BLAST2 result
BLASTP 2.2.2 [Dec-14-2001]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= TM0282.7
(463 letters)
Database: sprot
164,201 sequences; 59,974,054 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
HGD_ARATH (Q9ZRA2) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 761 0.0
HGD_DROME (Q9VKJ0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 503 e-142
HGD_MOUSE (O09173) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 501 e-141
HGD_HUMAN (Q93099) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 501 e-141
HGD_CAEEL (Q9Y041) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 481 e-135
HGD_RALSO (Q8XRZ0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 469 e-132
HGD_CAUCR (Q9A5B8) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 461 e-129
HGD_PSEAE (Q9X4G0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 460 e-129
HGD_XANCP (Q8PDA2) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 455 e-127
HGD_PSEPK (Q88E47) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 447 e-125
HGD_XANAC (Q8PQ74) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 444 e-124
HGD_PSESM (Q87Z79) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 440 e-123
HGD_STRAW (Q828S5) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 434 e-121
HGD_EMENI (Q00667) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 431 e-120
HGD_STRCO (Q9S2B5) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 428 e-119
HGD_RHILO (Q983J4) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 422 e-118
HGD_BRAJA (Q89XH1) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 420 e-117
HGD_RHIME (Q9X4F5) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 411 e-114
HGD_LEGPN (Q9S4T0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5) ... 394 e-109
YD45_VIBCH (Q9KSB4) Putative dioxygenase VC1345 (EC 1.13.-.-) 67 1e-10
>HGD_ARATH (Q9ZRA2) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 461
Score = 761 bits (1965), Expect = 0.0
Identities = 351/433 (81%), Positives = 384/433 (88%)
Query: 8 DDFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYR 67
++ Y SGFGNHFSSEA+AGALP QNSPL+CPYGLYAEQISGTSFTSPR LN SW YR
Sbjct: 9 EELKYQSGFGNHFSSEAIAGALPLDQNSPLLCPYGLYAEQISGTSFTSPRKLNQRSWLYR 68
Query: 68 VKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGS 127
VKPSVTHEPFKPRVP + +++SEF+ SNS TNPTQLRW+P D PDS DF+DGL T+CG+
Sbjct: 69 VKPSVTHEPFKPRVPAHKKLVSEFDASNSRTNPTQLRWRPEDIPDSEIDFVDGLFTICGA 128
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
GSSF+RHG+AIHMY AN M + AFCNADGDFL+VPQ GRL+I TECGRL V+PGEIA++
Sbjct: 129 GSSFLRHGFAIHMYVANTGMKDSAFCNADGDFLLVPQTGRLWIETECGRLLVTPGEIAVI 188
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
PQGFRF++DLPDG SRGYVAEI+G HFQLPDLGPIGANGLAA RDFL PTAWFED P
Sbjct: 189 PQGFRFSIDLPDGKSRGYVAEIYGAHFQLPDLGPIGANGLAASRDFLAPTAWFEDGLRPE 248
Query: 248 YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLT 307
YTIVQKFGGELF+A QDFSPFNVVAW GNYVPYKYDL KFCPYNTVL DH DPSINTVLT
Sbjct: 249 YTIVQKFGGELFTAKQDFSPFNVVAWHGNYVPYKYDLKKFCPYNTVLLDHGDPSINTVLT 308
Query: 308 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGA 367
APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLI+G YEAK DGFLPGGA
Sbjct: 309 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIYGAYEAKADGFLPGGA 368
Query: 368 SLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHD 427
SLHSCMTPHGPDT +YEATIAR N + P+K+T TMAFMFES LIPR+ WALESPFLDHD
Sbjct: 369 SLHSCMTPHGPDTTTYEATIARVNAMAPSKLTGTMAFMFESALIPRVCHWALESPFLDHD 428
Query: 428 YYQCWIGLRSHFN 440
YYQCWIGL+SHF+
Sbjct: 429 YYQCWIGLKSHFS 441
>HGD_DROME (Q9VKJ0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 439
Score = 503 bits (1294), Expect = e-142
Identities = 249/442 (56%), Positives = 307/442 (69%), Gaps = 13/442 (2%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
++ YLSGFG+HFSSE +LP QNSP +CPY LYAEQ+SG++FT+PR N+ +W Y
Sbjct: 3 EYKYLSGFGSHFSSEDERYPNSLPVGQNSPQVCPYKLYAEQLSGSAFTAPRTENMRTWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLST 123
R PS H PF+P G N NP QLRWKP D P +F++GL T
Sbjct: 63 RKLPSAAHLPFQP---FKGAEYFSQNWDEQPPNPNQLRWKPFDLPPKDGKNVNFVEGLHT 119
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
VCG+G RHG AIH+Y+ N SM+N AF N+DGDFLIVPQQG L ITTE GR+ V+P E
Sbjct: 120 VCGAGDPRSRHGLAIHIYSCNGSMDNSAFYNSDGDFLIVPQQGVLDITTEFGRMSVAPNE 179
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++PQG RF V++ D PSRGY+ E++ HF LPDLGPIGANGLA PRDF P AWF+D+
Sbjct: 180 ICVIPQGIRFAVNV-DSPSRGYILEVYDDHFVLPDLGPIGANGLANPRDFETPVAWFDDR 238
