sbjct: 361 SLHSMMTPHGPDHRCFEG--ASNADLKPERVADGTQAFMFESSLSMAVTRWGEETCQKLD 418
Query: 426 HDYYQCWIGLRSHFNV 441
YY+CW L HF++
Sbjct: 419 ARYYECWQALEKHFHL 434
>UniRef100_Q9GU65 Homogentisate 1,2-dioxygenase [Dictyostelium discoideum]
Length = 431
Score = 515 bits (1326), Expect = e-144
Identities = 255/435 (58%), Positives = 320/435 (72%), Gaps = 11/435 (2%)
Query: 9 DFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRV 68
D+ Y SGFGN F SEA+ G LP+ +N+P CP LYAEQ+SG +FT+PR+ SW YR+
Sbjct: 6 DYEYQSGFGNSFESEAIKGTLPKGRNAPQNCPLDLYAEQLSGNAFTAPRHTQQRSWLYRI 65
Query: 69 KPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMD-SPDSPTDFIDGLSTVCGS 127
+PSV H P KP + ++ + N N +P QLRWKP + D P DF++GL T+ G+
Sbjct: 66 RPSVCHTPLKP---IDSGLVCDLN--NLHVDPNQLRWKPFPITEDKPHDFVEGLITIAGA 120
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
G + +RHG AIH+YTA KSM N +F N+DGDFLIVPQQG L I TE G +KV GEI ++
Sbjct: 121 GHASVRHGLAIHIYTATKSMENKSFYNSDGDFLIVPQQGTLDIQTEFGFMKVKSGEICVI 180
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
+G F+V++ +GP+RGY+ E+FG+HF+LPDLGPIGANGLA PRDFL P A +E K
Sbjct: 181 QRGITFSVNV-EGPTRGYICEVFGSHFKLPDLGPIGANGLANPRDFLSPVAAYEKKEGIE 239
Query: 248 YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLT 307
+T + KF G+LFSA Q +SPFNVVAW GNY PYKYDLS FC N+V FDH DPSI TVLT
Sbjct: 240 HTKINKFLGKLFSATQTYSPFNVVAWHGNYCPYKYDLSLFCVVNSVSFDHLDPSIFTVLT 299
Query: 308 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGA 367
APT++ GVA DFVIFPPRWLV E+TFRPPY+HRNCMSEFMGLI G YEAK +GFLPGG
Sbjct: 300 APTNEVGVAAADFVIFPPRWLVQENTFRPPYFHRNCMSEFMGLIRGVYEAKKEGFLPGGG 359
Query: 368 SLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALESPFLDH 426
SLHSCMTPHGPD+ ++ A I ++ P KI D +AFMFES LI IS +A ++ F+D
Sbjct: 360 SLHSCMTPHGPDSDTFYAAIKA--ELKPTKIPDVALAFMFESSLILGISDYAKKN-FIDD 416
Query: 427 DYYQCWIGLRSHFNV 441
DY++CW GL+ + +
Sbjct: 417 DYWKCWQGLKDNSKI 431
>UniRef100_UPI00003A9B30 UPI00003A9B30 UniRef100 entry
Length = 436
Score = 504 bits (1298), Expect = e-141
Identities = 251/437 (57%), Positives = 313/437 (71%), Gaps = 15/437 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN +SE GALPE QN+P +CPYGLYAEQ+SG++FT PR N SW YR+
Sbjct: 3 YMSGFGNEHASEDPRCPGALPEGQNNPQVCPYGLYAEQLSGSAFTCPRATNRRSWLYRIL 62
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLSTVCG 126
PSV H+PF+P G + ++ +P QLRWKP + P + DF+ GL T+CG
Sbjct: 63 PSVCHKPFQPLH--EGHLTHYWDEVEP--DPNQLRWKPFEIPKASQNKLDFVSGLHTLCG 118
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+G R+G AIH++ N SM + N+DGDFLIV QQG+L ITTE G++ V P EI +
Sbjct: 119 AGEPRGRNGIAIHIFVCNTSMLDRCLYNSDGDFLIVSQQGKLLITTEFGKMLVEPNEICV 178
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+ QG RF+V++ G +RGY+ E++G HF+LPDLGPIGANGLA PRDFLVP AW+ED+ P
Sbjct: 179 IQQGMRFSVEV-FGETRGYILEVYGAHFELPDLGPIGANGLANPRDFLVPVAWYEDRKIP 237
Query: 247 G-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTV 305
G YT++ K+ G+LF+A QDFSPFNVVAW GNY PYKY L F N+V FDH+DPSI TV
Sbjct: 238 GGYTVISKYQGKLFAAQQDFSPFNVVAWHGNYTPYKYHLENFMVINSVAFDHADPSIFTV 297
Query: 306 LTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPG 365
LTA + +PGVA+ DFVIFPPRW VA +TFRPPYYHRNCMSEFMGLI G YEAK +GF PG
Sbjct: 298 LTAKSTRPGVAIADFVIFPPRWGVANNTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQPG 357