Query: 244 SYPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSIN 303
+ ++ KF G LF A Q+ + F+VVAW GNYVP+KYDLSKF N+V FDH DPSI
Sbjct: 239 DVKDFQVISKFQGRLFVAKQNHTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIF 298
Query: 304 TVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFL 363
TVLT P+ + G A+ DFVIFPPRW V EHTFRPPYYHRNCMSEFMGLI G YEAK DGF
Sbjct: 299 TVLTCPSLRAGTAIADFVIFPPRWSVQEHTFRPPYYHRNCMSEFMGLILGKYEAKEDGFA 358
Query: 364 PGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES- 421
GGA+LHS MTPHGPD K +E A + P ++ + T AFMFES L +++W E+
Sbjct: 359 AGGATLHSMMTPHGPDVKCFEG--ASNAKLVPERVAEGTQAFMFESSLSLAVTKWGEETC 416
Query: 422 PFLDHDYYQCWIGLRSHFNVTE 443
LD YY+CW L+++F +T+
Sbjct: 417 QKLDAAYYECWQALKNNFQITK 438
>HGD_MOUSE (O09173) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 445
Score = 501 bits (1291), Expect = e-141
Identities = 247/449 (55%), Positives = 312/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN +SE G+LP+ QN+P +CPY LYAEQ+SG++FT PRN N SW Y
Sbjct: 3 ELKYISGFGNECASEDPRCPGSLPKGQNNPQVCPYNLYAEQLSGSAFTCPRNTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSP---DSPTDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--QGHVTH--NWDEVGPDPNQLRWKPFEIPKASEKKVDFVSGLYT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G A+H++ N SM N F N+DGDFLIVPQ+G+L I TE G++ + P E
Sbjct: 119 LCGAGDIKSNNGLAVHIFLCNSSMENRCFYNSDGDFLIVPQKGKLLIYTEFGKMSLQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF+VD+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSVDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ KF G+LF+ QD SPFNVV W GNY PYKY+L F N V FDH+DPSI
Sbjct: 238 RVPGGYTVINKFQGKLFACKQDVSPFNVVTWHGNYTPYKYNLENFMVINAVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSLRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALES 421
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L++
Sbjct: 358 LPGGGSLHSAMTPHGPDADCFEK--ASKAKLEPERIADGTMAFMFESSLSLAVTKWGLKT 415
Query: 422 -PFLDHDYYQCWIGLRSHFNVTEISPRTP 449
LD +YY+CW LRSHF SP P
Sbjct: 416 CSCLDENYYKCWEPLRSHFTPNSRSPTEP 444
>HGD_HUMAN (Q93099) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 445
Score = 501 bits (1289), Expect = e-141
Identities = 248/449 (55%), Positives = 314/449 (69%), Gaps = 15/449 (3%)
Query: 9 DFNYLSGFGNHFSSE--ALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFY 66
+ Y+SGFGN SSE G+LPE QN+P +CPY LYAEQ+SG++FT PR+ N SW Y
Sbjct: 3 ELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSWLY 62
Query: 67 RVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP---TDFIDGLST 123
R+ PSV+H+PF+ G + N +P QLRWKP + P + DF+ GL T
Sbjct: 63 RILPSVSHKPFESID--EGHVTH--NWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHT 118
Query: 124 VCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGE 183
+CG+G +G AIH++ N SM N F N+DGDFLIVPQ+G L I TE G++ V P E
Sbjct: 119 LCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNE 178
Query: 184 IAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDK 243
I ++ +G RF++D+ + +RGY+ E++G HF+LPDLGPIGANGLA PRDFL+P AW+ED+
Sbjct: 179 ICVIQRGMRFSIDVFE-ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDR 237
Query: 244 SYPG-YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
PG YT++ K+ G+LF+A QD SPFNVVAW GNY PYKY+L F N+V FDH+DPSI
Sbjct: 238 QVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSI 297
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTA + +PGVA+ DFVIFPPRW VA+ TFRPPYYHRNCMSEFMGLI G YEAK GF
Sbjct: 298 FTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGF 357
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALE- 420
LPGG SLHS MTPHGPD +E A + P +I D TMAFMFES L +++W L+
Sbjct: 358 LPGGGSLHSTMTPHGPDADCFEK--ASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKA 415
Query: 421 SPFLDHDYYQCWIGLRSHFNVTEISPRTP 449
S LD +Y++CW L+SHF +P P
Sbjct: 416 SRCLDENYHKCWEPLKSHFTPNSRNPAEP 444
>HGD_CAEEL (Q9Y041) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 437
Score = 481 bits (1238), Expect = e-135
Identities = 248/438 (56%), Positives = 297/438 (67%), Gaps = 11/438 (2%)
Query: 8 DDFNYLSGFGNHF--SSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWF 65
D+ YL+GFGN S + ALP QNSP C +GLYAEQ+SGT+FT+PR+ N SW
Sbjct: 5 DELKYLTGFGNEHATSDPRVPDALPVGQNSPQKCSHGLYAEQLSGTAFTAPRSQNQRSWL 64
Query: 66 YRVKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSP-TDFIDGLSTV 124
YR++PSV H PF+ + + F S+ NP Q RW P P F+D L TV
Sbjct: 65 YRIRPSVIHRPFEAMKENDQHWTNNF--SSIPPNPNQYRWNPFPLPTKEGVTFVDNLYTV 122
Query: 125 CGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEI 184
CG G R G AIH ++ N SM + A N+DGDFLIVPQQG L ITTE GRL V+P EI
Sbjct: 123 CGGGDVISRTGLAIHQFSCNASMEHTAMYNSDGDFLIVPQQGALEITTEFGRLLVNPQEI 182
Query: 185 AMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKS 244
A++PQG RF+V + GPSRGY+ E++GTHFQLPDLGPIGANGLA PRDF P AWFED
Sbjct: 183 AVIPQGIRFSVAVR-GPSRGYILEVYGTHFQLPDLGPIGANGLANPRDFEAPVAWFEDLD 241
Query: 245 YPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINT 304
+TI+ K+ G F A Q SPF+VV W GNYVPYKYDL KF NTV FDH DPSI T
Sbjct: 242 VE-FTIINKYQGSWFQAKQGHSPFDVVGWHGNYVPYKYDLKKFMVINTVSFDHCDPSIFT 300
Query: 305 VLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLP 364
VLTAP+ K G A+ DFVIFPPRW A++TFRPPYYHRNCMSE+MGLI G YEAK GF P
Sbjct: 301 VLTAPSVKHGTAIADFVIFPPRWGCADNTFRPPYYHRNCMSEYMGLITGCYEAKEGGFKP 360
Query: 365 GGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALESPF 423
GG SLHS MTPHGPD +E +A D+ P ++ + TM+FMFES L I+ WA+
Sbjct: 361 GGGSLHSMMTPHGPDFNCFE--MASNADLKPQRVAEGTMSFMFESSLNMAITNWAVYQN- 417
Query: 424 LDHDYYQCWIGLRSHFNV 441
+D DYY+ W L+ HF +
Sbjct: 418 VDKDYYKDWQPLKKHFTM 435
>HGD_RALSO (Q8XRZ0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 448
Score = 469 bits (1206), Expect = e-132
Identities = 233/429 (54%), Positives = 297/429 (68%), Gaps = 6/429 (1%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
Y SGFGN F++EAL GALP QNSP PYGLYAEQ+SGT+FT+PR N +W YR++P+
Sbjct: 22 YQSGFGNEFATEALPGALPHGQNSPQQAPYGLYAEQLSGTAFTAPRAHNRRAWLYRIRPA 81
Query: 72 VTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSGSSF 131
H PF+P R S+F+ +S P QLRW P+ +P + TDFIDG+ T G+G
Sbjct: 82 AVHLPFEPIA--QDRFHSDFHAVPAS--PNQLRWDPLPAPAAGTDFIDGIVTFAGNGGPD 137
Query: 132 MRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQGF 191
+ G IH+Y AN SM F NADG+ LIVPQQGRL + TE G L V P EIA++P+G
Sbjct: 138 AQTGCGIHLYAANASMTGRFFYNADGELLIVPQQGRLRLLTELGVLDVEPLEIAVIPRGV 197
Query: 192 RFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGYTIV 251
RF V+LPDG +RGY+ E FG F+LPDLG IG+NGLA PRDFL P AW+ED+ + +V
Sbjct: 198 RFRVELPDGEARGYLCENFGAIFRLPDLGVIGSNGLANPRDFLTPHAWYEDRE-GDFELV 256
Query: 252 QKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTAPTD 311
KF G L+ A SP +VVAW GNY PYKYDL F ++ +DH DPSI VL + +D
Sbjct: 257 AKFHGNLWRARIGHSPLDVVAWHGNYAPYKYDLRLFNTIGSISYDHPDPSIFLVLQSVSD 316
Query: 312 KPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGASLHS 371
PGV +DFVIFPPRWL EH+FRPP++HRN SEFMGLI G Y+AK +GF+PGGASLH+
Sbjct: 317 TPGVDAIDFVIFPPRWLAMEHSFRPPWFHRNIASEFMGLIQGVYDAKAEGFVPGGASLHN 376
Query: 372 CMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDYYQC 431
CMT HGPD +++E + + P+K+ TMAFMFE+ + R +R+A ES L Y++C
Sbjct: 377 CMTGHGPDAETFEKA-SHADTTQPHKVEATMAFMFETRGVIRPTRFAAESAQLQARYFEC 435
Query: 432 WIGLRSHFN 440
W GL+ HF+
Sbjct: 436 WQGLKKHFD 444
>HGD_CAUCR (Q9A5B8) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 425
Score = 461 bits (1186), Expect = e-129
Identities = 230/426 (53%), Positives = 294/426 (68%), Gaps = 9/426 (2%)
Query: 9 DFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRV 68
D Y +GFG++F +EA GALP +NSP P+GLYAEQ+SG++FT+PR+ N +W YR+
Sbjct: 2 DLRYQTGFGSYFETEAHPGALPVGRNSPQKVPFGLYAEQLSGSAFTAPRHENRRTWLYRL 61
Query: 69 KPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSG 128
+PS HE ++P +++S F P +LRW P++ P +PTDF+DGL ++ G+
Sbjct: 62 RPSAGHEAYQPYA--QDKLVSAFP---GPATPNRLRWSPLEIPAAPTDFVDGLVSLAGNA 116
Query: 129 SSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLP 188
+ G A H+Y N SM N F NADG+ LIVPQ G L + TE G LK PG IA++P
Sbjct: 117 DAATLGGIAAHVYLVNVSMKNRVFYNADGEMLIVPQMGELTLVTEMGVLKAGPGHIAVIP 176
Query: 189 QGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGY 248
+G RF V++ +GP+RGYV E +G F+LP+LGPIGANGLA PRDF P A FED P
Sbjct: 177 RGVRFRVEV-EGPARGYVCENYGAAFRLPELGPIGANGLANPRDFEAPVAAFEDIDTPTQ 235
Query: 249 TIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTA 308
++QKF G L++A D SP +VVAW GN PY+YDLS+F NTV +DH DPSI TVLT+
Sbjct: 236 -VIQKFQGALWAATWDHSPLDVVAWHGNLTPYRYDLSRFNTINTVSYDHPDPSIFTVLTS 294
Query: 309 PTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGAS 368
P+D PG A DFVIFPPRW+VAE TFRPP++HRN MSEFMGLIHG Y+AK GF+PGGAS
Sbjct: 295 PSDTPGTANCDFVIFPPRWMVAEDTFRPPWFHRNVMSEFMGLIHGAYDAKAGGFVPGGAS 354
Query: 369 LHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDY 428
LH+CM+ HGPD S++ A + P+KI TMAFMFES + R + ALES L DY
Sbjct: 355 LHNCMSDHGPDVASHKK--ATEVVLAPHKIDGTMAFMFESRWVFRPTHLALESAALQSDY 412
Query: 429 YQCWIG 434
CW G
Sbjct: 413 DACWTG 418