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALE-SPF 423
GASLHS MTPHGPD +E A + P ++ + TMAFMFES L ++ W L+ S
Sbjct: 358 GASLHSMMTPHGPDADCFEK--ASKAKLEPERVAEGTMAFMFESSLSMAVTEWGLKTSNR 415
Query: 424 LDHDYYQCWIGLRSHFN 440
LD +YY+CW L+SHFN
Sbjct: 416 LDKNYYKCWEPLKSHFN 432
>UniRef100_UPI00003A9B2F UPI00003A9B2F UniRef100 entry
Length = 439
Score = 504 bits (1298), Expect = e-141
Identities = 251/437 (57%), Positives = 313/437 (71%), Gaps = 15/437 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN +SE GALPE QN+P +CPYGLYAEQ+SG++FT PR N SW YR+
Sbjct: 6 YMSGFGNEHASEDPRCPGALPEGQNNPQVCPYGLYAEQLSGSAFTCPRATNRRSWLYRIL 65
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLSTVCG 126
PSV H+PF+P G + ++ +P QLRWKP + P + DF+ GL T+CG
Sbjct: 66 PSVCHKPFQPLH--EGHLTHYWDEVEP--DPNQLRWKPFEIPKASQNKLDFVSGLHTLCG 121
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+G R+G AIH++ N SM + N+DGDFLIV QQG+L ITTE G++ V P EI +
Sbjct: 122 AGEPRGRNGIAIHIFVCNTSMLDRCLYNSDGDFLIVSQQGKLLITTEFGKMLVEPNEICV 181
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+ QG RF+V++ G +RGY+ E++G HF+LPDLGPIGANGLA PRDFLVP AW+ED+ P
Sbjct: 182 IQQGMRFSVEV-FGETRGYILEVYGAHFELPDLGPIGANGLANPRDFLVPVAWYEDRKIP 240
Query: 247 G-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTV 305
G YT++ K+ G+LF+A QDFSPFNVVAW GNY PYKY L F N+V FDH+DPSI TV
Sbjct: 241 GGYTVISKYQGKLFAAQQDFSPFNVVAWHGNYTPYKYHLENFMVINSVAFDHADPSIFTV 300
Query: 306 LTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPG 365
LTA + +PGVA+ DFVIFPPRW VA +TFRPPYYHRNCMSEFMGLI G YEAK +GF PG
Sbjct: 301 LTAKSTRPGVAIADFVIFPPRWGVANNTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQPG 360
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALE-SPF 423
GASLHS MTPHGPD +E A + P ++ + TMAFMFES L ++ W L+ S
Sbjct: 361 GASLHSMMTPHGPDADCFEK--ASKAKLEPERVAEGTMAFMFESSLSMAVTEWGLKTSNR 418
Query: 424 LDHDYYQCWIGLRSHFN 440
LD +YY+CW L+SHFN
Sbjct: 419 LDKNYYKCWEPLKSHFN 435
>UniRef100_UPI000035F164 UPI000035F164 UniRef100 entry
Length = 446
Score = 504 bits (1297), Expect = e-141
Identities = 253/438 (57%), Positives = 311/438 (70%), Gaps = 17/438 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN FSSE GALPE QNSP +CPYGLYAEQ+SG++FT PR N SW YR+
Sbjct: 15 YMSGFGNEFSSEDPRCPGALPEGQNSPQVCPYGLYAEQLSGSAFTCPRPANKRSWLYRIL 74
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPT----DFIDGLSTVC 125
PSV H+PF PC L+E N + +P QLRW P P +PT DF GL T+C
Sbjct: 75 PSVKHKPFIA-APCGD--LTE-NWNEVEPDPNQLRWLPFSIP-TPTKKKVDFATGLHTIC 129
Query: 126 GSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIA 185
G+G + R+G +H+YT N SM + F N+DGDFLIVPQQG + ITTE G++ V P EI
Sbjct: 130 GAGDAKSRNGIGVHIYTCNASMVDMCFNNSDGDFLIVPQQGEILITTEFGKMLVEPNEIC 189
Query: 186 MLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSY 245
++ QG RF+VD+ G +RGY+ E++G HF+LPDLGPIG NGLA PRDF P AW+ED+
Sbjct: 190 VIQQGMRFSVDV-FGATRGYILEVYGAHFELPDLGPIGGNGLANPRDFQCPVAWYEDRHV 248
Query: 246 P-GYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINT 304
GYTI+ K+ G+LF+ QDFSPFNVVAW GNY PYKY+L+ F N V FDH+DPSI T
Sbjct: 249 AAGYTIINKYQGKLFACQQDFSPFNVVAWHGNYTPYKYNLTNFMVINCVAFDHADPSIFT 308
Query: 305 VLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLP 364
VLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK +GF P