>HGD_PSEAE (Q9X4G0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 432
Score = 460 bits (1184), Expect = e-129
Identities = 235/430 (54%), Positives = 295/430 (67%), Gaps = 12/430 (2%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
Y SGFGN FSSEAL GALP QNSP PYGLYAE +SGT+FT R+ +W YR+ PS
Sbjct: 10 YQSGFGNEFSSEALPGALPVGQNSPQKAPYGLYAELLSGTAFTMARSEARRTWLYRITPS 69
Query: 72 VTHEPFKPRVPCNGRILSEFNHSN-SSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSGSS 130
H PF+ R+ + + + P +LRW P+ P+ PTDF+DGL + +
Sbjct: 70 AKHPPFR-------RLERQIAGAELDAPTPNRLRWDPLALPEQPTDFLDGLLRMAANAPG 122
Query: 131 FMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQG 190
G +I+ Y AN+SM C F +ADG+ L+VPQ GRL + TE G L+V P EIA++P+G
Sbjct: 123 DKPAGVSIYQYLANRSMERC-FYDADGELLLVPQLGRLRLCTELGALQVEPLEIAVIPRG 181
Query: 191 FRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGYTI 250
+F V+L DG +RGY+AE G +LPDLGPIG+NGLA PRDFL P A +ED P +
Sbjct: 182 MKFRVELLDGEARGYIAENHGAPLRLPDLGPIGSNGLANPRDFLTPVARYEDSRQP-LQL 240
Query: 251 VQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTAPT 310
VQK+ GEL++ D SP +VVAW GN VPYKYDL +F TV FDH DPSI TVLT+PT
Sbjct: 241 VQKYLGELWACELDHSPLDVVAWHGNNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPT 300
Query: 311 DKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGASLH 370
PG+A +DFVIFPPRW+VAE+TFRPP++HRN M+EFMGLI G Y+AK GF+PGGASLH
Sbjct: 301 SVPGLANIDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIQGAYDAKAGGFVPGGASLH 360
Query: 371 SCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDYYQ 430
SCM+ HGPD +S + IA D+ P++I TMAFMFE+ + R SR ALE+P L +DY
Sbjct: 361 SCMSAHGPDAESCDKAIAA--DLKPHRIDQTMAFMFETSQVLRPSRAALETPALQNDYDA 418
Query: 431 CWIGLRSHFN 440
CW L S FN
Sbjct: 419 CWASLVSTFN 428
>HGD_XANCP (Q8PDA2) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 455
Score = 455 bits (1171), Expect = e-127
Identities = 227/438 (51%), Positives = 294/438 (66%), Gaps = 6/438 (1%)
Query: 8 DDFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYR 67
+D Y++GFGN F+SEA+A LP QNSP +GLYAEQ+SGT+FT+PR N SW YR
Sbjct: 24 NDQRYMTGFGNEFASEAVADTLPVGQNSPQRVAHGLYAEQLSGTAFTAPRGENRRSWLYR 83
Query: 68 VKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGS 127
++P+ H F + + ++F H P QLRW P+ P +PTDFIDGL T+ G+
Sbjct: 84 MRPAAVHGTFS--LIEQSQFHNDFGHG--PVPPDQLRWSPLPLPQTPTDFIDGLYTMAGN 139
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
GS +G A+H+Y AN SM + F NADG+ L+VPQ GRL + TE G L++ P +I ++
Sbjct: 140 GSPEAMNGVAVHLYAANASMQDRFFYNADGELLLVPQLGRLRVHTELGMLELEPQQIGVI 199
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
P+G RF V+L DG +RGYV E FG LPDLGPIG+NGLA PRDF P A FE +
Sbjct: 200 PRGVRFRVELRDGTARGYVCENFGGLLHLPDLGPIGSNGLANPRDFETPCAAFEQRE-GR 258
Query: 248 YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLT 307
+ +V KF G L+ A SP +VVAW GNY PY+YDL +F ++ FDH DPSI TVLT
Sbjct: 259 FELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSIFTVLT 318
Query: 308 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGA 367
+P+D G A +DF IFPPRWLVA+HTFRPP++HRN SEFMGL+HG Y+AK DGF PGGA
Sbjct: 319 SPSDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKADGFAPGGA 378
Query: 368 SLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHD 427
SLH+CM+ HGPD +++ ++ + P+ IT+TMAFMFE+ + R + AL +P D
Sbjct: 379 SLHNCMSGHGPDAATFDKA-SQADLSRPDVITETMAFMFETRAVLRPTAQALHAPHRQGD 437
Query: 428 YYQCWIGLRSHFNVTEIS 445
Y QCW GLR F S
Sbjct: 438 YQQCWAGLRKAFQAPPAS 455
>HGD_PSEPK (Q88E47) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 433
Score = 447 bits (1149), Expect = e-125
Identities = 232/434 (53%), Positives = 292/434 (66%), Gaps = 14/434 (3%)
Query: 9 DFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRV 68
D +YLSGFGN F+SEAL GALP QNSP PYGLYAE +SGT+FT R+ +W YR+
Sbjct: 8 DLHYLSGFGNEFASEALPGALPVGQNSPQKAPYGLYAELLSGTAFTMARSELRRTWLYRI 67
Query: 69 KPSVTHEPFK--PRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCG 126
+PS H F+ R P G + NP +LRW P P PTDFI+G +
Sbjct: 68 RPSALHPRFERLARQPLGGPL--------GGINPNRLRWSPQPIPAEPTDFIEGWLPMAA 119
Query: 127 SGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAM 186
+ + G +I++Y AN+SM F NADG+ L+VP+QGRL I TE G ++V P EIA+
Sbjct: 120 NAGAEKPAGVSIYIYRANRSMER-VFFNADGELLLVPEQGRLRIATELGVMEVEPLEIAV 178
Query: 187 LPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYP 246
+P+G +F V+L DG +RGY+AE G +LPDLGPIG+NGLA PRDFL P A +E+ P
Sbjct: 179 IPRGMKFRVELLDGQARGYIAENHGAPLRLPDLGPIGSNGLANPRDFLTPVAHYEEAEGP 238
Query: 247 GYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVL 306
+VQKF GE ++ SP +VVAW G+ VPYKYDL +F TV FDH DPSI TVL
Sbjct: 239 -VQLVQKFLGEHWACELQHSPLDVVAWHGSNVPYKYDLRRFNTIGTVSFDHPDPSIFTVL 297
Query: 307 TAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGG 366
T+PT G+A +DFVIFPPRW+VAE+TFRPP++HRN M+EFMGLI+G Y+AK +GFLPGG
Sbjct: 298 TSPTSVHGMANMDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLINGAYDAKAEGFLPGG 357
Query: 367 ASLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDH 426
ASLH M+ HGPD ++ E IA D+ P+KI +TMAFMFE+ + R S ALE P L
Sbjct: 358 ASLHGVMSAHGPDAETCEKAIAA--DLAPHKIDNTMAFMFETSQVLRPSLQALECPQLQA 415
Query: 427 DYYQCWIGLRSHFN 440
DY CW L S FN
Sbjct: 416 DYDSCWATLPSTFN 429
>HGD_XANAC (Q8PQ74) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 458
Score = 444 bits (1143), Expect = e-124
Identities = 222/437 (50%), Positives = 291/437 (65%), Gaps = 16/437 (3%)
Query: 8 DDFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYR 67
+D Y++GFGN F++EA+AG+LP QNSP +GLYAEQ+SGT+FT+PR N SW YR
Sbjct: 24 NDQRYMTGFGNEFATEAVAGSLPIGQNSPQRVAHGLYAEQLSGTAFTAPRGQNRRSWLYR 83
Query: 68 VKPSVTHEPFKPRVPCNGRILSEFNHSNSSTN-----PTQLRWKPMDSPDSPTDFIDGLS 122
++P+ H F L E +H ++ P QLRW P+ P PTDF+DGL
Sbjct: 84 IRPAAVHGSFS---------LVEQSHFHNDFGAGPVPPDQLRWSPLPLPSVPTDFVDGLY 134
Query: 123 TVCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPG 182
T+ G+G G +H+Y AN SM + F +ADG+ L+VPQQGRL + TE G L + P
Sbjct: 135 TMAGNGGPEAMSGVGVHVYAANASMQDRFFYDADGELLLVPQQGRLRVHTELGVLALEPQ 194
Query: 183 EIAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFED 242
+I ++P+G RF V+L D +RGYV E FG +LPDLGPIGANGLA PRDF P A FE
Sbjct: 195 QIGVIPRGMRFRVELLDAAARGYVCENFGGLLRLPDLGPIGANGLANPRDFETPHAAFEQ 254
Query: 243 KSYPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
+ + +V KF G L+ A SP +VVAW GNY PY+YDL +F ++ FDH DPSI
Sbjct: 255 REGT-FELVAKFQGHLWRADIGHSPLDVVAWHGNYAPYRYDLRRFNTIGSISFDHPDPSI 313
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLT+P+D G A +DF IFPPRWLVA+HTFRPP++HRN SEFMGL+HG Y+AK +GF
Sbjct: 314 FTVLTSPSDTHGTANMDFAIFPPRWLVAQHTFRPPWFHRNVASEFMGLVHGVYDAKAEGF 373
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESP 422
PGGASLH+CM+ HGPD +++ ++ + P+ I DTMAFMFE+ + R ++ AL +
Sbjct: 374 APGGASLHNCMSGHGPDAATFDKA-SQADLTRPDVIADTMAFMFETRAVLRPTQQALSAA 432
Query: 423 FLDHDYYQCWIGLRSHF 439
DY QCW GLR+ F
Sbjct: 433 HRQADYQQCWSGLRAAF 449
>HGD_PSESM (Q87Z79) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 434
Score = 440 bits (1131), Expect = e-123
Identities = 230/429 (53%), Positives = 285/429 (65%), Gaps = 10/429 (2%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
Y SGF N FSSEAL GALP QNSP P GLYAEQ SGT+FT RN +W YR+KPS
Sbjct: 12 YQSGFANQFSSEALPGALPMGQNSPQKHPLGLYAEQFSGTAFTVARNEARRTWLYRIKPS 71
Query: 72 VTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSGSSF 131
H PR R ++ NP +LRW D P P DFIDGL + + ++
Sbjct: 72 AAH----PRYQRMDRQIT--GREQGPINPNRLRWNAFDIPAEPVDFIDGLIALASTSAAD 125
Query: 132 MRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQGF 191
G ++++Y AN SM AF +ADG++LIVPQQGRL I TE G L + P EIA+LP+G
Sbjct: 126 QAEGVSVYVYAANTSMQR-AFFSADGEWLIVPQQGRLRIITEMGVLDIGPLEIAVLPRGL 184
Query: 192 RFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGYTIV 251
+F+V L DG +RGY+ E G +LP+LGPIG+NGLA PRDFL P AWFE++ P +V
Sbjct: 185 KFSVQLLDGSARGYLCENHGGVLRLPELGPIGSNGLANPRDFLTPVAWFEERDEP-VQLV 243
Query: 252 QKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTAPTD 311
QKF GEL++ SPF+VV W GN VPY YDL +F TV +DH DPSI TVLT+P
Sbjct: 244 QKFLGELWTTQLQHSPFDVVGWHGNNVPYTYDLRRFNTIGTVSYDHPDPSIFTVLTSPGA 303
Query: 312 KPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGASLHS 371
G A +DFVIFPPRW+VAE+TFRPP++HRN M+EFMGLI G Y+AK +GF+PGG+SLH+
Sbjct: 304 VHGQANIDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLIDGAYDAKAEGFMPGGSSLHN 363
Query: 372 CMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDYYQC 431
CM+ HGPD + E IA D+ P+KI +TMAFMFE+ + R S AL P L DY C
Sbjct: 364 CMSAHGPDNITAEKAIAA--DLKPHKIENTMAFMFETGKVLRPSLHALACPQLQADYDAC 421
Query: 432 WIGLRSHFN 440
W G+ FN
Sbjct: 422 WNGMARTFN 430
>HGD_STRAW (Q828S5) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 438
Score = 434 bits (1115), Expect = e-121
Identities = 219/432 (50%), Positives = 289/432 (66%), Gaps = 7/432 (1%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
+L+GFGN +SEA+ GALPE +NSP P GLYAEQ+SG++FT PR N SW YR++PS
Sbjct: 14 HLTGFGNEHASEAVPGALPEGRNSPQRAPLGLYAEQLSGSAFTEPRAHNRRSWLYRIRPS 73
Query: 72 VTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSGSSF 131