Sbjct: 309 VLTAKSTRPGVAIADFVIFPPRWGVADRTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQP 368
Query: 365 GGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES-P 422
GGASLHS MTPHGPD +E ++ P ++ + TMAFMFES +++W L++
Sbjct: 369 GGASLHSIMTPHGPDVDCFEKNSRA--ELKPERVAEGTMAFMFESSFSMAVTKWGLQTCQ 426
Query: 423 FLDHDYYQCWIGLRSHFN 440
LD +YYQCW L SHF+
Sbjct: 427 TLDKNYYQCWEDLCSHFD 444
>UniRef100_Q7TPP2 Homogentisate 1, 2-dioxygenase [Mus musculus]
Length = 445
Score = 503 bits (1295), Expect = e-141
Identities = 248/449 (55%), Positives = 313/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN +SE G+LP+ QN+P +CPY LYAEQ+SG++FT PRN N SW Y
Sbjct: 3 ELKYISGFGNECASEDPRCPGSLPKGQNNPQVCPYNLYAEQLSGSAFTCPRNTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--QGHVTH--NWDEVGPDPNQLRWKPFEIPKASEKKVDFVSGLYT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G A+H++ N SM N F N+DGDFLIVPQ+G+L I TE G++ + P E
Sbjct: 119 LCGAGDIKSNNGLAVHIFLCNSSMENRCFYNSDGDFLIVPQKGKLLIYTEFGKMSLQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF+VD+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSVDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ KF G+LF+ QD SPFNVVAW GNY PYKY+L F N V FDH+DPSI
Sbjct: 238 RVPGGYTVINKFQGKLFACKQDVSPFNVVAWHGNYTPYKYNLENFMVINAVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES 421
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L++
Sbjct: 358 LPGGGSLHSAMTPHGPDADCFEK--ASKAKLEPERIADGTMAFMFESSLSLAVTKWGLKT 415
Query: 422 -PFLDHDYYQCWIGLRSHFNVTEISPRTP 449
LD +YY+CW LRSHF SP P
Sbjct: 416 CSCLDENYYKCWEPLRSHFTPNSRSPTEP 444
>UniRef100_Q9VKJ0 Homogentisate 1,2-dioxygenase [Drosophila melanogaster]
Length = 439
Score = 503 bits (1294), Expect = e-141
Identities = 249/442 (56%), Positives = 307/442 (69%), Gaps = 13/442 (2%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
++ YLSGFG+HFSSE +LP QNSP +CPY LYAEQ+SG++FT+PR N+ +W Y
Sbjct: 3 EYKYLSGFGSHFSSEDERYPNSLPVGQNSPQVCPYKLYAEQLSGSAFTAPRTENMRTWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLST 123
R PS H PF+P G N NP QLRWKP D P +F++GL T
Sbjct: 63 RKLPSAAHLPFQP---FKGAEYFSQNWDEQPPNPNQLRWKPFDLPPKDGKNVNFVEGLHT 119
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
VCG+G RHG AIH+Y+ N SM+N AF N+DGDFLIVPQQG L ITTE GR+ V+P E
Sbjct: 120 VCGAGDPRSRHGLAIHIYSCNGSMDNSAFYNSDGDFLIVPQQGVLDITTEFGRMSVAPNE 179
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++PQG RF V++ D PSRGY+ E++ HF LPDLGPIGANGLA PRDF P AWF+D+
Sbjct: 180 ICVIPQGIRFAVNV-DSPSRGYILEVYDDHFVLPDLGPIGANGLANPRDFETPVAWFDDR 238
Query: 244 SYPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSIN 303
+ ++ KF G LF A Q+ + F+VVAW GNYVP+KYDLSKF N+V FDH DPSI
Sbjct: 239 DVKDFQVISKFQGRLFVAKQNHTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIF 298
Query: 304 TVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFL 363
TVLT P+ + G A+ DFVIFPPRW V EHTFRPPYYHRNCMSEFMGLI G YEAK DGF
Sbjct: 299 TVLTCPSLRAGTAIADFVIFPPRWSVQEHTFRPPYYHRNCMSEFMGLILGKYEAKEDGFA 358
Query: 364 PGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES- 421
GGA+LHS MTPHGPD K +E A + P ++ + T AFMFES L +++W E+
Sbjct: 359 AGGATLHSMMTPHGPDVKCFEG--ASNAKLVPERVAEGTQAFMFESSLSLAVTKWGEETC 416
Query: 422 PFLDHDYYQCWIGLRSHFNVTE 443
LD YY+CW L+++F +T+
Sbjct: 417 QKLDAAYYECWQALKNNFQITK 438
>UniRef100_O09173 Homogentisate 1,2-dioxygenase [Mus musculus]