H PF NG I + + ++ +P +LRW P+ P + TDF+ GL T+ G+G +
Sbjct: 74 AAHPPFTRAD--NGAIRTA-PFTETAPDPNRLRWNPLPEPPAGTDFVGGLWTLGGNGDAT 130
Query: 132 MRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQGF 191
R G A+H+Y AN SM+ F +ADG+ LIVP++G L + TE G L PG++A++P+G
Sbjct: 131 QRTGMAVHLYHANSSMDR-VFSDADGELLIVPERGGLLLRTEFGLLHAEPGQVALVPRGV 189
Query: 192 RFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGYTIV 251
RF VDL D +RGYV E +G FQLPDLGPIGANGLAA RDF P A +ED P +V
Sbjct: 190 RFRVDLLDESARGYVCENYGAPFQLPDLGPIGANGLAAARDFKAPVAAYEDVEGP-VEVV 248
Query: 252 QKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTAPTD 311
KF G L++A D SP +VVAW GN+VPY YDL +F T+ +DH DPSI TVLT+P+D
Sbjct: 249 NKFCGNLWTATYDHSPLDVVAWHGNHVPYTYDLRRFNVLGTISYDHPDPSIFTVLTSPSD 308
Query: 312 KPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGASLHS 371
PG+A +DFV+F PRWLV E TFRPPY+HRN MSE+MGLI G Y+AK GF+PGG SLH+
Sbjct: 309 TPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLIEGAYDAKAAGFVPGGGSLHN 368
Query: 372 CMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDYYQC 431
M+ HGPD ++++ A ++ P KI D +AFMFE+ + A + L Y
Sbjct: 369 MMSAHGPDRETFDR--ASAAELRPQKIDDGLAFMFETRWPVTATAQAARAEHLQPAYDDV 426
Query: 432 WIGLRSHFNVTE 443
W GL+ HF ++
Sbjct: 427 WQGLQRHFRPSD 438
>HGD_EMENI (Q00667) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 448
Score = 431 bits (1107), Expect = e-120
Identities = 226/437 (51%), Positives = 281/437 (63%), Gaps = 10/437 (2%)
Query: 8 DDFNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYR 67
D + Y +GF ++ SEA+ GALP NSP PYGLYAE++SGT+FT+PR+ N +W YR
Sbjct: 10 DPYTYQNGFDSYHESEAIEGALPVGHNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYR 69
Query: 68 VKPSVTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGS 127
+ P+ HE F + LS+ P QLRW P D D D++ GL V GS
Sbjct: 70 ILPAAAHENFVEEDASSYHTLSDAKKLQHI--PNQLRWDPFDL-DETVDWVHGLHLVAGS 126
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
G ++ G I +Y A K M AF +ADGDFLIV Q G L I TE GRL V P EI ++
Sbjct: 127 GDPTVKQGLGILLYAAGKDMGKEAFYSADGDFLIVAQHGVLDIQTELGRLLVRPNEICVI 186
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
P+G R+ V LPDGP RGY+ E++ H+QLP+LGPIG+NGLA RDF P A F+D+ P
Sbjct: 187 PRGVRYRVTLPDGPVRGYICELYQGHYQLPELGPIGSNGLANARDFQAPVAAFDDEEGPT 246
Query: 248 -YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVL 306
Y + KF LFSA QD +PF++VAW GNY PYKYDL +F +V FDH DPSI TVL
Sbjct: 247 EYRLYSKFNNHLFSARQDHTPFDIVAWHGNYYPYKYDLGRFNTMGSVSFDHPDPSIYTVL 306
Query: 307 TAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKV-DGFLPG 365
T P+D G A+ DFVIFPPRWLVAE TFRPP+YHRN MSEFMGLI G Y+AK GF P
Sbjct: 307 TGPSDHVGTAIADFVIFPPRWLVAEKTFRPPWYHRNTMSEFMGLITGNYDAKTGGGFQPA 366
Query: 366 GASLHSCMTPHGPDTKSYEATIARGNDVGPNKITD-TMAFMFESCLIPRISRWALESPFL 424
GASLH+ M+ HGPD ++E A D+ P KI D +MAFMFES L+ +S W L++
Sbjct: 367 GASLHNIMSAHGPDMHAFEG--ASNADLKPTKIGDGSMAFMFESSLMVGVSEWGLKTCQK 424
Query: 425 DHDYY--QCWIGLRSHF 439
+ Y W L+ HF
Sbjct: 425 VQEEYNEHSWQPLKRHF 441
>HGD_STRCO (Q9S2B5) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 441
Score = 428 bits (1100), Expect = e-119
Identities = 221/431 (51%), Positives = 287/431 (66%), Gaps = 10/431 (2%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
YLSGFGN +SEA+AGALPE +NSP P GLYAEQ+SGT+FT PR N SW YR++PS
Sbjct: 14 YLSGFGNEHASEAVAGALPEGRNSPQRAPLGLYAEQLSGTAFTEPRAHNRRSWLYRIRPS 73
Query: 72 VTHEPFKPRVPCNGRI-LSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSGSS 130
H F NG I + FN + +P +LRW P+ P TDF++GL T+ G+G +
Sbjct: 74 AAHPAFTRSG--NGTIRTAPFNQA--VPDPNRLRWNPLPVPGPATDFVEGLWTLGGNGDA 129
Query: 131 FMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQG 190
R G A+H+Y A SM+ F +ADG+ LIVP++G L + TE G L PG +A++P+G
Sbjct: 130 TQRTGMAVHLYHATASMDR-VFSDADGELLIVPERGGLLLRTEFGLLHAEPGHVALIPRG 188
Query: 191 FRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFED-KSYPG-Y 248
RF V L D +RGYV E +G FQLPDLGPIGANGLA RDF P A +ED +S PG
Sbjct: 189 VRFRVQLLDEDARGYVCENYGAPFQLPDLGPIGANGLANARDFRAPVAAYEDDESTPGPV 248
Query: 249 TIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTA 308
+V KF G L++A D SP +VVAW GN+VPY YDL +F ++ +DH DPSI TVLT+
Sbjct: 249 EVVNKFCGNLWTAEYDHSPLDVVAWHGNHVPYVYDLRRFNVIGSISYDHPDPSIFTVLTS 308
Query: 309 PTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGAS 368
P+D PG+A +DFV+F PRWLV E TFRPPY+HRN MSE+MGLI G Y+AK +GF+PGG S
Sbjct: 309 PSDTPGLAGVDFVVFAPRWLVGEDTFRPPYFHRNVMSEYMGLIEGAYDAKAEGFVPGGGS 368
Query: 369 LHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDY 428
LH+ M+ HGPD ++++ A ++ P +I D +AFMFE+ ++ A + L Y