Length = 445
Score = 501 bits (1291), Expect = e-140
Identities = 247/449 (55%), Positives = 312/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN +SE G+LP+ QN+P +CPY LYAEQ+SG++FT PRN N SW Y
Sbjct: 3 ELKYISGFGNECASEDPRCPGSLPKGQNNPQVCPYNLYAEQLSGSAFTCPRNTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--QGHVTH--NWDEVGPDPNQLRWKPFEIPKASEKKVDFVSGLYT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G A+H++ N SM N F N+DGDFLIVPQ+G+L I TE G++ + P E
Sbjct: 119 LCGAGDIKSNNGLAVHIFLCNSSMENRCFYNSDGDFLIVPQKGKLLIYTEFGKMSLQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF+VD+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSVDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ KF G+LF+ QD SPFNVV W GNY PYKY+L F N V FDH+DPSI
Sbjct: 238 RVPGGYTVINKFQGKLFACKQDVSPFNVVTWHGNYTPYKYNLENFMVINAVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES 421
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L++
Sbjct: 358 LPGGGSLHSAMTPHGPDADCFEK--ASKAKLEPERIADGTMAFMFESSLSLAVTKWGLKT 415
Query: 422 -PFLDHDYYQCWIGLRSHFNVTEISPRTP 449
LD +YY+CW LRSHF SP P
Sbjct: 416 CSCLDENYYKCWEPLRSHFTPNSRSPTEP 444
>UniRef100_Q8CI38 Homogentisate 1, 2-dioxygenase [Mus musculus]
Length = 445
Score = 501 bits (1290), Expect = e-140
Identities = 247/449 (55%), Positives = 313/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN +SE G+LP+ QN+P +CPY LYAEQ+SG++FT PRN N SW Y
Sbjct: 3 ELKYISGFGNECASEDPRCPGSLPKGQNNPQVCPYNLYAEQLSGSAFTCPRNTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--QGHVTH--NWDEVGPDPNQLRWKPFEIPKASEKKVDFVSGLYT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G A+H++ N SM + F N+DGDFLIVPQ+G+L I TE G++ + P E
Sbjct: 119 LCGAGDIKSNNGLAVHIFLCNSSMESRCFYNSDGDFLIVPQKGKLLIYTEFGKMSLQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF+VD+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSVDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ KF G+LF+ QD SPFNVVAW GNY PYKY+L F N V FDH+DPSI
Sbjct: 238 RVPGGYTVINKFQGKLFACKQDVSPFNVVAWHGNYTPYKYNLENFMVINAVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES 421
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L++
Sbjct: 358 LPGGGSLHSAMTPHGPDADCFEK--ASKAKLEPERIADGTMAFMFESSLSLAVTKWGLKT 415
Query: 422 -PFLDHDYYQCWIGLRSHFNVTEISPRTP 449
LD +YY+CW LRSHF SP P
Sbjct: 416 CSCLDENYYKCWEPLRSHFTPNSRSPTEP 444
>UniRef100_UPI000036B6DA UPI000036B6DA UniRef100 entry
Length = 445
Score = 501 bits (1289), Expect = e-140
Identities = 248/449 (55%), Positives = 314/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN SSE G+LPE QN+P +CPY LYAEQ+SG++FT PR+ N SW Y
Sbjct: 3 ELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--EGHVTH--NWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G AIH++ N SM N F N+DGDFLIVPQ+G L I TE G++ V P E
Sbjct: 119 LCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF++D+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSIDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ K+ G+LF+A QD SPFNVVAW GNY PYKY+L F N+V FDH+DPSI
Sbjct: 238 QAPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALE- 420
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L+
Sbjct: 358 LPGGGSLHSTMTPHGPDADCFEK--ASKAKLAPERIADGTMAFMFESSLSLAVTKWGLKA 415
Query: 421 SPFLDHDYYQCWIGLRSHFNVTEISPRTP 449
S LD +Y++CW L+SHF +P P