Sbjct: 369 LHNMMSAHGPDRETFDR--ASAAELKPQRIDDGLAFMFETRWPVTLTPQAARAEHLQPGY 426
Query: 429 YQCWIGLRSHF 439
W GL HF
Sbjct: 427 DDVWQGLERHF 437
>HGD_RHILO (Q983J4) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 457
Score = 422 bits (1085), Expect = e-118
Identities = 219/441 (49%), Positives = 272/441 (61%), Gaps = 20/441 (4%)
Query: 10 FNYLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVK 69
F+Y+ GFGN F +E L G+LP+ +NSP YGLYAEQ+SG+ FT+PR N SW YR++
Sbjct: 23 FSYMPGFGNDFETETLPGSLPQGRNSPQRPAYGLYAEQLSGSPFTAPRGTNERSWLYRIR 82
Query: 70 PSVTHE--------PFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGL 121
PSV H P P N + Q RW P+ P PTDFI G+
Sbjct: 83 PSVKHTGRFKAASYPLWKTAP---------NVGDHELALGQYRWNPVPMPKEPTDFIQGM 133
Query: 122 STVCGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSP 181
++ +G + G A H+Y AN+SM + F NADG+ L+VPQ G L TE G +++ P
Sbjct: 134 RSITTAGDVLGQTGMAAHVYVANRSMVDDHFFNADGELLVVPQVGALRFVTEMGVIELRP 193
Query: 182 GEIAMLPQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFE 241
GEIA+LP+G F +L D RGYV E +G LPD GPIGAN LA PRDF P AWFE
Sbjct: 194 GEIAVLPRGLVFKAELVDKDVRGYVCENYGAKLTLPDRGPIGANCLANPRDFKTPCAWFE 253
Query: 242 DKSYPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPS 301
+K P IV K+ G SP +VVAW GNY PYKYDL+ F P +LFDH DPS
Sbjct: 254 EKETPCRLIV-KWCGNFHVTEIGHSPLDVVAWHGNYAPYKYDLATFSPVGAILFDHPDPS 312
Query: 302 INTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDG 361
I TVLTAP+ + G A +DFVIFPPRWLVAE TFRPP+YHRN MSEFMGLIHG Y+AK +G
Sbjct: 313 IFTVLTAPSGEEGTANIDFVIFPPRWLVAEDTFRPPWYHRNIMSEFMGLIHGQYDAKEEG 372
Query: 362 FLPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALES 421
F+PGG SLH+ M HGPD +E A D+ P K+ +TMAFMFE+ ++R+ E
Sbjct: 373 FVPGGISLHNLMLAHGPDAPGFEK--ASRADLKPVKLDNTMAFMFETRFPQMLTRYGAEL 430
Query: 422 PFLDHDYYQCWIGLRSHFNVT 442
+Y CW L+ FN T
Sbjct: 431 ETRQDNYIDCWADLKKRFNGT 451
>HGD_BRAJA (Q89XH1) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 448
Score = 420 bits (1079), Expect = e-117
Identities = 214/429 (49%), Positives = 272/429 (62%), Gaps = 5/429 (1%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
Y+SGFGN F +EAL GALP +NSP C YGLYAEQ+SG+ FT+PR N SW YR++PS
Sbjct: 21 YMSGFGNSFETEALPGALPIGRNSPQRCAYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS 80
Query: 72 VTHEPFKPRVPCNGRILSEFNHSNSSTNPTQLRWKPMDSPDSPTDFIDGLSTVCGSGSSF 131
V H + G S H Q+RW P P F+ G+ T+ +G
Sbjct: 81 VKHSGRFEKADA-GLWRSAPCHEYDLPI-AQMRWDPTPVPKEEVTFVQGVQTMTTAGDVN 138
Query: 132 MRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQGF 191
+ G A H+Y KSM + F NADG+ + V QQG L + TE GR+ PGEI ++P+G
Sbjct: 139 TQAGMAAHVYLITKSMVDQHFYNADGELMFVLQQGNLRLVTEFGRIDAEPGEIVVIPRGV 198
Query: 192 RFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPGYTIV 251
+F V++P+GP+RGY+ E +G F LP+ GPIGAN LA RDFL P A +EDK P V
Sbjct: 199 KFRVEIPNGPARGYLCENYGGAFTLPERGPIGANCLANARDFLTPVANYEDKDTPTELFV 258
Query: 252 QKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTAPTD 311
K+GG LF SP +VVAW GNY PYKYDL F P + FDH DPSI TVLT+P++
Sbjct: 259 -KWGGSLFKTTLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSE 317
Query: 312 KPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGASLHS 371
G A +DFVIFP RW+VA++TFRPP+YH N MSEFMGLI+G Y+AK GF+PGG SLH+
Sbjct: 318 TAGTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYGVYDAKPQGFVPGGMSLHN 377
Query: 372 CMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHDYYQC 431
CM PHGPD ++E A ++ P K+T TMAFMFE+ R++ A + L DY C
Sbjct: 378 CMLPHGPDRDAFEH--ASNGELKPVKLTGTMAFMFETRYPQRVTAHAANASTLQDDYADC 435
Query: 432 WIGLRSHFN 440
W GL F+
Sbjct: 436 WKGLEKRFD 444
>HGD_RHIME (Q9X4F5) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 453
Score = 411 bits (1056), Expect = e-114
Identities = 214/440 (48%), Positives = 272/440 (61%), Gaps = 20/440 (4%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
Y+ GFGN F +E+L GALP+ QNSP C YGLYAEQ+SG+ FT+PR N SW YR++PS
Sbjct: 21 YMPGFGNDFETESLPGALPQGQNSPQKCNYGLYAEQLSGSPFTAPRGTNERSWLYRIRPS 80
Query: 72 VTHEPFKPRVPCNGRILSEFNHSNSSTNPT-------QLRWKPMDSPDSPTDFIDGLSTV 124
V H RV ++ H ++ + QLRW P+ +P DF+ G+ T+
Sbjct: 81 VRHTGRFRRV--------DYPHWKTAPHVGEHSLALGQLRWSPLPAPSEALDFLQGIRTM 132
Query: 125 CGSGSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEI 184
+G + + G A H Y N M + F NADG+ LIVP+ G + + TE GR+ V P EI
Sbjct: 133 TTAGDALTQAGMAAHAYAFNADMVDDYFFNADGELLIVPETGAIQVFTELGRMDVEPSEI 192
Query: 185 AMLPQGFRFTVDL--PDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFED 242