Sbjct: 416 SRCLDENYHKCWEPLKSHFTPNSRNPAEP 444
>UniRef100_Q93099 Homogentisate 1,2-dioxygenase [Homo sapiens]
Length = 445
Score = 501 bits (1289), Expect = e-140
Identities = 248/449 (55%), Positives = 314/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN SSE G+LPE QN+P +CPY LYAEQ+SG++FT PR+ N SW Y
Sbjct: 3 ELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--EGHVTH--NWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G AIH++ N SM N F N+DGDFLIVPQ+G L I TE G++ V P E
Sbjct: 119 LCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF++D+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSIDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ K+ G+LF+A QD SPFNVVAW GNY PYKY+L F N+V FDH+DPSI
Sbjct: 238 QVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALE- 420
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L+
Sbjct: 358 LPGGGSLHSTMTPHGPDADCFEK--ASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKA 415
Query: 421 SPFLDHDYYQCWIGLRSHFNVTEISPRTP 449
S LD +Y++CW L+SHF +P P
Sbjct: 416 SRCLDENYHKCWEPLKSHFTPNSRNPAEP 444
>UniRef100_UPI00002DA81C UPI00002DA81C UniRef100 entry
Length = 436
Score = 500 bits (1288), Expect = e-140
Identities = 247/437 (56%), Positives = 309/437 (70%), Gaps = 15/437 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN FSSE G+LPE QNSP CPYGLYAEQ+SG++FT PR N SW YR+
Sbjct: 6 YMSGFGNEFSSEDPRCPGSLPEGQNSPQACPYGLYAEQLSGSAFTCPRPANKRSWLYRIL 65
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLSTVCG 126
PSV H+PF V C G + +++ +P QLRW P P + DF+ GL T+CG
Sbjct: 66 PSVKHKPFAA-VSC-GNLTEDWDEVEP--DPNQLRWLPFSIPKPTEKKVDFVSGLHTICG 121
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+G + R+G +H+Y N SM + F N+DGDFLIVPQQG + ITTE G++ V P EI +
Sbjct: 122 AGDARSRNGIGVHVYACNASMADRCFNNSDGDFLIVPQQGEILITTEFGKMLVEPNEICV 181
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+ QG RF+VD+ G +RGY+ E++G HF+LPDLGPIGANGLA PRDF P AW+ED+
Sbjct: 182 IQQGMRFSVDV-FGATRGYILEVYGAHFELPDLGPIGANGLANPRDFQCPVAWYEDRRVA 240
Query: 247 -GYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTV 305
GYT++ K+ G+LF+ QDFSPFNVVAW GNY PYKY+L F N V FDH+DPSI TV
Sbjct: 241 TGYTVINKYQGKLFACQQDFSPFNVVAWHGNYTPYKYNLDDFMVINCVAFDHADPSIFTV 300
Query: 306 LTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPG 365
LTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK +GF PG
Sbjct: 301 LTAKSTRPGVAVADFVIFPPRWGVADRTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQPG 360
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES-PF 423
GASLHS MTPHGPD +E ++ P ++ D TMAFMFES +++W L++
Sbjct: 361 GASLHSIMTPHGPDADCFEKNSTA--ELKPERVADGTMAFMFESSFSMAVTKWGLQTCQK 418
Query: 424 LDHDYYQCWIGLRSHFN 440
LD +Y++CW LRSHF+
Sbjct: 419 LDKNYHRCWEDLRSHFD 435
>UniRef100_Q6AYR0 Hypothetical protein [Rattus norvegicus]
Length = 445
Score = 499 bits (1284), Expect = e-140
Identities = 247/449 (55%), Positives = 313/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN +SE G+LP+ QN+P ICPY LYAEQ+SG++FT PRN N SW Y
Sbjct: 3 ELKYISGFGNECASEDPRCPGSLPKGQNNPQICPYNLYAEQLSGSAFTCPRNTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDS---PTDFIDGLST 123
R+ PSV+H+PF G I N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFASID--QGHI--NHNWDEVGPDPNQLRWKPFEIPKACQKKVDFVSGLHT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G A+H++ N M N F N+DGDFLIVPQ+G+L I TE G++ + P E
Sbjct: 119 LCGAGDIRSNNGLAVHIFLCNSPMENRCFYNSDGDFLIVPQKGKLLIYTEFGKMFLQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF+VD+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSVDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG +T++ K+ G+LF++ QD SPFNVVAW GNY PYKY+L F N V FDH+DPSI
Sbjct: 238 QVPGGFTVINKYQGKLFASKQDVSPFNVVAWHGNYTPYKYNLENFMVINAVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES 421
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L++
Sbjct: 358 LPGGGSLHSAMTPHGPDADCFEK--ASKAKLEPERIADGTMAFMFESSLSLAVTKWGLKT 415
Query: 422 -PFLDHDYYQCWIGLRSHFNVTEISPRTP 449
LD DYY+CW L++HF T SP P
Sbjct: 416 CGCLDEDYYKCWEPLQAHFTPTSRSPTEP 444
>UniRef100_Q5RF05 Hypothetical protein DKFZp469K2032 [Pongo pygmaeus]
Length = 445
Score = 495 bits (1274), Expect = e-138
Identities = 246/446 (55%), Positives = 310/446 (69%), Gaps = 15/446 (3%)
Query: 12 YLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
Y+SGFGN SSE G+LPE QN+P +CPY LYAEQ+SG++FT PR+ N SW YR+
Sbjct: 6 YISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLYRIP 65
Query: 70 PSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLSTVCG 126
PSV+H+PF+ G + N +P QLRWKP + P D + GL T+CG
Sbjct: 66 PSVSHKPFESID--EGHVTH--NWDEVDPDPNQLRWKPFEIPKVSQKKVDLVSGLHTLCG 121
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+G +G AIH++ N SM N F N+DGDFLIVPQ+G L I TE G++ V P EI +
Sbjct: 122 AGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEICV 181
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+ +G RF++D+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+ P
Sbjct: 182 IQRGMRFSIDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDRQVP 240
Query: 247 G-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTV 305
G YT++ K+ G+LF+A Q SPFNVVAW GNY PYKY+L F N+V FDH+DPSI TV
Sbjct: 241 GGYTVIDKYQGKLFAAKQGVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV 300
Query: 306 LTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPG 365
LTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GFLPG
Sbjct: 301 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG 360
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALE-SPF 423
G SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L+ S
Sbjct: 361 GGSLHSTMTPHGPDADCFEK--ASKAKLAPERIADGTMAFMFESSLSLAVTKWGLKASRC 418
Query: 424 LDHDYYQCWIGLRSHFNVTEISPRTP 449
LD +Y++CW L+SHF +P P
Sbjct: 419 LDENYHKCWEPLKSHFTPNFRNPAEP 444
Database: uniref100
Posted date: Jan 5, 2005 1:24 AM
Number of letters in database: 848,049,833
Number of sequences in database: 2,790,947
Lambda K H
0.321 0.139 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 899,502,508
Number of Sequences: 2790947
Number of extensions: 41024329
Number of successful extensions: 65297
Number of sequences better than 10.0: 146
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 64809
Number of HSP's gapped (non-prelim): 151
length of query: 463
length of database: 848,049,833
effective HSP length: 131
effective length of query: 332
effective length of database: 482,435,776
effective search space: 160168677632
effective search space used: 160168677632
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 77 (34.3 bits)
Lotus: description of TM0282.7