++P+G F V + RGY+ E +G F LPD GPIGAN LA PRDF P A +ED
Sbjct: 193 CLIPRGMMFKVTRLGEEKVWRGYICENYGAKFTLPDRGPIGANCLANPRDFKTPVAAYED 252
Query: 243 KSYPGYTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSI 302
K P V K+ G SP +VVAW GNY PYKYDL F P +LFDH DPSI
Sbjct: 253 KETPCRVQV-KWCGSFHMVEIGHSPLDVVAWHGNYAPYKYDLKTFSPVGAILFDHPDPSI 311
Query: 303 NTVLTAPTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGF 362
TVLTAP+ + G A +DFVIFPPRWLVAEHTFRPP+YHRN MSEFMGLI+G Y+AK +GF
Sbjct: 312 FTVLTAPSGEEGTANVDFVIFPPRWLVAEHTFRPPWYHRNIMSEFMGLIYGRYDAKEEGF 371
Query: 363 LPGGASLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESP 422
+PGG SLH+ M HGPD +E A ++ P K+ +TMAFMFE+ +++ +A E
Sbjct: 372 VPGGMSLHNMMLAHGPDFSGFEK--ASNGELKPVKLDNTMAFMFETRFPQQLTTFAAELD 429
Query: 423 FLDHDYYQCWIGLRSHFNVT 442
L DY CW GL F+ T
Sbjct: 430 TLQDDYMDCWSGLERKFDGT 449
>HGD_LEGPN (Q9S4T0) Homogentisate 1,2-dioxygenase (EC 1.13.11.5)
(Homogentisicase) (Homogentisate oxygenase)
(Homogentisic acid oxidase)
Length = 416
Score = 394 bits (1011), Expect = e-109
Identities = 211/433 (48%), Positives = 274/433 (62%), Gaps = 23/433 (5%)
Query: 12 YLSGFGNHFSSEALAGALPEAQNSPLICPYGLYAEQISGTSFTSPRNLNLFSWFYRVKPS 71
YL GFGN+ SEA+ GALP QNSP C GLYAEQ+SGT+FT PR+ NL SW YR+ P+
Sbjct: 2 YLQGFGNYHHSEAVKGALPPNQNSPQHCSLGLYAEQLSGTAFTRPRHNNLRSWLYRILPT 61
Query: 72 VTHEPFKPRVPCNGRILSEFNHSN---SSTNPTQLRWKPM-DSPDSPTDFIDGLSTVCGS 127
VT + P EFN +P +RW P+ +S DF++GL + GS
Sbjct: 62 VTQGTYYPY---------EFNIMQPFVDELSPNAMRWSPLYNSSQIKCDFVEGLFHIAGS 112
Query: 128 GSSFMRHGYAIHMYTANKSMNNCAFCNADGDFLIVPQQGRLFITTECGRLKVSPGEIAML 187
+ Y N SM++ F N DG+ L VP G + + TE G+L +S G IA++
Sbjct: 113 PL------VNTYTYYCNHSMSDKYFANNDGELLFVPYAGEIHLHTEFGKLMLSSGSIAVI 166
Query: 188 PQGFRFTVDLPDGPSRGYVAEIFGTHFQLPDLGPIGANGLAAPRDFLVPTAWFEDKSYPG 247
P+G +F V++ ++GY+ E G LP LGPIGANGLA PR F P A FE+ S
Sbjct: 167 PRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFEN-SGSE 225
Query: 248 YTIVQKFGGELFSAVQDFSPFNVVAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLT 307
+TI+ K +L+ V + SP NVVAW GNY PY YDLS F NTV FDH DPSI TVLT
Sbjct: 226 HTIICKNQKKLWFTVCNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLT 285
Query: 308 APTDKPGVALLDFVIFPPRWLVAEHTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGA 367
+ ++ PGV+ LDFVIFPPRW+VAEHTFRPPY+HRN M+E MGL++G Y+AK +GF+PGG
Sbjct: 286 SESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRNYMNELMGLVYGEYDAKKEGFIPGGI 345
Query: 368 SLHSCMTPHGPDTKSYEATIARGNDVGPNKITDTMAFMFESCLIPRISRWALESPFLDHD 427
S+H+CMTPHGPD +SYE IA D+ PN I +++AFMFE+ +++ A P D
Sbjct: 346 SIHNCMTPHGPDYESYE--IAASQDLKPNYI-NSLAFMFETKDYWQVTEQAYRHPSRQMD 402
Query: 428 YYQCWIGLRSHFN 440
Y CW G + F+
Sbjct: 403 YLNCWQGFKIEFS 415
>YD45_VIBCH (Q9KSB4) Putative dioxygenase VC1345 (EC 1.13.-.-)
Length = 378
Score = 66.6 bits (161), Expect = 1e-10
Identities = 65/259 (25%), Positives = 111/259 (42%), Gaps = 18/259 (6%)
Query: 154 NADGDFLIVPQQGRLFITTECGRLKVSPGEIAMLPQGFRFTVDLPDGPSRGYVAEIFGTH 213
NADGD L+ QG+ + + G + VS G+ A++P+ + ++ P P + E
Sbjct: 107 NADGDELLFIHQGKADLYCDYGHMVVSEGDYALIPRSTNWRLE-PIEPLFILMIENTDAA 165
Query: 214 FQLPDLGPIGANGLAAPRDFLVPTA--WFEDKSYPGYTIVQ-KFGGELFSAVQDFSPFNV 270
+ LP+ G +G + + P VP+ F + T VQ K G+L + F+P +
Sbjct: 166 YALPEKGLVGNHAVFDPAVLDVPSINDQFRAQYSEQQTQVQVKRHGQLSTITFPFNPLDA 225
Query: 271 VAWRGNYVPYKYDLSKFCPYNTVLFDHSDPSINTVLTAPTDKPGVALLDFVIFPPRWLVA 330
V W G+ + + P + + H PS +T G + FV PR + +
Sbjct: 226 VGWHGDLSVVRLNWRDIRPLMSHRY-HLPPSAHTTFVG----QGFVVCTFV---PRPIES 277
Query: 331 E-HTFRPPYYHRNCMSEFMGLIHGGYEAKVDGFLPGGASLHSCMTPHGPDTKSYEATIAR 389
+ + P+YH N + + H G D G + H HGP K+++A +
Sbjct: 278 DPGALKVPFYHNNDDYDEVLFYHAGDFFSRDNIEAGMVTFHPAGFTHGPHPKAFQAGLEY 337
Query: 390 GNDVGPNKITDTMAFMFES 408
K TD +A M ++
Sbjct: 338 -----RKKFTDEVAVMIDT 351
Database: sprot
Posted date: Nov 25, 2004 10:54 AM
Number of letters in database: 59,974,054
Number of sequences in database: 164,201
Lambda K H
0.321 0.139 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,546,457
Number of Sequences: 164201
Number of extensions: 2927132
Number of successful extensions: 5284
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 5180
Number of HSP's gapped (non-prelim): 27
length of query: 463
length of database: 59,974,054
effective HSP length: 114
effective length of query: 349
effective length of database: 41,255,140
effective search space: 14398043860
effective search space used: 14398043860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Lotus: description of TM0282.7